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Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
[中文简述(自动翻译):]  儿茶酚-O-甲基催化甲基从S-腺苷甲硫氨酸转移至儿茶酚胺,包括神经递质多巴胺,肾上腺素和去甲肾上腺素。此O-甲基化导致儿茶酚胺发射机的主要降解途径之一。除了其内源性物质的代谢作用,COMT是在高血压,哮喘,和帕金森病的治疗中使用儿茶酚药物的代谢重要。 COMT以两种形式在组织中,可溶形式的(S-COMT)和膜结合形式(MB-COMT)找到。的S-COMT和MB-COMT的区别驻留在N-末端内。几个转录变体通过使用替代翻译起始位点和启动子形成。 [由RefSeq的,2008年9月提供]
COMT基因(以及对应的蛋白质)的细胞分布位置:
COMT基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Schizophrenia | 0.345417491 | 275 | 10 | BeFree_CTD_human_GAD_LHGDN |
DiGeorge Syndrome | 0.279553364 | 26 | 3 | BeFree_CTD_human_GAD_LHGDN_ORPHANET |
HEARING LOSS, CISPLATIN-INDUCED, SUSCEPTIBILITY TO | 0.24 | 1 | 0 | CTD_human_ORPHANET |
Pain | 0.236471695 | 35 | 6 | BeFree_CTD_human_GAD_RGD |
Bipolar Disorder | 0.180627479 | 50 | 2 | BeFree_CTD_human_GAD_LHGDN |
Attention deficit hyperactivity disorder | 0.17780732 | 61 | 16 | BeFree_CTD_human_GAD |
Panic Disorder | 0.162449467 | 22 | 3 | BeFree_CTD_human_GAD_LHGDN |
Alcoholic Intoxication, Chronic | 0.157100455 | 27 | 3 | BeFree_CTD_human_GAD_LHGDN |
Mammary Neoplasms | 0.144161834 | 11 | 0 | CTD_human_GAD_LHGDN |
Shprintzen syndrome | 0.134581916 | 45 | 3 | BeFree_GAD_ORPHANET |
Mental disorders | 0.132410381 | 39 | 1 | BeFree_CTD_human_GAD |
Autistic Disorder | 0.125276948 | 5 | 1 | BeFree_CTD_human_GAD |
22q11 Deletion Syndrome | 0.124267125 | 8 | 1 | BeFree_GAD_ORPHANET |
Fetal Growth Retardation | 0.122367032 | 2 | 0 | CTD_human_GAD |
Animal Mammary Neoplasms | 0.122367032 | 2 | 0 | CTD_human_GAD |
Amphetamine-Related Disorders | 0.122367032 | 2 | 0 | CTD_human_GAD |
Cocaine-Related Disorders | 0.122367032 | 1 | 0 | CTD_human_GAD |
Liver carcinoma | 0.120542884 | 2 | 0 | BeFree_CTD_human |
Pheochromocytoma | 0.120271442 | 1 | 0 | BeFree_CTD_human |
Cognition Disorders | 0.12 | 1 | 0 | CTD_human |
Prostatic Neoplasms | 0.12 | 1 | 0 | CTD_human |
CONOTRUNCAL ANOMALY FACE SYNDROME | 0.12 | 0 | 0 | ORPHANET |
22q11 partial monosomy syndrome | 0.12 | 0 | 0 | ORPHANET |
Malignant neoplasm of breast | 0.101172466 | 99 | 10 | BeFree_GAD |
Hypertensive disease | 0.093006804 | 10 | 1 | BeFree_GAD_LHGDN_RGD |
Dyskinesia, Drug-Induced | 0.082367032 | 2 | 0 | GAD_RGD |
Pre-Eclampsia | 0.082367032 | 1 | 0 | GAD_MGD |
Parkinsonian Disorders | 0.080814326 | 4 | 0 | BeFree_RGD |
Catalepsy | 0.08 | 1 | 0 | RGD |
Diabetes Mellitus, Experimental | 0.08 | 1 | 0 | RGD |
Parkinson Disease | 0.057685225 | 28 | 1 | BeFree_GAD_LHGDN |
Mental Depression | 0.037633407 | 41 | 14 | BeFree_GAD |
Obsessive-Compulsive Disorder | 0.034352361 | 30 | 1 | BeFree_GAD_LHGDN |
Psychotic Disorders | 0.032051342 | 48 | 3 | BeFree_GAD_LHGDN |
Alzheimer's Disease | 0.026285049 | 11 | 0 | BeFree_GAD_LHGDN |
Fibromyalgia | 0.023451079 | 16 | 2 | BeFree_GAD_LHGDN |
Breast Carcinoma | 0.021172466 | 78 | 10 | BeFree |
Malignant neoplasm of prostate | 0.021107791 | 13 | 6 | BeFree_GAD |
Congenital diverticulum of pharynx | 0.018936256 | 8 | 0 | GAD |
Anxiety Disorders | 0.016948948 | 45 | 4 | BeFree_GAD |
Tobacco Use Disorder | 0.016569224 | 7 | 0 | GAD |
Fibroid Tumor | 0.015731154 | 6 | 0 | BeFree_GAD_LHGDN |
Major Depressive Disorder | 0.01560167 | 30 | 6 | BeFree_GAD_LHGDN |
Endometrial Neoplasms | 0.015274147 | 5 | 0 | GAD_LHGDN |
Mood Disorders | 0.014168516 | 20 | 2 | BeFree_GAD_LHGDN |
Marijuana Abuse | 0.01408264 | 20 | 10 | BeFree_GAD |
Endometrial Carcinoma | 0.014006695 | 12 | 3 | BeFree_GAD |
Malignant neoplasm of lung | 0.012649486 | 8 | 1 | BeFree_GAD |
Malignant neoplasm of ovary | 0.012649486 | 8 | 1 | BeFree_GAD |
Anorexia Nervosa | 0.012082858 | 7 | 1 | BeFree_GAD_LHGDN |
As If Personality | 0.01183516 | 5 | 0 | GAD |
Uterine Neoplasms | 0.01183516 | 5 | 0 | GAD |
Personality Traits | 0.01183516 | 5 | 0 | GAD |
Substance-Related Disorders | 0.01183516 | 5 | 0 | GAD |
Nonorganic psychosis | 0.011672 | 43 | 3 | BeFree |
Obesity | 0.010553895 | 6 | 0 | BeFree_GAD |
Pain, Postoperative | 0.009272631 | 10 | 0 | BeFree_GAD |
Depressive disorder | 0.009229024 | 34 | 14 | BeFree |
Unipolar Depression | 0.008414698 | 31 | 6 | BeFree |
Malignant neoplasm of urinary bladder | 0.007915422 | 4 | 0 | BeFree_GAD |
Heroin Dependence | 0.007915422 | 6 | 1 | BeFree_GAD |
Mental Retardation | 0.00764398 | 4 | 0 | BeFree_GAD |
Vitiligo | 0.00764398 | 4 | 0 | BeFree_GAD |
Colorectal Cancer | 0.00764398 | 5 | 0 | BeFree_GAD |
Malignant neoplasm of liver | 0.007372538 | 3 | 0 | BeFree_GAD |
Sleep Deprivation | 0.007101096 | 3 | 0 | GAD |
Endometriosis | 0.006905599 | 9 | 0 | BeFree_GAD |
Hallucinations | 0.006362715 | 7 | 4 | BeFree_GAD |
Temporomandibular Joint Disorders | 0.006362715 | 7 | 0 | BeFree_GAD |
Mammographic Density | 0.006362715 | 7 | 6 | BeFree_GAD |
Headache | 0.006091273 | 6 | 1 | BeFree_GAD |
Eating Disorders | 0.005819831 | 4 | 2 | BeFree_GAD |
Narcolepsy | 0.005819831 | 4 | 0 | BeFree_GAD |
Dyspepsia | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
NEUROTICISM | 0.005352893 | 11 | 1 | BeFree_GAD |
Low Back Pain | 0.005276948 | 4 | 1 | BeFree_GAD |
Shoulder Pain | 0.005276948 | 2 | 0 | BeFree_GAD |
Alcohol abuse | 0.005276948 | 4 | 0 | BeFree_GAD |
Osteochondritis Dissecans | 0.005157396 | 19 | 1 | BeFree |
PANIC DISORDER 1 | 0.005157396 | 19 | 3 | BeFree |
Venous Thrombosis | 0.005091382 | 1 | 0 | GAD_LHGDN |
Antisocial behavior | 0.005081451 | 10 | 1 | BeFree_GAD |
Prostate carcinoma | 0.005081451 | 10 | 6 | BeFree_GAD |
Lymphoma, Non-Hodgkin | 0.005005506 | 2 | 0 | BeFree_GAD |
Chromosome Aberrations | 0.004734064 | 2 | 0 | GAD |
Chromosome Deletion | 0.004734064 | 2 | 0 | GAD |
Esophageal Neoplasms | 0.004734064 | 2 | 0 | GAD |
Chronic Fatigue Syndrome | 0.004734064 | 2 | 0 | GAD |
Head and Neck Neoplasms | 0.004734064 | 2 | 0 | GAD |
Laryngeal neoplasm | 0.004734064 | 2 | 0 | GAD |
Memory Disorders | 0.004734064 | 2 | 0 | GAD |
Mouth Neoplasms | 0.004734064 | 2 | 0 | GAD |
Pharyngeal Neoplasms | 0.004734064 | 2 | 0 | GAD |
Prenatal Exposure Delayed Effects | 0.004734064 | 2 | 0 | GAD |
Psychoses, Substance-Induced | 0.004734064 | 2 | 0 | GAD |
Weight Gain | 0.004734064 | 2 | 0 | GAD |
Helicobacter Infections | 0.004734064 | 2 | 0 | GAD |
Menopause present (finding) | 0.004734064 | 2 | 0 | GAD |
Weight Gain Adverse Event | 0.004734064 | 2 | 0 | GAD |
Migraine Disorders | 0.004267125 | 7 | 2 | BeFree_GAD |
Dementia | 0.004267125 | 8 | 1 | BeFree_GAD |
Dyskinetic syndrome | 0.00408156 | 6 | 1 | BeFree_LHGDN |
Lingual-Facial-Buccal Dyskinesia | 0.003995683 | 6 | 1 | BeFree_GAD |
Carcinogenesis | 0.003800186 | 14 | 1 | BeFree |
MAJOR AFFECTIVE DISORDER 2 | 0.003724241 | 5 | 1 | BeFree_GAD |
MAJOR AFFECTIVE DISORDER 1 | 0.003724241 | 5 | 1 | BeFree_GAD |
MAJOR AFFECTIVE DISORDER 4 | 0.003724241 | 5 | 1 | BeFree_GAD |
MAJOR AFFECTIVE DISORDER 5 | 0.003724241 | 5 | 1 | BeFree_GAD |
MAJOR AFFECTIVE DISORDER 6 | 0.003724241 | 5 | 1 | BeFree_GAD |
MAJOR AFFECTIVE DISORDER 7 | 0.003724241 | 5 | 1 | BeFree_GAD |
MAJOR AFFECTIVE DISORDER 8 | 0.003724241 | 5 | 1 | BeFree_GAD |
MAJOR AFFECTIVE DISORDER 9 | 0.003724241 | 5 | 1 | BeFree_GAD |
Cardiovascular Diseases | 0.003452799 | 5 | 0 | BeFree_GAD |
Impaired cognition | 0.003257302 | 12 | 2 | BeFree |
Bulimia | 0.003181358 | 4 | 2 | BeFree_GAD |
Intervertebral Disc Degeneration | 0.003181358 | 3 | 0 | BeFree_GAD |
Psychotic symptom | 0.002985861 | 11 | 1 | BeFree |
Atherosclerosis | 0.002909916 | 2 | 0 | BeFree_GAD |
Renal Cell Carcinoma | 0.002909916 | 2 | 0 | BeFree_GAD |
Kidney Failure, Acute | 0.002909916 | 2 | 1 | BeFree_GAD |
Multiple Sclerosis | 0.002909916 | 3 | 1 | BeFree_GAD |
Myocardial Infarction | 0.002909916 | 2 | 1 | BeFree_GAD |
Oppositional Defiant Disorder | 0.002909916 | 3 | 1 | BeFree_GAD |
Gilles de la Tourette syndrome | 0.002909916 | 3 | 0 | BeFree_GAD |
Methamphetamine abuse | 0.002909916 | 2 | 0 | BeFree_GAD |
Bladder Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Colonic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Hereditary Nonpolyposis Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Wolfram Syndrome | 0.00272435 | 1 | 0 | LHGDN |
Polyneuropathy | 0.00272435 | 1 | 0 | LHGDN |
Depressive Symptoms | 0.002714419 | 10 | 1 | BeFree |
Adenocarcinoma | 0.002638474 | 2 | 1 | BeFree_GAD |
Alexithymia | 0.002638474 | 1 | 0 | BeFree_GAD |
Diabetes Mellitus | 0.002638474 | 2 | 0 | BeFree_GAD |
Diabetes Mellitus, Non-Insulin-Dependent | 0.002638474 | 1 | 0 | BeFree_GAD |
Diarrhea | 0.002638474 | 2 | 0 | BeFree_GAD |
Gastritis | 0.002638474 | 1 | 0 | BeFree_GAD |
Herpes Simplex Infections | 0.002638474 | 2 | 1 | BeFree_GAD |
Kidney Failure, Chronic | 0.002638474 | 2 | 0 | BeFree_GAD |
Lymphoma | 0.002638474 | 1 | 0 | BeFree_GAD |
Mycetoma | 0.002638474 | 1 | 0 | BeFree_GAD |
Osteoporosis | 0.002638474 | 2 | 0 | BeFree_GAD |
Personality Disorders | 0.002638474 | 2 | 0 | BeFree_GAD |
Subarachnoid Hemorrhage | 0.002638474 | 1 | 0 | BeFree_GAD |
Substance Withdrawal Syndrome | 0.002638474 | 2 | 1 | BeFree_GAD |
Vomiting | 0.002638474 | 2 | 1 | BeFree_GAD |
Depression, Postpartum | 0.002638474 | 2 | 1 | BeFree_GAD |
Common Migraine | 0.002638474 | 2 | 0 | BeFree_GAD |
Phobic anxiety disorder | 0.002638474 | 2 | 1 | BeFree_GAD |
Hepatitis C, Chronic | 0.002638474 | 1 | 0 | BeFree_GAD |
Hot flushes | 0.002638474 | 2 | 1 | BeFree_GAD |
Heroin Abuse | 0.002638474 | 2 | 1 | BeFree_GAD |
Epithelial ovarian cancer | 0.002638474 | 2 | 0 | BeFree_GAD |
Uterine Fibroids | 0.002442977 | 9 | 7 | BeFree |
Anxiety | 0.002367032 | 1 | 0 | GAD |
Arthralgia | 0.002367032 | 1 | 0 | GAD |
Neoplastic Cell Transformation | 0.002367032 | 1 | 0 | GAD |
Constipation | 0.002367032 | 1 | 0 | GAD |
Crohn Disease | 0.002367032 | 1 | 0 | GAD |
DNA Damage | 0.002367032 | 1 | 0 | GAD |
Endocrine System Diseases | 0.002367032 | 1 | 0 | GAD |
Gastrointestinal Diseases | 0.002367032 | 1 | 0 | GAD |
Female Genital Diseases | 0.002367032 | 1 | 0 | GAD |
Gout | 0.002367032 | 1 | 0 | GAD |
Hyperalgesia | 0.002367032 | 1 | 0 | GAD |
Kidney Neoplasm | 0.002367032 | 1 | 0 | GAD |
Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
Malignant Carcinoid Syndrome | 0.002367032 | 1 | 0 | GAD |
Mesothelioma | 0.002367032 | 1 | 0 | GAD |
Metaplasia | 0.002367032 | 1 | 0 | GAD |
Movement Disorders | 0.002367032 | 1 | 0 | GAD |
Musculoskeletal Diseases | 0.002367032 | 1 | 0 | GAD |
Opioid-Related Disorders | 0.002367032 | 1 | 0 | GAD |
Nausea | 0.002367032 | 1 | 0 | GAD |
Occupational Diseases | 0.002367032 | 1 | 0 | GAD |
Ocular Motility Disorders | 0.002367032 | 1 | 0 | GAD |
Osteoarthritis of hip | 0.002367032 | 1 | 0 | GAD |
Pain, Intractable | 0.002367032 | 1 | 0 | GAD |
Pleural Neoplasms | 0.002367032 | 1 | 0 | GAD |
Pregnancy Complications | 0.002367032 | 1 | 0 | GAD |
Restless Legs Syndrome | 0.002367032 | 1 | 0 | GAD |
Shock | 0.002367032 | 1 | 0 | GAD |
Speech Disorders | 0.002367032 | 1 | 0 | GAD |
Stomach Neoplasms | 0.002367032 | 1 | 0 | GAD |
Thyroid Neoplasm | 0.002367032 | 1 | 0 | GAD |
Bronchial Hyperreactivity | 0.002367032 | 1 | 0 | GAD |
Migraine with Aura | 0.002367032 | 1 | 0 | GAD |
Amyloid Neuropathies, Familial | 0.002367032 | 1 | 0 | GAD |
Leiomyomatosis | 0.002367032 | 1 | 0 | GAD |
Medullary carcinoma | 0.002367032 | 1 | 0 | GAD |
Oxidative Stress | 0.002367032 | 1 | 0 | GAD |
Physical aggression | 0.002367032 | 1 | 0 | GAD |
Response to pain finding | 0.002367032 | 1 | 0 | GAD |
Dyslexia | 0.002367032 | 1 | 0 | GAD |
Premenstrual Dysphoric Disorder | 0.002367032 | 1 | 0 | GAD |
Postoperative Nausea and Vomiting | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of esophagus | 0.002367032 | 1 | 0 | GAD |
Hyperhomocysteinemia | 0.002367032 | 1 | 0 | GAD |
Vasospasm, Intracranial | 0.002367032 | 1 | 0 | GAD |
Sleep Disorders | 0.002367032 | 1 | 0 | GAD |
Genomic Instability | 0.002367032 | 1 | 0 | GAD |
Acute Coronary Syndrome | 0.002367032 | 1 | 0 | GAD |
Testicular Germ Cell Tumor | 0.002367032 | 1 | 0 | GAD |
Cirrhosis | 0.002367032 | 1 | 0 | GAD |
Maduromycosis | 0.002367032 | 1 | 0 | GAD |
Weight Loss Adverse Event | 0.002367032 | 1 | 0 | GAD |
Borderline Personality Disorder | 0.002171535 | 8 | 2 | BeFree |
Nicotine Dependence | 0.002171535 | 8 | 1 | BeFree |
Chronic pain | 0.002171535 | 8 | 2 | BeFree |
Malignant neoplasm of endometrium | 0.001900093 | 7 | 1 | BeFree |
Uterine Corpus Cancer | 0.001900093 | 7 | 1 | BeFree |
Bronchopulmonary Dysplasia | 0.001628651 | 6 | 1 | BeFree |
Presenile dementia | 0.001628651 | 6 | 0 | BeFree |
Violence | 0.001628651 | 6 | 1 | BeFree |
Tardive Dyskinesia | 0.001628651 | 6 | 1 | BeFree |
Affective Disorders, Psychotic | 0.001357209 | 5 | 1 | BeFree |
Drug abuse | 0.001357209 | 5 | 0 | BeFree |
Irritable Bowel Syndrome | 0.001357209 | 5 | 1 | BeFree |
nervous system disorder | 0.001357209 | 5 | 2 | BeFree |
Post-Traumatic Stress Disorder | 0.001357209 | 5 | 1 | BeFree |
Temporomandibular Joint Dysfunction Syndrome | 0.001357209 | 5 | 1 | BeFree |
Chronic schizophrenia | 0.001357209 | 5 | 1 | BeFree |
Memory impairment | 0.001357209 | 5 | 1 | BeFree |
Absence of pain sensation | 0.001357209 | 5 | 0 | BeFree |
Autism Spectrum Disorders | 0.001357209 | 5 | 2 | BeFree |
TIBIAL MUSCULAR DYSTROPHY, TARDIVE | 0.001357209 | 5 | 1 | BeFree |
Atrial Septal Defects | 0.001085767 | 4 | 1 | BeFree |
Schizoaffective Disorder | 0.001085767 | 4 | 0 | BeFree |
Conduct Disorder | 0.001085767 | 4 | 1 | BeFree |
Drug usage | 0.001085767 | 4 | 1 | BeFree |
Manic | 0.001085767 | 4 | 1 | BeFree |
Mixed anxiety and depressive disorder | 0.001085767 | 4 | 1 | BeFree |
Ichthyosis Bullosa of Siemens | 0.001085767 | 4 | 1 | BeFree |
Cancer pain | 0.001085767 | 4 | 1 | BeFree |
Substance abuse problem | 0.001085767 | 4 | 0 | BeFree |
Bipolar I disorder | 0.001085767 | 4 | 0 | BeFree |
Malignant tumor of colon | 0.000814326 | 3 | 1 | BeFree |
Female Breast Carcinoma | 0.000814326 | 3 | 1 | BeFree |
Delusions | 0.000814326 | 3 | 2 | BeFree |
Ovarian Carcinoma | 0.000814326 | 3 | 1 | BeFree |
Hearing Loss, Mixed Conductive-Sensorineural | 0.000814326 | 3 | 0 | BeFree |
Psychiatric symptom | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of female breast | 0.000814326 | 3 | 1 | BeFree |
Bipolar II disorder | 0.000814326 | 3 | 0 | BeFree |
Pain Disorder | 0.000814326 | 3 | 0 | BeFree |
Metabolic Syndrome X | 0.000814326 | 3 | 0 | BeFree |
Carcinoma of lung | 0.000814326 | 3 | 1 | BeFree |
Colon Carcinoma | 0.000814326 | 3 | 1 | BeFree |
Carcinoma of bladder | 0.000814326 | 3 | 0 | BeFree |
homicidal | 0.000814326 | 3 | 2 | BeFree |
Acute postoperative pain | 0.000814326 | 3 | 0 | BeFree |
Bulimia Nervosa | 0.000814326 | 3 | 1 | BeFree |
Arteriosclerosis | 0.000542884 | 2 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 4 | BeFree |
Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Coronary Arteriosclerosis | 0.000542884 | 2 | 2 | BeFree |
Coronary heart disease | 0.000542884 | 2 | 1 | BeFree |
Eclampsia | 0.000542884 | 2 | 1 | BeFree |
Fatigue | 0.000542884 | 2 | 1 | BeFree |
Neuralgia | 0.000542884 | 2 | 0 | BeFree |
Polycystic Ovary Syndrome | 0.000542884 | 2 | 0 | BeFree |
Stress, Psychological | 0.000542884 | 2 | 0 | BeFree |
Substance Use Disorders | 0.000542884 | 2 | 0 | BeFree |
Tobacco Dependence | 0.000542884 | 2 | 0 | BeFree |
Spina Bifida | 0.000542884 | 2 | 1 | BeFree |
Apathy | 0.000542884 | 2 | 1 | BeFree |
Dysphoric mood | 0.000542884 | 2 | 3 | BeFree |
Extrapyramidal sign | 0.000542884 | 2 | 0 | BeFree |
Generalized Anxiety Disorder | 0.000542884 | 2 | 0 | BeFree |
Endometriosis of uterus | 0.000542884 | 2 | 0 | BeFree |
Abnormal involuntary movement | 0.000542884 | 2 | 1 | BeFree |
Inattention | 0.000542884 | 2 | 0 | BeFree |
Opiate Addiction | 0.000542884 | 2 | 2 | BeFree |
Cocaine Dependence | 0.000542884 | 2 | 1 | BeFree |
Premenopausal breast cancer | 0.000542884 | 2 | 2 | BeFree |
manic symptom | 0.000542884 | 2 | 0 | BeFree |
Schizophrenia and related disorders | 0.000542884 | 2 | 0 | BeFree |
Invasive breast carcinoma | 0.000542884 | 2 | 0 | BeFree |
Impulsive aggression | 0.000542884 | 2 | 1 | BeFree |
Mild cognitive disorder | 0.000542884 | 2 | 1 | BeFree |
Generalized vitiligo | 0.000542884 | 2 | 0 | BeFree |
Cognitive changes | 0.000542884 | 2 | 3 | BeFree |
Paranoia | 0.000542884 | 2 | 0 | BeFree |
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | 0.000542884 | 2 | 0 | BeFree |
Alcohol Withdrawal Delirium | 0.000271442 | 1 | 0 | BeFree |
Anaplasia | 0.000271442 | 1 | 0 | BeFree |
Anemia, Sickle Cell | 0.000271442 | 1 | 2 | BeFree |
Anorexia | 0.000271442 | 1 | 0 | BeFree |
Behavior Disorders | 0.000271442 | 1 | 0 | BeFree |
Depression, Bipolar | 0.000271442 | 1 | 0 | BeFree |
Cannabis Abuse | 0.000271442 | 1 | 0 | BeFree |
Rectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma | 0.000271442 | 1 | 2 | BeFree |
Carpal Tunnel Syndrome | 0.000271442 | 1 | 1 | BeFree |
Neck Pain | 0.000271442 | 1 | 0 | BeFree |
Endogenous depression | 0.000271442 | 1 | 0 | BeFree |
Disruptive Behavior Disorder | 0.000271442 | 1 | 0 | BeFree |
Dizziness | 0.000271442 | 1 | 0 | BeFree |
Endometrial Hyperplasia | 0.000271442 | 1 | 3 | BeFree |
Epilepsy | 0.000271442 | 1 | 3 | BeFree |
Breast Fibrocystic Disease | 0.000271442 | 1 | 0 | BeFree |
Flushing | 0.000271442 | 1 | 3 | BeFree |
Hepatitis C | 0.000271442 | 1 | 0 | BeFree |
Disruptive, Impulse Control, and Conduct Disorders | 0.000271442 | 1 | 0 | BeFree |
Liver diseases | 0.000271442 | 1 | 0 | BeFree |
Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Follicular | 0.000271442 | 1 | 1 | BeFree |
Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
Dental Fluorosis, Acquired | 0.000271442 | 1 | 0 | BeFree |
Narcissism | 0.000271442 | 1 | 0 | BeFree |
Nausea and vomiting | 0.000271442 | 1 | 0 | BeFree |
Neonatal Abstinence Syndrome | 0.000271442 | 1 | 0 | BeFree |
Neurotic Disorders | 0.000271442 | 1 | 0 | BeFree |
Ovarian Diseases | 0.000271442 | 1 | 0 | BeFree |
Pituitary Diseases | 0.000271442 | 1 | 0 | BeFree |
Psychoses, Drug | 0.000271442 | 1 | 1 | BeFree |
Paranoid Schizophrenia | 0.000271442 | 1 | 0 | BeFree |
Schizophreniform Disorders | 0.000271442 | 1 | 0 | BeFree |
Sciatica | 0.000271442 | 1 | 1 | BeFree |
Stereotyped Behavior | 0.000271442 | 1 | 0 | BeFree |
Vertigo | 0.000271442 | 1 | 0 | BeFree |
Seasonal Affective Disorder | 0.000271442 | 1 | 0 | BeFree |
Polydipsia | 0.000271442 | 1 | 0 | BeFree |
Depressive Syndrome | 0.000271442 | 1 | 0 | BeFree |
somatization | 0.000271442 | 1 | 0 | BeFree |
Central nervous system depression (disorder) | 0.000271442 | 1 | 0 | BeFree |
Drug withdrawal syndrome | 0.000271442 | 1 | 1 | BeFree |
Disorder of endocrine ovary | 0.000271442 | 1 | 0 | BeFree |
Acute onset pain | 0.000271442 | 1 | 2 | BeFree |
Kleine-Levin Syndrome | 0.000271442 | 1 | 0 | BeFree |
childhood brain tumor | 0.000271442 | 1 | 0 | BeFree |
Myalgia | 0.000271442 | 1 | 0 | BeFree |
Catch - Finding of sensory dimension of pain | 0.000271442 | 1 | 1 | BeFree |
Psychological symptom | 0.000271442 | 1 | 0 | BeFree |
Emotional disorder | 0.000271442 | 1 | 1 | BeFree |
Free-floating anxiety | 0.000271442 | 1 | 0 | BeFree |
Mechanical pain | 0.000271442 | 1 | 1 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Alcohol withdrawal syndrome | 0.000271442 | 1 | 0 | BeFree |
Alcohol or Other Drugs use | 0.000271442 | 1 | 0 | BeFree |
Desquamative interstitial pneumonia | 0.000271442 | 1 | 1 | BeFree |
Selenium deficiency | 0.000271442 | 1 | 0 | BeFree |
Prodrome | 0.000271442 | 1 | 0 | BeFree |
anxiety generalized | 0.000271442 | 1 | 0 | BeFree |
Impaired glucose tolerance | 0.000271442 | 1 | 0 | BeFree |
Malignant Childhood Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Liver and Intrahepatic Biliary Tract Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.000271442 | 1 | 0 | BeFree |
Prolapsed lumbar disc | 0.000271442 | 1 | 1 | BeFree |
Sexual abuse | 0.000271442 | 1 | 1 | BeFree |
Obesity, Abdominal | 0.000271442 | 1 | 1 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
Chronic tension-type headache | 0.000271442 | 1 | 1 | BeFree |
Chronic low back pain | 0.000271442 | 1 | 0 | BeFree |
Respiratory distress | 0.000271442 | 1 | 0 | BeFree |
Neurodegenerative Disorders | 0.000271442 | 1 | 0 | BeFree |
Aggressive personality | 0.000271442 | 1 | 1 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
Excessive daytime somnolence | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Anxiety state | 0.000271442 | 1 | 1 | BeFree |
Malignant neoplasm of kidney | 0.000271442 | 1 | 0 | BeFree |
Ovarian failure | 0.000271442 | 1 | 0 | BeFree |
Narcolepsy-Cataplexy Syndrome | 0.000271442 | 1 | 0 | BeFree |
Chronic Daily Headache | 0.000271442 | 1 | 0 | BeFree |
psychological distress | 0.000271442 | 1 | 0 | BeFree |
perfectionism | 0.000271442 | 1 | 0 | BeFree |
Carcinogenicity | 0.000271442 | 1 | 0 | BeFree |
social stress | 0.000271442 | 1 | 0 | BeFree |
Treatment related secondary malignancy | 0.000271442 | 1 | 0 | BeFree |
Ischemic stroke | 0.000271442 | 1 | 0 | BeFree |
Chronic pain syndrome | 0.000271442 | 1 | 0 | BeFree |
Chronic Cancer Pain | 0.000271442 | 1 | 1 | BeFree |
Hereditary Nonpolyposis Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
Sporadic Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Renal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Attention deficit-hyperactivity | 0.000271442 | 1 | 1 | BeFree |
Ovarian Insufficiency | 0.000271442 | 1 | 0 | BeFree |
Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
Benign Prostatic Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
COGNITIVE FUNCTION 1, SOCIAL | 0.000271442 | 1 | 0 | BeFree |
Coronary Artery Disease | 0.000271442 | 1 | 1 | BeFree |
Stimulant dependence | 0.000271442 | 1 | 0 | BeFree |
Executive dysfunction | 0.000271442 | 1 | 0 | BeFree |
headache severe | 0.000271442 | 1 | 0 | BeFree |
Nociceptive Pain | 0.000271442 | 1 | 0 | BeFree |
Ischemic Cerebrovascular Accident | 0.000271442 | 1 | 0 | BeFree |
dowling-degos disease | 0.000271442 | 1 | 0 | BeFree |
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