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This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
[中文简述(自动翻译):]  这个基因编码两种大麻素受体中的一个。大麻素,主要是δ-9-四氢大麻酚和合成的类似物,是大麻的精神成分。大麻素受体是偶联受体家族的鸟嘌呤核苷酸结合蛋白(G蛋白)的成员,其抑制腺苷酸环化酶活性的剂量依赖性,立体选择性和百日咳毒素敏感的方式。已发现两种受体是参与的大麻素诱导的CNS作用(包括情绪和认知改变)由大麻用户遇到。多个转录变异体的编码两种不同的蛋白异构体已经为这个基因描述。 [由RefSeq的,2009年5月提供]
CNR1基因(以及对应的蛋白质)的细胞分布位置:
CNR1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Schizophrenia | 0.243449358 | 29 | 0 | BeFree_CTD_human_GAD_LHGDN_RGD |
| Obesity | 0.232899343 | 40 | 1 | BeFree_CTD_human_GAD_RGD |
| Pain | 0.202367032 | 3 | 0 | CTD_human_GAD_RGD |
| Hypotension | 0.2 | 2 | 0 | CTD_human_RGD |
| Nerve Degeneration | 0.2 | 3 | 0 | CTD_human_RGD |
| Status Epilepticus | 0.2 | 1 | 0 | CTD_human_RGD |
| Marijuana Abuse | 0.134625523 | 21 | 0 | BeFree_CTD_human_GAD |
| Multiple Sclerosis | 0.125276948 | 4 | 0 | BeFree_CTD_human_GAD |
| Attention deficit hyperactivity disorder | 0.125005506 | 2 | 1 | BeFree_CTD_human_GAD |
| Liver Cirrhosis | 0.12272435 | 3 | 0 | CTD_human_LHGDN |
| Anxiety Disorders | 0.122442977 | 11 | 0 | BeFree_CTD_human |
| Substance Withdrawal Syndrome | 0.122367032 | 1 | 0 | CTD_human_GAD |
| Weight Gain | 0.122367032 | 2 | 0 | CTD_human_GAD |
| Cocaine-Related Disorders | 0.122367032 | 3 | 0 | CTD_human_GAD |
| Huntington Disease | 0.120542884 | 3 | 0 | BeFree_CTD_human |
| Rhabdomyosarcoma | 0.120271442 | 1 | 0 | BeFree_CTD_human |
| Catalepsy | 0.12 | 1 | 0 | CTD_human |
| Endometriosis | 0.12 | 1 | 0 | CTD_human |
| Epilepsy, Temporal Lobe | 0.12 | 1 | 0 | CTD_human |
| Hyperalgesia | 0.12 | 1 | 0 | CTD_human |
| Hypothermia, natural | 0.12 | 1 | 0 | CTD_human |
| Liver Cirrhosis, Experimental | 0.12 | 1 | 0 | CTD_human |
| Movement Disorders | 0.12 | 1 | 0 | CTD_human |
| Muscle Spasticity | 0.12 | 1 | 0 | CTD_human |
| Pancreatic Neoplasm | 0.12 | 1 | 0 | CTD_human |
| Pancreatitis | 0.12 | 1 | 0 | CTD_human |
| Seizures | 0.12 | 1 | 0 | CTD_human |
| Substance-Related Disorders | 0.12 | 3 | 0 | CTD_human |
| Insulin Resistance | 0.084734064 | 3 | 0 | GAD_RGD |
| Ascites | 0.08 | 1 | 0 | RGD |
| Diabetes Mellitus, Experimental | 0.08 | 1 | 0 | RGD |
| Diabetic Neuropathies | 0.08 | 1 | 0 | RGD |
| Epilepsies, Partial | 0.08 | 1 | 0 | RGD |
| Fever | 0.08 | 1 | 0 | RGD |
| Hypertensive disease | 0.08 | 1 | 0 | RGD |
| Myocardial Reperfusion Injury | 0.08 | 1 | 0 | RGD |
| Peptic Ulcer | 0.08 | 1 | 0 | RGD |
| Reperfusion Injury | 0.08 | 1 | 0 | RGD |
| Shock, Hemorrhagic | 0.08 | 1 | 0 | RGD |
| Erectile dysfunction | 0.08 | 1 | 0 | RGD |
| Parkinsonian Disorders | 0.08 | 1 | 0 | RGD |
| Mental Depression | 0.006362715 | 7 | 0 | BeFree_GAD |
| Parkinson Disease | 0.0054487 | 2 | 0 | LHGDN |
| Skin Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
| Post-Traumatic Stress Disorder | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
| Inflammation | 0.005091382 | 2 | 0 | GAD_LHGDN |
| Alcoholic Intoxication, Chronic | 0.004538567 | 8 | 0 | BeFree_GAD |
| Metabolic Syndrome X | 0.003995683 | 6 | 1 | BeFree_GAD |
| Drug Dependence | 0.003995683 | 7 | 0 | BeFree_GAD |
| Cannabis Dependence | 0.003724241 | 5 | 1 | BeFree_GAD |
| Colorectal Cancer | 0.003724241 | 5 | 0 | BeFree_GAD |
| Coronary Artery Disease | 0.003538676 | 3 | 1 | BeFree_LHGDN |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.003452799 | 4 | 2 | BeFree_GAD |
| Irritable Bowel Syndrome | 0.003452799 | 4 | 0 | BeFree_GAD |
| Alcohol Withdrawal Delirium | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Schizophrenia, Disorganized | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Cocaine Dependence | 0.003181358 | 3 | 0 | BeFree_GAD |
| Ectopic Pregnancy | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Dyslipidemias | 0.002909916 | 3 | 0 | BeFree_GAD |
| Substance abuse problem | 0.002909916 | 3 | 2 | BeFree_GAD |
| Rheumatoid Arthritis | 0.00272435 | 1 | 0 | LHGDN |
| Degenerative polyarthritis | 0.00272435 | 1 | 0 | LHGDN |
| Prostatic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Liver carcinoma | 0.00272435 | 1 | 0 | LHGDN |
| Substance Dependence | 0.002714419 | 10 | 0 | BeFree |
| Bipolar Disorder | 0.002638474 | 2 | 0 | BeFree_GAD |
| Ulcerative Colitis | 0.002638474 | 1 | 2 | BeFree_GAD |
| Migraine Disorders | 0.002638474 | 1 | 0 | BeFree_GAD |
| Malignant neoplasm of esophagus | 0.002638474 | 1 | 0 | BeFree_GAD |
| Abdominal Pain | 0.002367032 | 1 | 0 | GAD |
| Acute Disease | 0.002367032 | 1 | 0 | GAD |
| Antisocial Personality Disorder | 0.002367032 | 1 | 0 | GAD |
| Autistic Disorder | 0.002367032 | 1 | 0 | GAD |
| Febrile Convulsions | 0.002367032 | 1 | 0 | GAD |
| Crohn Disease | 0.002367032 | 1 | 0 | GAD |
| Heart Diseases | 0.002367032 | 1 | 0 | GAD |
| Low Back Pain | 0.002367032 | 1 | 0 | GAD |
| Myocardial Infarction | 0.002367032 | 1 | 0 | GAD |
| Obesity, Morbid | 0.002367032 | 1 | 0 | GAD |
| Osteoporosis | 0.002367032 | 1 | 0 | GAD |
| Psychoses, Substance-Induced | 0.002367032 | 1 | 0 | GAD |
| Sciatica | 0.002367032 | 1 | 0 | GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Weight Loss Adverse Event | 0.002367032 | 1 | 0 | GAD |
| Weight Gain Adverse Event | 0.002367032 | 1 | 0 | GAD |
| Chronic ulcerative colitis | 0.002367032 | 1 | 0 | GAD |
| IV drug use | 0.002367032 | 1 | 0 | GAD |
| Depressive disorder | 0.001628651 | 6 | 0 | BeFree |
| Mental disorders | 0.001357209 | 5 | 0 | BeFree |
| Colorectal Carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Metabolic Diseases | 0.001357209 | 5 | 0 | BeFree |
| Coronary Arteriosclerosis | 0.001085767 | 4 | 1 | BeFree |
| Coronary heart disease | 0.001085767 | 4 | 1 | BeFree |
| Unipolar Depression | 0.001085767 | 4 | 0 | BeFree |
| Ichthyosis Bullosa of Siemens | 0.001085767 | 4 | 0 | BeFree |
| Major Depressive Disorder | 0.001085767 | 4 | 0 | BeFree |
| Anorexia Nervosa | 0.000814326 | 3 | 0 | BeFree |
| Malignant tumor of colon | 0.000814326 | 3 | 0 | BeFree |
| Drug abuse | 0.000814326 | 3 | 0 | BeFree |
| Psychotic Disorders | 0.000814326 | 3 | 0 | BeFree |
| Impaired cognition | 0.000814326 | 3 | 0 | BeFree |
| Colon Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Arteriosclerosis | 0.000542884 | 2 | 0 | BeFree |
| Atherosclerosis | 0.000542884 | 2 | 0 | BeFree |
| Cardiovascular Diseases | 0.000542884 | 2 | 0 | BeFree |
| Diabetes | 0.000542884 | 2 | 0 | BeFree |
| Diabetes Mellitus | 0.000542884 | 2 | 0 | BeFree |
| Diabetic Retinopathy | 0.000542884 | 2 | 0 | BeFree |
| Glioma | 0.000542884 | 2 | 0 | BeFree |
| Inflammatory Bowel Diseases | 0.000542884 | 2 | 0 | BeFree |
| Lymphoma | 0.000542884 | 2 | 0 | BeFree |
| melanoma | 0.000542884 | 2 | 0 | BeFree |
| Neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
| Nicotine Dependence | 0.000542884 | 2 | 0 | BeFree |
| Substance Use Disorders | 0.000542884 | 2 | 0 | BeFree |
| Gilles de la Tourette syndrome | 0.000542884 | 2 | 0 | BeFree |
| Fibrosis, Liver | 0.000542884 | 2 | 0 | BeFree |
| Obesity, Abdominal | 0.000542884 | 2 | 0 | BeFree |
| Nonorganic psychosis | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
| Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Central neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
| Polysubstance abuse | 0.000542884 | 2 | 0 | BeFree |
| Bulimia Nervosa | 0.000542884 | 2 | 0 | BeFree |
| alcohol use disorder | 0.000271442 | 1 | 0 | BeFree |
| Angina, Unstable | 0.000271442 | 1 | 0 | BeFree |
| Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Diabetic Nephropathy | 0.000271442 | 1 | 0 | BeFree |
| Dyskinetic syndrome | 0.000271442 | 1 | 0 | BeFree |
| Eating Disorders | 0.000271442 | 1 | 0 | BeFree |
| Emotional Disturbances | 0.000271442 | 1 | 0 | BeFree |
| Experimental Autoimmune Encephalomyelitis | 0.000271442 | 1 | 0 | BeFree |
| Fatty Liver, Alcoholic | 0.000271442 | 1 | 0 | BeFree |
| Globus Hystericus | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis C | 0.000271442 | 1 | 0 | BeFree |
| Heroin Dependence | 0.000271442 | 1 | 0 | BeFree |
| Hodgkin Disease | 0.000271442 | 1 | 0 | BeFree |
| Hyperinsulinism | 0.000271442 | 1 | 0 | BeFree |
| Hyperlipidemia | 0.000271442 | 1 | 0 | BeFree |
| Liver diseases | 0.000271442 | 1 | 0 | BeFree |
| Nausea and vomiting | 0.000271442 | 1 | 0 | BeFree |
| Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
| Optic Neuritis | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Polycystic Ovary Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Respiratory Tract Infections | 0.000271442 | 1 | 0 | BeFree |
| Paranoid Schizophrenia | 0.000271442 | 1 | 0 | BeFree |
| Shared Paranoid Disorder | 0.000271442 | 1 | 0 | BeFree |
| Cerebrovascular accident | 0.000271442 | 1 | 0 | BeFree |
| Alcohol abuse | 0.000271442 | 1 | 0 | BeFree |
| Depressive Symptoms | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Lingual-Facial-Buccal Dyskinesia | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Anhedonia | 0.000271442 | 1 | 0 | BeFree |
| Alveolar rhabdomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Diastrophic dysplasia | 0.000271442 | 1 | 0 | BeFree |
| Abdominal discomfort | 0.000271442 | 1 | 0 | BeFree |
| Drug usage | 0.000271442 | 1 | 0 | BeFree |
| Coronary artery atheroma | 0.000271442 | 1 | 0 | BeFree |
| Impaired glucose tolerance | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of pancreas | 0.000271442 | 1 | 0 | BeFree |
| Stable angina | 0.000271442 | 1 | 0 | BeFree |
| Neurodegenerative Disorders | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis B, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis C, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Tardive Dyskinesia | 0.000271442 | 1 | 0 | BeFree |
| perfectionism | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
| Mammary Carcinoma, Human | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Autism Spectrum Disorders | 0.000271442 | 1 | 0 | BeFree |
| Non-Malignant Ascites Adverse Event | 0.000271442 | 1 | 0 | BeFree |
| Benign Prostatic Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
| NEUROTICISM | 0.000271442 | 1 | 0 | BeFree |
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