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The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
[中文简述(自动翻译):]  由该基因编码的蛋白在昼夜节律的调节中心作用。蛋白质编码碱性螺旋 - 环 - 螺旋(bHLH结构)家族的转录因子,并包含DNA结合组蛋白乙酰转移酶活性。编码的蛋白与ARNTL(BMAL1)结合E盒增强子周期(PER1,PER2,PER3)和隐花色素(CRY1,CRY2)基因的上游并激活这些基因转录的异源二聚体。 PER和CRY蛋白的异源二聚体,并通过与CLOCK / ARNTL复合反馈环路交互抑制自己的转录。在这种基因多态性可能与在特定人群和与肥胖和代谢综合症的行为变化相关联。选择性剪接结果在多个抄本变形。 [由RefSeq的,2014年1月提供]
CLOCK基因(以及对应的蛋白质)的细胞分布位置:
CLOCK基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Hypertensive disease | 0.081357209 | 6 | 2 | BeFree_RGD |
| Cholestasis | 0.08 | 1 | 0 | RGD |
| Hypoxia-Ischemia, Brain | 0.08 | 1 | 0 | RGD |
| Bipolar Disorder | 0.021074115 | 26 | 1 | BeFree_GAD_LHGDN |
| Sleep Disorders | 0.01482102 | 16 | 7 | BeFree_GAD |
| Schizophrenia | 0.014635455 | 10 | 0 | BeFree_GAD_LHGDN |
| Metabolic Syndrome X | 0.012453989 | 13 | 1 | BeFree_GAD |
| Obesity | 0.011715608 | 17 | 0 | BeFree_GAD |
| Major Depressive Disorder | 0.007177041 | 11 | 0 | BeFree_GAD |
| Fatty Liver | 0.005091382 | 1 | 1 | GAD_LHGDN |
| Mood Disorders | 0.004810009 | 9 | 0 | BeFree_GAD |
| Mental Depression | 0.004267125 | 8 | 6 | BeFree_GAD |
| Sleeplessness | 0.004267125 | 7 | 1 | BeFree_GAD |
| Colorectal Carcinoma | 0.003528744 | 13 | 0 | BeFree |
| Overweight | 0.003452799 | 5 | 1 | BeFree_GAD |
| Cardiovascular Diseases | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Malignant neoplasm of breast | 0.003257302 | 12 | 9 | BeFree |
| Breast Carcinoma | 0.003257302 | 12 | 9 | BeFree |
| Anorexia Nervosa | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Bulimia Nervosa | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Sleep disturbances | 0.002985861 | 11 | 7 | BeFree |
| Carcinogenesis | 0.002985861 | 11 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.002909916 | 2 | 12 | BeFree_GAD |
| Sleep Wake Disorders | 0.00272435 | 1 | 0 | LHGDN |
| Unipolar Depression | 0.002714419 | 10 | 0 | BeFree |
| Colorectal Cancer | 0.002714419 | 10 | 0 | BeFree |
| Endometriosis | 0.002638474 | 1 | 0 | BeFree_GAD |
| Malignant neoplasm of esophagus | 0.002638474 | 2 | 0 | BeFree_GAD |
| As If Personality | 0.002367032 | 1 | 1 | GAD |
| Cocaine Abuse | 0.002367032 | 1 | 0 | GAD |
| Thinness | 0.002367032 | 1 | 0 | GAD |
| Weight Gain | 0.002367032 | 1 | 0 | GAD |
| Anorexia and bulimia syndrome | 0.002367032 | 1 | 0 | GAD |
| Weight Gain Adverse Event | 0.002367032 | 1 | 0 | GAD |
| Mental disorders | 0.002171535 | 8 | 0 | BeFree |
| Depressive disorder | 0.001900093 | 7 | 6 | BeFree |
| Rheumatoid Arthritis | 0.001628651 | 6 | 0 | BeFree |
| Glioma | 0.001628651 | 6 | 1 | BeFree |
| Diabetes | 0.001357209 | 5 | 0 | BeFree |
| Diabetes Mellitus | 0.001357209 | 5 | 0 | BeFree |
| Delayed Sleep Phase Syndrome | 0.001357209 | 5 | 0 | BeFree |
| Alcoholic Intoxication, Chronic | 0.001085767 | 4 | 0 | BeFree |
| Alzheimer's Disease | 0.001085767 | 4 | 0 | BeFree |
| Anxiety Disorders | 0.001085767 | 4 | 0 | BeFree |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.001085767 | 4 | 0 | BeFree |
| Arteriosclerosis | 0.000814326 | 3 | 0 | BeFree |
| Atherosclerosis | 0.000814326 | 3 | 0 | BeFree |
| Borderline Personality Disorder | 0.000814326 | 3 | 0 | BeFree |
| Degenerative polyarthritis | 0.000814326 | 3 | 0 | BeFree |
| Smith-Magenis syndrome | 0.000814326 | 3 | 0 | BeFree |
| Attention deficit hyperactivity disorder | 0.000814326 | 3 | 0 | BeFree |
| alcohol use disorder | 0.000542884 | 2 | 0 | BeFree |
| Asthma | 0.000542884 | 2 | 0 | BeFree |
| Autistic Disorder | 0.000542884 | 2 | 0 | BeFree |
| Depression, Bipolar | 0.000542884 | 2 | 0 | BeFree |
| Bronchopulmonary Dysplasia | 0.000542884 | 2 | 0 | BeFree |
| Chronic Lymphocytic Leukemia | 0.000542884 | 2 | 0 | BeFree |
| Myeloid Leukemia, Chronic | 0.000542884 | 2 | 0 | BeFree |
| melanoma | 0.000542884 | 2 | 0 | BeFree |
| Metabolic Diseases | 0.000542884 | 2 | 0 | BeFree |
| Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
| Gestational Diabetes | 0.000542884 | 2 | 0 | BeFree |
| Esophageal carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
| Sleep Apnea, Obstructive | 0.000542884 | 2 | 0 | BeFree |
| Early Awakening | 0.000542884 | 2 | 0 | BeFree |
| Prostate carcinoma | 0.000542884 | 2 | 12 | BeFree |
| Malignant neoplasm of kidney | 0.000542884 | 2 | 0 | BeFree |
| Circadian Rhythm Disorders | 0.000542884 | 2 | 0 | BeFree |
| Delayed sleep phase | 0.000542884 | 2 | 0 | BeFree |
| Squamous cell carcinoma of the head and neck | 0.000542884 | 2 | 0 | BeFree |
| Postoperative confusion | 0.000542884 | 2 | 0 | BeFree |
| Renal carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Autoimmune Diseases | 0.000271442 | 1 | 0 | BeFree |
| Brain Diseases | 0.000271442 | 1 | 0 | BeFree |
| Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Cluster Headache | 0.000271442 | 1 | 0 | BeFree |
| Eating Disorders | 0.000271442 | 1 | 0 | BeFree |
| Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
| Hay fever | 0.000271442 | 1 | 0 | BeFree |
| Sensorineural Hearing Loss (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis C | 0.000271442 | 1 | 0 | BeFree |
| Heroin Dependence | 0.000271442 | 1 | 0 | BeFree |
| Male infertility | 0.000271442 | 1 | 0 | BeFree |
| Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
| Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Lymphoma | 0.000271442 | 1 | 1 | BeFree |
| Single major depressive episode | 0.000271442 | 1 | 0 | BeFree |
| Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Nevus | 0.000271442 | 1 | 0 | BeFree |
| Melanocytic nevus | 0.000271442 | 1 | 0 | BeFree |
| oligodendroglioma | 0.000271442 | 1 | 1 | BeFree |
| Pituitary Diseases | 0.000271442 | 1 | 0 | BeFree |
| Pneumococcal Infections | 0.000271442 | 1 | 0 | BeFree |
| Q Fever | 0.000271442 | 1 | 0 | BeFree |
| Restless Legs Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Skin Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Post-Traumatic Stress Disorder | 0.000271442 | 1 | 0 | BeFree |
| Seasonal Affective Disorder | 0.000271442 | 1 | 0 | BeFree |
| Photophobia | 0.000271442 | 1 | 0 | BeFree |
| Depressive Symptoms | 0.000271442 | 1 | 1 | BeFree |
| Cutaneous Melanoma | 0.000271442 | 1 | 0 | BeFree |
| Adrenoleukodystrophy | 0.000271442 | 1 | 0 | BeFree |
| Jet Lag Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Premature aging syndrome | 0.000271442 | 1 | 0 | BeFree |
| Dyslipidemias | 0.000271442 | 1 | 0 | BeFree |
| Cancer of Head and Neck | 0.000271442 | 1 | 0 | BeFree |
| Anaplastic Oligodendroglioma | 0.000271442 | 1 | 1 | BeFree |
| Impaired cognition | 0.000271442 | 1 | 0 | BeFree |
| Manic | 0.000271442 | 1 | 0 | BeFree |
| Hematologic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Well Differentiated Oligodendroglioma | 0.000271442 | 1 | 1 | BeFree |
| Hypersomnolence, Idiopathic | 0.000271442 | 1 | 0 | BeFree |
| Advanced Sleep Phase Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Malignant Pleural Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
| Advanced sleep phase | 0.000271442 | 1 | 0 | BeFree |
| Adult attention deficit hyperactivity disorder | 0.000271442 | 1 | 0 | BeFree |
| winter depression | 0.000271442 | 1 | 0 | BeFree |
| Mild cognitive disorder | 0.000271442 | 1 | 0 | BeFree |
| Adenoma of large intestine | 0.000271442 | 1 | 0 | BeFree |
| Benign melanocytic nevus | 0.000271442 | 1 | 0 | BeFree |
| Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Hepatocarcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| MAJOR AFFECTIVE DISORDER 2 | 0.000271442 | 1 | 0 | BeFree |
| NEUROTICISM | 0.000271442 | 1 | 4 | BeFree |
| MAJOR AFFECTIVE DISORDER 1 | 0.000271442 | 1 | 0 | BeFree |
| MAJOR AFFECTIVE DISORDER 4 | 0.000271442 | 1 | 0 | BeFree |
| MAJOR AFFECTIVE DISORDER 5 | 0.000271442 | 1 | 0 | BeFree |
| MAJOR AFFECTIVE DISORDER 6 | 0.000271442 | 1 | 0 | BeFree |
| Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
| MAJOR AFFECTIVE DISORDER 7 | 0.000271442 | 1 | 0 | BeFree |
| MAJOR AFFECTIVE DISORDER 8 | 0.000271442 | 1 | 0 | BeFree |
| MAJOR AFFECTIVE DISORDER 9 | 0.000271442 | 1 | 0 | BeFree |
| High-functioning autism | 0.000271442 | 1 | 0 | BeFree |
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