CLDN4(claudin 4)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

7q11.23
基因染色体位置图

基因简述

基因简述

The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]

[中文简述(自动翻译):]  由该内含子基因编码的蛋白质属于紧密连接蛋白家族。 Claudins是整合膜蛋白是上皮细胞的紧密连接，它通过细胞旁空间调节溶质和离子的移动的部件。这种蛋白质是产气荚膜梭菌肠毒素（CPE）的高亲和力受体和产前和产后寿命期间可能在内部器官的发育和功能的作用。该基因的Williams-博伊伦综合征，影响多个系统的神经发育障碍被删除。 [由RefSeq的，2013年9月提供]

OMIM数据库中对CLDN4基因的介绍     Wikipedia数据库中对CLDN4基因的介绍

基因序列

基因序列

CLDN4基因的碱基序列：[NCBI]

基因突变

基因突变

CLDN4基因的碱基突变：           显示全部snp
rs8629       rs11316       rs1127155       rs1127156       rs1127193       rs1127195       rs1127206       rs1127237       rs1127238       rs1127240       rs1127244       rs1127248       rs3211173       rs3211188       rs4304220       rs4458741       rs4640941       rs4717822       rs7793169       rs7793313       rs9691413       rs11284359       rs34646484       rs59385293       rs60916100       rs72466474       rs72466475       rs72466476       rs73702577       rs75600983       rs76078101       rs76512876       rs77189242       rs79021531       rs79080389       rs80013478       rs112541814      
rs115290917       rs116036351       rs117373285       rs138373200       rs138663238       rs139694614       rs139833538       rs141535832       rs141788310       rs142910620       rs143559313       rs143670115       rs144163828       rs144432450       rs146017284       rs146345112       rs146691861       rs147074853       rs147217825       rs147879657       rs148026351       rs149558448       rs150259342       rs151081297       rs180780542       rs185733953       rs187752503       rs189814802       rs193143779       rs199567908       rs199697067       rs200176069       rs200226062       rs200434919       rs200778903       rs200967710       rs201050730       rs201477654       rs201701409       rs201842156       rs202009827       rs202228697       rs368020684       rs368820080       rs368855545       rs369534695       rs369886802       rs371121791       rs371517967       rs372116449       rs372233301       rs372585037       rs372882134       rs372920291       rs373626567       rs374844316       rs375114165       rs375797371       rs376016774       rs376107583       rs376263596       rs376899077       rs377384994       rs377764675       rs528202745       rs528305581       rs528525265       rs528770785       rs529012641       rs529431450       rs529760536       rs530486827       rs531834480       rs532690423       rs532944600       rs533273255       rs533576017       rs534774397       rs535008828       rs535379767       rs536211848       rs536278990       rs537442983       rs539837737       rs540126421       rs541609450       rs541920837       rs542550321       rs542612728       rs543553738       rs543861019       rs543869811       rs544304590       rs545328403       rs545747602       rs546395083       rs548039810       rs550083038       rs550501576       rs551341108       rs553042024       rs554674496       rs554958583       rs555069727       rs556755801       rs556788551       rs557716297       rs558124576       rs558474249       rs558831373       rs560117590       rs560185830       rs561546540       rs562110498       rs562706476       rs563276473       rs564064512       rs564801766       rs566801129       rs567876469       rs567994840       rs568147161       rs568546416       rs569441115       rs569636497       rs569764016       rs570525514       rs570729167       rs570834693       rs572543446       rs573274301       rs573386208       rs575040623       rs575127499       rs575158419       rs575881946       rs575930601       rs576110462       rs576941663       rs577404362       rs781795561       rs781798709       rs781811608       rs781839221       rs781852351       rs781860549       rs781882770       rs781885725       rs781886975       rs781913308       rs781920933       rs781935849       rs781948407       rs781956087       rs781960841       rs781977891       rs782007311       rs782028199       rs782033926       rs782041866       rs782058994       rs782061804       rs782062913       rs782066179       rs782093339       rs782099865       rs782101104       rs782103198       rs782109277       rs782122717       rs782131135       rs782134932       rs782146307       rs782151684       rs782176010       rs782191312       rs782198043       rs782221735       rs782258246       rs782263774       rs782267647       rs782291578       rs782293751       rs782299940       rs782320250       rs782320722       rs782328282       rs782337604       rs782346350       rs782354536       rs782360042       rs782372522       rs782377694       rs782378736       rs782390551       rs782399679       rs782402406       rs782411325       rs782432494       rs782437505       rs782441051       rs782448196       rs782476036       rs782478855       rs782479124       rs782488509       rs782506122       rs782516201       rs782540326       rs782547531       rs782565979       rs782566860       rs782587695       rs782593567       rs782599409       rs782608225       rs782612684       rs782626506       rs782628449       rs782629194       rs782629608       rs782630775       rs782633820       rs782656664       rs782661763       rs782664208       rs782681015       rs782700133       rs782701130       rs782702331       rs782708053       rs782732212       rs782733838       rs782737256       rs782776359       rs782789724       rs782800833       rs782812690       rs782815880      

基因表达

基因表达

CLDN4基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TTCTTAGGGCCACAGATGG
59
TAACCTGGGAGATGGAGGT
59
CCCAAGGACATCCTTCTGG
60
ATAGAGCGAGACTCCATGC
59
GACCACAGATGGAGTCTCG
60
TTTAACCTGGGAGATGGAGG
59
CTTAGGGCCACAGATGGAG
60
TTTAACCTGGGAGATGGAGG
59
CTGAGCTACTGGCTGATCC
60
ATAGAGCGAGACTCCATGC
59
GACATCCTTCTGGCCTCTC
60
ATAGAGCGAGACTCCATGC
59
GACCACAGATGGAGTCTCG
60
TAACCTGGGAGATGGAGGT
59
GGACCACAGATGGAGTCTC
59
TAACCTGGGAGATGGAGGT
59
TTATGGTGATAGTGCCGGT
59
CGGATTGTAGAAGTCTTGGA
57
CTTAGGGCCACAGATGGAG
60
TAACCTGGGAGATGGAGGT
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

CLDN4基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

CLDN4基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004888
O14493(UniProtKB)
TAS
GO:0005198
O14493(UniProtKB)
IEA
GO:0005886
O14493(UniProtKB)
TAS
GO:0005887
O14493(UniProtKB)
IMP
GO:0005923
O14493(UniProtKB)
ISS
GO:0005923
O14493(UniProtKB)
IDA
GO:0007165
O14493(UniProtKB)
IEA
GO:0007565
O14493(UniProtKB)
IEA
GO:0007623
O14493(UniProtKB)
IEA
GO:0009925
O14493(UniProtKB)
IEA
GO:0016324
O14493(UniProtKB)
IEA
GO:0016327
O14493(UniProtKB)
IEA
GO:0016327
O14493(UniProtKB)
IEA
GO:0016328
O14493(UniProtKB)
IEA
GO:0016338
O14493(UniProtKB)
ISS
GO:0032570
O14493(UniProtKB)
IEA
GO:0042802
O14493(UniProtKB)
ISS
GO:0061436
O14493(UniProtKB)
IMP

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控CLDN4基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Mammary Neoplasms 0.120542884 2 0 BeFree_CTD_human
Neoplasm Recurrence, Local 0.12 1 0 CTD_human
Polycystic Ovary Syndrome 0.12 1 0 CTD_human
Invasive Ductal Breast Carcinoma 0.12 1 0 CTD_human
Peptic Esophagitis 0.08 1 0 RGD
Reperfusion Injury 0.08 1 0 RGD
Stomach Neoplasms 0.010897401 4 0 LHGDN
Metaplasia 0.0054487 2 0 LHGDN
Adenocarcinoma 0.004624443 8 0 BeFree_LHGDN
Ovarian Carcinoma 0.004614512 17 0 BeFree
Malignant neoplasm of ovary 0.00434307 16 0 BeFree
Squamous cell carcinoma 0.003267234 3 0 BeFree_LHGDN
Neuroendocrine Tumors 0.003267234 2 0 BeFree_LHGDN
Liver carcinoma 0.003267234 2 0 BeFree_LHGDN
Carcinoma, Papillary 0.002995792 1 0 BeFree_LHGDN
Biliary Tract Neoplasm 0.00272435 1 0 LHGDN
Carcinoid Tumor 0.00272435 1 0 LHGDN
Carcinosarcoma 0.00272435 1 0 LHGDN
Colorectal Neoplasms 0.00272435 1 0 LHGDN
Endometrial Neoplasms 0.00272435 1 0 LHGDN
Pancreatic Neoplasm 0.00272435 1 0 LHGDN
Thyroid Neoplasm 0.00272435 1 0 LHGDN
Carcinoma, Lobular 0.00272435 1 0 LHGDN
ovarian neoplasm 0.00272435 1 0 LHGDN
Prostatic Hyperplasia 0.00272435 1 0 LHGDN
Neoplasm Metastasis 0.002714419 10 0 BeFree
Pancreatic carcinoma 0.001900093 7 0 BeFree
Malignant neoplasm of pancreas 0.001900093 7 0 BeFree
Malignant neoplasm of breast 0.001628651 6 0 BeFree
Breast Carcinoma 0.001628651 6 0 BeFree
Carcinogenesis 0.001357209 5 0 BeFree
Stomach Carcinoma 0.001085767 4 1 BeFree
Tumor Progression 0.000814326 3 0 BeFree
Malignant neoplasm of prostate 0.000814326 3 0 BeFree
Prostate carcinoma 0.000814326 3 0 BeFree
Epithelial ovarian cancer 0.000814326 3 0 BeFree
Secondary malignant neoplasm of lymph node 0.000814326 3 0 BeFree
Pancreatic Ductal Adenocarcinoma 0.000814326 3 0 BeFree
Endometriosis 0.000542884 2 0 BeFree
Williams Syndrome 0.000542884 2 0 BeFree
Squamous cell carcinoma of esophagus 0.000542884 2 0 BeFree
Ductal Carcinoma 0.000542884 2 0 BeFree
Non-Neoplastic Disorder 0.000542884 2 0 BeFree
Adenoma 0.000271442 1 0 BeFree
Bladder Neoplasm 0.000271442 1 0 BeFree
Malignant neoplasm of endometrium 0.000271442 1 0 BeFree
Ulcerative Colitis 0.000271442 1 0 BeFree
Cyst 0.000271442 1 0 BeFree
Encephalomyelitis 0.000271442 1 0 BeFree
Experimental Autoimmune Encephalomyelitis 0.000271442 1 0 BeFree
Gastrointestinal Neoplasms 0.000271442 1 0 BeFree
Hypercalcemia 0.000271442 1 0 BeFree
Malignant neoplasm of stomach 0.000271442 1 0 BeFree
Ovarian Diseases 0.000271442 1 0 BeFree
Precancerous Conditions 0.000271442 1 0 BeFree
Pulmonary Edema 0.000271442 1 0 BeFree
Respiratory Syncytial Virus Infections 0.000271442 1 0 BeFree
Severe Combined Immunodeficiency 0.000271442 1 0 BeFree
Benign Neoplasm 0.000271442 1 0 BeFree
Malignant neoplasm of gallbladder 0.000271442 1 0 BeFree
Secondary malignant neoplasm of lung 0.000271442 1 0 BeFree
Neoplastic disease of uncertain behavior 0.000271442 1 0 BeFree
Cystadenocarcinoma, Mucinous 0.000271442 1 0 BeFree
Cystadenocarcinoma, Serous 0.000271442 1 0 BeFree
Gastric Adenocarcinoma 0.000271442 1 0 BeFree
Lobular carcinoma in situ of breast 0.000271442 1 0 BeFree
Solid tumour 0.000271442 1 0 BeFree
Apocrine metaplasia 0.000271442 1 0 BeFree
Non-infiltrating lobular carcinoma 0.000271442 1 0 BeFree
Intrahepatic Cholangiocarcinoma 0.000271442 1 0 BeFree
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site 0.000271442 1 0 BeFree
Endometrial Carcinoma 0.000271442 1 0 BeFree
Necrotizing Enterocolitis 0.000271442 1 0 BeFree
Recurrent tumor 0.000271442 1 0 BeFree
Carcinoma of bladder 0.000271442 1 0 BeFree
Biliary Tract Cancer 0.000271442 1 0 BeFree
AICARDI-GOUTIERES SYNDROME 1 0.000271442 1 0 BeFree
Intraepithelial Neoplasia 0.000271442 1 0 BeFree
Metastatic Prostate Carcinoma 0.000271442 1 0 BeFree
Xenograft Model 0.000271442 1 0 BeFree
Ductal Breast Carcinoma 0.000271442 1 0 BeFree
Uterine Corpus Cancer 0.000271442 1 0 BeFree

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