CKMT1A(creatine kinase, mitochondrial 1A) 转至新版数据库
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Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):] 线粒体肌酸（MtCK）激酶是负责高能磷酸从线粒体转移到胞质载体，肌酸。它属于肌酸激酶同工酶的家庭。它的存在为两种同工酶，肌节MtCK和无处不在的MtCK，由不同的基因编码。线粒体肌酸激酶发生在两个不同的寡聚形式：二聚物和八聚体，与此相反的独占二聚体胞质肌酸激酶同工酶。预后较差，许多恶性肿瘤显示无处不在线粒体肌酸激酶的表达;这可能与高能量周转并未能经由凋亡来消除癌细胞。无处不在线粒体肌酸激酶具有肌节线粒体肌酸激酶的编码外显子的80％的同源性。靠近对方15号染色体上两个基因已经确定编码相同的线粒体肌酸激酶蛋白质。 [由RefSeq的，2008年7月提供]
基因本体信息
CKMT1A基因（以及对应的蛋白质）的细胞分布位置：
- 溶酶体
- 内涵体
- 细胞核
- 细胞质
- 液泡
- 细胞膜
- 细胞外基质
- 内质网
- 线粒体
- 高尔基体
- 细胞骨架
CKMT1A基因的本体（GO）信息：
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