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This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码的丝氨酸/苏氨酸蛋白激酶家族的一个成员。编码的蛋白质,细胞因子活化的蛋白复合物,它是必不可少的转录因子NF-κ-B复合的抑制剂的组分,磷酸经由泛素化途径触发抑制剂的降解,从而激活转录因子的网站。 [由RefSeq的,2008年7月提供]
CHUK基因(以及对应的蛋白质)的细胞分布位置:
CHUK基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
COCOON SYNDROME | 0.320271442 | 1 | 1 | BeFree_CLINVAR_CTD_human_MGD |
Bone Diseases, Developmental | 0.12 | 1 | 0 | CTD_human |
Cleft Palate | 0.12 | 1 | 0 | CTD_human |
Fetal Diseases | 0.12 | 4 | 0 | CTD_human |
IGA Glomerulonephritis | 0.12 | 1 | 0 | CTD_human |
Skin Abnormalities | 0.12 | 3 | 0 | CTD_human |
Limb Deformities, Congenital | 0.12 | 4 | 0 | CTD_human |
Colitis | 0.08 | 1 | 0 | RGD |
Muscular Atrophy | 0.08 | 1 | 0 | RGD |
Prostatic Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
Squamous cell carcinoma | 0.003810118 | 5 | 0 | BeFree_LHGDN |
Ectodermal Dysplasia | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Rheumatoid Arthritis | 0.002909916 | 3 | 1 | BeFree_GAD |
Malignant neoplasm of breast | 0.002909916 | 3 | 0 | BeFree_GAD |
Adenocarcinoma | 0.00272435 | 1 | 0 | LHGDN |
Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Degenerative polyarthritis | 0.00272435 | 1 | 0 | LHGDN |
Pancreatic Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Liver Failure | 0.00272435 | 1 | 0 | LHGDN |
Infection | 0.00272435 | 1 | 0 | LHGDN |
Fatty Liver | 0.002638474 | 2 | 0 | BeFree_GAD |
Hepatitis C | 0.002638474 | 2 | 0 | BeFree_GAD |
Multiple Myeloma | 0.002638474 | 2 | 0 | BeFree_GAD |
Asthma | 0.002367032 | 1 | 0 | GAD |
Atherosclerosis | 0.002367032 | 1 | 0 | GAD |
Bronchiolitis, Viral | 0.002367032 | 1 | 0 | GAD |
HIV Infections | 0.002367032 | 1 | 0 | GAD |
Hodgkin Disease | 0.002367032 | 1 | 0 | GAD |
Lymphoma, Non-Hodgkin | 0.002367032 | 1 | 0 | GAD |
Respiratory Syncytial Virus Infections | 0.002367032 | 1 | 0 | GAD |
Cerebrovascular accident | 0.002367032 | 1 | 0 | GAD |
Subarachnoid Hemorrhage | 0.002367032 | 1 | 0 | GAD |
Intracranial Hemorrhages | 0.002367032 | 1 | 0 | GAD |
Sjogren's Syndrome | 0.002367032 | 1 | 0 | GAD |
Cerebral Hemorrhage | 0.002367032 | 1 | 0 | GAD |
Tumor Progression | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000814326 | 3 | 0 | BeFree |
Carcinogenesis | 0.000814326 | 3 | 0 | BeFree |
Prostate carcinoma | 0.000814326 | 3 | 0 | BeFree |
Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
Papilloma | 0.000542884 | 2 | 0 | BeFree |
Skin Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of lung | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
Congenital Abnormality | 0.000271442 | 1 | 0 | BeFree |
Basal Cell Nevus Syndrome | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of skin | 0.000271442 | 1 | 0 | BeFree |
Primary biliary cirrhosis | 0.000271442 | 1 | 0 | BeFree |
Colonic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Hepatitis B | 0.000271442 | 1 | 0 | BeFree |
Immunologic Deficiency Syndromes | 0.000271442 | 1 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.000271442 | 1 | 0 | BeFree |
Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
Pneumonia | 0.000271442 | 1 | 0 | BeFree |
B-Cell Lymphomas | 0.000271442 | 1 | 0 | BeFree |
Cancer of Head and Neck | 0.000271442 | 1 | 0 | BeFree |
Non-alcoholic Fatty Liver Disease | 0.000271442 | 1 | 0 | BeFree |
Tumor Initiation | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Skin Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma Multiforme | 0.000271442 | 1 | 0 | BeFree |
Steatohepatitis | 0.000271442 | 1 | 0 | BeFree |
Nasopharyngeal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Nonalcoholic Steatohepatitis | 0.000271442 | 1 | 0 | BeFree |
Experimental Organism Basal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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