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This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码的丝氨酸/苏氨酸蛋白激酶家族的一个成员。编码的蛋白质,细胞因子活化的蛋白复合物,它是必不可少的转录因子NF-κ-B复合的抑制剂的组分,磷酸经由泛素化途径触发抑制剂的降解,从而激活转录因子的网站。 [由RefSeq的,2008年7月提供]
CHUK基因(以及对应的蛋白质)的细胞分布位置:
CHUK基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| COCOON SYNDROME | 0.320271442 | 1 | 1 | BeFree_CLINVAR_CTD_human_MGD |
| Bone Diseases, Developmental | 0.12 | 1 | 0 | CTD_human |
| Cleft Palate | 0.12 | 1 | 0 | CTD_human |
| Fetal Diseases | 0.12 | 4 | 0 | CTD_human |
| IGA Glomerulonephritis | 0.12 | 1 | 0 | CTD_human |
| Skin Abnormalities | 0.12 | 3 | 0 | CTD_human |
| Limb Deformities, Congenital | 0.12 | 4 | 0 | CTD_human |
| Colitis | 0.08 | 1 | 0 | RGD |
| Muscular Atrophy | 0.08 | 1 | 0 | RGD |
| Prostatic Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
| Squamous cell carcinoma | 0.003810118 | 5 | 0 | BeFree_LHGDN |
| Ectodermal Dysplasia | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Rheumatoid Arthritis | 0.002909916 | 3 | 1 | BeFree_GAD |
| Malignant neoplasm of breast | 0.002909916 | 3 | 0 | BeFree_GAD |
| Adenocarcinoma | 0.00272435 | 1 | 0 | LHGDN |
| Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Degenerative polyarthritis | 0.00272435 | 1 | 0 | LHGDN |
| Pancreatic Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Liver Failure | 0.00272435 | 1 | 0 | LHGDN |
| Infection | 0.00272435 | 1 | 0 | LHGDN |
| Fatty Liver | 0.002638474 | 2 | 0 | BeFree_GAD |
| Hepatitis C | 0.002638474 | 2 | 0 | BeFree_GAD |
| Multiple Myeloma | 0.002638474 | 2 | 0 | BeFree_GAD |
| Asthma | 0.002367032 | 1 | 0 | GAD |
| Atherosclerosis | 0.002367032 | 1 | 0 | GAD |
| Bronchiolitis, Viral | 0.002367032 | 1 | 0 | GAD |
| HIV Infections | 0.002367032 | 1 | 0 | GAD |
| Hodgkin Disease | 0.002367032 | 1 | 0 | GAD |
| Lymphoma, Non-Hodgkin | 0.002367032 | 1 | 0 | GAD |
| Respiratory Syncytial Virus Infections | 0.002367032 | 1 | 0 | GAD |
| Cerebrovascular accident | 0.002367032 | 1 | 0 | GAD |
| Subarachnoid Hemorrhage | 0.002367032 | 1 | 0 | GAD |
| Intracranial Hemorrhages | 0.002367032 | 1 | 0 | GAD |
| Sjogren's Syndrome | 0.002367032 | 1 | 0 | GAD |
| Cerebral Hemorrhage | 0.002367032 | 1 | 0 | GAD |
| Tumor Progression | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000814326 | 3 | 0 | BeFree |
| Carcinogenesis | 0.000814326 | 3 | 0 | BeFree |
| Prostate carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
| Papilloma | 0.000542884 | 2 | 0 | BeFree |
| Skin Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000542884 | 2 | 0 | BeFree |
| Carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
| Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Congenital Abnormality | 0.000271442 | 1 | 0 | BeFree |
| Basal Cell Nevus Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of skin | 0.000271442 | 1 | 0 | BeFree |
| Primary biliary cirrhosis | 0.000271442 | 1 | 0 | BeFree |
| Colonic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis B | 0.000271442 | 1 | 0 | BeFree |
| Immunologic Deficiency Syndromes | 0.000271442 | 1 | 0 | BeFree |
| Myeloid Leukemia, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Pneumonia | 0.000271442 | 1 | 0 | BeFree |
| B-Cell Lymphomas | 0.000271442 | 1 | 0 | BeFree |
| Cancer of Head and Neck | 0.000271442 | 1 | 0 | BeFree |
| Non-alcoholic Fatty Liver Disease | 0.000271442 | 1 | 0 | BeFree |
| Tumor Initiation | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Skin Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
| Glioblastoma Multiforme | 0.000271442 | 1 | 0 | BeFree |
| Steatohepatitis | 0.000271442 | 1 | 0 | BeFree |
| Nasopharyngeal carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Nonalcoholic Steatohepatitis | 0.000271442 | 1 | 0 | BeFree |
| Experimental Organism Basal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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