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The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  的毒蕈碱胆碱能受体属于较大家族的G蛋白偶联受体。这些受体的功能的多样性是由结合的乙酰胆碱的限定,并包括细胞应答如腺苷酸环化酶的抑制,磷酸变性,和钾通道的调解。毒蕈碱受体影响在中枢和外周神经系统的乙酰胆碱的许多效果。毒蕈碱胆碱受体3控制平滑肌收缩和刺激引起腺体组织的分泌。 [由RefSeq的,2008年7月提供]
CHRM3基因(以及对应的蛋白质)的细胞分布位置:
CHRM3基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Prune Belly Syndrome | 0.36 | 1 | 1 | CLINVAR_CTD_human_ORPHANET |
Urinary Bladder Diseases | 0.120271442 | 1 | 0 | BeFree_CTD_human |
Epilepsy | 0.120271442 | 2 | 1 | BeFree_GWASCAT |
Ascites | 0.12 | 1 | 0 | CTD_human |
Cryptorchidism | 0.12 | 1 | 0 | CTD_human |
Liver Cirrhosis | 0.12 | 1 | 0 | CTD_human |
Urethral obstruction sequence | 0.12 | 0 | 0 | ORPHANET |
Drug-Induced Liver Injury | 0.12 | 1 | 0 | CTD_human |
Visceral Myopathy | 0.08 | 0 | 0 | MGD |
Asthma | 0.010639772 | 6 | 0 | BeFree_GAD_LHGDN |
melanoma | 0.00272435 | 1 | 0 | LHGDN |
Retinoblastoma | 0.00272435 | 1 | 0 | LHGDN |
Sjogren's Syndrome | 0.00272435 | 1 | 0 | LHGDN |
Bronchial Hyperreactivity | 0.002638474 | 2 | 0 | BeFree_GAD |
Immediate hypersensitivity | 0.002367032 | 1 | 0 | GAD |
Hypertensive disease | 0.002367032 | 1 | 1 | GAD |
Marijuana Abuse | 0.002367032 | 1 | 0 | GAD |
Multiple Sclerosis | 0.002367032 | 1 | 0 | GAD |
Psychoses, Substance-Induced | 0.002367032 | 1 | 0 | GAD |
Weight Gain | 0.002367032 | 1 | 0 | GAD |
Glomerular filtration rate finding | 0.002367032 | 1 | 1 | GAD |
Weight Gain Adverse Event | 0.002367032 | 1 | 0 | GAD |
Congenital Abnormality | 0.000271442 | 1 | 0 | BeFree |
Bipolar Disorder | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Colonic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Diabetes | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus, Non-Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
Heart Diseases | 0.000271442 | 1 | 0 | BeFree |
Chronic Obstructive Airway Disease | 0.000271442 | 1 | 0 | BeFree |
Myopia | 0.000271442 | 1 | 0 | BeFree |
Nausea and vomiting | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Unipolar Depression | 0.000271442 | 1 | 0 | BeFree |
Postoperative Nausea and Vomiting | 0.000271442 | 1 | 0 | BeFree |
Mood Disorders | 0.000271442 | 1 | 0 | BeFree |
Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Major Depressive Disorder | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
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