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The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  的毒蕈碱胆碱能受体属于较大家族的G蛋白偶联受体。这些受体的功能的多样性是由结合的乙酰胆碱的定义为这些受体,并包括细胞应答如腺苷酸环化酶的抑制,磷酸变性,和钾通道的调解。毒蕈碱受体影响在中枢和外周神经系统的乙酰胆碱的许多效果。毒蕈碱胆碱受体2参与心动过缓调解和心肌收缩力下降。多个可变剪接转录物变体已被用于这个基因说明。 [由RefSeq的,2008年7月提供]
CHRM2基因(以及对应的蛋白质)的细胞分布位置:
CHRM2基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Neurogenic Urinary Bladder | 0.12272435 | 2 | 0 | CTD_human_LHGDN |
| Diabetes Mellitus, Experimental | 0.12 | 1 | 0 | CTD_human |
| Diabetes Mellitus, Insulin-Dependent | 0.12 | 1 | 0 | CTD_human |
| Diabetic Neuropathies | 0.12 | 1 | 0 | CTD_human |
| Epilepsy | 0.12 | 1 | 0 | CTD_human |
| Substance-Related Disorders | 0.12 | 1 | 0 | CTD_human |
| Bradycardia | 0.12 | 1 | 0 | CTD_human |
| Depressive disorder | 0.081085767 | 5 | 0 | BeFree_RGD |
| Alcoholic Intoxication, Chronic | 0.007534359 | 11 | 0 | BeFree_GAD_LHGDN |
| Mental Depression | 0.005819831 | 4 | 0 | BeFree_GAD |
| Alzheimer's Disease | 0.005720142 | 3 | 0 | BeFree_LHGDN |
| Asthma | 0.00554839 | 5 | 0 | BeFree_GAD |
| Cardiomyopathy, Dilated | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
| Myocardial Infarction | 0.004734064 | 2 | 0 | GAD |
| Unipolar Depression | 0.003181358 | 3 | 3 | BeFree_GAD |
| Major Depressive Disorder | 0.003181358 | 3 | 3 | BeFree_GAD |
| Drug Dependence | 0.003181358 | 3 | 0 | BeFree_GAD |
| Anoxia | 0.00272435 | 1 | 0 | LHGDN |
| Nicotine Dependence | 0.002638474 | 1 | 0 | BeFree_GAD |
| Schizophrenia | 0.002638474 | 1 | 0 | BeFree_GAD |
| Affective Disorders, Psychotic | 0.002367032 | 1 | 0 | GAD |
| Heart Diseases | 0.002367032 | 1 | 0 | GAD |
| Inflammation | 0.002367032 | 1 | 0 | GAD |
| Multiple Sclerosis | 0.002367032 | 1 | 0 | GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Alcohol abuse | 0.002367032 | 1 | 0 | GAD |
| Personality Traits | 0.002367032 | 1 | 0 | GAD |
| Substance Dependence | 0.001357209 | 5 | 0 | BeFree |
| Depressive Syndrome | 0.000542884 | 2 | 0 | BeFree |
| Familial dilated cardiomyopathy | 0.000542884 | 2 | 0 | BeFree |
| Mental disorders | 0.000271442 | 1 | 0 | BeFree |
| Bipolar Disorder | 0.000271442 | 1 | 0 | BeFree |
| Myopia | 0.000271442 | 1 | 0 | BeFree |
| Obesity | 0.000271442 | 1 | 0 | BeFree |
| Recurrent major depressive episodes | 0.000271442 | 1 | 0 | BeFree |
| Acute myocardial infarction | 0.000271442 | 1 | 0 | BeFree |
| Fibrillation | 0.000271442 | 1 | 0 | BeFree |
| Mood Disorders | 0.000271442 | 1 | 0 | BeFree |
| INTELLIGENCE QUANTITATIVE TRAIT LOCUS 1 | 0.000271442 | 1 | 0 | BeFree |
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