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The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
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CGA基因(以及对应的蛋白质)的细胞分布位置:
CGA基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Adrenal Gland Diseases | 0.12 | 1 | 0 | CTD_human |
Hemiplegia | 0.12 | 1 | 0 | CTD_human |
Oligospermia | 0.12 | 1 | 0 | CTD_human |
Ovarian Diseases | 0.12 | 1 | 0 | CTD_human |
Uterine Diseases | 0.12 | 1 | 0 | CTD_human |
Disease Progression | 0.12 | 1 | 0 | CTD_human |
Thyroid cancer, follicular | 0.12 | 1 | 0 | CTD_human |
Malignant neoplasm of prostate | 0.005819831 | 6 | 0 | BeFree_GAD |
Down Syndrome | 0.00408156 | 6 | 0 | BeFree_LHGDN |
Malignant neoplasm of breast | 0.003995683 | 7 | 0 | BeFree_GAD |
Mammary Neoplasms | 0.003810118 | 5 | 0 | BeFree_LHGDN |
Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Pregnancy, Tubal | 0.00272435 | 1 | 0 | LHGDN |
Malignant neoplasm of urinary bladder | 0.002638474 | 2 | 0 | BeFree_GAD |
Malignant neoplasm of lung | 0.002638474 | 2 | 3 | BeFree_GAD |
Autistic Disorder | 0.002367032 | 1 | 0 | GAD |
Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Breast Carcinoma | 0.001628651 | 6 | 0 | BeFree |
Amnesia, Transient Global | 0.001085767 | 4 | 0 | BeFree |
Prostate carcinoma | 0.001085767 | 4 | 0 | BeFree |
Choriocarcinoma | 0.000814326 | 3 | 0 | BeFree |
Adenoma | 0.000542884 | 2 | 0 | BeFree |
Adrenal Gland Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Nevus | 0.000542884 | 2 | 0 | BeFree |
Melanocytic nevus | 0.000542884 | 2 | 0 | BeFree |
Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Pituitary Adenoma | 0.000542884 | 2 | 0 | BeFree |
Aortic Aneurysm, Thoracic | 0.000542884 | 2 | 0 | BeFree |
Follicular thyroid carcinoma | 0.000542884 | 2 | 0 | BeFree |
Endometrial Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Benign melanocytic nevus | 0.000542884 | 2 | 0 | BeFree |
Benign Prostatic Hyperplasia | 0.000542884 | 2 | 0 | BeFree |
AURAL ATRESIA, CONGENITAL | 0.000542884 | 2 | 0 | BeFree |
Anemia, Hemolytic | 0.000271442 | 1 | 0 | BeFree |
Aortic Aneurysm | 0.000271442 | 1 | 0 | BeFree |
Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of endometrium | 0.000271442 | 1 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma, Papillary | 0.000271442 | 1 | 0 | BeFree |
Cardiovascular Diseases | 0.000271442 | 1 | 0 | BeFree |
Hemophilia B | 0.000271442 | 1 | 0 | BeFree |
Ehlers-Danlos Syndrome | 0.000271442 | 1 | 0 | BeFree |
Yolk Sac Tumor | 0.000271442 | 1 | 0 | BeFree |
Gynecomastia | 0.000271442 | 1 | 0 | BeFree |
Male infertility | 0.000271442 | 1 | 0 | BeFree |
Leprosy, Lepromatous | 0.000271442 | 1 | 0 | BeFree |
Lesch-Nyhan Syndrome | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
Acute Promyelocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Leukopenia | 0.000271442 | 1 | 0 | BeFree |
Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Neurofibromatosis 1 | 0.000271442 | 1 | 0 | BeFree |
Neutropenia | 0.000271442 | 1 | 0 | BeFree |
Prostatic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Retinoblastoma | 0.000271442 | 1 | 0 | BeFree |
Giant Cell Arteritis | 0.000271442 | 1 | 0 | BeFree |
Trisomy | 0.000271442 | 1 | 0 | BeFree |
von Willebrand Disease | 0.000271442 | 1 | 0 | BeFree |
Ovarian Hyperstimulation Syndrome | 0.000271442 | 1 | 0 | BeFree |
Synovial Cyst | 0.000271442 | 1 | 0 | BeFree |
Small cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Thyroid Gland Follicular Adenoma | 0.000271442 | 1 | 0 | BeFree |
Complete trisomy 18 syndrome | 0.000271442 | 1 | 0 | BeFree |
Liver Failure, Acute | 0.000271442 | 1 | 0 | BeFree |
Agenesis of corpus callosum | 0.000271442 | 1 | 0 | BeFree |
Follicular adenoma | 0.000271442 | 1 | 0 | BeFree |
Undifferentiated carcinoma | 0.000271442 | 1 | 0 | BeFree |
Germ cell tumor | 0.000271442 | 1 | 0 | BeFree |
Trophoblastic Tumor, Placental Site | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of Male Breast | 0.000271442 | 1 | 0 | BeFree |
Gastrointestinal Stromal Tumors | 0.000271442 | 1 | 0 | BeFree |
Stickler syndrome (disorder) | 0.000271442 | 1 | 0 | BeFree |
Severe hereditary factor VIII deficiency disease | 0.000271442 | 1 | 0 | BeFree |
Antithrombin III Deficiency | 0.000271442 | 1 | 0 | BeFree |
Endometriosis of uterus | 0.000271442 | 1 | 0 | BeFree |
3 beta-Hydroxysteroid dehydrogenase deficiency | 0.000271442 | 1 | 0 | BeFree |
pseudohermaphrodite (non-specific) | 0.000271442 | 1 | 0 | BeFree |
Activated Protein C Resistance | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 3 | BeFree |
Carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
Familial Retinoblastoma | 0.000271442 | 1 | 0 | BeFree |
ovarian neoplasm | 0.000271442 | 1 | 0 | BeFree |
hormone related neoplasm/cancer | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
Myxoid cyst | 0.000271442 | 1 | 0 | BeFree |
Nonseminomatous germ cell tumor | 0.000271442 | 1 | 0 | BeFree |
Mediastinal (Thymic) Large B-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Apocrine Gland Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Hypoparathyroidism familial isolated | 0.000271442 | 1 | 0 | BeFree |
Uterine Corpus Cancer | 0.000271442 | 1 | 0 | BeFree |
Epidermolysa bullosa simplex and limb girdle muscular dystrophy | 0.000271442 | 1 | 0 | BeFree |
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