CFP基因详情-基因数据库-基因云馆

CFP(complement factor properdin) 转至新版数据库

基因简称(symbol)

CFP [HGNC] [GeneCards] [NCBI]

基因种类(locus group)

protein-coding gene

同源简称(alias symbol)

基因家族代码(gene_family_id)

492 [HGNC] [GenScript]

omim代码

300383

entrez码

5199 [Vega]

vega基因码

OTTHUMG00000021451

ensembl基因码

ENSG00000126759 [Ensembl]

基因家族(gene family)

Complement system

refseq数据库代号

NM_002621

更多...

基因种类(locus_type)

gene with protein product

基因名称状态(status)

Approved

location_sortable

Xp11.4

同源基因名称(alias name)

基因名称批准使用时间(date_approved_reserved)

1989-06-07T00:00:00Z

基因简称更名时间(date_symbol_changed)

2006-03-02T00:00:00Z

基因名称更名时间(date_name_changed)

2006-03-02T00:00:00Z

更新时间(date_modified)

2015-04-22T00:00:00Z

ucsc码

uc004dih.3

ena

M83652

ccds数据码

CCDS14282

uniprot数据码

P27918

pubmed代码

1783405

mgd码

MGI:97545

rgd码

RGD:1594557

生命科学数据库(lsdb)

更新时间(date modified)

2015-04-22T00:00:00Z

cosmic

CFP

mirbase

基因曾用简称(prev symbol)

PFC

基因曾用名称(prev name)

properdin P factor, complement

homeodb

cosmic

CFP

snornabase

bioparadigms slc

orphanet

119379

假基因信息(pseudogeneorg)

horde id

merops

imgt

iuphar

kznf基因类别

mamit-trnadb

cd

LncRNA数据库

酶代码

中间纤维数据库

收起

Xp11.4

This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009]

[中文简述(自动翻译):] 此基因编码一种血浆糖蛋白正调节先天免疫系统的补体旁路。该蛋白质结合许多微生物的表面和凋亡细胞并稳定C 3和C 5转化酶复合在反馈回路中，最终导致形成靶细胞的膜攻击复合物和裂解。突变在该基因导致两种形式备解不足，这导致在高敏感性脑膜炎球菌感染。多个可变剪接变体，编码相同的蛋白质，也已确定。[通过的RefSeq，2009年2月提供]

OMIM数据库中对CFP基因的介绍 Wikipedia数据库中对CFP基因的介绍

CFP基因的碱基序列：[NCBI]

CFP基因的碱基突变：显示全部snp

rs781659413 rs781697408 rs781720598 rs781475195 rs781262315 rs781361688 rs781213158 rs781177696 rs781033322 rs780473122 rs780807177 rs779848395 rs779608807 rs779638780 rs779353585 rs778252094 rs779108735 rs779178140 rs778070027 rs778024732 rs777757134 rs777846332 rs777935714 rs777682849 rs777563861 rs777287352 rs777282156 rs776785115 rs777202205 rs776769942 rs776701402 rs776208193 rs776418763 rs776648443 rs775853893 rs775840560 rs775436648

rs775387030 rs775387328 rs775191694 rs774978130 rs775178096 rs774575309 rs774426833 rs774523258 rs774215404 rs773974183 rs774205180 rs773880034 rs773671774 rs773814594 rs773460874 rs773649333 rs773292236 rs773405705 rs772735314 rs773063425 rs772374297 rs771963405 rs772260126 rs771626265 rs771566525 rs771003975 rs771159055 rs770789423 rs770396604 rs770631549 rs770633141 rs769946055 rs770119377 rs770172472 rs769720636 rs769840231 rs769857317 rs769714078 rs769210799 rs769690133 rs768926430 rs768994510 rs768780525 rs768797857 rs768545409 rs768144373 rs768300105 rs767667124 rs767897679 rs767295636 rs767499808 rs766932988 rs767157838 rs767263997 rs766596739 rs766164302 rs766410484 rs766161629 rs766160459 rs766141144 rs765952187 rs765707357 rs765722844 rs765005275 rs765043659 rs765506323 rs764618893 rs764638136 rs764956547 rs764600840 rs764569430 rs764398330 rs764237301 rs764326751 rs763903539 rs764064120 rs763653323 rs763859314 rs762959952 rs763260548 rs763575663 rs762642051 rs762270639 rs762448844 rs762231424 rs762041412 rs762181423 rs762027656 rs761962858 rs761497394 rs761431026 rs761224914 rs761295659 rs761103038 rs760708566 rs761068523 rs760669571 rs760303151 rs760597082 rs760251844 rs759649291 rs759981172 rs759611187 rs759595599 rs759560770 rs759575887 rs759424363 rs759507756 rs759534525 rs759401485 rs759249664 rs759260923 rs759212643 rs759045985 rs758858124 rs758696265 rs758728637 rs758670583 rs758636954 rs757900268 rs758224868 rs758264701 rs757743217 rs757339568 rs757262582 rs757140746 rs757206174 rs757024260 rs756946812 rs756460607 rs756621805 rs756806250 rs756251236 rs756274336 rs755929329 rs754834825 rs755279703 rs755652074 rs754515236 rs754681918 rs754406508 rs754316891 rs754182635 rs754268864 rs753702471 rs753693226 rs753666227 rs753398830 rs753315681 rs752660612 rs752922242 rs752493725 rs752645314 rs752429653 rs752325590 rs752350564 rs752027963 rs752196898 rs752263292 rs751977684 rs751796510 rs751557156 rs751421714 rs751475559 rs750975354 rs751266279 rs750940456 rs750509066 rs750713214 rs750234257 rs750164333 rs749722640 rs750018657 rs749663336 rs749262665 rs748846927 rs749021048 rs748506327 rs748160018 rs748425010 rs748064490 rs747792199 rs747277925 rs747543016 rs747581281 rs747100588 rs746857415 rs746716714 rs746293085 rs746706301 rs746230454 rs746156064 rs746109144 rs746138980 rs745424947 rs745901112 rs745319542 rs745382863 rs550129266 rs557918263 rs531999103 rs539948417 rs529927211 rs376282485 rs376333570 rs377699424 rs375725149 rs376054334 rs375455564 rs374687577 rs375010244 rs373434543 rs373099034 rs373347141 rs371932812 rs372336803 rs373037904 rs371893096 rs371398463 rs371401758 rs371351644 rs371036084 rs371132642 rs370592348 rs370014336 rs369493455 rs369761235 rs368084414 rs369319515 rs369411474 rs367914849 rs367959975 rs367635632 rs202033715 rs200131215 rs201094506 rs200036265 rs200004565 rs199849597 rs193211334 rs192169029 rs191627866 rs191377269 rs190387515 rs189625309 rs188915155 rs188871019 rs188505507 rs188064497 rs187235840 rs185895601 rs185480444 rs185323842 rs185246758 rs185087446 rs184314311 rs183833621 rs183445513 rs182671247 rs182525527 rs181794402 rs180949340 rs151069560 rs150754273 rs150351914 rs149808100 rs150041295 rs147421467 rs149494404 rs145814387 rs146840844 rs145674770 rs144021755 rs142749724 rs141133000 rs142706087 rs140986480 rs140550997 rs140252020 rs138644424 rs138581545 rs138456565 rs138490907 rs138055257 rs112031241 rs137980601 rs61737993 rs55972826 rs55806203 rs55641350 rs11558787 rs28694808 rs41297326 rs8177085 rs11436787 rs8177084 rs8177083 rs8177081 rs8177080 rs8177079 rs8177078 rs8177077 rs8177076 rs8177074 rs8177075 rs8177073 rs8177072 rs8177071 rs8177070 rs8177069 rs8177068 rs8177067 rs8177066 rs8177065 rs7060246 rs6609541 rs2239455 rs2239454 rs2235182 rs1048118 rs909523

CFP基因在不同组织中的表达： [UniProt]

正向引物序列

正向引物Tm值

反向引物序列

反向引物Tm值

rank

GACTGCTGTCTCAACACTG

58

GTAAGCAAAGGTAAGGACTGC

59

GAAGACTGCTGTCTCAACAC

58

AGCAAAGGTAAGGACTGCA

59

TTTGACGGACATCGATGTG

58

CTGACCATGATCCTTTCAAGG

58

TTTGACGGACATCGATGTG

58

GACCATGATCCTTTCAAGGG

58

CAGCCACAGTATGAAGAATCC

58

GTTGAGACAGCAGTCTTCC

58

AGCCACAGTATGAAGAATCCT

59

CAGTGTTGAGACAGCAGTC

58

CAGCCACAGTATGAAGAATCC

58

CAGTGTTGAGACAGCAGTC

58

TTTGACGGACATCGATGTG

58

TGACCATGATCCTTTCAAGG

57

GACTGCTGTCTCAACACTG

58

TAAGCAAAGGTAAGGACTGC

57

尚未收录相关数据

CFP基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

溶酶体
内涵体
细胞核
细胞质
液泡
细胞膜
细胞外基质
内质网
线粒体
高尔基体
细胞骨架

CFP基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0005576

P27918(UniProtKB)

TAS

GO:0005576

P27918(UniProtKB)

TAS

GO:0005576

P27918(UniProtKB)

TAS

GO:0005576

P27918(UniProtKB)

TAS

GO:0005576

P27918(UniProtKB)

TAS

GO:0005615

P27918(UniProtKB)

TAS

GO:0005788

P27918(UniProtKB)

TAS

GO:0005788

P27918(UniProtKB)

TAS

GO:0005788

P27918(UniProtKB)

TAS

GO:0006955

P27918(UniProtKB)

TAS

GO:0006956

P27918(UniProtKB)

TAS

GO:0006957

P27918(UniProtKB)

TAS

GO:0030449

P27918(UniProtKB)

TAS

GO:0036066

P27918(UniProtKB)

TAS

GO:0042742

P27918(UniProtKB)

TAS

GO:0031012

P27918(UniProtKB)

IDA

序号	作用方式	资源库来源/分值	基因名称	基因名称

可能调控CFP基因的相关microRNA：

hsa-miR-335

通路基因列表

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
PROPERDIN DEFICIENCY, X-LINKED	0.36	4	3	CLINVAR_CTD_human_UNIPROT
Properdin deficiency disease	0.120542884	2	0	BeFree_ORPHANET
Meningococcal meningitis	0.12	2	0	CTD_human
Properdin Deficiency, Type II	0.12	0	1	CLINVAR
Properdin Deficiency, Type III	0.12	0	1	CLINVAR
Tuberculosis	0.002985861	11	0	BeFree
Vascular Diseases	0.00272435	1	0	LHGDN
Alzheimer's Disease	0.002367032	1	0	GAD
Schizophrenia	0.000814326	3	0	BeFree
Leprosy	0.000542884	2	0	BeFree
Meningococcal Infections	0.000542884	2	0	BeFree
Tuberculosis, Pulmonary	0.000542884	2	0	BeFree
Age related macular degeneration	0.000542884	2	0	BeFree
Alcoholic Intoxication, Chronic	0.000271442	1	0	BeFree
Febrile Convulsions	0.000271442	1	0	BeFree
Epilepsy, Temporal Lobe	0.000271442	1	0	BeFree
HIV Infections	0.000271442	1	0	BeFree
Liver neoplasms	0.000271442	1	0	BeFree
Unipolar Depression	0.000271442	1	0	BeFree
Seizure, Febrile, Simple	0.000271442	1	0	BeFree
Memory impairment	0.000271442	1	0	BeFree
Myoclonic Epilepsy, Juvenile	0.000271442	1	0	BeFree
Attention deficit hyperactivity disorder	0.000271442	1	0	BeFree
Major Depressive Disorder	0.000271442	1	0	BeFree
Papillary Renal Cell Carcinoma	0.000271442	1	0	BeFree
Hippocampal sclerosis	0.000271442	1	0	BeFree
Non-Malignant Ascites Adverse Event	0.000271442	1	0	BeFree
Liver carcinoma	0.000271442	1	0	BeFree