CFL1(cofilin 1 (non-muscle)) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

11q13.1
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]

[中文简述(自动翻译):]  由该基因编码的可以聚合及解聚F-肌动蛋白和G-肌动蛋白中的pH依赖方式的蛋白。由LIM激酶艾滋病的肌动蛋白骨架的卢致重组增加这种蛋白质的磷酸化。丝切蛋白是结合并解聚丝状F-肌动蛋白并抑制单体G-肌动蛋白的聚合中的pH依赖方式广泛分布的细胞内肌动蛋白调节蛋白质。它参与肌动蛋白丝切蛋白复合物的易位从细胞质至细胞核。[由OMIM，2004年四月供给]

OMIM数据库中对CFL1基因的介绍     Wikipedia数据库中对CFL1基因的介绍

基因序列

基因序列

CFL1基因的碱基序列：[NCBI]

基因突变

基因突变

CFL1基因的碱基突变：           显示全部snp
rs4621       rs508328       rs508548       rs631101       rs635375       rs652021       rs665306       rs667555       rs669300       rs1059681       rs1939212       rs3201150       rs3208585       rs3208690       rs7125986       rs7947741       rs7947929       rs11227332       rs11550148       rs11550151       rs11550156       rs11550158       rs11550160       rs12223734       rs34416745       rs36052446       rs58523108       rs60857277       rs61893864       rs78780936       rs79486948       rs79983394       rs111520700       rs112357246       rs112906941       rs113764507       rs115074329      
rs117076705       rs117231452       rs117370256       rs117871119       rs138305476       rs138571177       rs139012730       rs139174092       rs140556162       rs140754612       rs140761498       rs140831932       rs142004150       rs142117713       rs142147292       rs143739345       rs144232822       rs144617488       rs144718277       rs146419107       rs147490639       rs148853340       rs148907386       rs149641509       rs149713636       rs149968959       rs150280069       rs150460822       rs151197635       rs180849802       rs180958198       rs181806885       rs183523447       rs183546274       rs184589974       rs185253597       rs185326217       rs185502186       rs186295179       rs186307039       rs186767729       rs187956339       rs188109157       rs188792804       rs189713553       rs189827459       rs190398062       rs190950942       rs191218158       rs191736004       rs192789185       rs200151328       rs200515388       rs201061085       rs201110785       rs201465961       rs202067956       rs368181911       rs368970393       rs369158323       rs370088055       rs370856681       rs371333230       rs371721199       rs371944392       rs372596408       rs373497422       rs373617544       rs374475263       rs374932124       rs375037867       rs375789255       rs376789464       rs377003738       rs377357130       rs527466002       rs527549205       rs528638903       rs528725388       rs529332750       rs529658410       rs530221576       rs530317206       rs531529485       rs532137008       rs532275504       rs532698031       rs532732280       rs533432066       rs533548146       rs534402124       rs534532658       rs534707568       rs535777518       rs535999956       rs536265821       rs536980550       rs537048069       rs537197786       rs537258935       rs537714002       rs538172530       rs538459202       rs538642137       rs539649516       rs540398742       rs540644983       rs541170544       rs541807075       rs541947676       rs542018102       rs542555902       rs542961133       rs543333236       rs543741946       rs544890597       rs544951736       rs545130360       rs545835894       rs546962018       rs547935797       rs548667712       rs548875618       rs549653584       rs549919223       rs550655459       rs551095526       rs551303347       rs552286902       rs552304595       rs552348286       rs552439685       rs552489200       rs552982567       rs553177416       rs554173267       rs554438181       rs554779916       rs554949135       rs555355558       rs555642258       rs556204092       rs556422872       rs556837180       rs557065648       rs557153344       rs557165247       rs557302334       rs557608247       rs558357816       rs558614679       rs559417880       rs560317647       rs560655342       rs561387730       rs562409658       rs562569417       rs562989734       rs563308961       rs563573230       rs563652187       rs563839765       rs564013664       rs564509765       rs564769013       rs565164802       rs565733309       rs566109073       rs567371173       rs567885156       rs567908129       rs568422546       rs568470023       rs568475793       rs569007792       rs569696370       rs569792331       rs569966695       rs570438711       rs570637969       rs570918399       rs571167784       rs571912022       rs572164940       rs573015366       rs573128560       rs573193525       rs573424423       rs573955475       rs574533168       rs575117797       rs575232788       rs575636138       rs575779678       rs576006133       rs576058434       rs576094066       rs577175211       rs577289310       rs745557946       rs745644010       rs745850520       rs745946941       rs746595026       rs746674518       rs747046660       rs747655529       rs747851129       rs748312579       rs748516891       rs748711056       rs748878840       rs749463530       rs749518832       rs749669934       rs749819712       rs750011467       rs750964102       rs751529006       rs751763589       rs752029718       rs752336492       rs752545828       rs753944820       rs754238275       rs754853368       rs755088407       rs755421041       rs755596910       rs755866633       rs755947950       rs756071134       rs756543435       rs757140359       rs757149210       rs757761586       rs758149427       rs758663162       rs758694884       rs759130150       rs759505655       rs759558490       rs759715499       rs759921465       rs760138893       rs760700515       rs760995765       rs761419542       rs761533310       rs761897563       rs762181259       rs762365959       rs762750150       rs763127971       rs763800691       rs763811440       rs764209377       rs764405459       rs764416604       rs764969465       rs765189573       rs765398412       rs765868917       rs766232417       rs766406826       rs767107042       rs767289144       rs767913964       rs767995387       rs768231783       rs769311784       rs769348819       rs769824611       rs770063039       rs770410313       rs770790472       rs771359919       rs771702676       rs771780921       rs772212753       rs772426024       rs773034551       rs773140553       rs773315558       rs773406998       rs773636606       rs773806387       rs774112410       rs774638401       rs775000372       rs775777892       rs776602377       rs776644270       rs776713076       rs776830820       rs776843362       rs777493261       rs778160844       rs779206752       rs779369428       rs779662228       rs780043853       rs780510961       rs780529226       rs781181147       rs781291815      

基因表达

基因表达

CFL1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GTGTTTATCTTCTGGGCCC
58
TTCTTCTTGATGGCGTCCT
59
ATACGCGTTTCTGCATTGG
59
CGTTGAAGACTTACGCACC
59
AGGATCTGGTGTTTATCTTCTG
58
CATGCTTGATCCCTGTCAG
58
GTGTTTATCTTCTGGGCCC
58
TTCTTCTTGATGGCGTCCT
59
GGTGTTTATCTTCTGGGCC
58
TTCTTCTTGATGGCGTCCT
59
AGGATCTGGTGTTTATCTTCTG
58
CATGCTTGATCCCTGTCAG
58
ATACGCGTTTCTGCATTGG
59
GCGTTGAAGACTTACGCAC
59
GTGTTTATCTTCTGGGCCC
58
TTCTTCTTGATGGCGTCCT
59
GTGTTTATCTTCTGGGCCC
58
TTCTTCTTGATGGCGTCCT
59
GGTGTTTATCTTCTGGGCC
58
TTCTTCTTGATGGCGTCCT
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

CFL1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

CFL1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0003779
E9PK25(UniProtKB)
IEA
GO:0015629
E9PK25(UniProtKB)
IEA
GO:0030042
E9PK25(UniProtKB)
IEA
GO:0003779
E9PLJ3(UniProtKB)
IEA
GO:0015629
E9PLJ3(UniProtKB)
IEA
GO:0030042
E9PLJ3(UniProtKB)
IEA
GO:0003779
E9PP50(UniProtKB)
IEA
GO:0015629
E9PP50(UniProtKB)
IEA
GO:0030042
E9PP50(UniProtKB)
IEA
GO:0003779
E9PQB7(UniProtKB)
IEA
GO:0015629
E9PQB7(UniProtKB)
IEA
GO:0030042
E9PQB7(UniProtKB)
IEA
GO:0003779
E9PS23(UniProtKB)
IEA
GO:0015629
E9PS23(UniProtKB)
IEA
GO:0030042
E9PS23(UniProtKB)
IEA
GO:0003779
G3V1A4(UniProtKB)
IEA
GO:0015629
G3V1A4(UniProtKB)
IEA
GO:0030042
G3V1A4(UniProtKB)
IEA
GO:0003779
P23528(UniProtKB)
IEA
GO:0005515
P23528(UniProtKB)
IPI
GO:0005515
P23528(UniProtKB)
IPI
GO:0005515
P23528(UniProtKB)
IPI
GO:0005515
P23528(UniProtKB)
IPI
GO:0005515
P23528(UniProtKB)
IPI
GO:0005515
P23528(UniProtKB)
IPI
GO:0005515
P23528(UniProtKB)
IPI
GO:0005515
P23528(UniProtKB)
IPI
GO:0005515
P23528(UniProtKB)
IPI
GO:0005515
P23528(UniProtKB)
IPI
GO:0005515
P23528(UniProtKB)
IPI
GO:0005515
P23528(UniProtKB)
IPI
GO:0005515
P23528(UniProtKB)
IPI
GO:0005515
P23528(UniProtKB)
IPI
GO:0005515
P23528(UniProtKB)
IPI
GO:0005515
P23528(UniProtKB)
IPI
GO:0005515
P23528(UniProtKB)
IPI
GO:0005615
P23528(UniProtKB)
IDA
GO:0005634
P23528(UniProtKB)
TAS
GO:0005737
P23528(UniProtKB)
TAS
GO:0005737
P23528(UniProtKB)
IDA
GO:0005925
P23528(UniProtKB)
IDA
GO:0007010
P23528(UniProtKB)
IMP
GO:0007266
P23528(UniProtKB)
TAS
GO:0009615
P23528(UniProtKB)
IEP
GO:0015629
P23528(UniProtKB)
IEA
GO:0016020
P23528(UniProtKB)
IDA
GO:0016363
P23528(UniProtKB)
IEA
GO:0022604
P23528(UniProtKB)
IMP
GO:0030036
P23528(UniProtKB)
TAS
GO:0030042
P23528(UniProtKB)
IEA
GO:0031258
P23528(UniProtKB)
IEA
GO:0031982
P23528(UniProtKB)
IDA
GO:0032587
P23528(UniProtKB)
IEA
GO:0043066
P23528(UniProtKB)
TAS
GO:0044794
P23528(UniProtKB)
IMP
GO:0061001
P23528(UniProtKB)
IMP
GO:0070062
P23528(UniProtKB)
IDA
GO:0070062
P23528(UniProtKB)
IDA
GO:0070062
P23528(UniProtKB)
IDA
GO:0070062
P23528(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控CFL1基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Spina Bifida 0.122995792 1 0 BeFree_CTD_human_LHGDN
Neoplasm Metastasis 0.120542884 3 0 BeFree_CTD_human
Squamous cell carcinoma of esophagus 0.120271442 2 0 BeFree_CTD_human
Neoplasm Invasiveness 0.12 1 0 CTD_human
Precancerous Conditions 0.12 1 0 CTD_human
Mammary Neoplasms 0.12 1 0 CTD_human
Asthma 0.002995792 1 0 BeFree_LHGDN
Colonic Neoplasms 0.00272435 1 0 LHGDN
Schizophrenia 0.00272435 1 0 LHGDN
Neural Tube Defects 0.002367032 1 0 GAD
Malignant neoplasm of breast 0.001628651 6 0 BeFree
leukemia 0.001357209 5 0 BeFree
Carcinogenesis 0.001357209 5 0 BeFree
Breast Carcinoma 0.001357209 5 0 BeFree
Non-Small Cell Lung Carcinoma 0.001085767 4 0 BeFree
Adenocarcinoma 0.000814326 3 0 BeFree
Acute leukemia 0.000814326 3 0 BeFree
Tumor Progression 0.000814326 3 0 BeFree
Malignant neoplasm of lung 0.000814326 3 0 BeFree
Endometriosis 0.000542884 2 0 BeFree
Hemorrhagic Fevers, Viral 0.000542884 2 0 BeFree
Meningioma 0.000542884 2 0 BeFree
Multiple Myeloma 0.000542884 2 0 BeFree
Neuroblastoma 0.000542884 2 0 BeFree
Retinopathy of Prematurity 0.000542884 2 0 BeFree
Parathyroid Adenoma 0.000542884 2 0 BeFree
Carcinoma of lung 0.000542884 2 0 BeFree
Central neuroblastoma 0.000542884 2 0 BeFree
Liver carcinoma 0.000542884 2 0 BeFree
Malignant tumor of colon 0.000271442 1 0 BeFree
melanoma 0.000271442 1 0 BeFree
Obesity 0.000271442 1 0 BeFree
Secondary malignant neoplasm of lung 0.000271442 1 0 BeFree
Malignant neoplasm of prostate 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
Colon Carcinoma 0.000271442 1 0 BeFree
Intraepithelial Neoplasia 0.000271442 1 0 BeFree
Invasive Carcinoma 0.000271442 1 0 BeFree

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