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Centrosome-associated protein E (CENPE) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. This protein is required for stable spindle microtubule capture at kinetochores which is a necessary step in chromosome alignment during prometaphase. This protein also couples chromosome position to microtubule depolymerizing activity. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Nov 2014]
[中文简述(自动翻译):]  
CENPE基因(以及对应的蛋白质)的细胞分布位置:
CENPE基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Seckel syndrome | 0.12 | 0 | 0 | ORPHANET |
| Testicular Germ Cell Tumor | 0.12 | 2 | 1 | GWASCAT |
| MICROCEPHALY 13, PRIMARY, AUTOSOMAL RECESSIVE | 0.12 | 1 | 2 | UNIPROT |
| Malignant neoplasm of breast | 0.002638474 | 2 | 0 | BeFree_GAD |
| Alcoholic Intoxication, Chronic | 0.002367032 | 1 | 0 | GAD |
| Testicular Neoplasms | 0.002367032 | 1 | 1 | GAD |
| Neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
| Central neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
| Dwarfism | 0.000271442 | 1 | 0 | BeFree |
| Microcephaly | 0.000271442 | 1 | 0 | BeFree |
| Pituitary Diseases | 0.000271442 | 1 | 0 | BeFree |
| Systemic Scleroderma | 0.000271442 | 1 | 0 | BeFree |
| PITUITARY DWARFISM I | 0.000271442 | 1 | 0 | BeFree |
| Breast Cancer, Familial | 0.000271442 | 1 | 0 | BeFree |
| Developmental delay (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Triple Negative Breast Neoplasms | 0.000271442 | 1 | 0 | BeFree |
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