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The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  
CEL基因(以及对应的蛋白质)的细胞分布位置:
CEL基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 8, WITH EXOCRINE DYSFUNCTION | 0.241357209 | 5 | 1 | BeFree_CLINVAR_CTD_human |
| Pancreatitis, Chronic | 0.120542884 | 2 | 0 | BeFree_CTD_human |
| Diabetes Mellitus, Experimental | 0.08 | 1 | 0 | RGD |
| Adenomatous Polyposis Coli | 0.005428837 | 20 | 0 | BeFree |
| Pancreatitis | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
| Amyloid Neuropathies, Familial | 0.003257302 | 12 | 0 | BeFree |
| Colorectal Cancer | 0.003257302 | 12 | 0 | BeFree |
| Cholesterol Ester Storage Disease | 0.002985861 | 11 | 0 | BeFree |
| Colorectal Carcinoma | 0.002985861 | 11 | 0 | BeFree |
| Atherosclerosis | 0.002909916 | 3 | 0 | BeFree_GAD |
| Adenoma | 0.002714419 | 10 | 0 | BeFree |
| Pancreatitis, Alcoholic | 0.002638474 | 1 | 0 | BeFree_GAD |
| Alcoholic Intoxication, Chronic | 0.002367032 | 1 | 0 | GAD |
| HIV Infections | 0.001900093 | 7 | 0 | BeFree |
| Asthma | 0.001628651 | 6 | 0 | BeFree |
| Diabetes | 0.001628651 | 6 | 0 | BeFree |
| Diabetes Mellitus | 0.001628651 | 6 | 0 | BeFree |
| Polyneuropathy | 0.001628651 | 6 | 0 | BeFree |
| Multiple polyps | 0.001628651 | 6 | 0 | BeFree |
| Wolman Disease | 0.001357209 | 5 | 0 | BeFree |
| Chronic eosinophilic leukemia | 0.001357209 | 5 | 0 | BeFree |
| Hereditary Nonpolyposis Colorectal Cancer | 0.001357209 | 5 | 0 | BeFree |
| Adenocarcinoma | 0.001085767 | 4 | 0 | BeFree |
| Idiopathic Hypereosinophilic Syndrome | 0.001085767 | 4 | 0 | BeFree |
| FAMILIAL ADENOMATOUS POLYPOSIS, ATTENUATED (disorder) | 0.001085767 | 4 | 0 | BeFree |
| MUTYH-Associate Polyposis | 0.001085767 | 4 | 0 | BeFree |
| Amyloidosis | 0.000814326 | 3 | 0 | BeFree |
| Malignant tumor of colon | 0.000814326 | 3 | 0 | BeFree |
| Coronary heart disease | 0.000814326 | 3 | 2 | BeFree |
| Lipomatosis | 0.000814326 | 3 | 0 | BeFree |
| Pneumonia | 0.000814326 | 3 | 0 | BeFree |
| polyps | 0.000814326 | 3 | 0 | BeFree |
| Sarcoidosis | 0.000814326 | 3 | 0 | BeFree |
| Fibromatosis, Aggressive | 0.000814326 | 3 | 0 | BeFree |
| Disseminated eosinophilic collagen disease | 0.000814326 | 3 | 0 | BeFree |
| Maturity onset diabetes mellitus in young | 0.000814326 | 3 | 0 | BeFree |
| Colon Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Hypereosinophilic syndrome | 0.000814326 | 3 | 0 | BeFree |
| Pneumonia, Ventilator-Associated | 0.000814326 | 3 | 0 | BeFree |
| Benign symmetrical lipomatosis | 0.000814326 | 3 | 0 | BeFree |
| Arteriosclerosis | 0.000542884 | 2 | 0 | BeFree |
| Coronary Arteriosclerosis | 0.000542884 | 2 | 0 | BeFree |
| Gardner Syndrome | 0.000542884 | 2 | 0 | BeFree |
| Hepatitis B | 0.000542884 | 2 | 0 | BeFree |
| Chronic Obstructive Airway Disease | 0.000542884 | 2 | 0 | BeFree |
| Pancreatic Diseases | 0.000542884 | 2 | 0 | BeFree |
| Pulmonary Alveolar Proteinosis | 0.000542884 | 2 | 0 | BeFree |
| Sarcoidosis, Pulmonary | 0.000542884 | 2 | 0 | BeFree |
| Systemic Scleroderma | 0.000542884 | 2 | 0 | BeFree |
| Tuberculosis, Pulmonary | 0.000542884 | 2 | 0 | BeFree |
| Acute leukemia | 0.000542884 | 2 | 0 | BeFree |
| Cervical Intraepithelial Neoplasia | 0.000542884 | 2 | 0 | BeFree |
| Senile cardiac amyloidosis | 0.000542884 | 2 | 0 | BeFree |
| Invasive Pulmonary Aspergillosis | 0.000542884 | 2 | 0 | BeFree |
| Congenital hypertrophy | 0.000542884 | 2 | 0 | BeFree |
| Neuropathy | 0.000542884 | 2 | 0 | BeFree |
| Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
| Familial Amyloid Polyneuropathy, Type IV | 0.000542884 | 2 | 1 | BeFree |
| Sarcoma | 0.000542884 | 2 | 0 | BeFree |
| Pneumocystis jiroveci pneumonia | 0.000542884 | 2 | 0 | BeFree |
| Idiopathic Pulmonary Fibrosis | 0.000542884 | 2 | 0 | BeFree |
| Coronary Artery Disease | 0.000542884 | 2 | 0 | BeFree |
| Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Plaque, Amyloid | 0.000542884 | 2 | 0 | BeFree |
| Bacterial Infections | 0.000271442 | 1 | 0 | BeFree |
| Cachexia | 0.000271442 | 1 | 0 | BeFree |
| Rectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Cardiovascular Diseases | 0.000271442 | 1 | 0 | BeFree |
| Carpal Tunnel Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Colonic Polyps | 0.000271442 | 1 | 0 | BeFree |
| Coughing | 0.000271442 | 1 | 0 | BeFree |
| Diarrhea | 0.000271442 | 1 | 0 | BeFree |
| Kartagener Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Actinic keratosis | 0.000271442 | 1 | 0 | BeFree |
| Chronic Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Chronic Neutrophilic Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Lymphoproliferative Disorders | 0.000271442 | 1 | 0 | BeFree |
| Malaria | 0.000271442 | 1 | 0 | BeFree |
| Mycoplasma Infections | 0.000271442 | 1 | 0 | BeFree |
| Neuralgia | 0.000271442 | 1 | 0 | BeFree |
| Obesity | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic Cyst | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Polycythemia Vera | 0.000271442 | 1 | 0 | BeFree |
| Pulmonary Edema | 0.000271442 | 1 | 0 | BeFree |
| Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Respiration Disorders | 0.000271442 | 1 | 0 | BeFree |
| Retinoblastoma | 0.000271442 | 1 | 0 | BeFree |
| Tuberculosis | 0.000271442 | 1 | 0 | BeFree |
| Wheezing | 0.000271442 | 1 | 0 | BeFree |
| Liver Failure | 0.000271442 | 1 | 0 | BeFree |
| Atrophy of pancreas | 0.000271442 | 1 | 0 | BeFree |
| Malnutrition | 0.000271442 | 1 | 0 | BeFree |
| Liver Failure, Acute | 0.000271442 | 1 | 0 | BeFree |
| Lung Diseases, Interstitial | 0.000271442 | 1 | 0 | BeFree |
| Amyloid Neuropathies | 0.000271442 | 1 | 0 | BeFree |
| Simple Pulmonary Eosinophilia | 0.000271442 | 1 | 0 | BeFree |
| Mucosa-Associated Lymphoid Tissue Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Acute respiratory disease | 0.000271442 | 1 | 0 | BeFree |
| Familial Amyloid Neuropathy, Portuguese Type | 0.000271442 | 1 | 0 | BeFree |
| Coinfection | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of duodenum | 0.000271442 | 1 | 0 | BeFree |
| Alcohol-induced chronic pancreatitis | 0.000271442 | 1 | 0 | BeFree |
| Idiopathic chronic pancreatitis | 0.000271442 | 1 | 0 | BeFree |
| Metabolic Syndrome X | 0.000271442 | 1 | 0 | BeFree |
| Oropharyngeal disorders | 0.000271442 | 1 | 0 | BeFree |
| Hereditary Breast and Ovarian Cancer Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Ulnar Nerve Entrapment Syndrome | 0.000271442 | 1 | 0 | BeFree |
| psychological distress | 0.000271442 | 1 | 0 | BeFree |
| Endothelial dysfunction | 0.000271442 | 1 | 0 | BeFree |
| Stromal Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Polyp of large intestine | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
| Primary HIV infection | 0.000271442 | 1 | 0 | BeFree |
| Precursor B-cell lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Myelodysplastic/myeloproliferative neoplasm, unclassifiable | 0.000271442 | 1 | 0 | BeFree |
| Severe diarrhea | 0.000271442 | 1 | 0 | BeFree |
| Gardner fibroma | 0.000271442 | 1 | 0 | BeFree |
| Protein Misfolding Disorders | 0.000271442 | 1 | 0 | BeFree |
| AMYLOIDOSIS, HEREDITARY, TRANSTHYRETIN-RELATED | 0.000271442 | 1 | 0 | BeFree |
| Acid cholesteryl ester hydrolase deficiency, type 2 | 0.000271442 | 1 | 0 | BeFree |
| Neutrophilia (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Pneumonitis | 0.000271442 | 1 | 0 | BeFree |
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