CEBPA(CCAAT/enhancer binding protein (C/EBP), alpha)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

基因染色体位置

基因染色体位置

19q13.1
基因染色体位置图

基因简述

基因简述

This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]

[中文简述(自动翻译):]  此内含子基因编码包含基本的亮氨酸拉链（bZIP蛋白）结构域，并且识别在靶基因的启动子的CCAAT基序的转录因子。在同型二聚体所编码的蛋白质的功能，并与CCAAT /增强子结合蛋白β和γ异二聚体。这种蛋白质的活性可以调节参与细胞周期调控，以及在体重平衡的基因的表达。此基因的突变与急性骨髓性白血病有关。使用替代框内非AUG（GUG）和AUG的开始与不同长度的蛋白异构体密码子的结果。差动翻译起始由一个外的帧，上游开放阅读其位于GUG和第一个AUG起始密码子之间的帧介导的。 [由RefSeq的，2013年12月提供]

OMIM数据库中对CEBPA基因的介绍     Wikipedia数据库中对CEBPA基因的介绍

基因序列

基因序列

CEBPA基因的碱基序列：[NCBI]

基因突变

基因突变

CEBPA基因的碱基突变：           显示全部snp
rs1049967       rs1049969       rs3745971       rs4142943       rs16967952       rs34508287       rs34529039       rs34665205       rs41367646       rs41428545       rs41434054       rs41480346       rs41490344       rs111826037       rs112479912       rs114693382       rs114719837       rs115716467       rs116624689       rs117038217       rs140616244       rs141430731       rs143479458       rs144806149       rs147743825       rs148740083       rs148855907       rs150933693       rs180821724       rs181362001       rs184179542       rs184628798       rs184965384       rs186271451       rs187307877       rs187751931       rs188978450      
rs192240793       rs201061067       rs369632687       rs371444741       rs371719077       rs372468940       rs372931505       rs375735989       rs375833261       rs375876732       rs376092627       rs376093748       rs376856647       rs377329266       rs528683666       rs528742989       rs529669912       rs529693519       rs530569305       rs531131224       rs531440788       rs531967390       rs533307993       rs534040063       rs535980233       rs537022582       rs538025670       rs538441046       rs539168437       rs542791634       rs543005870       rs543081565       rs543441756       rs544606700       rs545609635       rs546333243       rs547697609       rs550308123       rs551219482       rs551883914       rs552131738       rs552634598       rs553546702       rs554836514       rs557100333       rs557829102       rs558332186       rs558462037       rs559734130       rs559864275       rs561281746       rs562602878       rs565439406       rs565493507       rs566218380       rs567184841       rs568248679       rs568335136       rs568772808       rs569007332       rs571299327       rs571969199       rs572666955       rs573238886       rs573384982       rs573982509       rs574660183       rs575078525       rs575182822       rs575777586       rs575793859       rs577659401       rs587778192       rs746226987       rs746447033       rs746522150       rs746895795       rs747606716       rs747773004       rs747881336       rs748977615       rs749657088       rs750194212       rs750527466       rs750852645       rs751616001       rs752254340       rs753024389       rs754400471       rs755311871       rs755401672       rs756436149       rs756632245       rs757273086       rs757720364       rs758092761       rs758531608       rs758726582       rs760372994       rs761752002       rs762447023       rs762459325       rs763641832       rs764177294       rs764419883       rs767166906       rs767293321       rs767444679       rs767673311       rs768306446       rs770262748       rs770636941       rs771005232       rs771363863       rs771453655       rs772999335       rs773844593       rs773869623       rs774915318       rs775099224       rs776590829       rs777090929       rs777375579       rs778040955       rs779373951       rs780335632       rs780345232       rs780423965       rs781549846       rs12691       rs707656       rs10403561       rs34017519       rs34995897       rs41355649       rs41464746       rs41476047       rs72291806       rs113670631       rs116528776       rs146104564       rs187516157       rs192371350       rs372919877       rs376667577       rs527726726       rs528278380       rs533138144       rs533270582       rs535297087       rs536283229       rs541022562       rs543498805       rs544875977       rs546946624       rs547395645       rs549322947       rs549827431       rs550273098       rs556765660       rs559364629       rs563625019       rs564092451       rs564155517       rs566231195       rs568411293       rs569033502       rs570121196       rs572803705       rs573809108       rs577824983      

基因表达

基因表达

CEBPA基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CTGACCAGTGACAATGACC
58
CCTTGACCAAGGAGCTCTC
60
GCTGACCAGTGACAATGAC
59
CCTTGACCAAGGAGCTCTC
60
AAGAACAGCAACGAGTACC
58
ATTGTCACTGGTCAGCTCC
60

转录因子

转录因子

转录因子
影响类型
PubMed链接
AFP
Unknown
15924879
ALB
Unknown
10542249
BCL2
Repression
12970736
CCL2
Activation
24429361
CD163
Unknown
10725797
CRMP1
Unknown
18524846
CSF1
Unknown
9632776
CSF2RA
Unknown
7565736
CSF3R
Activation
10453008
CXCR2
Unknown
18555777

基因本体信息

CEBPA基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

CEBPA基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000050
P49715(UniProtKB)
IEA
GO:0000122
P49715(UniProtKB)
IEA
GO:0000978
P49715(UniProtKB)
IEA
GO:0001013
P49715(UniProtKB)
IDA
GO:0001077
P49715(UniProtKB)
IEA
GO:0001228
P49715(UniProtKB)
IMP
GO:0001889
P49715(UniProtKB)
ISS
GO:0001892
P49715(UniProtKB)
IEA
GO:0003677
P49715(UniProtKB)
TAS
GO:0003700
P49715(UniProtKB)
IDA
GO:0003700
P49715(UniProtKB)
IDA
GO:0003700
P49715(UniProtKB)
IDA
GO:0003705
P49715(UniProtKB)
NAS
GO:0003713
P49715(UniProtKB)
ISS
GO:0005515
P49715(UniProtKB)
IPI
GO:0005515
P49715(UniProtKB)
IPI
GO:0005515
P49715(UniProtKB)
IPI
GO:0005515
P49715(UniProtKB)
IPI
GO:0005515
P49715(UniProtKB)
IPI
GO:0005515
P49715(UniProtKB)
IPI
GO:0005515
P49715(UniProtKB)
IPI
GO:0005515
P49715(UniProtKB)
IPI
GO:0005515
P49715(UniProtKB)
IPI
GO:0005515
P49715(UniProtKB)
IPI
GO:0005515
P49715(UniProtKB)
IPI
GO:0005515
P49715(UniProtKB)
IPI
GO:0005634
P49715(UniProtKB)
IDA
GO:0005634
P49715(UniProtKB)
NAS
GO:0005730
P49715(UniProtKB)
IEA
GO:0005730
P49715(UniProtKB)
IDA
GO:0006091
P49715(UniProtKB)
TAS
GO:0006351
P49715(UniProtKB)
IDA
GO:0006351
P49715(UniProtKB)
NAS
GO:0006360
P49715(UniProtKB)
IDA
GO:0006366
P49715(UniProtKB)
IEA
GO:0007005
P49715(UniProtKB)
IEA
GO:0007219
P49715(UniProtKB)
IEA
GO:0008134
P49715(UniProtKB)
IPI
GO:0008203
P49715(UniProtKB)
IEA
GO:0008285
P49715(UniProtKB)
ISS
GO:0008285
P49715(UniProtKB)
ISS
GO:0008285
P49715(UniProtKB)
IDA
GO:0016032
P49715(UniProtKB)
IEA
GO:0019221
P49715(UniProtKB)
NAS
GO:0019900
P49715(UniProtKB)
IPI
GO:0019900
P49715(UniProtKB)
IPI
GO:0030099
P49715(UniProtKB)
NAS
GO:0030225
P49715(UniProtKB)
IEA
GO:0030324
P49715(UniProtKB)
ISS
GO:0030851
P49715(UniProtKB)
ISS
GO:0032436
P49715(UniProtKB)
TAS
GO:0042593
P49715(UniProtKB)
ISS
GO:0042803
P49715(UniProtKB)
ISS
GO:0044212
P49715(UniProtKB)
IDA
GO:0045444
P49715(UniProtKB)
ISS
GO:0045444
P49715(UniProtKB)
ISS
GO:0045600
P49715(UniProtKB)
IEA
GO:0045669
P49715(UniProtKB)
IEA
GO:0045736
P49715(UniProtKB)
TAS
GO:0045892
P49715(UniProtKB)
ISS
GO:0045892
P49715(UniProtKB)
ISS
GO:0045944
P49715(UniProtKB)
IMP
GO:0045944
P49715(UniProtKB)
IDA
GO:0045945
P49715(UniProtKB)
IDA
GO:0048469
P49715(UniProtKB)
IEA
GO:0048839
P49715(UniProtKB)
IEA
GO:0050872
P49715(UniProtKB)
IEA
GO:0050873
P49715(UniProtKB)
IEA
GO:0055088
P49715(UniProtKB)
ISS
GO:0071285
P49715(UniProtKB)
IEA
GO:0071407
P49715(UniProtKB)
IEA
GO:0090575
P49715(UniProtKB)
IMP

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控CEBPA基因的相关microRNA：      显示全部miRNA

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Leukemia, Myelocytic, Acute 0.553105144 161 11 BeFree_CLINVAR_CTD_human_GAD_LHGDN_MGD_UNIPROT
Squamous cell carcinoma 0.12272435 3 0 CTD_human_LHGDN
Liver carcinoma 0.122442977 11 0 BeFree_CTD_human
Acute Promyelocytic Leukemia 0.121357209 6 0 BeFree_CTD_human
Head and Neck Neoplasms 0.12 1 0 CTD_human
Female infertility 0.12 1 0 CTD_human
Neoplasms, Radiation-Induced 0.12 1 0 CTD_human
Precancerous Conditions 0.12 1 0 CTD_human
Skin Neoplasms 0.12 1 0 CTD_human
Acute-Phase Reaction 0.08 1 0 RGD
Transient Ischemic Attack 0.08 1 0 RGD
Myeloid Leukemia 0.019750581 11 0 BeFree_GAD
leukemia 0.010053281 28 0 BeFree_LHGDN
MYELODYSPLASTIC SYNDROME 0.0089015 6 0 BeFree_GAD_LHGDN
Obesity 0.006091273 6 0 BeFree_GAD
Lung Neoplasms 0.0054487 2 0 LHGDN
Mammary Neoplasms 0.0054487 2 0 LHGDN
Pancreatic Neoplasm 0.005091382 2 0 GAD_LHGDN
Lymphoma 0.003538676 4 0 BeFree_LHGDN
Hematologic Neoplasms 0.003538676 3 0 BeFree_LHGDN
Cytogenetically normal acute myeloid leukemia 0.003528744 13 0 BeFree
Leukopenia 0.003267234 2 0 BeFree_LHGDN
Hepatoblastoma 0.002995792 2 0 BeFree_LHGDN
Lymphoma, Non-Hodgkin 0.002909916 2 0 BeFree_GAD
Multiple Myeloma 0.002909916 2 0 BeFree_GAD
Precursor Cell Lymphoblastic Leukemia Lymphoma 0.00272435 1 0 LHGDN
Hyperlipidemia 0.002638474 1 0 BeFree_GAD
Metabolic Syndrome X 0.002638474 2 0 BeFree_GAD
Leukemogenesis 0.002442977 9 0 BeFree
Alzheimer's Disease 0.002367032 1 0 GAD
Chromosome Aberrations 0.002367032 1 0 GAD
Peripheral Vascular Diseases 0.002367032 1 0 GAD
Myocardial Ischemia 0.002367032 1 0 GAD
Liver neoplasms 0.001085767 4 0 BeFree
Preleukemia 0.001085767 4 0 BeFree
Malignant neoplasm of lung 0.001085767 4 0 BeFree
Carcinoma of lung 0.001085767 4 0 BeFree
Myeloproliferative disease 0.000814326 3 0 BeFree
Acute leukemia 0.000814326 3 0 BeFree
Adult Acute Myeloblastic Leukemia 0.000814326 3 0 BeFree
pediatric acute myeloblastic leukemia 0.000814326 3 0 BeFree
Liver and Intrahepatic Biliary Tract Carcinoma 0.000814326 3 0 BeFree
Malignant neoplasm of liver 0.000814326 3 0 BeFree
Non-alcoholic Fatty Liver Disease 0.000814326 3 0 BeFree
Carcinogenesis 0.000814326 3 0 BeFree
Myeloid neoplasm 0.000814326 3 0 BeFree
Carcinoma, Transitional Cell 0.000542884 2 0 BeFree
Congenital chromosomal disease 0.000542884 2 0 BeFree
Fatty Liver 0.000542884 2 0 BeFree
Neuroblastoma 0.000542884 2 0 BeFree
Lymphoma, Large-Cell, Follicular 0.000542884 2 0 BeFree
Liposarcoma, Dedifferentiated 0.000542884 2 0 BeFree
Central neuroblastoma 0.000542884 2 0 BeFree
Pancreatic Ductal Adenocarcinoma 0.000542884 2 0 BeFree
Urothelial Carcinoma 0.000542884 2 0 BeFree
Blood Platelet Disorders 0.000271442 1 0 BeFree
Malignant neoplasm of breast 0.000271442 1 0 BeFree
Malignant neoplasm of skin 0.000271442 1 0 BeFree
Cardiovascular Diseases 0.000271442 1 0 BeFree
Malignant tumor of cervix 0.000271442 1 0 BeFree
Diabetes Mellitus 0.000271442 1 0 BeFree
Diabetes Mellitus, Non-Insulin-Dependent 0.000271442 1 0 BeFree
Hypoglycemia 0.000271442 1 0 BeFree
Lymphoid leukemia 0.000271442 1 0 BeFree
Myeloid Leukemia, Chronic 0.000271442 1 0 BeFree
Acute myelomonocytic leukemia 0.000271442 1 0 BeFree
Monosomy 0.000271442 1 0 BeFree
Acute Myeloid Leukemia, M1 0.000271442 1 0 BeFree
Osteosarcoma 0.000271442 1 0 BeFree
Kaposi Sarcoma 0.000271442 1 0 BeFree
B-Cell Lymphomas 0.000271442 1 0 BeFree
Diffuse Large B-Cell Lymphoma 0.000271442 1 0 BeFree
Carcinoma of unknown primary 0.000271442 1 0 BeFree
Pancreatic carcinoma 0.000271442 1 0 BeFree
Chronic cervicitis 0.000271442 1 0 BeFree
Cervical Squamous Cell Carcinoma 0.000271442 1 0 BeFree
Acute Undifferentiated Leukemia 0.000271442 1 0 BeFree
Cervix carcinoma 0.000271442 1 0 BeFree
Obesity, Abdominal 0.000271442 1 0 BeFree
Malignant neoplasm of pancreas 0.000271442 1 0 BeFree
Malignant neoplasm of prostate 0.000271442 1 0 BeFree
Osteosarcoma of bone 0.000271442 1 0 BeFree
Tumor Initiation 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
Breast Carcinoma 0.000271442 1 0 BeFree
Squamous cell carcinoma of the head and neck 0.000271442 1 0 BeFree
Precursor B-cell lymphoblastic leukemia 0.000271442 1 0 BeFree
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative 0.000271442 1 0 BeFree
Chronic myeloproliferative disorder 0.000271442 1 0 BeFree
Mature B-Cell Non-Hodgkin Lymphoma 0.000271442 1 0 BeFree
Undifferentiated leukemia 0.000271442 1 0 BeFree
Hepatocarcinogenesis 0.000271442 1 0 BeFree
Skin Carcinogenesis 0.000271442 1 0 BeFree
MYELOID TUMOR SUPPRESSOR 0.000271442 1 0 BeFree
Steatohepatitis 0.000271442 1 0 BeFree
Familial Acute Myeloid Leukemia with Mutated Cebpa 0.000271442 1 0 BeFree

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