CDKN1C(cyclin-dependent kinase inhibitor 1C (p57, Kip2)) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

11p15.5
基因染色体位置图

基因简述

基因简述

This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

[中文简述(自动翻译):]  该基因印记，与产妇等位基因优先表达。所编码的蛋白质是几种G1细胞周期蛋白/ CDK复合物的紧密结合，强抑制剂和细胞增殖的负调节剂。在这种基因突变牵连零星癌症和贝克威思-威德曼syndorome，这表明该基因是一种肿瘤抑制候选。已发现该基因编码的两种不同亚型三个抄本变形。 [由RefSeq的，2010年10月提供]

OMIM数据库中对CDKN1C基因的介绍     Wikipedia数据库中对CDKN1C基因的介绍

基因序列

基因序列

CDKN1C基因的碱基序列：[NCBI]

基因突变

基因突变

CDKN1C基因的碱基突变：           显示全部snp
rs13563       rs13563       rs393572       rs393572       rs398331       rs398331       rs400377       rs400377       rs420902       rs420902       rs420903       rs420903       rs420935       rs420935       rs428704       rs428704       rs428730       rs428730       rs431222       rs431222       rs445084       rs445084       rs450563       rs450563       rs452338       rs452338       rs1054463       rs1054463       rs3741341       rs3741341       rs3852522       rs3852522       rs9282657       rs9282657       rs11024437       rs11024437       rs12293538      
rs34289096       rs34289096       rs34738237       rs34738237       rs111472963       rs111472963       rs112762165       rs112762165       rs114261594       rs114261594       rs114419783       rs114419783       rs115414892       rs115414892       rs116430081       rs116430081       rs139369096       rs139369096       rs140800911       rs140800911       rs141005361       rs141005361       rs141913643       rs141913643       rs143992355       rs143992355       rs144694499       rs144694499       rs147317732       rs147317732       rs147479631       rs147479631       rs148533938       rs148533938       rs149717696       rs181752108       rs181752108       rs185258228       rs185258228       rs186693699       rs186693699       rs188494894       rs191294997       rs191294997       rs201368350       rs201368350       rs201715947       rs201715947       rs368106038       rs368106038       rs370352968       rs370352968       rs370564696       rs370564696       rs372696229       rs373252940       rs374634184       rs374634184       rs374748742       rs374748742       rs375331269       rs375331269       rs377216794       rs377216794       rs483352970       rs483352970       rs483352987       rs483352987       rs528330778       rs528330778       rs528634940       rs528634940       rs528762846       rs528762846       rs529006417       rs529006417       rs529092366       rs529092366       rs529223353       rs529223353       rs529326848       rs529326848       rs530970152       rs530970152       rs531059713       rs531059713       rs532796198       rs532796198       rs533326001       rs533326001       rs533485167       rs533485167       rs533665238       rs533665238       rs534471786       rs534471786       rs534934487       rs534934487       rs535384026       rs535384026       rs535959184       rs535959184       rs537277110       rs537277110       rs538476740       rs538476740       rs539042081       rs540697744       rs540923047       rs541422709       rs541918893       rs543081577       rs543984932       rs544892298       rs544929471       rs545065667       rs546016935       rs546464981       rs546920371       rs546941251       rs550429501       rs550978405       rs551067521       rs551139928       rs551582789       rs551619623       rs551863674       rs551909142       rs552454538       rs552952278       rs552955353       rs553903122       rs555399624       rs555704763       rs556519658       rs556682082       rs556775435       rs556936950       rs557448742       rs557872383       rs558762873       rs558847674       rs558934701       rs559161477       rs560380736       rs560671896       rs561563503       rs562237921       rs562468390       rs562886157       rs562997014       rs563130102       rs564477040       rs564726941       rs565544512       rs566352198       rs566434849       rs567863959       rs568449657       rs568491395       rs568798726       rs569953999       rs570525745       rs570636789       rs572833536       rs573428261       rs574250291       rs574318429       rs574366375       rs578104871       rs745815931       rs746208740       rs747104008       rs747360016       rs747757242       rs747982670       rs748266511       rs748680303       rs748889587       rs749473196       rs749702191       rs749713233       rs750153240       rs750526402       rs750581456       rs750876855       rs751055532       rs751324426       rs751650132       rs751669088       rs752255760       rs752274161       rs752482298       rs752846343       rs753022994       rs753342439       rs753651871       rs753973370       rs754196288       rs754283907       rs754671425       rs754679898       rs754972138       rs755160554       rs755391541       rs755586297       rs756321814       rs756961090       rs757359164       rs757586907       rs757811709       rs757986512       rs758011168       rs758244300       rs758576724       rs758620755       rs759365577       rs759474789       rs759616401       rs760038657       rs760584588       rs760758691       rs760980314       rs761296394       rs761539484       rs761689994       rs762106424       rs762337324       rs762520730       rs762619956       rs763176740       rs763289302       rs763525000       rs763529383       rs763621138       rs764083468       rs764328739       rs764536797       rs764972822       rs765026706       rs765255367       rs765542916       rs765932400       rs766680588       rs766858608       rs767540210       rs768242627       rs768656669       rs768889550       rs769255937       rs769907193       rs770109299       rs770277810       rs771450542       rs771502215       rs771731330       rs771897365       rs772130948       rs772497485       rs772684721       rs773166985       rs773257476       rs773741430       rs773881541       rs773932111       rs774392534       rs774447378       rs774548414       rs774805080       rs775227462       rs775427512       rs775458829       rs775842083       rs775889163       rs776240688       rs776541692       rs776594994       rs777011860       rs777465972       rs777855717       rs778520280       rs778772076       rs779172459       rs779262119       rs779975908       rs780288064       rs780417247       rs780549417       rs780580834       rs781340171       rs781428134       rs781782166      

基因表达

基因表达

CDKN1C基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GATCTCCGATTTCTTCGCC
59
GGTTGCTGCTACATGAACG
60
ATTACGACTTCCAGCAGGA
58
CGAAGAAATCTGCACCGTC
59
GATCTCCGATTTCTTCGCC
59
GTTGCTGCTACATGAACGG
60
ATTACGACTTCCAGCAGGAC
60
CGAAGAAATCTGCACCGTC
59
GATCTCCGATTTCTTCGCC
59
CTCTAAATTGGCTCACCGC
59
GATCTCCGATTTCTTCGCC
59
CTCTAAATTGGCTCACCGC
59
CTGATCTCCGATTTCTTCGC
59
CTAAATTGGCTCACCGCAG
59
GTGAGCCAATTTAGAGCCC
59
GTTGCTGCTACATGAACGG
60
TGATCTCCGATTTCTTCGC
58
GTTGCTGCTACATGAACGG
60
GATCTCCGATTTCTTCGCC
59
CTAAATTGGCTCACCGCAG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

CDKN1C基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

CDKN1C基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004861
A0A0G2JH30(UniProtKB)
IEA
GO:0005634
A0A0G2JH30(UniProtKB)
IEA
GO:0007050
A0A0G2JH30(UniProtKB)
IEA
GO:0007346
A0A0G2JH30(UniProtKB)
IEA
GO:0071901
A0A0G2JH30(UniProtKB)
IEA
GO:0004861
A0A0G2JPX0(UniProtKB)
IEA
GO:0005634
A0A0G2JPX0(UniProtKB)
IEA
GO:0007050
A0A0G2JPX0(UniProtKB)
IEA
GO:0007346
A0A0G2JPX0(UniProtKB)
IEA
GO:0071901
A0A0G2JPX0(UniProtKB)
IEA
GO:0004861
A6NK88(UniProtKB)
IEA
GO:0005634
A6NK88(UniProtKB)
IEA
GO:0007050
A6NK88(UniProtKB)
IEA
GO:0007346
A6NK88(UniProtKB)
IEA
GO:0071901
A6NK88(UniProtKB)
IEA
GO:0000122
P49918(UniProtKB)
IEA
GO:0001501
P49918(UniProtKB)
IEA
GO:0001822
P49918(UniProtKB)
IEA
GO:0004861
P49918(UniProtKB)
IEA
GO:0005515
P49918(UniProtKB)
IPI
GO:0005515
P49918(UniProtKB)
IPI
GO:0005515
P49918(UniProtKB)
IPI
GO:0005515
P49918(UniProtKB)
IPI
GO:0005634
P49918(UniProtKB)
IDA
GO:0005737
P49918(UniProtKB)
IDA
GO:0007050
P49918(UniProtKB)
IEA
GO:0007346
P49918(UniProtKB)
IEA
GO:0007568
P49918(UniProtKB)
IEA
GO:0030099
P49918(UniProtKB)
IEA
GO:0030325
P49918(UniProtKB)
IEA
GO:0030511
P49918(UniProtKB)
IMP
GO:0033673
P49918(UniProtKB)
IDA
GO:0035264
P49918(UniProtKB)
IEA
GO:0042326
P49918(UniProtKB)
IDA
GO:0042551
P49918(UniProtKB)
IEA
GO:0043010
P49918(UniProtKB)
IEA
GO:0045892
P49918(UniProtKB)
IDA
GO:0045893
P49918(UniProtKB)
IGI
GO:0050680
P49918(UniProtKB)
IMP
GO:0055123
P49918(UniProtKB)
IEA
GO:0060065
P49918(UniProtKB)
IEA
GO:0060669
P49918(UniProtKB)
IEA
GO:0071514
P49918(UniProtKB)
IEA
GO:0071901
P49918(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控CDKN1C基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies 0.361628651 6 6 BeFree_CLINVAR_ORPHANET_UNIPROT
Beckwith-Wiedemann Syndrome 0.266088214 66 15 BeFree_CLINVAR_CTD_human_LHGDN
Adenocarcinoma 0.12 1 0 CTD_human
Endometrial Neoplasms 0.12 1 0 CTD_human
Endometrial Hyperplasia 0.12 1 0 CTD_human
Lung Neoplasms 0.12 2 0 CTD_human
melanoma 0.12 1 0 CTD_human
Pancreatic Neoplasm 0.0054487 2 0 LHGDN
Hydatidiform Mole 0.005428837 20 0 BeFree
Complete hydatidiform mole 0.005428837 20 0 BeFree
leukemia 0.003538676 3 0 BeFree_LHGDN
Hydatidiform Mole, Partial 0.003528744 13 0 BeFree
Carcinogenesis 0.003528744 13 0 BeFree
Glioblastoma 0.003267234 2 0 BeFree_LHGDN
Mammary Neoplasms 0.003267234 3 0 BeFree_LHGDN
Atherosclerosis 0.002995792 1 0 BeFree_LHGDN
Esophageal Neoplasms 0.002995792 1 0 BeFree_LHGDN
Mesothelioma 0.002995792 1 0 BeFree_LHGDN
Myocardial Infarction 0.002995792 1 0 BeFree_LHGDN
Thyroid Neoplasm 0.002995792 1 0 BeFree_LHGDN
Mucosa-Associated Lymphoid Tissue Lymphoma 0.002995792 1 0 BeFree_LHGDN
ovarian neoplasm 0.002995792 2 0 BeFree_LHGDN
Russell-Silver syndrome 0.002985861 11 0 BeFree
HYDATIDIFORM MOLE, RECURRENT, 1 0.002985861 11 0 BeFree
Malignant neoplasm of urinary bladder 0.002909916 3 0 BeFree_GAD
Malignant neoplasm of lung 0.002909916 3 0 BeFree_GAD
Liver carcinoma 0.002714419 10 0 BeFree
Diabetes Mellitus, Non-Insulin-Dependent 0.002638474 1 0 BeFree_GAD
Chronic Obstructive Airway Disease 0.002638474 2 0 BeFree_GAD
Epithelial ovarian cancer 0.002638474 2 0 BeFree_GAD
Nephroblastoma 0.002442977 9 0 BeFree
Multiple Endocrine Neoplasia Type 1 0.002367032 1 0 GAD
body mass 0.002367032 1 0 GAD
Triploidy syndrome 0.001900093 7 0 BeFree
Malignant neoplasm of breast 0.001628651 6 0 BeFree
Nevus 0.001628651 6 0 BeFree
Melanocytic nevus 0.001628651 6 0 BeFree
Breast Carcinoma 0.001628651 6 0 BeFree
Benign melanocytic nevus 0.001628651 6 0 BeFree
Acute lymphocytic leukemia 0.001357209 5 0 BeFree
Neoplasm Metastasis 0.001357209 5 0 BeFree
Tumor Progression 0.001357209 5 0 BeFree
Umbilical hernia 0.001085767 4 0 BeFree
Congenital exomphalos 0.001085767 4 0 BeFree
Overgrowth Syndrome 0.001085767 4 0 BeFree
Congenital Abnormality 0.000814326 3 0 BeFree
Choriocarcinoma 0.000814326 3 0 BeFree
Hyperinsulinism 0.000814326 3 0 BeFree
Lymphoid leukemia 0.000814326 3 0 BeFree
Malignant neoplasm of stomach 0.000814326 3 0 BeFree
Ovarian Carcinoma 0.000814326 3 0 BeFree
Retinoblastoma 0.000814326 3 0 BeFree
Adrenal Cortical Adenoma 0.000814326 3 0 BeFree
Stomach Carcinoma 0.000814326 3 0 BeFree
Adult Acute Lymphocytic Leukemia 0.000814326 3 0 BeFree
Congenital omphalocele 0.000814326 3 0 BeFree
Gestational Trophoblastic Neoplasms 0.000814326 3 0 BeFree
Adenoma 0.000542884 2 0 BeFree
Squamous cell carcinoma 0.000542884 2 0 BeFree
Cleft Palate 0.000542884 2 0 BeFree
Colorectal Carcinoma 0.000542884 2 0 BeFree
Diabetes 0.000542884 2 0 BeFree
Diabetes Mellitus 0.000542884 2 0 BeFree
Glioma 0.000542884 2 0 BeFree
Leukemia, Myelocytic, Acute 0.000542884 2 0 BeFree
Lymphoma, Follicular 0.000542884 2 0 BeFree
Neuroblastoma 0.000542884 2 0 BeFree
Prader-Willi Syndrome 0.000542884 2 0 BeFree
Rhabdomyosarcoma 0.000542884 2 0 BeFree
B-Cell Lymphomas 0.000542884 2 0 BeFree
Diffuse Large B-Cell Lymphoma 0.000542884 2 0 BeFree
Polycystic Kidney, Autosomal Dominant 0.000542884 2 0 BeFree
Malignant neoplasm of pancreas 0.000542884 2 0 BeFree
Carcinoma of lung 0.000542884 2 0 BeFree
Secondary malignant neoplasm of lymph node 0.000542884 2 0 BeFree
Carcinoma of bladder 0.000542884 2 0 BeFree
Central neuroblastoma 0.000542884 2 0 BeFree
Malignant neoplasm of ovary 0.000542884 2 0 BeFree
Precursor Cell Lymphoblastic Leukemia Lymphoma 0.000542884 2 0 BeFree
Tumors of Adrenal Cortex 0.000271442 1 0 BeFree
Adrenal gland hypofunction 0.000271442 1 0 BeFree
Adrenal Gland Neoplasms 0.000271442 1 0 BeFree
Arteriosclerosis 0.000271442 1 0 BeFree
Blast Phase 0.000271442 1 0 BeFree
Rectal Carcinoma 0.000271442 1 0 BeFree
Non-Small Cell Lung Carcinoma 0.000271442 1 0 BeFree
Congenital chromosomal disease 0.000271442 1 0 BeFree
Down Syndrome 0.000271442 1 0 BeFree
Muscular Dystrophy, Duchenne 0.000271442 1 0 BeFree
Dwarfism 0.000271442 1 0 BeFree
IGA Glomerulonephritis 0.000271442 1 0 BeFree
Hemangioma 0.000271442 1 0 BeFree
Hydrocephalus 0.000271442 1 0 BeFree
insulinoma 0.000271442 1 0 BeFree
Leukemia, Lymphocytic, Acute, L1 0.000271442 1 0 BeFree
Leukemia, T-Cell 0.000271442 1 0 BeFree
Adult T-Cell Lymphoma/Leukemia 0.000271442 1 0 BeFree
Liver neoplasms 0.000271442 1 0 BeFree
Mitral Valve Stenosis 0.000271442 1 0 BeFree
Multiple Sclerosis 0.000271442 1 0 BeFree
Pheochromocytoma 0.000271442 1 0 BeFree
Preleukemia 0.000271442 1 0 BeFree
Prostatic Neoplasms 0.000271442 1 0 BeFree
Rectal Neoplasms 0.000271442 1 0 BeFree
Low Grade Lymphoma (neoplasm) 0.000271442 1 0 BeFree
Lymphoma, T-Cell, Cutaneous 0.000271442 1 0 BeFree
Benign Neoplasm 0.000271442 1 0 BeFree
Oral Cavity Carcinoma 0.000271442 1 0 BeFree
Esophageal carcinoma 0.000271442 1 0 BeFree
HELLP Syndrome 0.000271442 1 0 BeFree
Williams Syndrome 0.000271442 1 0 BeFree
Glomerulosclerosis (disorder) 0.000271442 1 0 BeFree
Hepatoblastoma 0.000271442 1 0 BeFree
Rhabdomyosarcoma, Embryonal 0.000271442 1 0 BeFree
Adrenocortical carcinoma 0.000271442 1 0 BeFree
Lip and Oral Cavity Carcinoma 0.000271442 1 0 BeFree
Pancreatic carcinoma 0.000271442 1 0 BeFree
Neoplasm, Residual 0.000271442 1 0 BeFree
Transient neonatal diabetes mellitus 0.000271442 1 0 BeFree
Gestational choriocarcinoma 0.000271442 1 0 BeFree
Malignant neoplasm of prostate 0.000271442 1 0 BeFree
Adrenal cortical hypofunction 0.000271442 1 0 BeFree
Malignant neoplasm of esophagus 0.000271442 1 0 BeFree
Malignant Glioma 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 1 0.000271442 1 0 BeFree
Helicobacter pylori infection 0.000271442 1 0 BeFree
Squamous cell carcinoma of the head and neck 0.000271442 1 0 BeFree
Sarcoma 0.000271442 1 0 BeFree
Xenograft Model 0.000271442 1 0 BeFree
Colorectal Cancer 0.000271442 1 0 BeFree
Rectal Tumors 0.000271442 1 0 BeFree
MULTICYSTIC RENAL DYSPLASIA, BILATERAL 0.000271442 1 0 BeFree
Glucocorticoid Receptor Deficiency 0.000271442 1 0 BeFree
Relative macrocephaly 0.000271442 1 0 BeFree
Gestational trophoblastic disease 0.000271442 1 0 BeFree
Nasopharyngeal carcinoma 0.000271442 1 0 BeFree
MYELODYSPLASTIC SYNDROME 0.000271442 1 0 BeFree

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