更多...
收起
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是高度类似于酿酒酵母的Cdc6,DNA复制的起始所必需的蛋白质。该蛋白质作为在DNA复制的早期步骤的调节器。它细胞cyle G1期间本地化在细胞核,但在S期的开始转运至细胞质中。这种蛋白质的细胞cyle在亚细胞易位通过由的Cdks其磷酸化调节。据报道这种蛋白质转录的通过涉及E2F蛋白转录调控机制,应对有丝分裂信号加以规范。 [由RefSeq的,2008年7月提供]
CDC6基因(以及对应的蛋白质)的细胞分布位置:
CDC6基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
EAR, PATELLA, SHORT STATURE SYNDROME | 0.240542884 | 3 | 0 | BeFree_CTD_human_ORPHANET |
MEIER-GORLIN SYNDROME 5 | 0.24 | 1 | 1 | CLINVAR_UNIPROT |
Peripheral Neuropathy | 0.12 | 1 | 0 | CTD_human |
Polycystic Ovary Syndrome | 0.12 | 1 | 0 | CTD_human |
Liver carcinoma | 0.008001298 | 2 | 1 | BeFree_GAD_LHGDN |
Prostatic Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
Liver neoplasms | 0.004734064 | 2 | 0 | GAD |
Squamous cell carcinoma | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Lymphoma, Non-Hodgkin | 0.002638474 | 1 | 1 | BeFree_GAD |
Uterine Cervical Neoplasm | 0.002367032 | 1 | 0 | GAD |
Chronic Lymphocytic Leukemia | 0.002367032 | 1 | 0 | GAD |
Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of prostate | 0.001900093 | 7 | 0 | BeFree |
Carcinogenesis | 0.001900093 | 7 | 1 | BeFree |
Prostate carcinoma | 0.001900093 | 7 | 0 | BeFree |
Neoplasm Metastasis | 0.000814326 | 3 | 0 | BeFree |
Cervix carcinoma | 0.000542884 | 2 | 1 | BeFree |
Squamous cell carcinoma of tongue | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Cervical dysplasia | 0.000271442 | 1 | 0 | BeFree |
Endometriosis | 0.000271442 | 1 | 0 | BeFree |
Microcephaly | 0.000271442 | 1 | 0 | BeFree |
Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
Cervical Intraepithelial Neoplasia | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Cervical Squamous Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Non-Neoplastic Disorder | 0.000271442 | 1 | 0 | BeFree |
忘记密码? 点击找回密码.
扫一扫右方二维码,关注微信订阅号,实时查看信息,关注医学生物学动态。