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The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
[中文简述(自动翻译):]  该基??因联营公司与Ⅱ类主要组织相容性复合体(MHC)编码的蛋白质,是一种调节抗原提呈的免疫反应的重要伴侣。它也可作为细胞因子巨噬细胞迁移抑制因子(MIF),当结合到编码蛋白质,启动存活途径和细胞增殖细胞表面受体。这种蛋白也与淀粉样前体蛋白(APP)相互作用,并抑制生产淀粉样蛋白β(Abeta的)的。编码不同亚型多重选择性剪接转录变异体已经确定。 [由RefSeq的,2011年8月提供]
CD74基因(以及对应的蛋白质)的细胞分布位置:
CD74基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Non-Small Cell Lung Carcinoma | 0.121085767 | 5 | 0 | BeFree_CTD_human |
Mammary Neoplasms | 0.120542884 | 3 | 0 | BeFree_CTD_human |
Liver Failure, Acute | 0.12 | 1 | 0 | CTD_human |
Diabetic Nephropathy | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Lung Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Multiple Myeloma | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Kidney Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Prostatic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Liver carcinoma | 0.00272435 | 1 | 0 | LHGDN |
Celiac Disease | 0.002367032 | 1 | 0 | GAD |
Chronic Lymphocytic Leukemia | 0.001085767 | 4 | 0 | BeFree |
Lymphoma | 0.001085767 | 4 | 0 | BeFree |
Carcinogenesis | 0.000814326 | 3 | 0 | BeFree |
Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
Conventional (Clear Cell) Renal Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Solid tumour | 0.000542884 | 2 | 0 | BeFree |
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.000542884 | 2 | 0 | BeFree |
Hematologic Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Adenoma | 0.000271442 | 1 | 0 | BeFree |
Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
Atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of thyroid | 0.000271442 | 1 | 0 | BeFree |
Mucinous Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
Cardiovascular Diseases | 0.000271442 | 1 | 0 | BeFree |
Carotid Stenosis | 0.000271442 | 1 | 0 | BeFree |
Primary biliary cirrhosis | 0.000271442 | 1 | 0 | BeFree |
Ulcerative Colitis | 0.000271442 | 1 | 0 | BeFree |
Dermatitis | 0.000271442 | 1 | 0 | BeFree |
Diabetic Retinopathy | 0.000271442 | 1 | 0 | BeFree |
Experimental Autoimmune Encephalomyelitis | 0.000271442 | 1 | 0 | BeFree |
Endometriosis | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Glioma | 0.000271442 | 1 | 0 | BeFree |
HIV Infections | 0.000271442 | 1 | 0 | BeFree |
Immune System Diseases | 0.000271442 | 1 | 0 | BeFree |
Ischemia | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
Chronic Obstructive Airway Disease | 0.000271442 | 1 | 0 | BeFree |
Lupus Vulgaris | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus, Discoid | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus, Systemic | 0.000271442 | 1 | 0 | BeFree |
melanoma | 0.000271442 | 1 | 0 | BeFree |
Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
Metabolic Diseases | 0.000271442 | 1 | 0 | BeFree |
Myositis | 0.000271442 | 1 | 0 | BeFree |
Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Emphysema | 0.000271442 | 1 | 0 | BeFree |
Virus Diseases | 0.000271442 | 1 | 0 | BeFree |
Epstein-Barr Virus Infections | 0.000271442 | 1 | 0 | BeFree |
Thyroid Gland Follicular Adenoma | 0.000271442 | 1 | 0 | BeFree |
Intervertebral Disc Degeneration | 0.000271442 | 1 | 0 | BeFree |
Follicular adenoma | 0.000271442 | 1 | 0 | BeFree |
Alphavirus Infections | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Papillary thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Hepatitis, Autoimmune | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Anaplastic astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus | 0.000271442 | 1 | 0 | BeFree |
Thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Malignant Pleural Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
Oestrogen deficiency | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of lung, stage IV | 0.000271442 | 1 | 0 | BeFree |
Adenoma of large intestine | 0.000271442 | 1 | 0 | BeFree |
Renal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Alphaviral infection | 0.000271442 | 1 | 0 | BeFree |
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