更多...
收起
This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
[中文简述(自动翻译):]  这个基因编码的免疫球蛋白样受体的CD2亚科,其中包括SLAM(信令淋巴细胞活化的分子)的蛋白质的成员。所编码的蛋白质被淋巴细胞和其他免疫细胞,树突细胞和内皮细胞的表面上发现,而在这些细胞的活化和分化途径参与。所编码的蛋白质不具有跨膜结构域,然而,但在细胞表面通过经由这可能裂解,得到受体的可溶形式的C-末端结构域的GPI锚定保持。已发现该基因编码不同亚型的多个抄本变形。 [由RefSeq的,2011年12月提供]
CD48基因(以及对应的蛋白质)的细胞分布位置:
CD48基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Inflammation | 0.00272435 | 1 | 0 | LHGDN |
| Schizophrenia | 0.002638474 | 2 | 0 | BeFree_GAD |
| HIV Infections | 0.000814326 | 3 | 0 | BeFree |
| Tuberculosis | 0.000814326 | 3 | 0 | BeFree |
| Aplastic Anemia | 0.000542884 | 2 | 0 | BeFree |
| Rheumatoid Arthritis | 0.000542884 | 2 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.000542884 | 2 | 0 | BeFree |
| Lupus Erythematosus, Systemic | 0.000542884 | 2 | 0 | BeFree |
| Lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Paroxysmal nocturnal hemoglobinuria | 0.000542884 | 2 | 0 | BeFree |
| Refractory anemias | 0.000271442 | 1 | 0 | BeFree |
| Asthma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
| Dermatitis, Atopic | 0.000271442 | 1 | 0 | BeFree |
| Eczema | 0.000271442 | 1 | 0 | BeFree |
| Tick-Borne Encephalitis | 0.000271442 | 1 | 0 | BeFree |
| Influenza | 0.000271442 | 1 | 0 | BeFree |
| leukemia | 0.000271442 | 1 | 0 | BeFree |
| Acute lymphocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Lupus Vulgaris | 0.000271442 | 1 | 0 | BeFree |
| Lupus Erythematosus, Discoid | 0.000271442 | 1 | 0 | BeFree |
| Lyme Disease | 0.000271442 | 1 | 0 | BeFree |
| Mycoses | 0.000271442 | 1 | 0 | BeFree |
| Peritonitis | 0.000271442 | 1 | 0 | BeFree |
| Tn Syndrome | 0.000271442 | 1 | 0 | BeFree |
| secondary acute myeloid leukemia | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
| Lupus Erythematosus | 0.000271442 | 1 | 0 | BeFree |
| Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Autoimmune Lymphoproliferative Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Refractory anemia, without ringed sideroblasts, without excess blasts | 0.000271442 | 1 | 0 | BeFree |
| Allergic disposition | 0.000271442 | 1 | 0 | BeFree |
忘记密码? 点击找回密码.
扫一扫右方二维码,关注微信订阅号,实时查看信息,关注医学生物学动态。