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The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白是跨膜4超家族的成员,也称为四旋家族。大多数这些成员是细胞表面蛋白质的特征在于四个疏水区的存在。蛋白质介导其在细胞发育,活化,生长和运动的调节作用的信号转导事件。这个编码的蛋白质是已知的复合物与整合素和其他跨膜4超家族的蛋白质的细胞表面糖蛋白。它可能在T细胞的B细胞的相互作用的作用。在多个备选的转录剪接变异体导致编码不同亚型。 [由RefSeq的,2008年7月提供]
CD37基因(以及对应的蛋白质)的细胞分布位置:
CD37基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
IGA Glomerulonephritis | 0.12 | 1 | 0 | CTD_human |
Chronic Lymphocytic Leukemia | 0.000542884 | 2 | 0 | BeFree |
Lymphoma, Non-Hodgkin | 0.000542884 | 2 | 0 | BeFree |
Influenza | 0.000271442 | 1 | 0 | BeFree |
leukemia | 0.000271442 | 1 | 0 | BeFree |
Acute lymphocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.000271442 | 1 | 0 | BeFree |
Sacroiliitis | 0.000271442 | 1 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000271442 | 1 | 0 | BeFree |
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