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The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]
[中文简述(自动翻译):]  由该基因编码的蛋白质是血小板表面的第四个主要的糖蛋白,并作为血小板和各种细胞系血小板反应蛋白的受体。因为thrombospondins分布广泛参与了各种粘合剂过程的蛋白质,这种蛋白质可具有作为细胞粘附分子的重要功能。它结合到胶原蛋白,血小板反应蛋白,阴离子磷脂和氧化的LDL。它直接介导恶性疟原虫寄生红细胞的细胞粘附和其结合长链脂肪酸和在运输和/或作为脂肪酸转运的调节器可起作用。突变这个基因导致血小板膜糖蛋白缺乏症。多重选择性剪接转录变异体也发现了这种基因。 [由RefSeq的,2014年2月提供]
CD36基因(以及对应的蛋白质)的细胞分布位置:
CD36基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Platelet Glycoprotein IV Deficiency | 0.444071628 | 16 | 4 | BeFree_CLINVAR_CTD_human_MGD_UNIPROT |
Hypertensive disease | 0.211454097 | 11 | 1 | BeFree_CTD_human_GAD_LHGDN_RGD |
Insulin Resistance | 0.202367032 | 3 | 0 | CTD_human_GAD_RGD |
Malaria | 0.133973019 | 25 | 1 | BeFree_CTD_human_GAD_LHGDN |
Coronary heart disease | 0.124624443 | 7 | 1 | BeFree_CTD_human_LHGDN |
Impaired glucose tolerance | 0.123538676 | 4 | 0 | BeFree_CTD_human_LHGDN |
Cardiomyopathy, Dilated | 0.120271442 | 2 | 0 | BeFree_CTD_human |
IGA Glomerulonephritis | 0.12 | 1 | 0 | CTD_human |
Immunologic Deficiency Syndromes | 0.12 | 1 | 0 | CTD_human |
Reperfusion Injury | 0.12 | 1 | 0 | CTD_human |
Staphylococcal Infections | 0.12 | 1 | 0 | CTD_human |
Weight Gain | 0.12 | 1 | 0 | CTD_human |
Myocardial Ischemia | 0.12 | 1 | 0 | CTD_human |
Dermatitis, Allergic Contact | 0.12 | 1 | 0 | CTD_human |
Platelet mean volume finding | 0.12 | 1 | 1 | GWASCAT |
PLASMODIUM FALCIPARUM BLOOD INFECTION LEVEL | 0.12 | 0 | 0 | CTD_human |
MALARIA, CEREBRAL, SUSCEPTIBILITY TO (finding) | 0.12 | 0 | 0 | CLINVAR |
MALARIA, CEREBRAL, RESISTANCE TO | 0.12 | 0 | 0 | CLINVAR |
CORONARY HEART DISEASE, SUSCEPTIBILITY TO, 7 | 0.12 | 0 | 0 | CLINVAR |
Obesity | 0.094701468 | 30 | 0 | BeFree_GAD_RGD |
Diabetes Mellitus, Non-Insulin-Dependent | 0.094625523 | 23 | 1 | BeFree_GAD_RGD |
Metabolic Syndrome X | 0.089348576 | 18 | 2 | BeFree_GAD_RGD |
Myocardial Infarction | 0.085905708 | 6 | 0 | BeFree_GAD_LHGDN_RGD |
Age related macular degeneration | 0.085362824 | 2 | 0 | BeFree_GAD_LHGDN_RGD |
Hypertrophic Cardiomyopathy | 0.080271442 | 2 | 0 | BeFree_RGD |
Diabetic Nephropathy | 0.080271442 | 1 | 0 | BeFree_RGD |
Osteoarthritis, Knee | 0.080271442 | 2 | 0 | BeFree_RGD |
Cardiac Arrhythmia | 0.08 | 1 | 0 | RGD |
Diabetes Mellitus, Experimental | 0.08 | 1 | 0 | RGD |
Nephrosis | 0.08 | 1 | 0 | RGD |
Pulmonary Fibrosis | 0.08 | 1 | 0 | RGD |
Pterygium Of Conjunctiva And Cornea | 0.08 | 0 | 0 | MGD |
Atherosclerosis | 0.022136138 | 39 | 0 | BeFree_GAD_LHGDN |
Malaria, Falciparum | 0.013192369 | 8 | 0 | BeFree_GAD |
Arteriosclerosis | 0.012224816 | 36 | 0 | BeFree_LHGDN |
Diabetes Mellitus | 0.007338862 | 17 | 1 | BeFree_LHGDN |
Hyperlipidemia | 0.005991584 | 4 | 0 | BeFree_LHGDN |
Colorectal Cancer | 0.005276948 | 2 | 0 | BeFree_GAD |
Cardiovascular Diseases | 0.004624443 | 8 | 0 | BeFree_LHGDN |
Heart Diseases | 0.004624443 | 7 | 0 | BeFree_LHGDN |
Diabetes | 0.004614512 | 17 | 1 | BeFree |
Coronary Arteriosclerosis | 0.004538567 | 9 | 1 | BeFree_GAD |
Coronary Artery Disease | 0.004267125 | 7 | 0 | BeFree_GAD |
melanoma | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Malaria, Cerebral | 0.003452799 | 4 | 0 | BeFree_GAD |
Polycystic Ovary Syndrome | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Hyperlipidemia, Familial Combined | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Osteosarcoma | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Inclusion Body Myositis (disorder) | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Idiopathic Pulmonary Fibrosis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Hypertriglyceridemia | 0.00272435 | 1 | 0 | LHGDN |
Acute Megakaryocytic Leukemias | 0.00272435 | 1 | 0 | LHGDN |
Retinal Degeneration | 0.00272435 | 1 | 0 | LHGDN |
Thrombocytopenia | 0.00272435 | 1 | 0 | LHGDN |
Mammary Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Infection | 0.00272435 | 1 | 0 | LHGDN |
Anemia | 0.002638474 | 1 | 0 | BeFree_GAD |
Liver diseases | 0.002638474 | 2 | 0 | BeFree_GAD |
Degenerative polyarthritis | 0.002638474 | 2 | 0 | BeFree_GAD |
Angina Pectoris | 0.002367032 | 1 | 0 | GAD |
Kidney Failure, Chronic | 0.002367032 | 1 | 0 | GAD |
Left ventricular mass | 0.002367032 | 1 | 1 | GAD |
body mass | 0.002367032 | 1 | 0 | GAD |
Blood pressure finding | 0.002367032 | 1 | 0 | GAD |
Systemic arterial pressure | 0.002367032 | 1 | 0 | GAD |
HIV Infections | 0.001628651 | 6 | 0 | BeFree |
Cerebrovascular accident | 0.001357209 | 5 | 1 | BeFree |
Dyslipidemias | 0.001357209 | 5 | 1 | BeFree |
Blood Coagulation Disorders | 0.001085767 | 4 | 0 | BeFree |
Fatty Liver | 0.001085767 | 4 | 0 | BeFree |
Alzheimer's Disease | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of breast | 0.000814326 | 3 | 0 | BeFree |
Hypercholesterolemia | 0.000814326 | 3 | 2 | BeFree |
Hyperglycemia | 0.000814326 | 3 | 0 | BeFree |
Neoplasm Metastasis | 0.000814326 | 3 | 0 | BeFree |
Non-alcoholic Fatty Liver Disease | 0.000814326 | 3 | 0 | BeFree |
Carcinogenesis | 0.000814326 | 3 | 0 | BeFree |
Breast Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Steatohepatitis | 0.000814326 | 3 | 0 | BeFree |
Anemia, Sickle Cell | 0.000542884 | 2 | 0 | BeFree |
Bipolar Disorder | 0.000542884 | 2 | 0 | BeFree |
Malignant tumor of colon | 0.000542884 | 2 | 0 | BeFree |
Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Diabetic Retinopathy | 0.000542884 | 2 | 0 | BeFree |
Endometriosis | 0.000542884 | 2 | 0 | BeFree |
Inflammatory Bowel Diseases | 0.000542884 | 2 | 0 | BeFree |
Liver neoplasms | 0.000542884 | 2 | 0 | BeFree |
Metabolic Diseases | 0.000542884 | 2 | 0 | BeFree |
Essential Hypertension | 0.000542884 | 2 | 0 | BeFree |
Exudative age-related macular degeneration | 0.000542884 | 2 | 0 | BeFree |
Colon Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Cardiomyopathies | 0.000542884 | 2 | 0 | BeFree |
Mammographic Density | 0.000542884 | 2 | 0 | BeFree |
Parvovirus B19 (disease) | 0.000542884 | 2 | 0 | BeFree |
Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
Blood Platelet Disorders | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
Mental Depression | 0.000271442 | 1 | 4 | BeFree |
Depressive disorder | 0.000271442 | 1 | 4 | BeFree |
Dermatitis, Atopic | 0.000271442 | 1 | 1 | BeFree |
Diabetes Mellitus, Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
Eczema | 0.000271442 | 1 | 1 | BeFree |
pathologic fistula | 0.000271442 | 1 | 0 | BeFree |
Nodular glomerulosclerosis | 0.000271442 | 1 | 0 | BeFree |
Heart failure | 0.000271442 | 1 | 0 | BeFree |
Congestive heart failure | 0.000271442 | 1 | 0 | BeFree |
Hunger | 0.000271442 | 1 | 0 | BeFree |
Hyperinsulinism | 0.000271442 | 1 | 0 | BeFree |
Leprosy, Lepromatous | 0.000271442 | 1 | 0 | BeFree |
leukemia | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
Liver Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
Spinal Muscular Atrophy | 0.000271442 | 1 | 0 | BeFree |
Polycythemia Vera | 0.000271442 | 1 | 0 | BeFree |
Prader-Willi Syndrome | 0.000271442 | 1 | 0 | BeFree |
Preleukemia | 0.000271442 | 1 | 0 | BeFree |
Skin Diseases, Infectious | 0.000271442 | 1 | 0 | BeFree |
Tuberculosis | 0.000271442 | 1 | 0 | BeFree |
Diffuse Large B-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Seasonal Affective Disorder | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of mouth | 0.000271442 | 1 | 0 | BeFree |
Asymmetric Septal Hypertrophy | 0.000271442 | 1 | 0 | BeFree |
Liposarcoma, Dedifferentiated | 0.000271442 | 1 | 0 | BeFree |
Acinar Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Lip and Oral Cavity Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Impaired cognition | 0.000271442 | 1 | 0 | BeFree |
Ischemic cardiomyopathy | 0.000271442 | 1 | 0 | BeFree |
Septal hypertrophy | 0.000271442 | 1 | 0 | BeFree |
Hepatitis C, Chronic | 0.000271442 | 1 | 0 | BeFree |
Exercise-induced angina | 0.000271442 | 1 | 1 | BeFree |
cardiac event | 0.000271442 | 1 | 0 | BeFree |
Breast Liposarcoma | 0.000271442 | 1 | 0 | BeFree |
Desmoplastic | 0.000271442 | 1 | 0 | BeFree |
Leprosy, Paucibacillary | 0.000271442 | 1 | 0 | BeFree |
Peripheral Arterial Diseases | 0.000271442 | 1 | 0 | BeFree |
Non-Neoplastic Disorder | 0.000271442 | 1 | 0 | BeFree |
Dysglycemia | 0.000271442 | 1 | 0 | BeFree |
Alcoholic Steatohepatitis | 0.000271442 | 1 | 0 | BeFree |
Acute malaria | 0.000271442 | 1 | 0 | BeFree |
MYELODYSPLASTIC SYNDROME | 0.000271442 | 1 | 0 | BeFree |
Intracranial glioma | 0.000271442 | 1 | 0 | BeFree |
Insulin resistance syndrome | 0.000271442 | 1 | 1 | BeFree |
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