CD27(CD27 molecule) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

12p13
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  由该基因编码的蛋白质是TNF受体超家族的成员。这种受体是必需的用于产生和长期维持T细胞免疫的。其结合到配体CD70，和在调节B细胞活化和免疫球蛋白合成的关键作用。这种受体转导，导致NF-κB和MAPK8 / JNK的活化信号。适配器蛋白TRAF2和TRAF5已经显示介导此受体的信号传导过程。 CD27结合蛋白（SIVA），促凋亡蛋白，可以结合到该受体，并认为在由该受体诱导的凋亡中起重要作用。 [由RefSeq的，2008年7月提供]

OMIM数据库中对CD27基因的介绍     Wikipedia数据库中对CD27基因的介绍

基因序列

基因序列

CD27基因的碱基序列：[NCBI]

基因突变

基因突变

CD27基因的碱基突变：           显示全部snp
rs25680       rs1059501       rs2250246       rs2253610       rs2267965       rs2267966       rs2286596       rs2286597       rs2286598       rs2532502       rs2532503       rs2532504       rs2532507       rs2532508       rs2532509       rs2532510       rs2532511       rs2532512       rs2534719       rs2534725       rs2534726       rs2534727       rs3087275       rs3087280       rs3136550       rs3136551       rs3759341       rs7132503       rs7133238       rs10849457       rs11064195       rs11064196       rs11064198       rs11064200       rs11569351       rs11569356       rs11569357      
rs11569359       rs11569360       rs11569361       rs11569362       rs11569363       rs11569364       rs11569365       rs11569366       rs11569367       rs11569368       rs11569369       rs11569370       rs11569372       rs11569373       rs11569375       rs11569376       rs11569377       rs11569378       rs11569379       rs11569380       rs11569381       rs11569382       rs11569383       rs11569384       rs11569385       rs11569387       rs11569388       rs11569389       rs11569390       rs11569391       rs11569392       rs11574999       rs11575000       rs11830902       rs11836025       rs12302768       rs12821743       rs16932601       rs16932602       rs28364777       rs34540052       rs34805566       rs57646021       rs57682654       rs60329534       rs60982224       rs61916429       rs71445108       rs71450153       rs71450643       rs71450644       rs71584821       rs71584822       rs71584831       rs71584832       rs73054312       rs73267395       rs73267398       rs73267400       rs75016164       rs75244065       rs75524088       rs76719479       rs77323161       rs77965587       rs78573170       rs78671610       rs78978027       rs79050548       rs79113704       rs111341292       rs111922468       rs112245958       rs112575076       rs112745097       rs112783225       rs112845907       rs113930505       rs113938992       rs115414403       rs117371500       rs117684743       rs137996763       rs138193082       rs138258693       rs138821224       rs138947801       rs139318215       rs139337300       rs139518811       rs139759647       rs139916142       rs140355669       rs140605423       rs140845603       rs142745106       rs142783818       rs142898686       rs143035415       rs143042937       rs143249431       rs144098443       rs144208131       rs144240256       rs144957657       rs145143384       rs145433356       rs145969473       rs146726863       rs146916740       rs147386535       rs147769443       rs148570996       rs149051653       rs149579617       rs149755907       rs149898489       rs150212301       rs150346668       rs150524707       rs150578547       rs150872364       rs181119636       rs181928307       rs182803668       rs182839904       rs182856126       rs183017614       rs183719813       rs183851465       rs184089735       rs184502399       rs185030106       rs185866847       rs186174389       rs186192864       rs186442830       rs187577925       rs187919029       rs188225311       rs189066596       rs189817940       rs190599386       rs190649666       rs190831094       rs190887089       rs192100378       rs193253590       rs199612439       rs199640884       rs199646473       rs199876113       rs199970363       rs200353714       rs200546990       rs200673347       rs200745064       rs201288349       rs201302819       rs201916358       rs201968067       rs202034916       rs202102890       rs202127301       rs367968738       rs368018700       rs368076353       rs368256133       rs368591904       rs368811895       rs369839468       rs370332174       rs370335791       rs370603141       rs371256239       rs371761387       rs372444145       rs372668698       rs372790118       rs373040540       rs373359870       rs373368586       rs373598636       rs373809759       rs374055287       rs374145044       rs374671310       rs375150093       rs375674638       rs376133215       rs376316408       rs376329676       rs377143297       rs377343532       rs377373487       rs377402413       rs528133908       rs528296992       rs528546045       rs529096536       rs529287988       rs529313270       rs529561576       rs529767771       rs530275441       rs530743896       rs530880628       rs531518741       rs532208890       rs532998122       rs533028352       rs533340002       rs533415638       rs533437041       rs533535193       rs533550145       rs534581037       rs534691677       rs534703338       rs534764787       rs535024814       rs535186586       rs535230645       rs535939434       rs536063749       rs537252651       rs537450252       rs537507962       rs537586025       rs538650093       rs538888746       rs539820271       rs539835805       rs540102415       rs540165593       rs540580279       rs540763192       rs541183712       rs541829339       rs542436498       rs543641405       rs543643180       rs543655448       rs543806313       rs543851817       rs544743053       rs544879540       rs544994095       rs545075716       rs545178725       rs545323002       rs545942294       rs546347332       rs546408663       rs546411170       rs547034888       rs547138719       rs547361999       rs547543567       rs548168862       rs548323486       rs548511519       rs548730409       rs549470618       rs549507398       rs549873485       rs549905322       rs550337203       rs550516837       rs550878858       rs551336869       rs551575753       rs551905278       rs551906238       rs552158315       rs552296642       rs553686868       rs553747045       rs553750090       rs553793799       rs553818523       rs554494495       rs555283000       rs555631593       rs556660301       rs557072261       rs557297725       rs557410561       rs557610691       rs558068835       rs558501249       rs558608298       rs558671552       rs559445060       rs559487406       rs559489345       rs559501466       rs559632257       rs559958909       rs560027907       rs560545951       rs560625132       rs561398721       rs561632554       rs562047596       rs562204877       rs562781064       rs563402308       rs564047552       rs564414116       rs564580367       rs564599498       rs565254890       rs565835969       rs566004743       rs566952030       rs567145316       rs567161421       rs567252466       rs567625931       rs568021068       rs568392656       rs568879953       rs569382418       rs569525491       rs569836395       rs569870398       rs570162477       rs570614972       rs570652375       rs570957609       rs571031406       rs571118813       rs571145229       rs571184585       rs571543037       rs572195935       rs572296732       rs572929674       rs572990162       rs573505026       rs573553045       rs573613927       rs573920707       rs575021216       rs575258498       rs576203813       rs576246800       rs576442244       rs576583284       rs577281246       rs577500200       rs745333631       rs745521506       rs745713273       rs746100203       rs746393687       rs746749786       rs746845729       rs747063632       rs747125906       rs747151664       rs747271704       rs747930868       rs748418658       rs748647585       rs748876729       rs749253347       rs749266346       rs749551392       rs749601699       rs749941117       rs750016472       rs750165204       rs750260259       rs750359267       rs750549892       rs750991471       rs751126612       rs751568717       rs751930967       rs752125182       rs752132858       rs752259578       rs752363527       rs752479103       rs752860747       rs752953971       rs753167393       rs753305875       rs753419238       rs753465972       rs753648171       rs754484328       rs755181640       rs755561093       rs755615493       rs755699729       rs755775043       rs755787331       rs755935794       rs756058870       rs756581909       rs756644852       rs756698161       rs756940583       rs757196156       rs757250628       rs757284025       rs757732791       rs757920860       rs758208788       rs758426151       rs758440909       rs758640583       rs758686809       rs758875176       rs759236596       rs759415054       rs759504816       rs759594617       rs759945641       rs760031217       rs760072720       rs760226591       rs760255533       rs760754193       rs760989493       rs761113232       rs761400986       rs761470007       rs761757129       rs761928597       rs762215347       rs762628936       rs762729598       rs762832382       rs762885174       rs762976129       rs763226101       rs763556515       rs763617266       rs763774879       rs763988270       rs764932819       rs765331418       rs765491274       rs765702056       rs765725985       rs766067287       rs766174138       rs766179003       rs766298479       rs766375594       rs766652363       rs766655010       rs767220328       rs767297512       rs767508630       rs768020684       rs768064484       rs768200900       rs768228520       rs768640085       rs768803245       rs768843825       rs769004909       rs769168367       rs769865342       rs769967539       rs770101157       rs770178882       rs770201739       rs770816422       rs770989481       rs771383803       rs771471713       rs771476874       rs771670473       rs771715961       rs771831234       rs771949875       rs772039830       rs772208557       rs772449872       rs772733163       rs772814106       rs773079710       rs773505770       rs773567512       rs773702298       rs773773944       rs773943561       rs773972949       rs774146467       rs774207253       rs774428964       rs774666974       rs774837749       rs774902396       rs775031871       rs775215741       rs775402251       rs775662515       rs776220176       rs776430772       rs776469650       rs776792594       rs776856547       rs776882476       rs776987485       rs776987985       rs777413374       rs777824114       rs777855449       rs777917514       rs778001062       rs778137725       rs778408730       rs778598904       rs778705752       rs778890218       rs778972882       rs779092602       rs779243312       rs779368031       rs779618340       rs779725109       rs779787155       rs779828669       rs780394378       rs780668415       rs780709831       rs781452204       rs781593353       rs781758331      

基因表达

基因表达

CD27基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GTGTGATCCTTGCATACCG
59
ACGAGAAGACCAGAGTTACAG
59
TGAGCCAGGAACATTCCTC
59
CAGTTGCGAACGAGAAGAC
59
TGTGATCCTTGCATACCGG
60
ACGAGAAGACCAGAGTTACAG
59
AGTGTGATCCTTGCATACC
57
CGAGAAGACCAGAGTTACAG
58
GTGAGCCAGGAACATTCCT
60
AGAGTTACAGTGCCGACAG
60
TGTGATCCTTGCATACCGG
59
ACGAGAAGACCAGAGTTACAG
59
AGTGTGATCCTTGCATACC
57
CGAGAAGACCAGAGTTACAG
57
GTGTGATCCTTGCATACCG
58
ACGAGAAGACCAGAGTTACAG
59
TGAGCCAGGAACATTCCTC
59
AGAGTTACAGTGCCGACAG
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

CD27基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

CD27基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004888
P26842(UniProtKB)
NAS
GO:0005031
P26842(UniProtKB)
IBA
GO:0005515
P26842(UniProtKB)
IPI
GO:0005515
P26842(UniProtKB)
IPI
GO:0005515
P26842(UniProtKB)
IPI
GO:0005515
P26842(UniProtKB)
IPI
GO:0005515
P26842(UniProtKB)
IPI
GO:0005576
P26842(UniProtKB)
NAS
GO:0005634
P26842(UniProtKB)
IBA
GO:0005886
P26842(UniProtKB)
TAS
GO:0005887
P26842(UniProtKB)
IBA
GO:0005887
P26842(UniProtKB)
NAS
GO:0006954
P26842(UniProtKB)
IBA
GO:0006955
P26842(UniProtKB)
IBA
GO:0007166
P26842(UniProtKB)
NAS
GO:0007420
P26842(UniProtKB)
IBA
GO:0008588
P26842(UniProtKB)
NAS
GO:0008625
P26842(UniProtKB)
IBA
GO:0009897
P26842(UniProtKB)
IEA
GO:0016064
P26842(UniProtKB)
NAS
GO:0032496
P26842(UniProtKB)
IBA
GO:0033209
P26842(UniProtKB)
TAS
GO:0042127
P26842(UniProtKB)
IBA
GO:0043005
P26842(UniProtKB)
IBA
GO:0043027
P26842(UniProtKB)
IDA
GO:0043066
P26842(UniProtKB)
IDA
GO:0043154
P26842(UniProtKB)
IEA
GO:0043410
P26842(UniProtKB)
IBA
GO:0045471
P26842(UniProtKB)
IEA
GO:0045579
P26842(UniProtKB)
NAS
GO:0046330
P26842(UniProtKB)
ISS
GO:0070062
P26842(UniProtKB)
IDA
GO:0070233
P26842(UniProtKB)
IEA
GO:0097191
P26842(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控CD27基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
LYMPHOPROLIFERATIVE SYNDROME 2 0.120271442 2 0 BeFree_UNIPROT
Cachexia 0.12 1 0 CTD_human
Peripheral Neuropathy 0.12 1 0 CTD_human
Alcoholic Liver Diseases 0.08 1 0 RGD
HIV Infections 0.008153188 21 0 BeFree_LHGDN
Lymphoma 0.007077352 7 0 BeFree_LHGDN
Lupus Erythematosus, Systemic 0.006534468 5 0 BeFree_LHGDN
Waldenstrom Macroglobulinemia 0.003267234 3 0 BeFree_LHGDN
Asthma 0.002909916 3 0 BeFree_GAD
Multiple Myeloma 0.002909916 3 0 BeFree_GAD
Biliary cirrhosis 0.00272435 1 0 LHGDN
Tuberculosis, Pulmonary 0.00272435 1 0 LHGDN
Infection 0.00272435 1 0 LHGDN
Bronchial Hyperreactivity 0.002367032 1 0 GAD
Common Variable Immunodeficiency 0.002171535 8 0 BeFree
leukemia 0.001085767 4 0 BeFree
Hyper-IgM Immunodeficiency Syndrome, Type 1 0.001085767 4 0 BeFree
Mixed cryoglobulinemia 0.001085767 4 0 BeFree
Chronic Lymphocytic Leukemia 0.000814326 3 0 BeFree
Acute lymphocytic leukemia 0.000814326 3 0 BeFree
Precursor Cell Lymphoblastic Leukemia Lymphoma 0.000814326 3 0 BeFree
Rheumatoid Arthritis 0.000542884 2 0 BeFree
Chronic granulomatous disease 0.000542884 2 0 BeFree
melanoma 0.000542884 2 0 BeFree
Psoriasis 0.000542884 2 3 BeFree
Tuberculosis 0.000542884 2 0 BeFree
Virus Diseases 0.000542884 2 0 BeFree
Epstein-Barr Virus Infections 0.000542884 2 0 BeFree
Hyperimmunoglobulin M syndrome 0.000542884 2 0 BeFree
Persistent Polyclonal B-Cell Lymphocytosis 0.000542884 2 0 BeFree
Arthritis 0.000271442 1 0 BeFree
Autoimmune Diseases 0.000271442 1 0 BeFree
Malignant neoplasm of breast 0.000271442 1 0 BeFree
Dermatitis, Atopic 0.000271442 1 0 BeFree
Diabetes 0.000271442 1 0 BeFree
Diabetes Mellitus 0.000271442 1 0 BeFree
Diabetes Mellitus, Insulin-Dependent 0.000271442 1 0 BeFree
DiGeorge Syndrome 0.000271442 1 0 BeFree
Eczema 0.000271442 1 0 BeFree
Glioma 0.000271442 1 0 BeFree
Graft-vs-Host Disease 0.000271442 1 0 BeFree
Influenza 0.000271442 1 0 BeFree
Ischemia 0.000271442 1 0 BeFree
Hairy Cell Leukemia 0.000271442 1 0 BeFree
Leukemia, Myelocytic, Acute 0.000271442 1 0 BeFree
Myeloid Leukemia, Chronic 0.000271442 1 0 BeFree
Leukemia, Plasma Cell 0.000271442 1 0 BeFree
Lupus Vulgaris 0.000271442 1 0 BeFree
Lupus Erythematosus, Discoid 0.000271442 1 0 BeFree
Lupus Erythematosus, Subacute Cutaneous 0.000271442 1 0 BeFree
Lymphocytosis 0.000271442 1 1 BeFree
Lymphopenia 0.000271442 1 0 BeFree
Lymphoproliferative Disorders 0.000271442 1 0 BeFree
Monoclonal Gammopathy of Undetermined Significance 0.000271442 1 0 BeFree
Mycosis Fungoides 0.000271442 1 0 BeFree
Tropical Spastic Paraparesis 0.000271442 1 0 BeFree
Plasmacytoma 0.000271442 1 0 BeFree
Purpura, Thrombotic Thrombocytopenic 0.000271442 1 0 BeFree
Systemic Scleroderma 0.000271442 1 0 BeFree
Chagas Disease 0.000271442 1 0 BeFree
B-Cell Lymphomas 0.000271442 1 0 BeFree
Diffuse Large B-Cell Lymphoma 0.000271442 1 0 BeFree
T-Cell Lymphoma 0.000271442 1 0 BeFree
Active tuberculosis 0.000271442 1 0 BeFree
Aortic Aneurysm, Thoracic 0.000271442 1 0 BeFree
Shprintzen syndrome 0.000271442 1 0 BeFree
Neoplasm, Residual 0.000271442 1 0 BeFree
Conventional (Clear Cell) Renal Cell Carcinoma 0.000271442 1 0 BeFree
Malonic aciduria 0.000271442 1 0 BeFree
Hereditary hemochromatosis 0.000271442 1 0 BeFree
Seronegative rheumatoid arthritis 0.000271442 1 0 BeFree
Lupus Erythematosus 0.000271442 1 0 BeFree
Trisomy 12 0.000271442 1 0 BeFree
Combined immunodeficiency 0.000271442 1 0 BeFree
Malignant Glioma 0.000271442 1 0 BeFree
Carcinogenesis 0.000271442 1 0 BeFree
Breast Carcinoma 0.000271442 1 0 BeFree
Tuberculosis, extrapulmonary 0.000271442 1 0 BeFree
Carcinoma of lung 0.000271442 1 0 BeFree
Secondary malignant neoplasm of lymph node 0.000271442 1 0 BeFree
Chronic graft-versus-host disease 0.000271442 1 0 BeFree
Anemia, Diamond-Blackfan 0.000271442 1 0 BeFree
Attention deficit hyperactivity disorder 0.000271442 1 0 BeFree
Autoimmune Lymphoproliferative Syndrome 0.000271442 1 0 BeFree
Sporadic Breast Carcinoma 0.000271442 1 0 BeFree
Tumor Immunity 0.000271442 1 0 BeFree
Macular dystrophy, corneal type 1 0.000271442 1 0 BeFree
Chromosome 11p11.2 Deletion Syndrome 0.000271442 1 0 BeFree
MULTICYSTIC RENAL DYSPLASIA, BILATERAL 0.000271442 1 0 BeFree
PEELING SKIN SYNDROME 0.000271442 1 0 BeFree
Diamond-Blackfan Anemia 1 0.000271442 1 0 BeFree
Immunoglobulin G4 related sclerosing disease 0.000271442 1 0 BeFree
IMMUNODEFICIENCY 13 0.000271442 1 0 BeFree

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