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This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]
[中文简述(自动翻译):]  这个基因编码的跨膜受体,并且通常被称为DC-SIGN,因为它的树突状细胞和巨噬细胞的表面上表达的。所编码的蛋白质是参与先天免疫系统,并认识许多进化分歧病原体从寄生虫对公众健康有很大的影响的病毒。该蛋白质被分为三个不同的结构域:N-末端跨膜结构域,串联重复颈域和C型凝集素的碳水化合物识别结构域。由C型凝集素和颈结构域的胞外区具有双重功能作为病原体识别受体和由微生物和内源性细胞的表面上的结合糖的配体的细胞粘附受体。颈部区域为同型寡聚允许受体结合的多价配体以高亲合力重要。在此蛋白质的颈部域23氨基酸重复数变化是罕见的,但对配体结合的能力的显著影响。该基因是在这两个序列和功能到相邻基因的术语(;通常被称为L-SIGN GeneID 10332)密切相关的。 DC-SIGN和L-SIGN在其配体结合特性和分布不同。选择性剪接产生多个变种。[由RefSeq的,2009年2月提供]
CD209基因(以及对应的蛋白质)的细胞分布位置:
CD209基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO (finding) | 0.24 | 0 | 0 | CLINVAR_CTD_human |
HIV Infections | 0.147470506 | 19 | 1 | BeFree_CTD_human_GAD |
Tuberculosis, Pulmonary | 0.126448592 | 7 | 2 | BeFree_CTD_human_GAD_LHGDN |
Dengue Fever | 0.122985861 | 11 | 2 | BeFree_CTD_human |
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO | 0.12 | 0 | 0 | CLINVAR |
DENGUE FEVER, PROTECTION AGAINST | 0.12 | 0 | 0 | CLINVAR |
Tuberculosis | 0.023894273 | 16 | 1 | BeFree_GAD_LHGDN |
Infection | 0.016346101 | 6 | 0 | LHGDN |
Severe Acute Respiratory Syndrome | 0.010096888 | 4 | 0 | BeFree_GAD_LHGDN |
Hepatitis C | 0.005634266 | 4 | 1 | BeFree_GAD_LHGDN |
Celiac Disease | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
Ulcerative Colitis | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
Crohn Disease | 0.005362824 | 2 | 1 | BeFree_GAD_LHGDN |
Hepatitis C, Chronic | 0.002909916 | 2 | 0 | BeFree_GAD |
Acquired Immunodeficiency Syndrome | 0.00272435 | 1 | 0 | LHGDN |
Aspergillosis | 0.00272435 | 1 | 0 | LHGDN |
Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Leukemia, T-Cell | 0.00272435 | 1 | 0 | LHGDN |
Cytomegalovirus Infections | 0.002638474 | 2 | 0 | BeFree_GAD |
Leprosy | 0.002638474 | 2 | 0 | BeFree_GAD |
Liver diseases | 0.002638474 | 1 | 0 | BeFree_GAD |
Asthma | 0.002367032 | 1 | 0 | GAD |
Bronchiolitis, Viral | 0.002367032 | 1 | 0 | GAD |
Dermatitis, Atopic | 0.002367032 | 1 | 0 | GAD |
HTLV-I Infections | 0.002367032 | 1 | 0 | GAD |
Liver Cirrhosis | 0.002367032 | 1 | 0 | GAD |
Nasopharyngeal Neoplasms | 0.002367032 | 1 | 0 | GAD |
Respiratory Syncytial Virus Infections | 0.002367032 | 1 | 0 | GAD |
Sexually Transmitted Diseases | 0.002367032 | 1 | 0 | GAD |
Chronic ulcerative colitis | 0.002367032 | 1 | 0 | GAD |
Virus Diseases | 0.001628651 | 6 | 1 | BeFree |
Severe Dengue | 0.000814326 | 3 | 2 | BeFree |
Tick-Borne Encephalitis | 0.000542884 | 2 | 0 | BeFree |
Mucocutaneous Lymph Node Syndrome | 0.000542884 | 2 | 1 | BeFree |
Nasopharyngeal carcinoma | 0.000542884 | 2 | 2 | BeFree |
Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus, Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
Mycobacterium Infections | 0.000271442 | 1 | 0 | BeFree |
Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
Kaposi Sarcoma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma, Lewis Lung | 0.000271442 | 1 | 0 | BeFree |
Psoriasis vulgaris | 0.000271442 | 1 | 0 | BeFree |
Cavitation of lung | 0.000271442 | 1 | 0 | BeFree |
Fungal keratitis | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
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