CD209(CD209 molecule)

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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19p13
基因染色体位置图

This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]

[中文简述(自动翻译):]  这个基因编码的跨膜受体,并且通常被称为DC-SIGN,因为它的树突状细胞和巨噬细胞的表面上表达的。所编码的蛋白质是参与先天免疫系统,并认识许多进化分歧病原体从寄生虫对公众健康有很大的影响的病毒。该蛋白质被分为三个不同的结构域:N-末端跨膜结构域,串联重复颈域和C型凝集素的碳水化合物识别结构域。由C型凝集素和颈结构域的胞外区具有双重功能作为病原体识别受体和由微生物和内源性细胞的表面上的结合糖的配体的细胞粘附受体。颈部区域为同型寡聚允许受体结合的多价配体以高亲合力重要。在此蛋白质的颈部域23氨基酸重复数变化是罕见的,但对配体结合的能力的显著影响。该基因是在这两个序列和功能到相邻基因的术语(;通常被称为L-SIGN GeneID 10332)密切相关的。 DC-SIGN和L-SIGN在其配体结合特性和分布不同。选择性剪接产生多个变种。[由RefSeq的,2009年2月提供]

CD209基因的碱基序列:[NCBI]
CD209基因的碱基突变:           显示全部snp
rs735239       rs735240       rs1544766       rs1544767       rs2287886       rs4804800       rs4804801       rs4804802       rs4804803       rs4804804       rs6603119       rs7248637       rs7248772       rs7252229       rs7359874       rs8101949       rs8105483       rs8105572       rs8111321       rs8112555       rs8112852       rs10403018       rs10410342       rs10422473       rs11260027       rs11260028       rs11465355       rs11465356       rs11465357       rs11465359       rs11465360       rs11465362       rs11465363       rs11465364       rs11465365       rs11465366       rs11465367      
rs11465369       rs11465370       rs11465371       rs11465372       rs11465373       rs11465374       rs11465375       rs11465377       rs11465379       rs11465380       rs11465381       rs11465382       rs11465383       rs11465384       rs11465385       rs11465386       rs11465387       rs11465388       rs11465390       rs11465391       rs11465392       rs11465393       rs11465394       rs11465395       rs11465396       rs11465397       rs11465400       rs11465401       rs11465402       rs11465403       rs11465404       rs11465405       rs11465406       rs11465408       rs11465409       rs11465410       rs11465411       rs11465412       rs11465413       rs11465414       rs11465415       rs11465416       rs11465417       rs11465418       rs11465419       rs11465420       rs11465421       rs11465422       rs11465423       rs11465425       rs11465426       rs11465427       rs11465428       rs12460694       rs17159887       rs17159889       rs35545365       rs41335247       rs41374747       rs57668221       rs57889796       rs58068141       rs58127026       rs58709946       rs60844751       rs61058460       rs61468896       rs61742035       rs71534255       rs73493965       rs73493966       rs73493968       rs73493971       rs73493973       rs73493975       rs73921550       rs73921551       rs74433604       rs75008183       rs75008691       rs76445911       rs77302107       rs77377087       rs77505063       rs77807955       rs77982873       rs78864650       rs78866372       rs79078188       rs111291868       rs111714467       rs111716431       rs111735318       rs111742529       rs112039104       rs112335707       rs112559811       rs112896114       rs113087447       rs113300854       rs113398041       rs113616226       rs113835329       rs113836492       rs113936914       rs114306670       rs114437818       rs114878389       rs115426752       rs115539852       rs115887142       rs138694095       rs138818051       rs138953036       rs139258657       rs139404177       rs139404269       rs139712001       rs139884631       rs139935725       rs140476940       rs140941672       rs141131967       rs141685143       rs142247295       rs142573150       rs142629179       rs142840174       rs143192119       rs143217457       rs143254698       rs143531930       rs144139292       rs144176155       rs144347526       rs144396299       rs145096191       rs145657531       rs145850292       rs145999419       rs146002807       rs146082308       rs146541119       rs147713865       rs147896873       rs148098554       rs148341013       rs148390138       rs148485547       rs148750071       rs149131470       rs149318064       rs149547349       rs149776499       rs149947547       rs150207510       rs150298356       rs150527315       rs151250046       rs181082774       rs181586807       rs181874569       rs181926571       rs181945967       rs182264960       rs182547515       rs182574144       rs182787324       rs183145639       rs183638737       rs183755924       rs184000491       rs184851252       rs185373670       rs185545863       rs185610900       rs185744882       rs186161990       rs186513902       rs186612602       rs187012361       rs187051357       rs187192438       rs187334590       rs187439891       rs188051185       rs188180193       rs188298555       rs188932736       rs189037227       rs189175136       rs189782238       rs189874499       rs190026563       rs190036112       rs190106388       rs190284057       rs190601505       rs190655764       rs191503190       rs191703008       rs192037845       rs192292898       rs192650157       rs192979112       rs193268842       rs199561478       rs199736139       rs199740591       rs199885227       rs199960291       rs199996214       rs200104082       rs200282091       rs200309698       rs200412510       rs200462219       rs200679545       rs200709349       rs200779816       rs200889450       rs201154005       rs201455927       rs201615634       rs201628081       rs201653870       rs201684036       rs201898991       rs201910512       rs201916963       rs201938697       rs202136182       rs202179938       rs267605765       rs367767330       rs368570264       rs368897572       rs368971770       rs369077812       rs369571663       rs369663667       rs369693201       rs370333676       rs370383103       rs370692532       rs370719430       rs370818822       rs371659647       rs372037869       rs372424665       rs372688873       rs372800166       rs373040894       rs373564213       rs373806865       rs373863001       rs373939599       rs373950030       rs374114895       rs374506182       rs374903130       rs374967274       rs375340194       rs375473990       rs375511440       rs375667157       rs376051585       rs376163704       rs376323759       rs376393724       rs376627702       rs376636419       rs376760827       rs376988840       rs377593489       rs377651911       rs527544022       rs528076277       rs528395931       rs528658540       rs528821276       rs528841974       rs528884293       rs529094961       rs529216188       rs529495430       rs529730335       rs530484762       rs530561741       rs531513041       rs531516962       rs531556256       rs531877662       rs532334099       rs532944619       rs533515835       rs534103184       rs534340413       rs534724071       rs534995365       rs535014704       rs535097059       rs535167552       rs535211851       rs535376999       rs536115286       rs536307627       rs536311629       rs537066989       rs537107314       rs537182979       rs538085590       rs539077871       rs539437036       rs539475772       rs539640019       rs539665911       rs539776558       rs540256548       rs540282680       rs540305083       rs540425317       rs540441724       rs541525999       rs541964084       rs542451078       rs543231457       rs544259737       rs544475565       rs544708930       rs544825671       rs544874106       rs544981403       rs546210661       rs546385583       rs546580297       rs546635685       rs546744845       rs547076316       rs547380264       rs547640938       rs548344631       rs548558262       rs548713304       rs548839611       rs549625432       rs549762603       rs549990133       rs550052955       rs550345053       rs550418394       rs550603471       rs550647118       rs550873905       rs550944826       rs551425556       rs551756815       rs552059243       rs552187030       rs552359512       rs552395487       rs553008652       rs553071887       rs553567549       rs554066504       rs554152802       rs554645402       rs554819754       rs554903870       rs554926524       rs555389378       rs555705389       rs555971875       rs556116854       rs556742276       rs556776334       rs557387594       rs557389033       rs557449416       rs557911139       rs558214910       rs558504713       rs558555834       rs558835747       rs558880959       rs559240864       rs560294624       rs560344977       rs560456451       rs560547049       rs560757501       rs560902253       rs561035164       rs561357784       rs561843078       rs561956295       rs562097599       rs562144201       rs562158673       rs562984149       rs563255539       rs563534836       rs563655029       rs564445371       rs564562150       rs564574231       rs564862388       rs564991658       rs565035664       rs565439078       rs565469678       rs565608551       rs565643352       rs565809638       rs566988623       rs567258680       rs567293520       rs568216711       rs568356156       rs568910734       rs568970102       rs569164331       rs569586705       rs569642139       rs570203160       rs570217206       rs570356048       rs570652705       rs570736811       rs570759781       rs570945021       rs570999623       rs571047910       rs571230911       rs571291609       rs571858671       rs572300630       rs572423438       rs572817510       rs573003882       rs573104311       rs573320818       rs573470137       rs573506619       rs573735640       rs574630415       rs574701207       rs575097014       rs575122452       rs575398923       rs575638687       rs576737274       rs578023555       rs745378205       rs745481559       rs745584651       rs745660447       rs745949019       rs746184099       rs746434437       rs746508965       rs746527222       rs746617009       rs746853437       rs747053615       rs747349194       rs747395841       rs747689588       rs747849049       rs747973993       rs748173036       rs748619338       rs748765635       rs748797359       rs749104962       rs749321899       rs749380919       rs749392016       rs749465042       rs749655694       rs749671561       rs749672042       rs749723284       rs749759932       rs749980312       rs750141810       rs750143965       rs750248451       rs750442689       rs750681138       rs750831892       rs750939229       rs751060553       rs751256137       rs751263500       rs751345631       rs751584461       rs751880063       rs752252987       rs752457226       rs752676697       rs752762064       rs752852796       rs753102094       rs753415943       rs753428693       rs753594080       rs753815149       rs753986681       rs754045946       rs754150508       rs754217149       rs754462130       rs754637180       rs754866691       rs754983304       rs755075001       rs755143789       rs755276062       rs755435491       rs755440431       rs755628295       rs755645551       rs755992712       rs756319987       rs756424156       rs756471999       rs756634871       rs756790510       rs757628289       rs757652654       rs757724640       rs757971690       rs758212726       rs758249066       rs758280744       rs758387033       rs758538927       rs758578326       rs758960447       rs759228474       rs759302465       rs759390544       rs759493413       rs759632613       rs759862642       rs759950332       rs760000323       rs760204370       rs760802082       rs760895698       rs761378871       rs761531453       rs761593739       rs761614211       rs761770382       rs761983807       rs762083998       rs762213375       rs762628366       rs762637062       rs762655613       rs762749338       rs763068172       rs763277592       rs763349278       rs763367047       rs763504034       rs763608847       rs763622470       rs763770706       rs763850707       rs763928105       rs764012175       rs764069493       rs764405613       rs764405668       rs764892169       rs764979869       rs764996390       rs765057843       rs765091163       rs765147780       rs765385504       rs765472244       rs765486330       rs765502701       rs765954889       rs766028272       rs766134819       rs766153951       rs766781241       rs766870945       rs766891081       rs767060536       rs767081048       rs767201321       rs767247319       rs767293157       rs767406726       rs767498403       rs767685744       rs768005982       rs768329042       rs768359455       rs768784100       rs768949282       rs769108504       rs769275113       rs769429463       rs769459892       rs769520149       rs769761518       rs769812151       rs769960164       rs770034550       rs770126743       rs770369583       rs770394774       rs770455259       rs770457295       rs770520268       rs770609786       rs770776053       rs770974493       rs770992849       rs771038221       rs771126165       rs771177136       rs771369666       rs771506047       rs771520976       rs771595634       rs771648411       rs771714968       rs772079670       rs772080070       rs772221525       rs772448797       rs772476580       rs772535109       rs772650321       rs772715069       rs772781960       rs773003473       rs773093361       rs773126419       rs773181876       rs773390619       rs773462318       rs773554300       rs773752339       rs773840556       rs773911494       rs773917097       rs773931530       rs774079703       rs774220438       rs774319424       rs774497538       rs774533179       rs774621010       rs774633210       rs774637229       rs774723187       rs774981477       rs775028274       rs775055595       rs775189015       rs775207450       rs775207483       rs775293749       rs775380632       rs775529234       rs775630404       rs775646663       rs775649064       rs775655494       rs775740307       rs776103883       rs776327212       rs776341389       rs776410965       rs776509741       rs776704702       rs776823008       rs776984893       rs777263886       rs777344893       rs777362632       rs777450783       rs777564858       rs777697218       rs777793204       rs778207508       rs778504585       rs778830508       rs778970833       rs779081808       rs779286111       rs779442828       rs779527826       rs779660756       rs779828040       rs779945623       rs780378461       rs780441267       rs780548412       rs780634236       rs780885497       rs781204704       rs781579855       rs781658151      

CD209基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TCATGTCTAACTCCCAGCG
59
TTCTGGAAGACTGCTCCTC
59
TCATGTCTAACTCCCAGCG
59
AATACTGCTTGAAGCTGCTC
59
TACAAGAGCTTAGCAGTGTC
57
GTCAGGTTCTGGTAGATCG
57
TCATGTCTAACTCCCAGCG
59
CTTCTGGAAGACTGCTCCT
59
GGGACTTTCAGATCTAAATCAGG
58
CCAATACTGCTTGAAGCTGG
59
ACAAGAGCTTAGCAGTGTC
58
GTCAGGTTCTGGTAGATCG
57
CTGAGGAGCAGAACTTCCT
59
CCTGATTTAGATCTGAAAGTCCC
59
ACAAGAGCTTAGCAGTGTC
57
GTCAGGTTCTGGTAGATCG
57
TGTCCAAGTGTCCAAGGTC
60
TAAGCTGGGTCAGGTTCTG
59
TTGTCCAAGTGTCCAAGGT
59
TAAGCTGGGTCAGGTTCTG
59
      尚未收录相关数据

CD209基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

CD209基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0001618
Q9NNX6(UniProtKB)
IEA
GO:0002223
Q9NNX6(UniProtKB)
TAS
GO:0002250
Q9NNX6(UniProtKB)
IEA
GO:0005515
Q9NNX6(UniProtKB)
IPI
GO:0005515
Q9NNX6(UniProtKB)
IPI
GO:0005515
Q9NNX6(UniProtKB)
IPI
GO:0005537
Q9NNX6(UniProtKB)
TAS
GO:0005737
Q9NNX6(UniProtKB)
NAS
GO:0005886
Q9NNX6(UniProtKB)
TAS
GO:0005886
Q9NNX6(UniProtKB)
TAS
GO:0005886
Q9NNX6(UniProtKB)
TAS
GO:0006897
Q9NNX6(UniProtKB)
IEA
GO:0007157
Q9NNX6(UniProtKB)
TAS
GO:0007159
Q9NNX6(UniProtKB)
NAS
GO:0009986
Q9NNX6(UniProtKB)
IDA
GO:0009988
Q9NNX6(UniProtKB)
TAS
GO:0016020
Q9NNX6(UniProtKB)
TAS
GO:0016021
Q9NNX6(UniProtKB)
IEA
GO:0019048
Q9NNX6(UniProtKB)
TAS
GO:0019062
Q9NNX6(UniProtKB)
TAS
GO:0019079
Q9NNX6(UniProtKB)
NAS
GO:0019882
Q9NNX6(UniProtKB)
NAS
GO:0030246
Q9NNX6(UniProtKB)
NAS
GO:0035556
Q9NNX6(UniProtKB)
NAS
GO:0042129
Q9NNX6(UniProtKB)
IDA
GO:0042605
Q9NNX6(UniProtKB)
NAS
GO:0045087
Q9NNX6(UniProtKB)
IEA
GO:0046718
Q9NNX6(UniProtKB)
IEA
GO:0046790
Q9NNX6(UniProtKB)
TAS
GO:0046872
Q9NNX6(UniProtKB)
IEA
GO:0046968
Q9NNX6(UniProtKB)
NAS
GO:0070062
Q9NNX6(UniProtKB)
IDA
GO:0075733
Q9NNX6(UniProtKB)
TAS
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控CD209基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO (finding) 0.24 0 0 CLINVAR_CTD_human
HIV Infections 0.147470506 19 1 BeFree_CTD_human_GAD
Tuberculosis, Pulmonary 0.126448592 7 2 BeFree_CTD_human_GAD_LHGDN
Dengue Fever 0.122985861 11 2 BeFree_CTD_human
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO 0.12 0 0 CLINVAR
DENGUE FEVER, PROTECTION AGAINST 0.12 0 0 CLINVAR
Tuberculosis 0.023894273 16 1 BeFree_GAD_LHGDN
Infection 0.016346101 6 0 LHGDN
Severe Acute Respiratory Syndrome 0.010096888 4 0 BeFree_GAD_LHGDN
Hepatitis C 0.005634266 4 1 BeFree_GAD_LHGDN
Celiac Disease 0.005362824 1 0 BeFree_GAD_LHGDN
Ulcerative Colitis 0.005362824 1 0 BeFree_GAD_LHGDN
Crohn Disease 0.005362824 2 1 BeFree_GAD_LHGDN
Hepatitis C, Chronic 0.002909916 2 0 BeFree_GAD
Acquired Immunodeficiency Syndrome 0.00272435 1 0 LHGDN
Aspergillosis 0.00272435 1 0 LHGDN
Colorectal Neoplasms 0.00272435 1 0 LHGDN
Leukemia, T-Cell 0.00272435 1 0 LHGDN
Cytomegalovirus Infections 0.002638474 2 0 BeFree_GAD
Leprosy 0.002638474 2 0 BeFree_GAD
Liver diseases 0.002638474 1 0 BeFree_GAD
Asthma 0.002367032 1 0 GAD
Bronchiolitis, Viral 0.002367032 1 0 GAD
Dermatitis, Atopic 0.002367032 1 0 GAD
HTLV-I Infections 0.002367032 1 0 GAD
Liver Cirrhosis 0.002367032 1 0 GAD
Nasopharyngeal Neoplasms 0.002367032 1 0 GAD
Respiratory Syncytial Virus Infections 0.002367032 1 0 GAD
Sexually Transmitted Diseases 0.002367032 1 0 GAD
Chronic ulcerative colitis 0.002367032 1 0 GAD
Virus Diseases 0.001628651 6 1 BeFree
Severe Dengue 0.000814326 3 2 BeFree
Tick-Borne Encephalitis 0.000542884 2 0 BeFree
Mucocutaneous Lymph Node Syndrome 0.000542884 2 1 BeFree
Nasopharyngeal carcinoma 0.000542884 2 2 BeFree
Rheumatoid Arthritis 0.000271442 1 0 BeFree
Renal Cell Carcinoma 0.000271442 1 0 BeFree
Colorectal Carcinoma 0.000271442 1 0 BeFree
Diabetes Mellitus, Insulin-Dependent 0.000271442 1 0 BeFree
Mycobacterium Infections 0.000271442 1 0 BeFree
Neoplasm Metastasis 0.000271442 1 0 BeFree
Kaposi Sarcoma 0.000271442 1 0 BeFree
Carcinoma, Lewis Lung 0.000271442 1 0 BeFree
Psoriasis vulgaris 0.000271442 1 0 BeFree
Cavitation of lung 0.000271442 1 0 BeFree
Fungal keratitis 0.000271442 1 0 BeFree
Colorectal Cancer 0.000271442 1 0 BeFree
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