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The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]
[中文简述(自动翻译):]  由该基因编码的蛋白质是一个分子伴侣是含有TCP1络合物(CCT)的伴侣蛋白的成员,也称为TCP1环络合物(TRIC)。这种复杂的由两个相同的堆叠环,每个都包含八个不同的蛋白质。未折叠的多肽进入复杂的中心空腔和一个ATP依赖的方式被折叠。复杂的折叠的各种蛋白质,包括肌动蛋白和微管蛋白。备用转录剪接变体已被表征为这样的基因。另外,该基因的假基因,已经发现在[通过的RefSeq,2010年8月提供]染色体8.
CCT3基因(以及对应的蛋白质)的细胞分布位置:
CCT3基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
HIV Infections | 0.12 | 1 | 0 | CTD_human |
Myotonic Dystrophy | 0.008143256 | 30 | 0 | BeFree |
Congenital Myotonic Dystrophy | 0.007871814 | 29 | 0 | BeFree |
Schizophrenia | 0.00272435 | 1 | 0 | LHGDN |
Liver carcinoma | 0.00272435 | 1 | 0 | LHGDN |
Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Micrognathism | 0.000271442 | 1 | 0 | BeFree |
Muscle degeneration | 0.000271442 | 1 | 0 | BeFree |
Degenerative disorder | 0.000271442 | 1 | 0 | BeFree |
Eosinophilic myositis (disorder) | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
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