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The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]
[中文简述(自动翻译):]  由该基因编码的蛋白质属于高度保守的细胞周期蛋白家族,其成员通过细胞周期的特征是急剧周期性的蛋白质丰度。细胞周期蛋白作为CDK激酶的监管。不同细胞周期蛋白表现出不同的表达和降解模式这有助于每个有丝分裂事件的时间协调。这个周期蛋白形成具有CDK4或CDK6和功能的复杂的复合物,其活性所需的细胞周期G1 / S期过渡的调节亚基。这种蛋白已经显示出交互和参与肿瘤抑制Rb蛋白的磷酸化。在小鼠的同源基因的敲除研究显示该基因在卵巢颗粒和生殖细胞增殖的重要作用。在卵巢和睾丸肿瘤中观察到这种基因的高水平表达。在这种基因突变与巨脑-多小脑-趾-积水综合征3(MPPH3)相关联。 [由RefSeq的,2014年9月提供]
CCND2基因(以及对应的蛋白质)的细胞分布位置:
CCND2基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Colonic Neoplasms | 0.2 | 1 | 0 | CTD_human_RGD |
Prostatic Neoplasms | 0.122995792 | 2 | 0 | BeFree_CTD_human_LHGDN |
Diabetes Mellitus, Non-Insulin-Dependent | 0.122909916 | 3 | 1 | BeFree_CTD_human_GAD |
Colorectal Cancer | 0.120542884 | 2 | 4 | BeFree_GWASCAT |
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome | 0.120271442 | 1 | 0 | BeFree_CTD_human |
Fibrosis | 0.12 | 1 | 0 | CTD_human |
Cardiomegaly | 0.12 | 1 | 0 | CTD_human |
Myocardial Ischemia | 0.12 | 1 | 0 | CTD_human |
ovarian neoplasm | 0.12 | 1 | 0 | CTD_human |
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 3 | 0.12 | 1 | 0 | UNIPROT |
Carcinoma, Transitional Cell | 0.08 | 1 | 0 | RGD |
Glaucoma | 0.08 | 1 | 0 | RGD |
Nephritis | 0.08 | 1 | 0 | RGD |
Erectile dysfunction | 0.08 | 1 | 0 | RGD |
Malignant neoplasm of ovary | 0.010011012 | 5 | 0 | BeFree_GAD |
Malignant neoplasm of breast | 0.009815515 | 13 | 0 | BeFree_GAD |
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.005438769 | 11 | 0 | BeFree_LHGDN |
Lymphoma | 0.004624443 | 8 | 0 | BeFree_LHGDN |
Carcinogenesis | 0.004071628 | 15 | 0 | BeFree |
Mammary Neoplasms | 0.003538676 | 4 | 0 | BeFree_LHGDN |
Squamous cell carcinoma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Liver carcinoma | 0.003181358 | 4 | 0 | BeFree_GAD |
Embryonal Carcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Hepatitis B | 0.002909916 | 2 | 0 | BeFree_GAD |
Neoplastic Cell Transformation | 0.00272435 | 1 | 0 | LHGDN |
Leukemia, T-Cell | 0.00272435 | 1 | 0 | LHGDN |
Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Breast Carcinoma | 0.002714419 | 10 | 0 | BeFree |
Lymphoid leukemia | 0.002367032 | 1 | 1 | GAD |
Liver neoplasms | 0.002367032 | 1 | 0 | GAD |
Narcolepsy | 0.002367032 | 1 | 0 | GAD |
Major Depressive Disorder | 0.002367032 | 1 | 1 | GAD |
Multiple Myeloma | 0.002171535 | 8 | 0 | BeFree |
Malignant neoplasm of stomach | 0.001628651 | 6 | 0 | BeFree |
Malignant neoplasm of prostate | 0.001628651 | 6 | 0 | BeFree |
Stomach Carcinoma | 0.001628651 | 6 | 0 | BeFree |
Prostate carcinoma | 0.001357209 | 5 | 0 | BeFree |
Chronic Lymphocytic Leukemia | 0.001085767 | 4 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.001085767 | 4 | 0 | BeFree |
Germ cell tumor | 0.001085767 | 4 | 0 | BeFree |
Acute lymphocytic leukemia | 0.000814326 | 3 | 0 | BeFree |
Neoplasm Metastasis | 0.000814326 | 3 | 0 | BeFree |
Diffuse Large B-Cell Lymphoma | 0.000814326 | 3 | 0 | BeFree |
Tumor Progression | 0.000814326 | 3 | 0 | BeFree |
Pancreatic carcinoma | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000814326 | 3 | 0 | BeFree |
Non-Neoplastic Disorder | 0.000814326 | 3 | 0 | BeFree |
Brain Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Noninfiltrating Intraductal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Congenital chromosomal disease | 0.000542884 | 2 | 0 | BeFree |
Colorectal Neoplasms | 0.000542884 | 2 | 0 | BeFree |
granulosa cell tumor | 0.000542884 | 2 | 0 | BeFree |
leukemia | 0.000542884 | 2 | 0 | BeFree |
Neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
B-Cell Lymphomas | 0.000542884 | 2 | 0 | BeFree |
Malignant mesothelioma | 0.000542884 | 2 | 0 | BeFree |
Thyroid carcinoma | 0.000542884 | 2 | 0 | BeFree |
Central neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Tumors of Adrenal Cortex | 0.000271442 | 1 | 0 | BeFree |
Bipolar Disorder | 0.000271442 | 1 | 0 | BeFree |
Blast Phase | 0.000271442 | 1 | 0 | BeFree |
Breast Diseases | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of thyroid | 0.000271442 | 1 | 0 | BeFree |
Choriocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 2 | BeFree |
insulinoma | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Lymphocytic, Acute, L1 | 0.000271442 | 1 | 1 | BeFree |
Myeloid Leukemia, Chronic | 0.000271442 | 1 | 0 | BeFree |
Lung Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Waldenstrom Macroglobulinemia | 0.000271442 | 1 | 0 | BeFree |
Medulloblastoma | 0.000271442 | 1 | 0 | BeFree |
Nephroblastoma | 0.000271442 | 1 | 0 | BeFree |
Peutz-Jeghers Syndrome | 0.000271442 | 1 | 0 | BeFree |
Plasmacytoma | 0.000271442 | 1 | 0 | BeFree |
Polycystic Ovary Syndrome | 0.000271442 | 1 | 0 | BeFree |
Rhabdomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
Schizophrenia | 0.000271442 | 1 | 0 | BeFree |
Testicular Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Thyroid Neoplasm | 0.000271442 | 1 | 0 | BeFree |
T-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
Small cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Follicular thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Uveal melanoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Non-small cell lung cancer stage III | 0.000271442 | 1 | 0 | BeFree |
Invasive Lobular Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of pancreas | 0.000271442 | 1 | 0 | BeFree |
Anaplastic astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Malignant lymphoma - lymphoplasmacytic | 0.000271442 | 1 | 0 | BeFree |
Hematopoietic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Hematologic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Trisomy 12 | 0.000271442 | 1 | 0 | BeFree |
Malignant Glioma | 0.000271442 | 1 | 0 | BeFree |
Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
Biliary Tract Cancer | 0.000271442 | 1 | 0 | BeFree |
Intraepithelial Neoplasia | 0.000271442 | 1 | 0 | BeFree |
Plasma cell dyscrasia | 0.000271442 | 1 | 0 | BeFree |
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Invasive Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Testicular Germ Cell Tumor | 0.000271442 | 1 | 0 | BeFree |
Hepatocarcinogenesis | 0.000271442 | 1 | 6 | BeFree |
Leukemia, B-Cell | 0.000271442 | 1 | 0 | BeFree |
Triple Negative Breast Neoplasms | 0.000271442 | 1 | 0 | BeFree |
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