CCL11(chemokine (C-C motif) ligand 11) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

17q21.1-q21.2
基因染色体位置图

基因简述

基因简述

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]

[中文简述(自动翻译):]  此抗微生物基因的聚集在17号染色??体的q臂上趋化因子构成涉及免疫调节和炎症过程的分泌蛋白的超家族几个趋化因子的基因之一。该超家族分为基于成熟的肽的N末端半胱氨酸残基的排列四个亚科。该趋化因子，所述CC亚家族的成员，显示嗜酸性粒细胞趋化活性，但不能单核细胞或中性粒细胞。这个特定嗜酸性粒细胞趋化因子被认为涉及嗜酸性炎症性疾病，如特应性皮炎，过敏性鼻炎，哮喘和寄生虫感染。 [由RefSeq的，2014年9月提供]

OMIM数据库中对CCL11基因的介绍     Wikipedia数据库中对CCL11基因的介绍

基因序列

基因序列

CCL11基因的碱基序列：[NCBI]

基因突变

基因突变

CCL11基因的碱基突变：           显示全部snp
rs1019109       rs1019110       rs1019111       rs1129844       rs1860184       rs3815341       rs4795895       rs4795896       rs4795898       rs5027581       rs6146040       rs12601294       rs12948058       rs16969415       rs17735961       rs17736027       rs17809012       rs34262946       rs35006408       rs35489517       rs41274294       rs41324752       rs41328245       rs41332149       rs41360251       rs41362349       rs41402446       rs41432444       rs41441446       rs41490146       rs41500855       rs41509752       rs41517247       rs55901334       rs56120942       rs56358892       rs76028040      
rs80326212       rs111976983       rs112994850       rs115764380       rs137995665       rs138176096       rs140081857       rs140141523       rs140496790       rs141461304       rs142944769       rs143782300       rs144424445       rs144517997       rs145149784       rs145197830       rs146596133       rs147015257       rs150412800       rs151154922       rs151281297       rs181679707       rs182268242       rs183026342       rs183901244       rs184000259       rs184278732       rs184861390       rs185606740       rs185677222       rs185980467       rs187182749       rs187732617       rs188888444       rs189001139       rs189179980       rs190092699       rs190489401       rs190846187       rs191484864       rs192449776       rs199525457       rs199528980       rs199541966       rs199636376       rs199758114       rs199775798       rs199898538       rs200074672       rs200078656       rs200085641       rs200119205       rs200124756       rs200153494       rs200213188       rs200339412       rs200369153       rs200381052       rs200594613       rs200612962       rs200721308       rs200783875       rs200877939       rs200920749       rs200955262       rs200955863       rs201112720       rs201269464       rs201467666       rs201590633       rs201593228       rs201600643       rs201621608       rs201817073       rs201906937       rs201936607       rs201940576       rs202030520       rs202050756       rs202159929       rs202174496       rs202178630       rs202189623       rs368039965       rs370775153       rs370969418       rs373476151       rs373603861       rs375131716       rs375377635       rs376562058       rs377267955       rs397723282       rs527455392       rs527805981       rs530277159       rs531485715       rs531651174       rs531817625       rs532290521       rs533410001       rs533750406       rs535119850       rs536069571       rs536735619       rs537684503       rs538656320       rs539001210       rs539088752       rs541296316       rs541382431       rs541992134       rs542028953       rs543839440       rs546068090       rs547168211       rs547478225       rs547574343       rs548983674       rs549369948       rs549389241       rs551139066       rs551220221       rs552096945       rs552127887       rs552490059       rs553349363       rs555329093       rs556607668       rs557017215       rs557677838       rs557784509       rs557917560       rs559276662       rs560789628       rs561713748       rs561889317       rs562729596       rs563924181       rs564302156       rs566206644       rs566855110       rs566855964       rs567765986       rs568063065       rs568943172       rs569178047       rs570539379       rs571863770       rs572328516       rs572538194       rs572628997       rs572874619       rs573192632       rs573666470       rs574108094       rs575340005       rs576221477       rs576809594       rs577376478       rs577487550       rs577536432       rs578157784       rs745408049       rs746191397       rs747124405       rs747402916       rs747562314       rs747824817       rs747918472       rs748251984       rs748488701       rs748816554       rs748978020       rs749416164       rs750819480       rs751231849       rs751319649       rs751333036       rs752111427       rs752337000       rs753277441       rs753778448       rs754408986       rs754507318       rs755021214       rs756514440       rs756537343       rs757013158       rs757174131       rs757660494       rs757670053       rs757750206       rs758267172       rs758511524       rs758759953       rs759569752       rs760449538       rs760842705       rs761411782       rs762114278       rs762429865       rs762752655       rs764321223       rs764694346       rs766246869       rs766334928       rs766635251       rs766653650       rs767017905       rs768733712       rs768878386       rs769349409       rs769555306       rs769693180       rs769827637       rs769892704       rs770319146       rs771115316       rs771528461       rs772904955       rs772949504       rs773852009       rs773869985       rs773956209       rs774569655       rs774687495       rs774729461       rs775748052       rs777040446       rs779102512       rs779278582       rs780893711       rs781455922       rs781762601      

基因表达

基因表达

CCL11基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
AAGCTGTGATCTTCAAGACC
58
ACTTCATGGAATCCTGCAC
58
AGCTGTGATCTTCAAGACC
57
TACTTCATGGAATCCTGCAC
58
GCTGTGATCTTCAAGACCA
58
ATACTTCATGGAATCCTGCAC
58

转录因子

转录因子

      尚未收录相关数据

基因本体信息

CCL11基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

CCL11基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0001938
P51671(UniProtKB)
IDA
GO:0002544
P51671(UniProtKB)
IEA
GO:0002548
P51671(UniProtKB)
IBA
GO:0002551
P51671(UniProtKB)
IEA
GO:0005515
P51671(UniProtKB)
IPI
GO:0005515
P51671(UniProtKB)
IPI
GO:0005515
P51671(UniProtKB)
IPI
GO:0005576
P51671(UniProtKB)
IDA
GO:0005576
P51671(UniProtKB)
TAS
GO:0005615
P51671(UniProtKB)
IBA
GO:0005622
P51671(UniProtKB)
IEA
GO:0006468
P51671(UniProtKB)
TAS
GO:0006874
P51671(UniProtKB)
TAS
GO:0006935
P51671(UniProtKB)
TAS
GO:0006954
P51671(UniProtKB)
TAS
GO:0007010
P51671(UniProtKB)
IDA
GO:0007015
P51671(UniProtKB)
IEA
GO:0007155
P51671(UniProtKB)
TAS
GO:0007165
P51671(UniProtKB)
TAS
GO:0007186
P51671(UniProtKB)
IBA
GO:0008009
P51671(UniProtKB)
IDA
GO:0008360
P51671(UniProtKB)
IDA
GO:0009314
P51671(UniProtKB)
TAS
GO:0009615
P51671(UniProtKB)
TAS
GO:0030335
P51671(UniProtKB)
IDA
GO:0030593
P51671(UniProtKB)
IBA
GO:0030838
P51671(UniProtKB)
IDA
GO:0035962
P51671(UniProtKB)
IEA
GO:0043547
P51671(UniProtKB)
IDA
GO:0045766
P51671(UniProtKB)
IEA
GO:0048020
P51671(UniProtKB)
IBA
GO:0048245
P51671(UniProtKB)
IDA
GO:0048247
P51671(UniProtKB)
IBA
GO:0050729
P51671(UniProtKB)
IBA
GO:0060444
P51671(UniProtKB)
IEA
GO:0060763
P51671(UniProtKB)
IEA
GO:0070098
P51671(UniProtKB)
IBA
GO:0070371
P51671(UniProtKB)
IEA
GO:0070374
P51671(UniProtKB)
IBA
GO:0070670
P51671(UniProtKB)
IEA
GO:0071346
P51671(UniProtKB)
IBA
GO:0071347
P51671(UniProtKB)
IBA
GO:0071356
P51671(UniProtKB)
IBA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控CCL11基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Asthma 0.237258395 23 0 BeFree_CTD_human_GAD_LHGDN_RGD
Pneumonia 0.200271442 4 0 BeFree_CTD_human_RGD
Inflammation 0.127101096 4 0 CTD_human_GAD
Dermatitis, Atopic 0.125362824 2 0 BeFree_CTD_human_GAD_LHGDN
HIV Infections 0.125005506 2 0 BeFree_CTD_human_GAD
Pulmonary Fibrosis 0.122995792 2 0 BeFree_CTD_human_LHGDN
Brain Ischemia 0.122367032 2 0 CTD_human_GAD
Drug Allergy 0.12 1 0 CTD_human
Hypersensitivity 0.12 1 0 CTD_human
Respiratory Hypersensitivity 0.12 1 0 CTD_human
ASTHMA, SUSCEPTIBILITY TO (finding) 0.12 0 0 CLINVAR
Immediate hypersensitivity 0.082367032 2 0 GAD_RGD
Diabetes Mellitus, Insulin-Dependent 0.080271442 2 0 BeFree_RGD
Experimental Autoimmune Encephalomyelitis 0.080271442 1 0 BeFree_RGD
Allergic Conjunctivitis 0.08 1 0 RGD
Endometriosis 0.08 1 0 RGD
Fibrosis 0.08 1 0 RGD
Granuloma, Respiratory Tract 0.08 1 0 RGD
Pleurisy 0.08 1 0 RGD
prostatitis 0.08 1 0 RGD
Reperfusion Injury 0.08 1 0 RGD
Rhinitis 0.08 1 0 RGD
Cataract 0.08 1 0 RGD
Sepsis 0.08 1 0 RGD
Allergic rhinitis (disorder) 0.08 1 0 RGD
Myocardial Infarction 0.008001298 3 0 BeFree_GAD_LHGDN
Ulcerative Colitis 0.005905708 5 0 BeFree_GAD_LHGDN
Coronary Artery Disease 0.005362824 2 0 BeFree_GAD_LHGDN
Diabetes Mellitus, Non-Insulin-Dependent 0.004734064 2 0 GAD
Multiple Sclerosis 0.004734064 2 0 GAD
Eosinophilia 0.002995792 2 0 BeFree_LHGDN
Chronic Obstructive Airway Disease 0.002995792 2 0 BeFree_LHGDN
Nasal Polyps 0.002995792 2 0 BeFree_LHGDN
Degenerative polyarthritis 0.002995792 1 0 BeFree_LHGDN
Cerebrovascular accident 0.002909916 3 3 BeFree_GAD
Bronchitis, Chronic 0.00272435 1 0 LHGDN
Esophagitis 0.00272435 1 0 LHGDN
Pemphigoid Gestationis 0.00272435 1 0 LHGDN
Pleural Effusion, Malignant 0.00272435 1 0 LHGDN
Atherosclerosis 0.002638474 2 0 BeFree_GAD
Trachoma 0.002638474 2 0 BeFree_GAD
Metabolic Syndrome X 0.002638474 2 0 BeFree_GAD
Bronchiolitis, Viral 0.002367032 1 0 GAD
Chlamydia Infections 0.002367032 1 0 GAD
Kidney Failure, Chronic 0.002367032 1 0 GAD
Respiratory Syncytial Virus Infections 0.002367032 1 0 GAD
Bronchial Hyperreactivity 0.002367032 1 0 GAD
Restenosis 0.002367032 1 0 GAD
Atopy 0.002367032 1 0 GAD
Acute Coronary Syndrome 0.002367032 1 0 GAD
Malignant neoplasm of ovary 0.002367032 1 0 GAD
Venous Thromboembolism 0.002367032 1 0 GAD
Eosinophilic esophagitis 0.000814326 3 0 BeFree
Ischemic stroke 0.000542884 2 6 BeFree
Ischemic Cerebrovascular Accident 0.000542884 2 6 BeFree
Renal Cell Carcinoma 0.000271442 1 0 BeFree
Chondrosarcoma 0.000271442 1 0 BeFree
Colitis 0.000271442 1 0 BeFree
Diabetes 0.000271442 1 3 BeFree
Diabetes Mellitus 0.000271442 1 3 BeFree
Eczema 0.000271442 1 0 BeFree
Inflammatory Bowel Diseases 0.000271442 1 0 BeFree
Irritable Bowel Syndrome 0.000271442 1 0 BeFree
Obesity 0.000271442 1 0 BeFree
Ki-1+ Anaplastic Large Cell Lymphoma 0.000271442 1 0 BeFree
Lung infiltration 0.000271442 1 0 BeFree
Childhood asthma 0.000271442 1 0 BeFree
Ichthyosis Bullosa of Siemens 0.000271442 1 0 BeFree
airway disease 0.000271442 1 0 BeFree
Eosinophilic disorder 0.000271442 1 0 BeFree
Disorder characterized by eosinophilia 0.000271442 1 0 BeFree
Allergic disposition 0.000271442 1 0 BeFree

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