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This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013]
[中文简述(自动翻译):]  该基因编码有倒钩端肌动蛋白结合蛋白,其属于F-肌动蛋白帽蛋白家族的β亚基。所述封盖蛋白质是异源二聚体的肌动蛋白帽蛋白阻断肌动蛋白丝组装和拆卸的快速增长(倒刺的)的纤维端部和功能在调节肌动蛋白丝动力学以及在肌肉和非肌肉细胞中稳定肌动蛋白丝的长度。该基因的假基因位于染色体长臂2.多个可变剪接转录变异体编码不同亚型已被发现。[由RefSeq的,2013年8月提供]
CAPZB基因(以及对应的蛋白质)的细胞分布位置:
CAPZB基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Animal Mammary Neoplasms | 0.12 | 1 | 0 | CTD_human |
Mammary Neoplasms, Experimental | 0.12 | 1 | 0 | CTD_human |
Acute Coronary Syndrome | 0.12 | 1 | 0 | CTD_human |
Dementia | 0.08 | 1 | 0 | RGD |
Goiter | 0.002367032 | 1 | 3 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of prostate | 0.001085767 | 4 | 0 | BeFree |
Prostate carcinoma | 0.000814326 | 3 | 0 | BeFree |
Autoimmune Diseases | 0.000271442 | 1 | 0 | BeFree |
Hypothyroidism | 0.000271442 | 1 | 0 | BeFree |
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