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This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
[中文简述(自动翻译):]  该基??因编码的肽类激素降钙素,降钙素基因相关肽和由该基因转录的组织特异性选择性RNA剪接和无活性的前体蛋白的裂解钙抑肽。降钙素参与钙调节,其作用是调节磷代谢。降钙素基因相关肽用作血管扩张剂和作为同时钙抑肽抗微生物肽是钙降肽??。多个转录变异体的编码不同亚型也发现了这种基因。[由RefSeq的,2014年8月提供]
CALCA基因(以及对应的蛋白质)的细胞分布位置:
CALCA基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Hyperalgesia | 0.2 | 4 | 0 | CTD_human_RGD |
| Inflammation | 0.2 | 2 | 0 | CTD_human_RGD |
| Migraine Disorders | 0.133787454 | 25 | 0 | BeFree_CTD_human_GAD_LHGDN |
| Hypertensive disease | 0.128815624 | 9 | 0 | BeFree_CTD_human_GAD_LHGDN |
| Prostatic Neoplasms | 0.126263026 | 5 | 0 | BeFree_CTD_human_LHGDN |
| Degenerative polyarthritis | 0.122909916 | 3 | 0 | BeFree_CTD_human_GAD |
| Hypercalcemia | 0.121357209 | 7 | 0 | BeFree_CTD_human |
| Pulmonary Hypertension | 0.120542884 | 3 | 0 | BeFree_CTD_human |
| Autistic Disorder | 0.12 | 1 | 0 | CTD_human |
| Catalepsy | 0.12 | 3 | 0 | CTD_human |
| Down Syndrome | 0.12 | 1 | 0 | CTD_human |
| Edema | 0.12 | 1 | 0 | CTD_human |
| Pulmonary Fibrosis | 0.12 | 1 | 0 | CTD_human |
| Bronchial Hyperreactivity | 0.12 | 2 | 0 | CTD_human |
| Sciatic Neuropathy | 0.12 | 1 | 0 | CTD_human |
| Common Migraine | 0.12 | 2 | 0 | CTD_human |
| Hyperactive behavior | 0.12 | 2 | 0 | CTD_human |
| Neurogenic Inflammation | 0.12 | 1 | 0 | CTD_human |
| Arthritis, Experimental | 0.12 | 1 | 0 | CTD_human |
| Intellectual Disability | 0.12 | 1 | 0 | CTD_human |
| Ischemia | 0.083267234 | 4 | 0 | BeFree_LHGDN_RGD |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.080271442 | 2 | 0 | BeFree_RGD |
| Diabetes Mellitus, Experimental | 0.08 | 2 | 0 | RGD |
| Stomach Diseases | 0.08 | 1 | 0 | RGD |
| Prediabetes syndrome | 0.08 | 1 | 0 | RGD |
| Medullary carcinoma of thyroid | 0.047230886 | 174 | 0 | BeFree |
| Sepsis | 0.00953026 | 8 | 0 | BeFree_LHGDN |
| Multiple Endocrine Neoplasia Type 2a | 0.008143256 | 30 | 0 | BeFree |
| Neoplasm Metastasis | 0.006524536 | 14 | 0 | BeFree_LHGDN |
| Thyroid carcinoma | 0.006243163 | 23 | 0 | BeFree |
| Bacterial Infections | 0.0054487 | 2 | 0 | LHGDN |
| Infection | 0.0054487 | 2 | 0 | LHGDN |
| Postoperative Complications | 0.005091382 | 2 | 0 | GAD_LHGDN |
| Osteoporosis | 0.004267125 | 7 | 0 | BeFree_GAD |
| Familial medullary thyroid carcinoma | 0.003800186 | 14 | 0 | BeFree |
| Pheochromocytoma | 0.003528744 | 13 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.003528744 | 13 | 0 | BeFree |
| Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Malignant neoplasm of thyroid | 0.003257302 | 12 | 0 | BeFree |
| Thyroid Nodule | 0.003257302 | 12 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Dermatitis, Atopic | 0.00272435 | 1 | 0 | LHGDN |
| Epilepsy | 0.00272435 | 1 | 0 | LHGDN |
| Pancreatitis | 0.00272435 | 1 | 0 | LHGDN |
| Pre-Eclampsia | 0.00272435 | 1 | 0 | LHGDN |
| Foot Ulcer | 0.00272435 | 1 | 0 | LHGDN |
| ovarian neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| MYELODYSPLASTIC SYNDROME | 0.00272435 | 1 | 0 | LHGDN |
| Prostate carcinoma | 0.002714419 | 10 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.002638474 | 1 | 0 | BeFree_GAD |
| Malignant neoplasm of prostate | 0.002442977 | 9 | 0 | BeFree |
| Carcinoma of lung | 0.002442977 | 9 | 0 | BeFree |
| Pain, Postoperative | 0.002367032 | 1 | 0 | GAD |
| Reflex Sympathetic Dystrophy | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of breast | 0.002171535 | 8 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.002171535 | 8 | 0 | BeFree |
| Breast Carcinoma | 0.002171535 | 8 | 0 | BeFree |
| Myeloid Leukemia, Chronic | 0.001900093 | 7 | 0 | BeFree |
| Multiple Endocrine Neoplasia Type 2b | 0.001628651 | 6 | 0 | BeFree |
| Thyroid Diseases | 0.001628651 | 6 | 0 | BeFree |
| Acute leukemia | 0.001628651 | 6 | 0 | BeFree |
| Small cell carcinoma of lung | 0.001628651 | 6 | 0 | BeFree |
| Malignant neoplasm of lung | 0.001628651 | 6 | 0 | BeFree |
| Multiple Endocrine Neoplasia | 0.001357209 | 5 | 0 | BeFree |
| Headache | 0.001085767 | 4 | 0 | BeFree |
| leukemia | 0.001085767 | 4 | 0 | BeFree |
| Acute lymphocytic leukemia | 0.001085767 | 4 | 0 | BeFree |
| Septicemia | 0.001085767 | 4 | 0 | BeFree |
| Thyroid Neoplasm | 0.001085767 | 4 | 0 | BeFree |
| Medullary carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Hyperparathyroidism, Primary | 0.001085767 | 4 | 0 | BeFree |
| Adenocarcinoma | 0.000814326 | 3 | 0 | BeFree |
| Endocrine Gland Neoplasms | 0.000814326 | 3 | 0 | BeFree |
| Lymphoma | 0.000814326 | 3 | 0 | BeFree |
| Osteoporosis, Postmenopausal | 0.000814326 | 3 | 0 | BeFree |
| Precancerous Conditions | 0.000814326 | 3 | 0 | BeFree |
| Essential Hypertension | 0.000814326 | 3 | 0 | BeFree |
| Tumor Progression | 0.000814326 | 3 | 0 | BeFree |
| Arthritis | 0.000542884 | 2 | 0 | BeFree |
| Asthma | 0.000542884 | 2 | 0 | BeFree |
| Bipolar Disorder | 0.000542884 | 2 | 0 | BeFree |
| Blast Phase | 0.000542884 | 2 | 0 | BeFree |
| Carcinoid Tumor | 0.000542884 | 2 | 0 | BeFree |
| Ulcerative Colitis | 0.000542884 | 2 | 0 | BeFree |
| Diabetes | 0.000542884 | 2 | 0 | BeFree |
| Diabetes Mellitus | 0.000542884 | 2 | 0 | BeFree |
| Endocrine System Diseases | 0.000542884 | 2 | 0 | BeFree |
| Goiter | 0.000542884 | 2 | 0 | BeFree |
| Nodular Goiter | 0.000542884 | 2 | 0 | BeFree |
| Lung Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
| Obesity | 0.000542884 | 2 | 0 | BeFree |
| Osteosarcoma | 0.000542884 | 2 | 0 | BeFree |
| Pain | 0.000542884 | 2 | 0 | BeFree |
| Chronic pain | 0.000542884 | 2 | 0 | BeFree |
| Williams Syndrome | 0.000542884 | 2 | 0 | BeFree |
| Teratocarcinoma | 0.000542884 | 2 | 0 | BeFree |
| Papillary thyroid carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Carcinoma, Small Cell | 0.000542884 | 2 | 0 | BeFree |
| Carcinoid tumor no ICD-O subtype | 0.000542884 | 2 | 0 | BeFree |
| C cell tumor | 0.000542884 | 2 | 0 | BeFree |
| Familial Hemiplegic Migraine | 0.000542884 | 2 | 0 | BeFree |
| Mass of thyroid gland | 0.000542884 | 2 | 0 | BeFree |
| Recurrent tumor | 0.000542884 | 2 | 0 | BeFree |
| Osteosarcoma of bone | 0.000542884 | 2 | 0 | BeFree |
| Central neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
| Non-toxic nodular goiter | 0.000542884 | 2 | 0 | BeFree |
| Plaque, Amyloid | 0.000542884 | 2 | 0 | BeFree |
| Adenoma | 0.000271442 | 1 | 0 | BeFree |
| Alcoholic Intoxication, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Supravalvular aortic stenosis | 0.000271442 | 1 | 0 | BeFree |
| Arthritis, Adjuvant-Induced | 0.000271442 | 1 | 0 | BeFree |
| Beckwith-Wiedemann Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Mental disorders | 0.000271442 | 1 | 0 | BeFree |
| Bone neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Cervix Diseases | 0.000271442 | 1 | 0 | BeFree |
| Cherubism | 0.000271442 | 1 | 0 | BeFree |
| Choriocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Colitis | 0.000271442 | 1 | 0 | BeFree |
| Colonic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Diabetes Mellitus, Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
| Distemper | 0.000271442 | 1 | 0 | BeFree |
| Drug abuse | 0.000271442 | 1 | 0 | BeFree |
| Ependymoma | 0.000271442 | 1 | 0 | BeFree |
| Von Hippel-Lindau Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Hirschsprung Disease | 0.000271442 | 1 | 2 | BeFree |
| Hydrops Fetalis | 0.000271442 | 1 | 0 | BeFree |
| Hyperparathyroidism | 0.000271442 | 1 | 0 | BeFree |
| Hypoparathyroidism | 0.000271442 | 1 | 0 | BeFree |
| insulinoma | 0.000271442 | 1 | 0 | BeFree |
| Keloid | 0.000271442 | 1 | 0 | BeFree |
| Chronic Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Myeloid Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Meningioma | 0.000271442 | 1 | 0 | BeFree |
| Premature Menopause | 0.000271442 | 1 | 0 | BeFree |
| Mixed Salivary Gland Tumor | 0.000271442 | 1 | 0 | BeFree |
| Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
| Myasthenia Gravis | 0.000271442 | 1 | 0 | BeFree |
| Mydriasis | 0.000271442 | 1 | 0 | BeFree |
| Myeloproliferative disease | 0.000271442 | 1 | 0 | BeFree |
| Nephroblastoma | 0.000271442 | 1 | 0 | BeFree |
| nervous system disorder | 0.000271442 | 1 | 0 | BeFree |
| Nervous System Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Paraganglioma | 0.000271442 | 1 | 0 | BeFree |
| Parathyroid Diseases | 0.000271442 | 1 | 0 | BeFree |
| Parkinson Disease | 0.000271442 | 1 | 0 | BeFree |
| Chronic peritoneal effusion (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Pituitary Diseases | 0.000271442 | 1 | 0 | BeFree |
| Pseudohypoparathyroidism | 0.000271442 | 1 | 0 | BeFree |
| Pseudopseudohypoparathyroidism | 0.000271442 | 1 | 0 | BeFree |
| Psoriasis | 0.000271442 | 1 | 0 | BeFree |
| Burn scar | 0.000271442 | 1 | 0 | BeFree |
| Subarachnoid Hemorrhage | 0.000271442 | 1 | 0 | BeFree |
| Thymoma | 0.000271442 | 1 | 0 | BeFree |
| Urticaria | 0.000271442 | 1 | 0 | BeFree |
| Werner Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Hypoalgesia | 0.000271442 | 1 | 0 | BeFree |
| Synovial Cyst | 0.000271442 | 1 | 0 | BeFree |
| Chronic Persistent Hepatitis | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of pharynx | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of bone | 0.000271442 | 1 | 0 | BeFree |
| Allergic asthma | 0.000271442 | 1 | 0 | BeFree |
| Idiopathic urticaria | 0.000271442 | 1 | 0 | BeFree |
| Intervertebral Disc Degeneration | 0.000271442 | 1 | 0 | BeFree |
| Nephrogenic Diabetes Insipidus | 0.000271442 | 1 | 0 | BeFree |
| Cicatrix, Hypertrophic | 0.000271442 | 1 | 0 | BeFree |
| Diabetes, Autoimmune | 0.000271442 | 1 | 0 | BeFree |
| Hepatoblastoma | 0.000271442 | 1 | 0 | BeFree |
| Giant Cell Tumor of Bone | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma, Large Cell | 0.000271442 | 1 | 0 | BeFree |
| Psoriasis vulgaris | 0.000271442 | 1 | 0 | BeFree |
| Cerebral Vasospasm | 0.000271442 | 1 | 0 | BeFree |
| Lingual Thyroid | 0.000271442 | 1 | 0 | BeFree |
| Philadelphia chromosome positive chronic myelogenous leukemia | 0.000271442 | 1 | 0 | BeFree |
| Condition, Preneoplastic | 0.000271442 | 1 | 0 | BeFree |
| Restenosis | 0.000271442 | 1 | 0 | BeFree |
| Ganglioneuromatosis | 0.000271442 | 1 | 0 | BeFree |
| Manic | 0.000271442 | 1 | 0 | BeFree |
| Multinodular goiter | 0.000271442 | 1 | 0 | BeFree |
| Hypocalciuric hypercalcemia, familial, type 1 | 0.000271442 | 1 | 0 | BeFree |
| Large cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
| Osteoarthritis, Knee | 0.000271442 | 1 | 0 | BeFree |
| Associated symptom | 0.000271442 | 1 | 0 | BeFree |
| Mood Disorders | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of kidney | 0.000271442 | 1 | 0 | BeFree |
| Pharyngeal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Allergic skin reaction | 0.000271442 | 1 | 0 | BeFree |
| Pain during injection | 0.000271442 | 1 | 0 | BeFree |
| Ductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Myxoid cyst | 0.000271442 | 1 | 0 | BeFree |
| Persistent infection | 0.000271442 | 1 | 0 | BeFree |
| Chronic myeloproliferative disorder | 0.000271442 | 1 | 0 | BeFree |
| Single tumor | 0.000271442 | 1 | 0 | BeFree |
| Hereditary Malignant Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Well Differentiated Pancreatic Endocrine Tumor | 0.000271442 | 1 | 0 | BeFree |
| Mixed Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Renal carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
| Familial benign hypercalcemia | 0.000271442 | 1 | 0 | BeFree |
| Hemiplegic migraine, familial type 1 | 0.000271442 | 1 | 0 | BeFree |
| TROPICAL CALCIFIC PANCREATITIS | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Small Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Nasopharyngeal carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Hirschsprung disease 1 | 0.000271442 | 1 | 2 | BeFree |
| Pseudohypoparathyroidism, Type Ia | 0.000271442 | 1 | 0 | BeFree |
| Neutrophilia (disorder) | 0.000271442 | 1 | 0 | BeFree |
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