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Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011]
[中文简述(自动翻译):]  钙调起着在T细胞受体介导的信号传导途径中起重要作用。由该基因编码的蛋白质特异性结合钙神经的活化形式,并且抑制钙调磷酸酶介导的信号转导。所编码的蛋白质在细胞核中发现,并包含亮氨酸拉链结构域以及一些PEST基序,其赋予靶向降解的那些含有它们蛋白的序列。在多个转录剪接变异体导致编码两个不同的亚型。 [由RefSeq的,2011年1月提供]
CABIN1基因(以及对应的蛋白质)的细胞分布位置:
CABIN1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Cardiomegaly | 0.12 | 1 | 0 | CTD_human |
| Hepatitis C | 0.002638474 | 2 | 0 | BeFree_GAD |
| Schizophrenia | 0.002638474 | 1 | 0 | BeFree_GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Liver carcinoma | 0.002367032 | 1 | 0 | GAD |
| Chronic Kidney Diseases | 0.001085767 | 4 | 0 | BeFree |
| Diabetes Mellitus | 0.000814326 | 3 | 0 | BeFree |
| Graft-vs-Host Disease | 0.000814326 | 3 | 0 | BeFree |
| Interstitial fibrosis | 0.000814326 | 3 | 0 | BeFree |
| Chronic Kidney Insufficiency | 0.000814326 | 3 | 0 | BeFree |
| Dermatitis, Atopic | 0.000542884 | 2 | 0 | BeFree |
| Diabetes | 0.000542884 | 2 | 0 | BeFree |
| Eczema | 0.000542884 | 2 | 0 | BeFree |
| Hypertensive disease | 0.000542884 | 2 | 0 | BeFree |
| Kidney Failure, Chronic | 0.000542884 | 2 | 0 | BeFree |
| Renal fibrosis | 0.000542884 | 2 | 0 | BeFree |
| Amyotrophic Lateral Sclerosis | 0.000271442 | 1 | 2 | BeFree |
| Arthritis | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Hypercholesterolemia | 0.000271442 | 1 | 0 | BeFree |
| Lymphocytic Choriomeningitis | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Tremor | 0.000271442 | 1 | 0 | BeFree |
| Non-arthropod borne lymphocytic choriomeningitis | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
| Schwannomatosis | 0.000271442 | 1 | 0 | BeFree |
| Nephrotic Syndrome, Minimal Change | 0.000271442 | 1 | 0 | BeFree |
| Thrombotic Microangiopathies | 0.000271442 | 1 | 0 | BeFree |
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