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Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. A peptide (C3a) derived from the encoded protein has antimicrobial activity, so people with C3 deficiency are susceptible to bacterial infection. [provided by RefSeq, Nov 2014]
[中文简述(自动翻译):]  补体成分C3起着补体系统的激活中心作用。它的激活是必需的古典和替代的补体活化途径。从编码蛋白的肽(C3a的)具有抗菌活性,所以人与C3缺陷很容易受到细菌感染。 [由RefSeq的,2014年11月提供]
C3基因(以及对应的蛋白质)的细胞分布位置:
C3基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 5 | 0.36 | 2 | 6 | CLINVAR_ORPHANET_UNIPROT |
COMPLEMENT COMPONENT 3 DEFICIENCY, AUTOSOMAL RECESSIVE | 0.32 | 1 | 0 | MGD_ORPHANET_UNIPROT |
Age related macular degeneration | 0.311039416 | 44 | 4 | BeFree_CTD_human_GAD_GWASCAT_LHGDN |
Macular Degeneration, Age-Related, 9 | 0.24 | 1 | 0 | CTD_human_UNIPROT |
Transient Ischemic Attack | 0.2 | 3 | 0 | CTD_human_RGD |
Atypical Hemolytic Uremic Syndrome | 0.121357209 | 5 | 0 | BeFree_CTD_human |
Diabetes Mellitus, Non-Insulin-Dependent | 0.120542884 | 3 | 0 | BeFree_CTD_human |
C3 Deficiency | 0.120542884 | 2 | 0 | BeFree_CLINVAR |
Immunologic Deficiency Syndromes | 0.12 | 1 | 0 | CTD_human |
Insulin Resistance | 0.12 | 1 | 0 | CTD_human |
Paratuberculosis | 0.12 | 1 | 0 | CTD_human |
Pemphigus | 0.12 | 1 | 0 | CTD_human |
Henoch-Schoenlein Purpura | 0.12 | 1 | 0 | CTD_human |
Infarction, Middle Cerebral Artery | 0.12 | 1 | 0 | CTD_human |
Drug-Induced Liver Injury | 0.12 | 1 | 0 | CTD_human |
Brain Ischemia | 0.085091382 | 3 | 0 | GAD_LHGDN_RGD |
Myocardial Infarction | 0.083267234 | 4 | 0 | BeFree_LHGDN_RGD |
Obesity | 0.082442977 | 10 | 4 | BeFree_RGD |
Amyotrophic Lateral Sclerosis | 0.080814326 | 4 | 1 | BeFree_RGD |
Glomerulonephritis | 0.080814326 | 4 | 0 | BeFree_RGD |
Experimental Autoimmune Encephalomyelitis | 0.080271442 | 2 | 0 | BeFree_RGD |
Pneumocystis jiroveci pneumonia | 0.080271442 | 2 | 0 | BeFree_RGD |
Membranous glomerulonephritis | 0.08 | 1 | 0 | RGD |
Hyperalgesia | 0.08 | 1 | 0 | RGD |
Myocardial Reperfusion Injury | 0.08 | 1 | 0 | RGD |
Ocular Hypertension | 0.08 | 1 | 0 | RGD |
Pneumonia | 0.08 | 1 | 0 | RGD |
Pre-Eclampsia | 0.08 | 1 | 0 | RGD |
Reperfusion Injury | 0.08 | 1 | 0 | RGD |
Retinal Degeneration | 0.08 | 2 | 0 | RGD |
Rhinitis | 0.08 | 1 | 0 | RGD |
Anterior uveitis | 0.08 | 1 | 0 | RGD |
Peripheral Vascular Diseases | 0.08 | 1 | 0 | RGD |
Sciatic Neuropathy | 0.08 | 1 | 0 | RGD |
Streptococcal pneumonia | 0.08 | 1 | 0 | RGD |
Sepsis | 0.08 | 1 | 0 | RGD |
Cerebral Hemorrhage | 0.08 | 1 | 0 | RGD |
Asthma | 0.023103692 | 9 | 0 | BeFree_GAD_LHGDN |
Lupus Erythematosus, Systemic | 0.016078541 | 15 | 0 | BeFree_GAD_LHGDN |
Inflammation | 0.009825446 | 4 | 0 | GAD_LHGDN |
Alzheimer's Disease | 0.007729856 | 4 | 0 | BeFree_GAD_LHGDN |
Hyperlipidemia, Familial Combined | 0.00680591 | 6 | 0 | BeFree_LHGDN |
Hemolytic-Uremic Syndrome | 0.005362824 | 3 | 0 | BeFree_GAD_LHGDN |
Cerebrovascular accident | 0.005362824 | 3 | 0 | BeFree_GAD_LHGDN |
Tuberculosis | 0.005362824 | 3 | 0 | BeFree_GAD_LHGDN |
Dermatitis, Atopic | 0.005091382 | 1 | 0 | GAD_LHGDN |
Retinal Drusen | 0.004734064 | 2 | 0 | GAD |
Choroidal Neovascularization | 0.004734064 | 2 | 0 | GAD |
Atherosclerosis | 0.003452799 | 5 | 0 | BeFree_GAD |
Coronary heart disease | 0.003181358 | 4 | 0 | BeFree_GAD |
Endometriosis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Metabolic Syndrome X | 0.002909916 | 2 | 0 | BeFree_GAD |
Coronary Artery Disease | 0.002909916 | 3 | 0 | BeFree_GAD |
Encephalomyelitis | 0.00272435 | 1 | 0 | LHGDN |
Hypertriglyceridemia | 0.00272435 | 1 | 0 | LHGDN |
Infertility | 0.00272435 | 1 | 0 | LHGDN |
Polycystic Ovary Syndrome | 0.00272435 | 1 | 0 | LHGDN |
Psoriasis | 0.00272435 | 1 | 0 | LHGDN |
Dyslipidemias | 0.00272435 | 1 | 0 | LHGDN |
Febrile Convulsions | 0.002638474 | 1 | 0 | BeFree_GAD |
Epilepsy, Temporal Lobe | 0.002638474 | 1 | 0 | BeFree_GAD |
Malignant neoplasm of ovary | 0.002638474 | 2 | 0 | BeFree_GAD |
Bronchiolitis, Viral | 0.002367032 | 1 | 0 | GAD |
Chlamydia Infections | 0.002367032 | 1 | 0 | GAD |
Mental Depression | 0.002367032 | 1 | 0 | GAD |
Erythema Nodosum | 0.002367032 | 1 | 0 | GAD |
Hypersensitivity | 0.002367032 | 1 | 0 | GAD |
Immediate hypersensitivity | 0.002367032 | 1 | 0 | GAD |
Lymphoma, Non-Hodgkin | 0.002367032 | 1 | 0 | GAD |
Parkinson Disease | 0.002367032 | 1 | 0 | GAD |
Respiratory Syncytial Virus Infections | 0.002367032 | 1 | 0 | GAD |
Sarcoidosis | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Trachoma | 0.002367032 | 1 | 0 | GAD |
Low Vision | 0.002367032 | 1 | 0 | GAD |
Bronchial Hyperreactivity | 0.002367032 | 1 | 0 | GAD |
Respiratory syncytial virus bronchiolitis | 0.002367032 | 1 | 0 | GAD |
Geographic Atrophy | 0.002367032 | 1 | 0 | GAD |
Cirrhosis | 0.002367032 | 1 | 0 | GAD |
Venous Thromboembolism | 0.002367032 | 1 | 0 | GAD |
exudative macular degeneration | 0.002367032 | 1 | 0 | GAD |
HIV Infections | 0.001628651 | 6 | 0 | BeFree |
Rheumatoid Arthritis | 0.001357209 | 5 | 0 | BeFree |
Arteriosclerosis | 0.001085767 | 4 | 0 | BeFree |
Macular degeneration | 0.001085767 | 4 | 0 | BeFree |
Crohn Disease | 0.000814326 | 3 | 0 | BeFree |
Leukemia, Lymphocytic, Acute, L1 | 0.000814326 | 3 | 0 | BeFree |
Lupus Vulgaris | 0.000814326 | 3 | 0 | BeFree |
Lupus Erythematosus, Discoid | 0.000814326 | 3 | 0 | BeFree |
Lupus Erythematosus | 0.000814326 | 3 | 0 | BeFree |
Juvenile rheumatoid arthritis | 0.000814326 | 3 | 0 | BeFree |
Arthritis | 0.000542884 | 2 | 0 | BeFree |
Autoimmune Diseases | 0.000542884 | 2 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Renal Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Diabetes Mellitus, Insulin-Dependent | 0.000542884 | 2 | 0 | BeFree |
Fibrodysplasia Ossificans Progressiva | 0.000542884 | 2 | 0 | BeFree |
IGA Glomerulonephritis | 0.000542884 | 2 | 0 | BeFree |
Glomerulonephritis, Membranoproliferative | 0.000542884 | 2 | 0 | BeFree |
Inflammatory Bowel Diseases | 0.000542884 | 2 | 0 | BeFree |
Antisocial behavior | 0.000542884 | 2 | 0 | BeFree |
Renal glomerular disease | 0.000542884 | 2 | 0 | BeFree |
Exudative age-related macular degeneration | 0.000542884 | 2 | 0 | BeFree |
AIDS related complex | 0.000271442 | 1 | 0 | BeFree |
Aortic Aneurysm | 0.000271442 | 1 | 0 | BeFree |
Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Cholelithiasis | 0.000271442 | 1 | 0 | BeFree |
Coronary Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
Eclampsia | 0.000271442 | 1 | 0 | BeFree |
Hyperlipidemia | 0.000271442 | 1 | 0 | BeFree |
Hyperlipoproteinemias | 0.000271442 | 1 | 0 | BeFree |
Acute lymphocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Adult T-Cell Lymphoma/Leukemia | 0.000271442 | 1 | 0 | BeFree |
Paroxysmal nocturnal hemoglobinuria | 0.000271442 | 1 | 0 | BeFree |
Medulloblastoma | 0.000271442 | 1 | 0 | BeFree |
Mitral Valve Stenosis | 0.000271442 | 1 | 0 | BeFree |
Multiple Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Mycoses | 0.000271442 | 1 | 0 | BeFree |
Myotonic Dystrophy | 0.000271442 | 1 | 0 | BeFree |
Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
Nephritis | 0.000271442 | 1 | 0 | BeFree |
Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Periodontitis | 0.000271442 | 1 | 0 | BeFree |
polyps | 0.000271442 | 1 | 0 | BeFree |
Retinopathy of Prematurity | 0.000271442 | 1 | 0 | BeFree |
Kaposi Sarcoma | 0.000271442 | 1 | 0 | BeFree |
Schizophrenia | 0.000271442 | 1 | 0 | BeFree |
Gestational Diabetes | 0.000271442 | 1 | 0 | BeFree |
Meningitis, Bacterial | 0.000271442 | 1 | 1 | BeFree |
Migraine Disorders | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Membranoproliferative Glomerulonephritis, Type II | 0.000271442 | 1 | 0 | BeFree |
Restenosis | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
Thrombophilia | 0.000271442 | 1 | 0 | BeFree |
Congenital Myotonic Dystrophy | 0.000271442 | 1 | 0 | BeFree |
Hepatitis C, Chronic | 0.000271442 | 1 | 1 | BeFree |
Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
airway disease | 0.000271442 | 1 | 0 | BeFree |
Mitochondrial Diseases | 0.000271442 | 1 | 0 | BeFree |
Acute GVH disease | 0.000271442 | 1 | 0 | BeFree |
Cholecystolithiasis | 0.000271442 | 1 | 0 | BeFree |
Ischemic stroke | 0.000271442 | 1 | 0 | BeFree |
Attention deficit hyperactivity disorder | 0.000271442 | 1 | 0 | BeFree |
Renal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Immune complex nephritis | 0.000271442 | 1 | 0 | BeFree |
Hyperlipoproteinemia Type IIb | 0.000271442 | 1 | 0 | BeFree |
Recurrent bacterial infection | 0.000271442 | 1 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Group B Streptococcal Infection | 0.000271442 | 1 | 0 | BeFree |
Immunoglobulin a deficiency 1 | 0.000271442 | 1 | 0 | BeFree |
Mitochondrial cardiomyopathy | 0.000271442 | 1 | 0 | BeFree |
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