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Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. A peptide (C3a) derived from the encoded protein has antimicrobial activity, so people with C3 deficiency are susceptible to bacterial infection. [provided by RefSeq, Nov 2014]
[中文简述(自动翻译):]  补体成分C3起着补体系统的激活中心作用。它的激活是必需的古典和替代的补体活化途径。从编码蛋白的肽(C3a的)具有抗菌活性,所以人与C3缺陷很容易受到细菌感染。 [由RefSeq的,2014年11月提供]
C3基因(以及对应的蛋白质)的细胞分布位置:
C3基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 5 | 0.36 | 2 | 6 | CLINVAR_ORPHANET_UNIPROT |
| COMPLEMENT COMPONENT 3 DEFICIENCY, AUTOSOMAL RECESSIVE | 0.32 | 1 | 0 | MGD_ORPHANET_UNIPROT |
| Age related macular degeneration | 0.311039416 | 44 | 4 | BeFree_CTD_human_GAD_GWASCAT_LHGDN |
| Macular Degeneration, Age-Related, 9 | 0.24 | 1 | 0 | CTD_human_UNIPROT |
| Transient Ischemic Attack | 0.2 | 3 | 0 | CTD_human_RGD |
| Atypical Hemolytic Uremic Syndrome | 0.121357209 | 5 | 0 | BeFree_CTD_human |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.120542884 | 3 | 0 | BeFree_CTD_human |
| C3 Deficiency | 0.120542884 | 2 | 0 | BeFree_CLINVAR |
| Immunologic Deficiency Syndromes | 0.12 | 1 | 0 | CTD_human |
| Insulin Resistance | 0.12 | 1 | 0 | CTD_human |
| Paratuberculosis | 0.12 | 1 | 0 | CTD_human |
| Pemphigus | 0.12 | 1 | 0 | CTD_human |
| Henoch-Schoenlein Purpura | 0.12 | 1 | 0 | CTD_human |
| Infarction, Middle Cerebral Artery | 0.12 | 1 | 0 | CTD_human |
| Drug-Induced Liver Injury | 0.12 | 1 | 0 | CTD_human |
| Brain Ischemia | 0.085091382 | 3 | 0 | GAD_LHGDN_RGD |
| Myocardial Infarction | 0.083267234 | 4 | 0 | BeFree_LHGDN_RGD |
| Obesity | 0.082442977 | 10 | 4 | BeFree_RGD |
| Amyotrophic Lateral Sclerosis | 0.080814326 | 4 | 1 | BeFree_RGD |
| Glomerulonephritis | 0.080814326 | 4 | 0 | BeFree_RGD |
| Experimental Autoimmune Encephalomyelitis | 0.080271442 | 2 | 0 | BeFree_RGD |
| Pneumocystis jiroveci pneumonia | 0.080271442 | 2 | 0 | BeFree_RGD |
| Membranous glomerulonephritis | 0.08 | 1 | 0 | RGD |
| Hyperalgesia | 0.08 | 1 | 0 | RGD |
| Myocardial Reperfusion Injury | 0.08 | 1 | 0 | RGD |
| Ocular Hypertension | 0.08 | 1 | 0 | RGD |
| Pneumonia | 0.08 | 1 | 0 | RGD |
| Pre-Eclampsia | 0.08 | 1 | 0 | RGD |
| Reperfusion Injury | 0.08 | 1 | 0 | RGD |
| Retinal Degeneration | 0.08 | 2 | 0 | RGD |
| Rhinitis | 0.08 | 1 | 0 | RGD |
| Anterior uveitis | 0.08 | 1 | 0 | RGD |
| Peripheral Vascular Diseases | 0.08 | 1 | 0 | RGD |
| Sciatic Neuropathy | 0.08 | 1 | 0 | RGD |
| Streptococcal pneumonia | 0.08 | 1 | 0 | RGD |
| Sepsis | 0.08 | 1 | 0 | RGD |
| Cerebral Hemorrhage | 0.08 | 1 | 0 | RGD |
| Asthma | 0.023103692 | 9 | 0 | BeFree_GAD_LHGDN |
| Lupus Erythematosus, Systemic | 0.016078541 | 15 | 0 | BeFree_GAD_LHGDN |
| Inflammation | 0.009825446 | 4 | 0 | GAD_LHGDN |
| Alzheimer's Disease | 0.007729856 | 4 | 0 | BeFree_GAD_LHGDN |
| Hyperlipidemia, Familial Combined | 0.00680591 | 6 | 0 | BeFree_LHGDN |
| Hemolytic-Uremic Syndrome | 0.005362824 | 3 | 0 | BeFree_GAD_LHGDN |
| Cerebrovascular accident | 0.005362824 | 3 | 0 | BeFree_GAD_LHGDN |
| Tuberculosis | 0.005362824 | 3 | 0 | BeFree_GAD_LHGDN |
| Dermatitis, Atopic | 0.005091382 | 1 | 0 | GAD_LHGDN |
| Retinal Drusen | 0.004734064 | 2 | 0 | GAD |
| Choroidal Neovascularization | 0.004734064 | 2 | 0 | GAD |
| Atherosclerosis | 0.003452799 | 5 | 0 | BeFree_GAD |
| Coronary heart disease | 0.003181358 | 4 | 0 | BeFree_GAD |
| Endometriosis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Metabolic Syndrome X | 0.002909916 | 2 | 0 | BeFree_GAD |
| Coronary Artery Disease | 0.002909916 | 3 | 0 | BeFree_GAD |
| Encephalomyelitis | 0.00272435 | 1 | 0 | LHGDN |
| Hypertriglyceridemia | 0.00272435 | 1 | 0 | LHGDN |
| Infertility | 0.00272435 | 1 | 0 | LHGDN |
| Polycystic Ovary Syndrome | 0.00272435 | 1 | 0 | LHGDN |
| Psoriasis | 0.00272435 | 1 | 0 | LHGDN |
| Dyslipidemias | 0.00272435 | 1 | 0 | LHGDN |
| Febrile Convulsions | 0.002638474 | 1 | 0 | BeFree_GAD |
| Epilepsy, Temporal Lobe | 0.002638474 | 1 | 0 | BeFree_GAD |
| Malignant neoplasm of ovary | 0.002638474 | 2 | 0 | BeFree_GAD |
| Bronchiolitis, Viral | 0.002367032 | 1 | 0 | GAD |
| Chlamydia Infections | 0.002367032 | 1 | 0 | GAD |
| Mental Depression | 0.002367032 | 1 | 0 | GAD |
| Erythema Nodosum | 0.002367032 | 1 | 0 | GAD |
| Hypersensitivity | 0.002367032 | 1 | 0 | GAD |
| Immediate hypersensitivity | 0.002367032 | 1 | 0 | GAD |
| Lymphoma, Non-Hodgkin | 0.002367032 | 1 | 0 | GAD |
| Parkinson Disease | 0.002367032 | 1 | 0 | GAD |
| Respiratory Syncytial Virus Infections | 0.002367032 | 1 | 0 | GAD |
| Sarcoidosis | 0.002367032 | 1 | 0 | GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Trachoma | 0.002367032 | 1 | 0 | GAD |
| Low Vision | 0.002367032 | 1 | 0 | GAD |
| Bronchial Hyperreactivity | 0.002367032 | 1 | 0 | GAD |
| Respiratory syncytial virus bronchiolitis | 0.002367032 | 1 | 0 | GAD |
| Geographic Atrophy | 0.002367032 | 1 | 0 | GAD |
| Cirrhosis | 0.002367032 | 1 | 0 | GAD |
| Venous Thromboembolism | 0.002367032 | 1 | 0 | GAD |
| exudative macular degeneration | 0.002367032 | 1 | 0 | GAD |
| HIV Infections | 0.001628651 | 6 | 0 | BeFree |
| Rheumatoid Arthritis | 0.001357209 | 5 | 0 | BeFree |
| Arteriosclerosis | 0.001085767 | 4 | 0 | BeFree |
| Macular degeneration | 0.001085767 | 4 | 0 | BeFree |
| Crohn Disease | 0.000814326 | 3 | 0 | BeFree |
| Leukemia, Lymphocytic, Acute, L1 | 0.000814326 | 3 | 0 | BeFree |
| Lupus Vulgaris | 0.000814326 | 3 | 0 | BeFree |
| Lupus Erythematosus, Discoid | 0.000814326 | 3 | 0 | BeFree |
| Lupus Erythematosus | 0.000814326 | 3 | 0 | BeFree |
| Juvenile rheumatoid arthritis | 0.000814326 | 3 | 0 | BeFree |
| Arthritis | 0.000542884 | 2 | 0 | BeFree |
| Autoimmune Diseases | 0.000542884 | 2 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Renal Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Diabetes Mellitus, Insulin-Dependent | 0.000542884 | 2 | 0 | BeFree |
| Fibrodysplasia Ossificans Progressiva | 0.000542884 | 2 | 0 | BeFree |
| IGA Glomerulonephritis | 0.000542884 | 2 | 0 | BeFree |
| Glomerulonephritis, Membranoproliferative | 0.000542884 | 2 | 0 | BeFree |
| Inflammatory Bowel Diseases | 0.000542884 | 2 | 0 | BeFree |
| Antisocial behavior | 0.000542884 | 2 | 0 | BeFree |
| Renal glomerular disease | 0.000542884 | 2 | 0 | BeFree |
| Exudative age-related macular degeneration | 0.000542884 | 2 | 0 | BeFree |
| AIDS related complex | 0.000271442 | 1 | 0 | BeFree |
| Aortic Aneurysm | 0.000271442 | 1 | 0 | BeFree |
| Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
| Cholelithiasis | 0.000271442 | 1 | 0 | BeFree |
| Coronary Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
| Eclampsia | 0.000271442 | 1 | 0 | BeFree |
| Hyperlipidemia | 0.000271442 | 1 | 0 | BeFree |
| Hyperlipoproteinemias | 0.000271442 | 1 | 0 | BeFree |
| Acute lymphocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Adult T-Cell Lymphoma/Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Paroxysmal nocturnal hemoglobinuria | 0.000271442 | 1 | 0 | BeFree |
| Medulloblastoma | 0.000271442 | 1 | 0 | BeFree |
| Mitral Valve Stenosis | 0.000271442 | 1 | 0 | BeFree |
| Multiple Sclerosis | 0.000271442 | 1 | 0 | BeFree |
| Mycoses | 0.000271442 | 1 | 0 | BeFree |
| Myotonic Dystrophy | 0.000271442 | 1 | 0 | BeFree |
| Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
| Nephritis | 0.000271442 | 1 | 0 | BeFree |
| Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Periodontitis | 0.000271442 | 1 | 0 | BeFree |
| polyps | 0.000271442 | 1 | 0 | BeFree |
| Retinopathy of Prematurity | 0.000271442 | 1 | 0 | BeFree |
| Kaposi Sarcoma | 0.000271442 | 1 | 0 | BeFree |
| Schizophrenia | 0.000271442 | 1 | 0 | BeFree |
| Gestational Diabetes | 0.000271442 | 1 | 0 | BeFree |
| Meningitis, Bacterial | 0.000271442 | 1 | 1 | BeFree |
| Migraine Disorders | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Membranoproliferative Glomerulonephritis, Type II | 0.000271442 | 1 | 0 | BeFree |
| Restenosis | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
| Thrombophilia | 0.000271442 | 1 | 0 | BeFree |
| Congenital Myotonic Dystrophy | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis C, Chronic | 0.000271442 | 1 | 1 | BeFree |
| Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| airway disease | 0.000271442 | 1 | 0 | BeFree |
| Mitochondrial Diseases | 0.000271442 | 1 | 0 | BeFree |
| Acute GVH disease | 0.000271442 | 1 | 0 | BeFree |
| Cholecystolithiasis | 0.000271442 | 1 | 0 | BeFree |
| Ischemic stroke | 0.000271442 | 1 | 0 | BeFree |
| Attention deficit hyperactivity disorder | 0.000271442 | 1 | 0 | BeFree |
| Renal carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Immune complex nephritis | 0.000271442 | 1 | 0 | BeFree |
| Hyperlipoproteinemia Type IIb | 0.000271442 | 1 | 0 | BeFree |
| Recurrent bacterial infection | 0.000271442 | 1 | 0 | BeFree |
| Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Group B Streptococcal Infection | 0.000271442 | 1 | 0 | BeFree |
| Immunoglobulin a deficiency 1 | 0.000271442 | 1 | 0 | BeFree |
| Mitochondrial cardiomyopathy | 0.000271442 | 1 | 0 | BeFree |
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