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This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013]
[中文简述(自动翻译):]  这个基因编码的细胞凋亡蛋白(IAP)家族的抑制剂的一个成员,并含有杆状病毒IAP重复(BIR),以及作为环型锌指结构域的单个副本。 BIR结构域对抑制活性必不可少的,与胱天蛋白酶进行交互,而无名指域有时增强抗凋亡活性,但不单独抑制细胞凋亡。所编码的蛋白质的水平升高可与癌症的发展有关,并起到化疗的敏感性的作用。选择性剪接结果在多个抄本变形[由RefSeq的,2013年7月提供]
BIRC7基因(以及对应的蛋白质)的细胞分布位置:
BIRC7基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Renal Cell Carcinoma | 0.128987376 | 4 | 0 | BeFree_CTD_human_LHGDN |
melanoma | 0.010616028 | 11 | 0 | BeFree_LHGDN |
Mammary Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
Bladder Neoplasm | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Osteosarcoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Lung Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Lymphoma, Non-Hodgkin | 0.00272435 | 1 | 0 | LHGDN |
Neoplasms, Germ Cell and Embryonal | 0.00272435 | 1 | 0 | LHGDN |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.00272435 | 1 | 0 | LHGDN |
Malignant tumor of colon | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of lung | 0.000814326 | 3 | 0 | BeFree |
Carcinoma of lung | 0.000814326 | 3 | 0 | BeFree |
Colon Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
Neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
Central neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Condylomata Acuminata | 0.000271442 | 1 | 0 | BeFree |
Melanocytic nevus | 0.000271442 | 1 | 0 | BeFree |
Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Acute leukemia | 0.000271442 | 1 | 0 | BeFree |
Carcinoma, Lewis Lung | 0.000271442 | 1 | 0 | BeFree |
Metastatic melanoma | 0.000271442 | 1 | 0 | BeFree |
Solid tumour | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
Intraocular pressure disorder | 0.000271442 | 1 | 0 | BeFree |
Malignant Pleural Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
Stage IV Skin Melanoma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of urinary bladder, superficial | 0.000271442 | 1 | 0 | BeFree |
Benign melanocytic nevus | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
Non-Neoplastic Disorder | 0.000271442 | 1 | 0 | BeFree |
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