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This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码缓激肽的受体。 9 AA缓激肽引发许多反应,包括血管扩张,水肿,平滑肌痉挛和疼痛纤维刺激。这种受体联营公司与刺激磷脂酰肌醇 - 钙第二信使系统的G蛋白。替代的起始密码子导致的蛋白质的两种同种型。 [由RefSeq的,2008年7月提供]
BDKRB2基因(以及对应的蛋白质)的细胞分布位置:
BDKRB2基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Hypertensive disease | 0.225027529 | 16 | 1 | BeFree_CTD_human_GAD_RGD |
Inflammation | 0.20272435 | 3 | 0 | CTD_human_LHGDN_RGD |
Hyperalgesia | 0.2 | 4 | 0 | CTD_human_RGD |
Rheumatoid Arthritis | 0.12 | 1 | 0 | CTD_human |
Epilepsy, Temporal Lobe | 0.12 | 1 | 0 | CTD_human |
Extravasation of Diagnostic and Therapeutic Materials | 0.12 | 1 | 0 | CTD_human |
Hemorrhage | 0.12 | 1 | 0 | CTD_human |
Hyperemia | 0.12 | 1 | 0 | CTD_human |
Hypotension | 0.12 | 2 | 0 | CTD_human |
Pain | 0.12 | 1 | 0 | CTD_human |
Thrombosis | 0.12 | 1 | 0 | CTD_human |
Cardiomyopathies | 0.12 | 1 | 0 | CTD_human |
Acute kidney injury | 0.12 | 1 | 0 | CTD_human |
Myocardial Infarction | 0.084734064 | 3 | 0 | GAD_RGD |
Left Ventricular Hypertrophy | 0.082909916 | 3 | 0 | BeFree_GAD_RGD |
Asthma | 0.082638474 | 3 | 0 | BeFree_GAD_RGD |
Diabetes Mellitus, Experimental | 0.08 | 2 | 0 | RGD |
Diabetic Retinopathy | 0.08 | 1 | 0 | RGD |
Epilepsy | 0.08 | 1 | 0 | RGD |
Glioma | 0.08 | 1 | 0 | RGD |
Hypertension, Portal | 0.08 | 1 | 0 | RGD |
Pulmonary Hypertension | 0.08 | 1 | 0 | RGD |
Lung diseases | 0.08 | 1 | 0 | RGD |
Pancreatitis | 0.08 | 1 | 0 | RGD |
Pleurisy | 0.08 | 1 | 0 | RGD |
Sciatic Neuropathy | 0.08 | 1 | 0 | RGD |
Kidney Failure, Chronic | 0.005634266 | 3 | 0 | BeFree_GAD_LHGDN |
Cardiovascular Diseases | 0.005005506 | 3 | 0 | BeFree_GAD |
Systemic arterial pressure | 0.004734064 | 2 | 0 | GAD |
Inflammatory Bowel Diseases | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Coughing | 0.002909916 | 3 | 6 | BeFree_GAD |
Kidney Failure | 0.002909916 | 2 | 0 | BeFree_GAD |
Alzheimer's Disease | 0.00272435 | 1 | 0 | LHGDN |
Hyperaldosteronism | 0.00272435 | 1 | 0 | LHGDN |
Pre-Eclampsia | 0.00272435 | 1 | 0 | LHGDN |
Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Gastric ulcer | 0.00272435 | 1 | 0 | LHGDN |
Alcoholic Intoxication, Chronic | 0.002367032 | 1 | 0 | GAD |
Altitude Sickness | 0.002367032 | 1 | 0 | GAD |
Coronary Arteriosclerosis | 0.002367032 | 1 | 0 | GAD |
Diabetes Mellitus, Non-Insulin-Dependent | 0.002367032 | 1 | 0 | GAD |
Diabetic Nephropathy | 0.002367032 | 1 | 0 | GAD |
Hemolytic-Uremic Syndrome | 0.002367032 | 1 | 0 | GAD |
Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
Acute Coronary Syndrome | 0.002367032 | 1 | 0 | GAD |
Blood pressure finding | 0.002367032 | 1 | 0 | GAD |
Coronary Artery Disease | 0.002367032 | 1 | 0 | GAD |
Weight Loss Adverse Event | 0.002367032 | 1 | 0 | GAD |
Essential Hypertension | 0.001357209 | 5 | 0 | BeFree |
Angioedemas, Hereditary | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000542884 | 2 | 0 | BeFree |
Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Mental disorders | 0.000271442 | 1 | 0 | BeFree |
Bipolar Disorder | 0.000271442 | 1 | 1 | BeFree |
Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 2 | BeFree |
Obsessive-Compulsive Disorder | 0.000271442 | 1 | 1 | BeFree |
Panic Disorder | 0.000271442 | 1 | 1 | BeFree |
Unipolar Depression | 0.000271442 | 1 | 1 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
Idiopathic pulmonary hypertension | 0.000271442 | 1 | 0 | BeFree |
Major Depressive Disorder | 0.000271442 | 1 | 1 | BeFree |
PANIC DISORDER 1 | 0.000271442 | 1 | 1 | BeFree |
Pulmonary arterial hypertension | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia | 0.000271442 | 1 | 0 | BeFree |
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