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This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码缓激肽的受体。 9 AA缓激肽引发许多反应,包括血管扩张,水肿,平滑肌痉挛和疼痛纤维刺激。这种受体联营公司与刺激磷脂酰肌醇 - 钙第二信使系统的G蛋白。替代的起始密码子导致的蛋白质的两种同种型。 [由RefSeq的,2008年7月提供]
BDKRB2基因(以及对应的蛋白质)的细胞分布位置:
BDKRB2基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Hypertensive disease | 0.225027529 | 16 | 1 | BeFree_CTD_human_GAD_RGD |
| Inflammation | 0.20272435 | 3 | 0 | CTD_human_LHGDN_RGD |
| Hyperalgesia | 0.2 | 4 | 0 | CTD_human_RGD |
| Rheumatoid Arthritis | 0.12 | 1 | 0 | CTD_human |
| Epilepsy, Temporal Lobe | 0.12 | 1 | 0 | CTD_human |
| Extravasation of Diagnostic and Therapeutic Materials | 0.12 | 1 | 0 | CTD_human |
| Hemorrhage | 0.12 | 1 | 0 | CTD_human |
| Hyperemia | 0.12 | 1 | 0 | CTD_human |
| Hypotension | 0.12 | 2 | 0 | CTD_human |
| Pain | 0.12 | 1 | 0 | CTD_human |
| Thrombosis | 0.12 | 1 | 0 | CTD_human |
| Cardiomyopathies | 0.12 | 1 | 0 | CTD_human |
| Acute kidney injury | 0.12 | 1 | 0 | CTD_human |
| Myocardial Infarction | 0.084734064 | 3 | 0 | GAD_RGD |
| Left Ventricular Hypertrophy | 0.082909916 | 3 | 0 | BeFree_GAD_RGD |
| Asthma | 0.082638474 | 3 | 0 | BeFree_GAD_RGD |
| Diabetes Mellitus, Experimental | 0.08 | 2 | 0 | RGD |
| Diabetic Retinopathy | 0.08 | 1 | 0 | RGD |
| Epilepsy | 0.08 | 1 | 0 | RGD |
| Glioma | 0.08 | 1 | 0 | RGD |
| Hypertension, Portal | 0.08 | 1 | 0 | RGD |
| Pulmonary Hypertension | 0.08 | 1 | 0 | RGD |
| Lung diseases | 0.08 | 1 | 0 | RGD |
| Pancreatitis | 0.08 | 1 | 0 | RGD |
| Pleurisy | 0.08 | 1 | 0 | RGD |
| Sciatic Neuropathy | 0.08 | 1 | 0 | RGD |
| Kidney Failure, Chronic | 0.005634266 | 3 | 0 | BeFree_GAD_LHGDN |
| Cardiovascular Diseases | 0.005005506 | 3 | 0 | BeFree_GAD |
| Systemic arterial pressure | 0.004734064 | 2 | 0 | GAD |
| Inflammatory Bowel Diseases | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Coughing | 0.002909916 | 3 | 6 | BeFree_GAD |
| Kidney Failure | 0.002909916 | 2 | 0 | BeFree_GAD |
| Alzheimer's Disease | 0.00272435 | 1 | 0 | LHGDN |
| Hyperaldosteronism | 0.00272435 | 1 | 0 | LHGDN |
| Pre-Eclampsia | 0.00272435 | 1 | 0 | LHGDN |
| Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Gastric ulcer | 0.00272435 | 1 | 0 | LHGDN |
| Alcoholic Intoxication, Chronic | 0.002367032 | 1 | 0 | GAD |
| Altitude Sickness | 0.002367032 | 1 | 0 | GAD |
| Coronary Arteriosclerosis | 0.002367032 | 1 | 0 | GAD |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.002367032 | 1 | 0 | GAD |
| Diabetic Nephropathy | 0.002367032 | 1 | 0 | GAD |
| Hemolytic-Uremic Syndrome | 0.002367032 | 1 | 0 | GAD |
| Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
| Acute Coronary Syndrome | 0.002367032 | 1 | 0 | GAD |
| Blood pressure finding | 0.002367032 | 1 | 0 | GAD |
| Coronary Artery Disease | 0.002367032 | 1 | 0 | GAD |
| Weight Loss Adverse Event | 0.002367032 | 1 | 0 | GAD |
| Essential Hypertension | 0.001357209 | 5 | 0 | BeFree |
| Angioedemas, Hereditary | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000542884 | 2 | 0 | BeFree |
| Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
| Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Mental disorders | 0.000271442 | 1 | 0 | BeFree |
| Bipolar Disorder | 0.000271442 | 1 | 1 | BeFree |
| Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
| Obesity | 0.000271442 | 1 | 2 | BeFree |
| Obsessive-Compulsive Disorder | 0.000271442 | 1 | 1 | BeFree |
| Panic Disorder | 0.000271442 | 1 | 1 | BeFree |
| Unipolar Depression | 0.000271442 | 1 | 1 | BeFree |
| Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Idiopathic pulmonary hypertension | 0.000271442 | 1 | 0 | BeFree |
| Major Depressive Disorder | 0.000271442 | 1 | 1 | BeFree |
| PANIC DISORDER 1 | 0.000271442 | 1 | 1 | BeFree |
| Pulmonary arterial hypertension | 0.000271442 | 1 | 0 | BeFree |
| Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia | 0.000271442 | 1 | 0 | BeFree |
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