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The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是一个锌指转录因子,并包含一个N-末端POZ域。该蛋白质作为转录的序列特异性阻抑,并且已显示调节的启动依赖的IL-4的B细胞应答的转录。该蛋白可与各种转录辅阻遏物是功能含POZ蛋白的相互作用。该基因被发现要经常易位和弥漫性大细胞淋巴瘤(DLCL)超突变,并可能参与DLCL的发病机制。已发现该基因编码不同的蛋白质亚型选择性剪接转录变异体。 [由RefSeq的,2008年9月提供]
BCL6基因(以及对应的蛋白质)的细胞分布位置:
BCL6基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Lymphoma, Follicular | 0.15999522 | 72 | 0 | BeFree_GAD_LHGDN_ORPHANET |
| Lymphoma, Non-Hodgkin | 0.135154595 | 21 | 0 | BeFree_CTD_human_GAD_LHGDN |
| T-Cell Lymphoma | 0.120814326 | 4 | 0 | BeFree_CTD_human |
| Mediastinal (Thymic) Large B-Cell Lymphoma | 0.120271442 | 1 | 0 | BeFree_ORPHANET |
| B-Cell Lymphomas | 0.08261122 | 140 | 0 | BeFree_GAD_LHGDN |
| Lymphoma | 0.065073612 | 146 | 0 | BeFree_GAD_LHGDN |
| Diffuse Large B-Cell Lymphoma | 0.033311405 | 115 | 1 | BeFree_GAD |
| Leukemogenesis | 0.012214884 | 45 | 0 | BeFree |
| Mucosa-Associated Lymphoid Tissue Lymphoma | 0.010606096 | 19 | 0 | BeFree_LHGDN |
| Chronic Lymphocytic Leukemia | 0.005624334 | 12 | 0 | BeFree_GAD |
| Myeloid Leukemia, Chronic | 0.005005506 | 3 | 0 | BeFree_GAD |
| HIV Infections | 0.004267125 | 8 | 0 | BeFree_GAD |
| Hodgkin Disease | 0.003538676 | 4 | 0 | BeFree_LHGDN |
| Burkitt Lymphoma | 0.003528744 | 13 | 0 | BeFree |
| Malignant neoplasm of breast | 0.003257302 | 12 | 0 | BeFree |
| Carcinogenesis | 0.003257302 | 12 | 0 | BeFree |
| Breast Carcinoma | 0.003257302 | 12 | 0 | BeFree |
| Carcinoma, Transitional Cell | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Immunoproliferative Small Intestinal Disease | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Lymphoma, AIDS-Related | 0.002909916 | 3 | 0 | BeFree_GAD |
| Ataxia | 0.00272435 | 1 | 0 | LHGDN |
| Metaplasia | 0.00272435 | 1 | 0 | LHGDN |
| Otitis Media with Effusion | 0.00272435 | 1 | 0 | LHGDN |
| Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
| Waldenstrom Macroglobulinemia | 0.002367032 | 1 | 0 | GAD |
| Pathologic Neovascularization | 0.002367032 | 1 | 0 | GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Central Nervous System Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of lung | 0.002367032 | 1 | 0 | GAD |
| Atopy | 0.002367032 | 1 | 0 | GAD |
| Congenital chromosomal disease | 0.002171535 | 8 | 0 | BeFree |
| leukemia | 0.002171535 | 8 | 0 | BeFree |
| Lymphoma, Large-Cell, Follicular | 0.002171535 | 8 | 0 | BeFree |
| Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.001900093 | 7 | 0 | BeFree |
| Gastric lymphoma | 0.001900093 | 7 | 0 | BeFree |
| Lymphoproliferative Disorders | 0.001357209 | 5 | 0 | BeFree |
| Multiple Myeloma | 0.001357209 | 5 | 0 | BeFree |
| Epstein-Barr Virus Infections | 0.001357209 | 5 | 0 | BeFree |
| Primary central nervous system lymphoma | 0.001357209 | 5 | 0 | BeFree |
| Marginal Zone B-Cell Lymphoma | 0.001357209 | 5 | 0 | BeFree |
| Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.001357209 | 5 | 0 | BeFree |
| Acute lymphocytic leukemia | 0.001085767 | 4 | 0 | BeFree |
| Trisomy | 0.001085767 | 4 | 0 | BeFree |
| Acquired Immunodeficiency Syndrome | 0.000814326 | 3 | 0 | BeFree |
| Common Variable Immunodeficiency | 0.000814326 | 3 | 0 | BeFree |
| Reticulosarcoma | 0.000814326 | 3 | 0 | BeFree |
| Peripheral T-Cell Lymphoma | 0.000814326 | 3 | 0 | BeFree |
| Aggressive Non-Hodgkin Lymphoma | 0.000814326 | 3 | 0 | BeFree |
| Leukemia, B-Cell | 0.000814326 | 3 | 0 | BeFree |
| Angioimmunoblastic Lymphadenopathy | 0.000542884 | 2 | 0 | BeFree |
| Lymphoid leukemia | 0.000542884 | 2 | 0 | BeFree |
| Acute Promyelocytic Leukemia | 0.000542884 | 2 | 0 | BeFree |
| Lymphoma, Small Noncleaved-Cell | 0.000542884 | 2 | 0 | BeFree |
| Severe Combined Immunodeficiency | 0.000542884 | 2 | 0 | BeFree |
| High grade B-cell lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Hepatitis C, Chronic | 0.000542884 | 2 | 0 | BeFree |
| Monocytoid B-cell lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Primary Effusion Lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Precursor B-cell lymphoblastic leukemia | 0.000542884 | 2 | 0 | BeFree |
| Mature B-Cell Non-Hodgkin Lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Gastric Diffuse Large B-Cell Lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Lymphoma, Diffuse | 0.000542884 | 2 | 0 | BeFree |
| Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
| Brain Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Noninfiltrating Intraductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Developmental Disabilities | 0.000271442 | 1 | 0 | BeFree |
| Chordoma | 0.000271442 | 1 | 0 | BeFree |
| Congenital ocular coloboma (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Down Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Exanthema | 0.000271442 | 1 | 0 | BeFree |
| Fanconi Anemia | 0.000271442 | 1 | 0 | BeFree |
| Fetal Alcohol Syndrome | 0.000271442 | 1 | 0 | BeFree |
| pathologic fistula | 0.000271442 | 1 | 0 | BeFree |
| Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis C | 0.000271442 | 1 | 0 | BeFree |
| Infectious Mononucleosis | 0.000271442 | 1 | 0 | BeFree |
| Fibroid Tumor | 0.000271442 | 1 | 0 | BeFree |
| leiomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
| melanoma | 0.000271442 | 1 | 0 | BeFree |
| Meningioma | 0.000271442 | 1 | 0 | BeFree |
| Monosomy | 0.000271442 | 1 | 0 | BeFree |
| Osteosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Retinoblastoma | 0.000271442 | 1 | 0 | BeFree |
| Superinfection | 0.000271442 | 1 | 0 | BeFree |
| synovial sarcoma | 0.000271442 | 1 | 0 | BeFree |
| Uterine Fibroids | 0.000271442 | 1 | 0 | BeFree |
| Fibromatosis, Aggressive | 0.000271442 | 1 | 0 | BeFree |
| Immunoblastic Large-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Precursor cell lymphoblastic lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Acute leukemia | 0.000271442 | 1 | 0 | BeFree |
| Complete trisomy 18 syndrome | 0.000271442 | 1 | 0 | BeFree |
| T-Lymphocytopenia, Idiopathic CD4-Positive | 0.000271442 | 1 | 0 | BeFree |
| Gallbladder Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Gastrointestinal Stromal Tumors | 0.000271442 | 1 | 0 | BeFree |
| HTLV Infections | 0.000271442 | 1 | 0 | BeFree |
| Lymphoid interstitial pneumonia | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma breast stage IV | 0.000271442 | 1 | 0 | BeFree |
| Gallbladder adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Acute Undifferentiated Leukemia | 0.000271442 | 1 | 0 | BeFree |
| stage, chronic lymphocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Diffuse Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
| Intraocular Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Post-transplant lymphoproliferative disorder | 0.000271442 | 1 | 0 | BeFree |
| Neurodegenerative Disorders | 0.000271442 | 1 | 0 | BeFree |
| Composite Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
| Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| early pregnancy | 0.000271442 | 1 | 0 | BeFree |
| Malignant Peripheral Nerve Sheath Tumor | 0.000271442 | 1 | 0 | BeFree |
| Perineurioma | 0.000271442 | 1 | 0 | BeFree |
| Invasive breast carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Solitary fibrous tumor | 0.000271442 | 1 | 0 | BeFree |
| Primary cutaneous B-cell lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Cutaneous lymphoma | 0.000271442 | 1 | 0 | BeFree |
| AIDS-Related Non-Hodgkin Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Classical Hodgkin's Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Primary Cutaneous Follicle Center Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Grade 3b Follicular Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Nodular Lymphocyte Predominant Hodgkin Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Undifferentiated leukemia | 0.000271442 | 1 | 0 | BeFree |
| Astler-Coller B1 Rectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
| Glioblastoma Multiforme | 0.000271442 | 1 | 0 | BeFree |
| Primary cutaneous large B-cell lymphoma of the leg | 0.000271442 | 1 | 0 | BeFree |
| Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type | 0.000271442 | 1 | 0 | BeFree |
| Meningioma, benign, no ICD-O subtype | 0.000271442 | 1 | 0 | BeFree |
| LATERAL MENINGOCELE SYNDROME | 0.000271442 | 1 | 0 | BeFree |
| Philadelphia chromosome-positive acute lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Low grade glioma | 0.000271442 | 1 | 0 | BeFree |
| Hodgkin lymphoma, nodular lymphocyte predominance | 0.000271442 | 1 | 0 | BeFree |
| Pediatric Follicular Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Promyelocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
| FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Plasmablastic lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Triple Negative Breast Neoplasms | 0.000271442 | 1 | 0 | BeFree |
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