BAK1(BCL2-antagonist/killer 1)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

基因染色体位置

基因染色体位置

6p21.31
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  由该基因编码的蛋白质属于BCL2蛋白家族。 BCL2家族成员形成低聚物或异，并作为所涉及的各种细胞活动抗或促凋亡调节剂。此蛋白质定位于线粒体，其作用是诱导细胞凋亡。它与交互和加速了线粒体电压依赖性阴离子通道，这导致在膜电位损失和细胞色素c释放的开口。这种蛋白也与接触细胞应激后肿瘤抑制基因p53相互作用。 [由RefSeq的，2008年7月提供]

OMIM数据库中对BAK1基因的介绍     Wikipedia数据库中对BAK1基因的介绍

基因序列

基因序列

BAK1基因的碱基序列：[NCBI]

基因突变

基因突变

BAK1基因的碱基突变：           显示全部snp
rs210134       rs210135       rs210136       rs210137       rs210138       rs210139       rs210140       rs210141       rs210142       rs210143       rs210144       rs210145       rs210146       rs210147       rs210148       rs511515       rs512399       rs513349       rs557559       rs561276       rs572824       rs806605       rs1051911       rs1051912       rs1051913       rs1051945       rs2227925       rs2284828       rs2284829       rs2395456       rs2894353       rs2894354       rs3216621       rs4987115       rs5745564       rs5745565       rs5745567      
rs5745570       rs5745571       rs5745572       rs5745573       rs5745575       rs5745576       rs5745577       rs5745578       rs5745579       rs5745580       rs5745581       rs5745582       rs5745583       rs5745584       rs5745586       rs5745587       rs5745588       rs5745589       rs5745591       rs5745592       rs5745593       rs5745594       rs5745595       rs5745596       rs5745597       rs5745598       rs5745600       rs6457732       rs6907610       rs6924988       rs6925471       rs7341238       rs7741608       rs7746159       rs7762214       rs8180574       rs9282611       rs9296095       rs9357161       rs9469514       rs9469515       rs11757379       rs12211102       rs35550796       rs55707130       rs56740052       rs61292931       rs62407570       rs71565390       rs74499662       rs76774629       rs77009237       rs80065855       rs111358594       rs111804636       rs112843934       rs113219792       rs113398088       rs114453026       rs115597569       rs116819340       rs137860384       rs138561611       rs138609480       rs138928031       rs139218453       rs139807289       rs140087410       rs140505615       rs140648150       rs140652052       rs141088359       rs141335016       rs141588690       rs141617072       rs142643843       rs142850532       rs143054587       rs143214346       rs143389634       rs143676363       rs143727127       rs144422925       rs144443674       rs144676565       rs144984323       rs145148950       rs145968702       rs145972578       rs146892017       rs146926576       rs147213678       rs147899980       rs148199579       rs149467994       rs149960684       rs150272237       rs150482729       rs181108566       rs181393571       rs181458040       rs181749250       rs181851656       rs183239202       rs183295478       rs183363282       rs184812726       rs184939617       rs186141645       rs186426937       rs186474429       rs186506282       rs188089916       rs188742322       rs188955505       rs189627503       rs189736325       rs190767037       rs191612892       rs191850317       rs192349920       rs193078281       rs199754748       rs199913279       rs200108196       rs200387920       rs200462463       rs201643389       rs201779997       rs367573450       rs367606791       rs368045254       rs368144891       rs368163314       rs368302168       rs368600028       rs368815273       rs369663629       rs369856356       rs370944014       rs371320117       rs372139963       rs372257626       rs372657768       rs373619041       rs373778311       rs374000054       rs374498801       rs375013861       rs375089143       rs375153092       rs375549037       rs375888869       rs376265958       rs376712748       rs377341171       rs377347576       rs397741711       rs527548578       rs528736003       rs528797429       rs529317166       rs529435989       rs529566498       rs529629576       rs529634494       rs530082443       rs530420323       rs530421804       rs530625550       rs531268628       rs531465974       rs531593162       rs531594065       rs531652398       rs531658995       rs532062413       rs532258582       rs532268535       rs533681716       rs534139289       rs534772249       rs535334716       rs535394860       rs535663497       rs535977507       rs536238538       rs536574362       rs536576983       rs537321467       rs537321816       rs537384702       rs537398246       rs537851544       rs538640947       rs539267875       rs539692166       rs539851232       rs539913308       rs540936025       rs540963887       rs541193872       rs541568521       rs541570437       rs542800172       rs542821389       rs542988417       rs543617808       rs544908801       rs544970210       rs545420069       rs545521105       rs547117675       rs547190990       rs547236664       rs547391240       rs547448643       rs547867032       rs548190187       rs549053288       rs549128707       rs549160591       rs549219475       rs549441758       rs549786479       rs549939386       rs549943152       rs550500000       rs551156164       rs551218246       rs551302712       rs551565063       rs551893677       rs552572124       rs552785529       rs553186842       rs553364153       rs553427506       rs554280388       rs554776920       rs554840212       rs555106763       rs555215063       rs555242575       rs555690198       rs556208492       rs556289211       rs556815195       rs557344938       rs557489635       rs557490402       rs558088024       rs558472047       rs558565092       rs558742403       rs558801142       rs558839371       rs559004546       rs559034049       rs559254802       rs559458028       rs559671785       rs560706322       rs561156671       rs561697780       rs561874426       rs562253995       rs563033017       rs563105345       rs563897863       rs564633495       rs564902213       rs564902560       rs564966742       rs565090846       rs565118358       rs565170105       rs565525532       rs565780083       rs566643847       rs566859402       rs567285544       rs567376447       rs567432701       rs568177078       rs568265148       rs568388557       rs568665592       rs568816806       rs569276903       rs569315416       rs569958623       rs570018194       rs570018552       rs570678613       rs570756759       rs570939691       rs571069523       rs571328387       rs571436982       rs572591412       rs573146177       rs573721799       rs574526886       rs574614209       rs574861121       rs574926551       rs575256624       rs575692050       rs575750489       rs576145338       rs576272583       rs576364854       rs577008922       rs577291137       rs577547691       rs745314875       rs745605734       rs745708980       rs745878139       rs745992555       rs746563887       rs746711568       rs746743686       rs746935939       rs747024677       rs747223284       rs747344615       rs747643368       rs747731940       rs748450309       rs748646933       rs748774801       rs748778111       rs748982597       rs749409665       rs749997550       rs750654182       rs750765569       rs750857077       rs751021055       rs752006972       rs752120911       rs752492898       rs752584771       rs752727667       rs752817502       rs753158141       rs753341616       rs754059376       rs754210197       rs754274553       rs754404299       rs754552945       rs754663151       rs754713518       rs755026681       rs755256768       rs755412880       rs755786933       rs755973013       rs756132444       rs756326673       rs756347512       rs756559288       rs756774531       rs756968925       rs757510970       rs757517984       rs757842945       rs757957290       rs758281722       rs758307806       rs758884894       rs759142830       rs759519722       rs759941625       rs760488257       rs760867106       rs761327603       rs761535491       rs761926026       rs762004504       rs762195437       rs762958558       rs762960717       rs763052569       rs763163017       rs763678915       rs763976645       rs764068634       rs764414042       rs764437421       rs764595945       rs764966781       rs765284813       rs765300677       rs765477406       rs766540475       rs766561404       rs766939211       rs766999552       rs767030876       rs767196220       rs768052277       rs768325698       rs768589296       rs768710423       rs768965444       rs769110361       rs769198228       rs769426436       rs769479388       rs769923355       rs769950150       rs770151646       rs770531908       rs770571379       rs770713054       rs770817553       rs771133864       rs771637336       rs772385015       rs772427718       rs772953650       rs773075870       rs773391910       rs773586210       rs773859939       rs774645858       rs774666079       rs775106891       rs775198844       rs775422894       rs775583296       rs775679105       rs776079498       rs776171225       rs776437416       rs776547478       rs776825292       rs776913532       rs777128029       rs777335704       rs777705035       rs778071616       rs778171445       rs778260832       rs778415235       rs778549210       rs778565612       rs778587427       rs779411450       rs779690846       rs780157658       rs781040871       rs781130899       rs781587510       rs781638668       rs781674780       rs781732557      

基因表达

基因表达

BAK1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CTCTGCTTCTGAGGAGCAG
60
AACTCTGAGTCATAGCGTCG
60
CTCTGCTTCTGAGGAGCAG
60
GAGGTAAGGTGACCATCTCTG
60
CTCTGCTTCTGAGGAGCAG
60
GGTAAGGTGACCATCTCTGG
60
CTCTGCTTCTGAGGAGCAG
60
GTAAGGTGACCATCTCTGGG
60
CTCTGCTTCTGAGGAGCAG
60
ACTCTGAGTCATAGCGTCG
59
CTCTGCTTCTGAGGAGCAG
60
CTCTGAGTCATAGCGTCGG
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

BAK1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

BAK1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0016021
A0A0A0MRG8(UniProtKB)
IEA
GO:0043065
A0A0A0MRG8(UniProtKB)
IEA
GO:0001782
Q16611(UniProtKB)
IEA
GO:0001783
Q16611(UniProtKB)
IEA
GO:0001836
Q16611(UniProtKB)
IDA
GO:0001836
Q16611(UniProtKB)
IGI
GO:0001836
Q16611(UniProtKB)
IDA
GO:0001974
Q16611(UniProtKB)
IEA
GO:0002262
Q16611(UniProtKB)
IEA
GO:0002352
Q16611(UniProtKB)
IEA
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005515
Q16611(UniProtKB)
IPI
GO:0005739
Q16611(UniProtKB)
IDA
GO:0005741
Q16611(UniProtKB)
IBA
GO:0005741
Q16611(UniProtKB)
TAS
GO:0005741
Q16611(UniProtKB)
TAS
GO:0005741
Q16611(UniProtKB)
TAS
GO:0005783
Q16611(UniProtKB)
IEA
GO:0005829
Q16611(UniProtKB)
IEA
GO:0005829
Q16611(UniProtKB)
IEA
GO:0006987
Q16611(UniProtKB)
TAS
GO:0007420
Q16611(UniProtKB)
IEA
GO:0007568
Q16611(UniProtKB)
IEA
GO:0008053
Q16611(UniProtKB)
IEA
GO:0008283
Q16611(UniProtKB)
IEA
GO:0008285
Q16611(UniProtKB)
IEA
GO:0008630
Q16611(UniProtKB)
IBA
GO:0008635
Q16611(UniProtKB)
IEA
GO:0009620
Q16611(UniProtKB)
IEA
GO:0010046
Q16611(UniProtKB)
IEA
GO:0010225
Q16611(UniProtKB)
IEA
GO:0010248
Q16611(UniProtKB)
IDA
GO:0010332
Q16611(UniProtKB)
IEA
GO:0010524
Q16611(UniProtKB)
IEA
GO:0010629
Q16611(UniProtKB)
IEA
GO:0014070
Q16611(UniProtKB)
IEA
GO:0019835
Q16611(UniProtKB)
IMP
GO:0031018
Q16611(UniProtKB)
IEA
GO:0031072
Q16611(UniProtKB)
IEA
GO:0031100
Q16611(UniProtKB)
IEA
GO:0031307
Q16611(UniProtKB)
ISS
GO:0032469
Q16611(UniProtKB)
TAS
GO:0032471
Q16611(UniProtKB)
IEA
GO:0033137
Q16611(UniProtKB)
IEA
GO:0034644
Q16611(UniProtKB)
ISS
GO:0034644
Q16611(UniProtKB)
IMP
GO:0035108
Q16611(UniProtKB)
IEA
GO:0042493
Q16611(UniProtKB)
IEA
GO:0042542
Q16611(UniProtKB)
IEA
GO:0042802
Q16611(UniProtKB)
IPI
GO:0042802
Q16611(UniProtKB)
IPI
GO:0042802
Q16611(UniProtKB)
IPI
GO:0042802
Q16611(UniProtKB)
IPI
GO:0042802
Q16611(UniProtKB)
IPI
GO:0042803
Q16611(UniProtKB)
IBA
GO:0043065
Q16611(UniProtKB)
IMP
GO:0043496
Q16611(UniProtKB)
IDA
GO:0043497
Q16611(UniProtKB)
IDA
GO:0044325
Q16611(UniProtKB)
IPI
GO:0044346
Q16611(UniProtKB)
IEA
GO:0045471
Q16611(UniProtKB)
IEA
GO:0045862
Q16611(UniProtKB)
IDA
GO:0046872
Q16611(UniProtKB)
IEA
GO:0046902
Q16611(UniProtKB)
IDA
GO:0046902
Q16611(UniProtKB)
IDA
GO:0046930
Q16611(UniProtKB)
IDA
GO:0046982
Q16611(UniProtKB)
IPI
GO:0048597
Q16611(UniProtKB)
IEA
GO:0051087
Q16611(UniProtKB)
IEA
GO:0051400
Q16611(UniProtKB)
IEA
GO:0051726
Q16611(UniProtKB)
IEA
GO:0051881
Q16611(UniProtKB)
IDA
GO:0060068
Q16611(UniProtKB)
IEA
GO:0070059
Q16611(UniProtKB)
TAS
GO:0070242
Q16611(UniProtKB)
IEA
GO:0071260
Q16611(UniProtKB)
IEP
GO:0090200
Q16611(UniProtKB)
IEA
GO:0097190
Q16611(UniProtKB)
IMP
GO:0097192
Q16611(UniProtKB)
IBA
GO:0097202
Q16611(UniProtKB)
IDA
GO:1900103
Q16611(UniProtKB)
IMP
GO:1901030
Q16611(UniProtKB)
TAS
GO:1902262
Q16611(UniProtKB)
IEA
GO:1903896
Q16611(UniProtKB)
TAS

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控BAK1基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Chronic Lymphocytic Leukemia 0.122909916 4 1 BeFree_GAD_GWASCAT
Testicular Germ Cell Tumor 0.122638474 4 1 BeFree_GAD_GWASCAT
Colonic Neoplasms 0.12 1 0 CTD_human
Nerve Degeneration 0.12 1 0 CTD_human
Peripheral Neuropathy 0.12 1 0 CTD_human
Platelet mean volume finding 0.12 1 1 GWASCAT
Intermittent Claudication 0.08 1 0 RGD
Liver Cirrhosis, Experimental 0.08 1 0 RGD
Left Ventricular Hypertrophy 0.08 1 0 RGD
Lymphoma, Non-Hodgkin 0.004734064 2 0 GAD
Squamous cell carcinoma 0.002995792 2 0 BeFree_LHGDN
Fibroid Tumor 0.002995792 1 0 BeFree_LHGDN
Stomach Neoplasms 0.002995792 1 0 BeFree_LHGDN
Thyroid Neoplasm 0.002995792 2 0 BeFree_LHGDN
Anoxia 0.00272435 1 0 LHGDN
Cessation of life 0.00272435 1 0 LHGDN
Glaucoma 0.00272435 1 0 LHGDN
Graves Disease 0.00272435 1 0 LHGDN
Lung Neoplasms 0.00272435 1 0 LHGDN
melanoma 0.00272435 1 0 LHGDN
Lymphoproliferative Disorders 0.002638474 1 0 BeFree_GAD
Malignant neoplasm of lung 0.002638474 2 0 BeFree_GAD
Malignant neoplasm of urinary bladder 0.002367032 1 0 GAD
Chronic Obstructive Airway Disease 0.002367032 1 0 GAD
Testicular Neoplasms 0.002367032 1 1 GAD
Malignant neoplasm of breast 0.000814326 3 0 BeFree
Malignant neoplasm of stomach 0.000814326 3 0 BeFree
Breast Carcinoma 0.000814326 3 0 BeFree
Aortic Aneurysm, Abdominal 0.000542884 2 0 BeFree
Cervix carcinoma 0.000542884 2 0 BeFree
Malignant neoplasm of gastrointestinal tract 0.000542884 2 0 BeFree
Colorectal Cancer 0.000542884 2 0 BeFree
Adenoma 0.000271442 1 0 BeFree
Adrenal Gland Neoplasms 0.000271442 1 0 BeFree
Aortic Aneurysm 0.000271442 1 0 BeFree
Rheumatoid Arthritis 0.000271442 1 0 BeFree
Autoimmune Diseases 0.000271442 1 0 BeFree
Non-Small Cell Lung Carcinoma 0.000271442 1 0 BeFree
Celiac Disease 0.000271442 1 0 BeFree
Malignant tumor of cervix 0.000271442 1 0 BeFree
Colorectal Neoplasms 0.000271442 1 0 BeFree
Empyema 0.000271442 1 0 BeFree
Glioma 0.000271442 1 0 BeFree
Leukemia, Myelocytic, Acute 0.000271442 1 0 BeFree
Leukemia, T-Cell 0.000271442 1 0 BeFree
Adult T-Cell Lymphoma/Leukemia 0.000271442 1 0 BeFree
Mesothelioma 0.000271442 1 0 BeFree
Ovarian Carcinoma 0.000271442 1 0 BeFree
Rheumatism 0.000271442 1 0 BeFree
Uterine Fibroids 0.000271442 1 0 BeFree
Benign Neoplasm 0.000271442 1 0 BeFree
Germ cell tumor 0.000271442 1 1 BeFree
Adrenocortical carcinoma 0.000271442 1 0 BeFree
Pancreatic carcinoma 0.000271442 1 0 BeFree
Metastatic melanoma 0.000271442 1 0 BeFree
Malignant neoplasm of pancreas 0.000271442 1 0 BeFree
Papillary neoplasm 0.000271442 1 0 BeFree
Benign neurologic neoplasms 0.000271442 1 0 BeFree
Malignant Glioma 0.000271442 1 0 BeFree
Epithelial ovarian cancer 0.000271442 1 0 BeFree
Carcinoma of lung 0.000271442 1 0 BeFree
Stomach Carcinoma 0.000271442 1 0 BeFree

基因相关文献

基因相关文献

没有相关文献

基因相关服务

基因相关服务

基因评论

基因评论

我要说两句
热门评论
还没有评论，赶快来抢沙发吧。

登陆

用户名:

密    码:

联系方式

山东省济南市 高新区 崇华路359号 三庆世纪财富中心C1115室

电话： 0531-88819269

E-mail: product@genelibs.com

微信公众号

扫一扫右方二维码，关注微信订阅号，实时查看信息，关注医学生物学动态。

版权所有 © 2016.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2