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The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
[中文简述(自动翻译):]  由该基因编码的蛋白质是BAG1相关蛋白家族的一个成员。 BAG1是抗细胞凋亡蛋白质,通过相互作用与各种细胞的凋亡和生长相关蛋白如BCL-2,的Raf蛋白激酶,类固醇激素受体,生长因子受体和热休克蛋白70 kDa的家族成员的功能。此蛋白含有C末端,这可能结合和抑制的Hsc70 / Hsp70的伴侣活性附近的袋域。这种蛋白质被发现与肿瘤坏死因子受体1型(TNF-R1)和死亡受体-3(DR3)的死亡域相关联,并且由此负调控下游细胞死亡的信号。在细胞死亡这种蛋白的调节作用表现在其中进行细胞凋亡,而整介导的基质接触丢失上皮细胞。编码不同亚型选择性剪接转录变异体已经确定。 [由RefSeq的,2011年3月提供]
BAG4基因(以及对应的蛋白质)的细胞分布位置:
BAG4基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Lymphoma, Non-Hodgkin | 0.002367032 | 1 | 0 | GAD |
Acute lymphocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000271442 | 1 | 0 | BeFree |
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