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This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]
[中文简述(自动翻译):]  该基因编码在发现与主要组织相容性复合体(MHC)I类重链几乎所有有核细胞的表面上的血清蛋白。该蛋白质具有主要的β-折叠片结构可以形成在某些病理条件下淀粉样蛋白原纤维。所编码的抗微生物蛋白显示在羊水的抗菌活性。在这个基因的突变已显示导致hypercatabolic低蛋白血症。[通过的RefSeq,2014年8月提供]
B2M基因(以及对应的蛋白质)的细胞分布位置:
B2M基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Hypoproteinemia, Hypercatabolic | 0.360271442 | 1 | 1 | BeFree_CLINVAR_CTD_human_UNIPROT |
| Acute kidney injury | 0.2 | 3 | 0 | CTD_human_RGD |
| Prostatic Neoplasms | 0.12272435 | 2 | 0 | CTD_human_LHGDN |
| Kidney Diseases | 0.120542884 | 5 | 0 | BeFree_CTD_human |
| Diffuse Large B-Cell Lymphoma | 0.120542884 | 3 | 0 | BeFree_CTD_human |
| Autoimmune Diseases | 0.120271442 | 2 | 0 | BeFree_CTD_human |
| Heart Diseases | 0.12 | 1 | 0 | CTD_human |
| Hypergammaglobulinemia | 0.12 | 1 | 0 | CTD_human |
| Peripheral T-Cell Lymphoma | 0.12 | 1 | 0 | CTD_human |
| Amyloidosis, familial visceral | 0.12 | 0 | 1 | CLINVAR |
| Squamous cell carcinoma of esophagus | 0.12 | 1 | 0 | CTD_human |
| Bare Lymphocyte Syndrome, Type I | 0.12 | 0 | 0 | ORPHANET |
| Liver Cirrhosis, Experimental | 0.08 | 1 | 0 | RGD |
| Pyelonephritis | 0.08 | 1 | 0 | RGD |
| Ureteral obstruction | 0.08 | 1 | 0 | RGD |
| Multiple Myeloma | 0.009520329 | 17 | 0 | BeFree_LHGDN |
| Neoplasm Metastasis | 0.008444493 | 4 | 0 | BeFree_LHGDN |
| melanoma | 0.008434561 | 13 | 0 | BeFree_LHGDN |
| Amyloidosis | 0.007620235 | 10 | 0 | BeFree_LHGDN |
| Degenerative polyarthritis | 0.005362824 | 3 | 0 | BeFree_GAD_LHGDN |
| HIV Infections | 0.004071628 | 15 | 0 | BeFree |
| Renal Cell Carcinoma | 0.003538676 | 4 | 0 | BeFree_LHGDN |
| Carpal Tunnel Syndrome | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Colonic Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Lymphoma, Follicular | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Squamous cell carcinoma | 0.00272435 | 1 | 0 | LHGDN |
| Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Cytomegalovirus Infections | 0.00272435 | 1 | 0 | LHGDN |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.00272435 | 1 | 0 | LHGDN |
| Leukemia, Myelocytic, Acute | 0.00272435 | 1 | 0 | LHGDN |
| B-Cell Lymphomas | 0.00272435 | 1 | 0 | LHGDN |
| Rheumatoid Arthritis | 0.002367032 | 1 | 0 | GAD |
| Diabetes Mellitus, Insulin-Dependent | 0.002367032 | 1 | 0 | GAD |
| Gastritis | 0.002367032 | 1 | 0 | GAD |
| Parkinson Disease | 0.002367032 | 1 | 0 | GAD |
| Stomach Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Neuroblastoma | 0.001900093 | 7 | 0 | BeFree |
| Central neuroblastoma | 0.001900093 | 7 | 0 | BeFree |
| Congenital chromosomal disease | 0.001628651 | 6 | 0 | BeFree |
| Malignant neoplasm of breast | 0.001357209 | 5 | 0 | BeFree |
| Lymphoma | 0.001085767 | 4 | 0 | BeFree |
| Plasmacytosis | 0.001085767 | 4 | 0 | BeFree |
| Plasma cell inflammation | 0.001085767 | 4 | 0 | BeFree |
| Breast Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Colon Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Inflammatory disorder | 0.001085767 | 4 | 0 | BeFree |
| Malignant tumor of colon | 0.000814326 | 3 | 0 | BeFree |
| Colorectal Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Chronic Lymphocytic Leukemia | 0.000814326 | 3 | 0 | BeFree |
| Systemic amyloidosis | 0.000814326 | 3 | 0 | BeFree |
| Hemodialysis-associated amyloidosis | 0.000814326 | 3 | 0 | BeFree |
| Primary Systemic Amyloidosis | 0.000814326 | 3 | 0 | BeFree |
| Iron Overload | 0.000814326 | 3 | 0 | BeFree |
| Colorectal Cancer | 0.000814326 | 3 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Ulcerative Colitis | 0.000542884 | 2 | 0 | BeFree |
| Glioma | 0.000542884 | 2 | 0 | BeFree |
| Hemochromatosis | 0.000542884 | 2 | 1 | BeFree |
| Hepatitis, Chronic | 0.000542884 | 2 | 0 | BeFree |
| leukemia | 0.000542884 | 2 | 0 | BeFree |
| Myeloid Leukemia, Chronic | 0.000542884 | 2 | 0 | BeFree |
| Leukemia, Plasma Cell | 0.000542884 | 2 | 0 | BeFree |
| Lupus Erythematosus, Systemic | 0.000542884 | 2 | 0 | BeFree |
| Monosomy | 0.000542884 | 2 | 0 | BeFree |
| Kidney Failure | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000542884 | 2 | 0 | BeFree |
| Bare Lymphocyte Syndrome | 0.000542884 | 2 | 0 | BeFree |
| Primary amyloidosis | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
| Hereditary hemochromatosis | 0.000542884 | 2 | 0 | BeFree |
| Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
| Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
| Ewings sarcoma-primitive neuroectodermal tumor (PNET) | 0.000542884 | 2 | 0 | BeFree |
| Renal carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Bare lymphocyte syndrome 2 | 0.000542884 | 2 | 0 | BeFree |
| Nasopharyngeal carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Plaque, Amyloid | 0.000542884 | 2 | 0 | BeFree |
| Adenoma | 0.000271442 | 1 | 0 | BeFree |
| Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
| Oral candidiasis | 0.000271442 | 1 | 0 | BeFree |
| Choriocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Colitis | 0.000271442 | 1 | 0 | BeFree |
| Constitutional Symptom | 0.000271442 | 1 | 0 | BeFree |
| Endometriosis | 0.000271442 | 1 | 0 | BeFree |
| Arthropathy | 0.000271442 | 1 | 0 | BeFree |
| Adult T-Cell Lymphoma/Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Multiple Sclerosis | 0.000271442 | 1 | 0 | BeFree |
| Tropical Spastic Paraparesis | 0.000271442 | 1 | 0 | BeFree |
| Paraproteinemias | 0.000271442 | 1 | 0 | BeFree |
| Pituitary Diseases | 0.000271442 | 1 | 0 | BeFree |
| Adenomatous Polyposis Coli | 0.000271442 | 1 | 0 | BeFree |
| Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of gallbladder | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of bone | 0.000271442 | 1 | 0 | BeFree |
| Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
| Diabetes, Autoimmune | 0.000271442 | 1 | 0 | BeFree |
| Amyloid Neuropathies, Familial | 0.000271442 | 1 | 0 | BeFree |
| Embryonal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Gallbladder Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Papillary thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Neoplasm, Residual | 0.000271442 | 1 | 0 | BeFree |
| Laryngeal Squamous Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Common acute lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Hematologic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Combined immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of kidney | 0.000271442 | 1 | 0 | BeFree |
| Spondylarthropathies | 0.000271442 | 1 | 0 | BeFree |
| Classical Hodgkin's Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Cancer Cell Growth | 0.000271442 | 1 | 0 | BeFree |
| Undifferentiated Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Chronic ulcerative colitis | 0.000271442 | 1 | 0 | BeFree |
| Neuroepithelioma, Peripheral | 0.000271442 | 1 | 0 | BeFree |
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