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The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]
[中文简述(自动翻译):]  由该基因编码的蛋白质属于抗酶抑制剂家族,其在细胞生长和增殖的细胞内保持多胺动态平衡的作用。抗酶抑制剂鸟氨酸脱羧酶(ODC,在多胺生物合成的关键酶)已经失去了鸟氨酸脱羧酶的能力的同源物;然而,保留结合antizymes的能力。 Antizymes负面通过结合到ODC和定位使其降解,以及通过抑制多胺摄取细胞内的多胺的水平调节。抗酶抑制剂,通过螯合antizymes和中和其效果功能多胺水平是积极的监管机构。该基因编码抗酶抑制物1,该基因家族是遍在表达的第一个成员,而在细胞核和细胞质进行本地化。抗酶抑制物1基因的过表达已与增加的增殖,细胞转化和肿瘤发生有关。基因敲除研究表明,缺乏功能性抗酶抑制剂纯合子突变小鼠基因在出生死亡异常肝脏形态。该基因的RNA编辑,主要在肝脏组织中,已与肝细胞癌的发展。可变剪接转录物变体已被用于这个基因说明。 [由RefSeq的,2014年9月提供]
AZIN1基因(以及对应的蛋白质)的细胞分布位置:
AZIN1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 | 
| IGA Glomerulonephritis | 0.12 | 1 | 0 | CTD_human | 
| Liver carcinoma | 0.000542884 | 2 | 0 | BeFree | 
| Hepatitis C | 0.000271442 | 1 | 0 | BeFree | 
| Prostatic Neoplasms | 0.000271442 | 1 | 0 | BeFree | 
| Squamous cell carcinoma of esophagus | 0.000271442 | 1 | 0 | BeFree | 
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