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Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):] 自噬是由内源性蛋白和细胞器受损细胞内被破坏的过程。自噬是假设成为分化,变态,非凋亡的细胞死亡和衰老过程中细胞稳态和细胞重塑至关重要。自噬的降低水平已经在某些恶性肿瘤进行了描述,以及用于自噬在控制与癌症有关的不受调节的细胞生长的作用已被提出。该基因编码的autophagin蛋白家族的一个成员。所编码的蛋白质也被指定为Q-54家族的半胱氨酸蛋白酶的成员。编码不同亚型的变种成绩单已经确定。 [由RefSeq的,2008年7月提供]
ATG4A基因(以及对应的蛋白质)的细胞分布位置:
ATG4A基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Head and Neck Neoplasms | 0.002367032 | 1 | 0 | GAD |
Neoplasm Recurrence, Local | 0.002367032 | 1 | 0 | GAD |
Neoplasms, Second Primary | 0.002367032 | 1 | 0 | GAD |
Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
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