ATF4(activating transcription factor 4)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

基因染色体位置

基因染色体位置

22q13.1
基因染色体位置图

基因简述

基因简述

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]

[中文简述(自动翻译):]  这个基因编码最初被鉴定为可能在HTLV-1的LTR税响应增强子元件结合广泛表达的哺乳动物DNA结合蛋白的转录因子。所编码的蛋白质也被分离和表征为cAMP反应元件结合蛋白2（CREB-2）。由该基因编码的蛋白质属于DNA结合蛋白的一个家族，包括对AP-1家族的转录因子，cAMP反应元件结合蛋白（CREBs）及CREB样蛋白。这些转录因子分享是参与蛋白质 - 蛋白质相互作用亮氨酸拉链区域，位于C-末端的碱性氨基酸，其功能如同一个DNA结合结构域的一段。编码相同蛋白质两种备选的转录已经描述。两个假设在一个区域含有大量重复倒在Q28在X染色体上。 [由RefSeq的，2011年9月提供]

OMIM数据库中对ATF4基因的介绍     Wikipedia数据库中对ATF4基因的介绍

基因序列

基因序列

ATF4基因的碱基序列：[NCBI]

基因突变

基因突变

ATF4基因的碱基突变：           显示全部snp
rs4894       rs1060000       rs1060142       rs1803323       rs1803324       rs2228181       rs2229273       rs2267413       rs3171687       rs11556099       rs17001266       rs34679547       rs34854854       rs35920692       rs36059872       rs56117154       rs57926472       rs59161709       rs59478141       rs60284339       rs61737791       rs73885240       rs73885241       rs73885242       rs74751854       rs74813547       rs75353028       rs77157164       rs78742369       rs79412294       rs80105975       rs80142785       rs111719524       rs111937889       rs112198231       rs112303731       rs113910998      
rs115111682       rs115378447       rs117186267       rs138075537       rs138640471       rs138696573       rs138790746       rs139408953       rs140428747       rs140650335       rs140698880       rs140871401       rs141451590       rs141463329       rs141575018       rs141643322       rs141727778       rs142422504       rs142762810       rs142911753       rs144184225       rs144534656       rs144769713       rs145276115       rs145847419       rs146185967       rs146204295       rs146354334       rs146469032       rs146633351       rs147185335       rs147220267       rs147301363       rs147877175       rs147899546       rs148038848       rs148305437       rs148568771       rs148936525       rs149326054       rs149522605       rs149857296       rs149908720       rs150046216       rs150385569       rs151021575       rs151149967       rs181328727       rs181790280       rs182279511       rs182791688       rs183254244       rs184569610       rs185252202       rs186327285       rs188265360       rs188294982       rs189837769       rs189863215       rs189922789       rs192140214       rs192462598       rs193150673       rs193166285       rs199649119       rs200470722       rs200688485       rs200926784       rs201201452       rs201284334       rs201312683       rs202175644       rs367702784       rs368547976       rs368914495       rs369015417       rs369567094       rs369760669       rs369838694       rs369962392       rs370215013       rs370467448       rs370822144       rs371009074       rs371466949       rs371499412       rs371854043       rs371958399       rs372377952       rs372523612       rs372679887       rs373242816       rs373424533       rs373882883       rs374512039       rs374660871       rs374864123       rs375266335       rs375489476       rs375554234       rs375843215       rs376147271       rs376351770       rs376820946       rs376877986       rs377261776       rs377487629       rs527474447       rs527679261       rs527712972       rs528297025       rs528688932       rs528731705       rs528891567       rs528968230       rs529005939       rs529870594       rs529952053       rs530191722       rs530230780       rs530548939       rs531120521       rs531454040       rs532815479       rs533796405       rs534749286       rs534830181       rs534880186       rs536034941       rs536072398       rs536643352       rs536676221       rs537283675       rs538671530       rs539075223       rs539627686       rs539659147       rs540001357       rs540961734       rs541165975       rs541202623       rs541396864       rs541765130       rs542420026       rs543588866       rs543662166       rs544103363       rs544809451       rs545050284       rs545383144       rs545702275       rs545739446       rs546755748       rs546881794       rs547418746       rs547803084       rs547944682       rs547982920       rs549171107       rs549308193       rs549806403       rs549932508       rs550707660       rs551099467       rs551343895       rs552036293       rs552162021       rs552275262       rs552959677       rs553106565       rs553818232       rs554269913       rs555687659       rs555724348       rs557047390       rs557295065       rs557801435       rs558004697       rs559485003       rs560051439       rs561280964       rs561743761       rs561782393       rs561818653       rs562456003       rs562783366       rs562983939       rs563228324       rs563469938       rs564042258       rs564601363       rs565435762       rs566425803       rs566582294       rs566819541       rs566834234       rs567445335       rs567481645       rs567617025       rs568102933       rs568793240       rs569350490       rs569816160       rs570271419       rs570395027       rs571672362       rs572204009       rs572271249       rs572310099       rs572596597       rs573208652       rs573746924       rs573783413       rs573926252       rs574942377       rs575135566       rs575170457       rs576251334       rs576961618       rs577428565       rs577669136       rs577810097       rs745712018       rs745825795       rs746089688       rs746323130       rs746366547       rs746376611       rs746468641       rs746575830       rs746637544       rs746700301       rs746955630       rs747126359       rs747215775       rs747272986       rs747488604       rs747519249       rs747543814       rs747807293       rs747830080       rs747948440       rs748131287       rs748330323       rs748372305       rs748841276       rs748952205       rs748971103       rs749101924       rs749260078       rs749692770       rs749719594       rs749762484       rs749969874       rs750409615       rs750690606       rs751006341       rs751006399       rs751236282       rs751431913       rs751836565       rs752311404       rs752363008       rs752369664       rs752840127       rs752888565       rs753112995       rs753266567       rs753343637       rs753468336       rs753747328       rs753752402       rs754079438       rs754096991       rs754114703       rs754403045       rs754480311       rs754482333       rs754568653       rs754832232       rs755054646       rs755200555       rs755371414       rs755663587       rs755892560       rs756172316       rs756258147       rs756538551       rs757039754       rs757102478       rs757538227       rs757658895       rs757673491       rs757892971       rs757900168       rs758265085       rs758440007       rs758837809       rs759246444       rs759406925       rs759424161       rs759839365       rs760045225       rs760317005       rs760553685       rs760557862       rs760612945       rs760631397       rs760943141       rs761467344       rs761509481       rs761566773       rs761617273       rs761742541       rs761885223       rs761949909       rs762005484       rs762144715       rs762388843       rs762759423       rs763038389       rs763082397       rs763453138       rs763800470       rs763863444       rs764085250       rs764169884       rs764339006       rs764347691       rs764544798       rs765065019       rs765086046       rs765201376       rs765439697       rs765557801       rs765613696       rs765638221       rs765835344       rs765888817       rs766045339       rs766100228       rs766355529       rs766764304       rs766938280       rs767028222       rs767122150       rs767181464       rs767533408       rs767548425       rs767949359       rs768004321       rs768004395       rs768241118       rs768251819       rs768305008       rs768694488       rs768767576       rs768796191       rs768859496       rs768929209       rs769410051       rs769461525       rs769553378       rs769564982       rs769641664       rs769662388       rs769936180       rs770110284       rs770163255       rs770165338       rs770192882       rs770325317       rs770355543       rs770552438       rs770681729       rs770742676       rs771103079       rs771259116       rs771487056       rs771492320       rs771524268       rs771555732       rs772171586       rs772253684       rs772487305       rs772567775       rs772729966       rs772801965       rs772997758       rs773109981       rs773683906       rs773709050       rs773738739       rs773862346       rs774364445       rs774454112       rs774705715       rs774745103       rs774758731       rs775068459       rs775205463       rs775433091       rs775436808       rs775634104       rs775770534       rs775860856       rs775898432       rs776223971       rs776417886       rs776455859       rs776509275       rs776769438       rs776908104       rs777087053       rs777156994       rs777524346       rs777575460       rs777609927       rs777947241       rs777967380       rs778049781       rs778398197       rs778473174       rs778487966       rs778813682       rs778987567       rs779038575       rs779044628       rs779098982       rs779393729       rs779512289       rs779630800       rs779679328       rs779767311       rs780005904       rs780133133       rs780198861       rs780640405       rs780881509       rs780918174       rs781046850       rs781282473       rs781391904       rs781774201       rs781776700      

基因表达

基因表达

ATF4基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TCAGTCCCTCCAACAACAG
59
GTCGAACTCCTTCAAATCCA
58
TCAGTCCCTCCAACAACAG
59
TTTCTCCAACATCCAATCTGTC
59
TCAGTCCCTCCAACAACAG
59
TTTCTCCAACATCCAATCTGTC
59
CAAGGAGGATGCCTTCTCC
59
GTCGAACTCCTTCAAATCCA
58
TCAGTCCCTCCAACAACAG
59
GTCGAACTCCTTCAAATCCA
58
TCAGTCCCTCCAACAACAG
59
TTCTCCAACATCCAATCTGTC
58
TCAGTCCCTCCAACAACAG
59
GTCGAACTCCTTCAAATCCA
58
TCAGTCCCTCCAACAACAG
59
TTCTCCAACATCCAATCTGTC
58
CAAGGAGGATGCCTTCTCC
59
AGTCGAACTCCTTCAAATCCA
59
TCAGTCCCTCCAACAACAG
59
TTTCTCCAACATCCAATCTGTC
59

转录因子

转录因子

转录因子
影响类型
PubMed链接
APOE
Activation
22028770
ASNS
Activation
11960987     16164412     17276738    
ASNS
Unknown
15385533     23403946    
ATF3
Activation
16246168     21801305    
ATF3
Unknown
22819556
ATG5
Activation
20038797
BGLAP
Unknown
21866569
CA9
Unknown
19564335
CCL2
Unknown
16931790
CEBPB
Activation
16026328

基因本体信息

ATF4基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

ATF4基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000977
P18848(UniProtKB)
IBA
GO:0000978
P18848(UniProtKB)
IEA
GO:0000981
P18848(UniProtKB)
IDA
GO:0000981
P18848(UniProtKB)
IDA
GO:0000981
P18848(UniProtKB)
IC
GO:0001046
P18848(UniProtKB)
ISS
GO:0001076
P18848(UniProtKB)
IC
GO:0001077
P18848(UniProtKB)
IEA
GO:0001085
P18848(UniProtKB)
IPI
GO:0003677
P18848(UniProtKB)
ISS
GO:0003677
P18848(UniProtKB)
IDA
GO:0003677
P18848(UniProtKB)
IDA
GO:0003700
P18848(UniProtKB)
ISS
GO:0003700
P18848(UniProtKB)
TAS
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005515
P18848(UniProtKB)
IPI
GO:0005634
P18848(UniProtKB)
ISS
GO:0005634
P18848(UniProtKB)
IDA
GO:0005634
P18848(UniProtKB)
IDA
GO:0005634
P18848(UniProtKB)
IDA
GO:0005654
P18848(UniProtKB)
TAS
GO:0005737
P18848(UniProtKB)
ISS
GO:0005737
P18848(UniProtKB)
IDA
GO:0005815
P18848(UniProtKB)
IEA
GO:0006094
P18848(UniProtKB)
ISS
GO:0006355
P18848(UniProtKB)
ISS
GO:0006366
P18848(UniProtKB)
ISS
GO:0006520
P18848(UniProtKB)
TAS
GO:0007214
P18848(UniProtKB)
IEA
GO:0008022
P18848(UniProtKB)
IEA
GO:0010575
P18848(UniProtKB)
IMP
GO:0010628
P18848(UniProtKB)
IMP
GO:0032057
P18848(UniProtKB)
ISS
GO:0032590
P18848(UniProtKB)
IEA
GO:0032922
P18848(UniProtKB)
ISS
GO:0034198
P18848(UniProtKB)
ISS
GO:0034198
P18848(UniProtKB)
ISS
GO:0034399
P18848(UniProtKB)
IDA
GO:0034644
P18848(UniProtKB)
ISS
GO:0034976
P18848(UniProtKB)
IDA
GO:0034976
P18848(UniProtKB)
IMP
GO:0036003
P18848(UniProtKB)
IC
GO:0036091
P18848(UniProtKB)
IMP
GO:0036091
P18848(UniProtKB)
ISS
GO:0036499
P18848(UniProtKB)
TAS
GO:0036499
P18848(UniProtKB)
TAS
GO:0036499
P18848(UniProtKB)
TAS
GO:0042149
P18848(UniProtKB)
IMP
GO:0042789
P18848(UniProtKB)
ISS
GO:0043005
P18848(UniProtKB)
IDA
GO:0043065
P18848(UniProtKB)
TAS
GO:0043267
P18848(UniProtKB)
IEA
GO:0043522
P18848(UniProtKB)
IDA
GO:0043525
P18848(UniProtKB)
ISS
GO:0043565
P18848(UniProtKB)
IDA
GO:0044212
P18848(UniProtKB)
IDA
GO:0044212
P18848(UniProtKB)
TAS
GO:0045893
P18848(UniProtKB)
ISS
GO:0045893
P18848(UniProtKB)
IMP
GO:0045893
P18848(UniProtKB)
IDA
GO:0045893
P18848(UniProtKB)
IDA
GO:0045893
P18848(UniProtKB)
NAS
GO:0045943
P18848(UniProtKB)
IMP
GO:0045944
P18848(UniProtKB)
ISS
GO:0045944
P18848(UniProtKB)
IDA
GO:0045944
P18848(UniProtKB)
IDA
GO:0045944
P18848(UniProtKB)
IMP
GO:0045944
P18848(UniProtKB)
IDA
GO:0046982
P18848(UniProtKB)
NAS
GO:0061395
P18848(UniProtKB)
TAS
GO:0070059
P18848(UniProtKB)
ISS
GO:1903204
P18848(UniProtKB)
IGI
GO:1990037
P18848(UniProtKB)
IDA
GO:1990440
P18848(UniProtKB)
IDA
GO:1990440
P18848(UniProtKB)
IMP
GO:1990589
P18848(UniProtKB)
IDA
GO:1990590
P18848(UniProtKB)
IDA
GO:1990617
P18848(UniProtKB)
IDA
GO:1990617
P18848(UniProtKB)
NAS
GO:1990617
P18848(UniProtKB)
IPI
GO:1990737
P18848(UniProtKB)
IEA
GO:0044212
P18848(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控ATF4基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Anoxia 0.12 1 0 CTD_human
Necrosis 0.12 1 0 CTD_human
Invasive Ductal Breast Carcinoma 0.12 1 0 CTD_human
Schizophrenia 0.007729856 2 0 BeFree_GAD_LHGDN
Bipolar Disorder 0.005362824 1 0 BeFree_GAD_LHGDN
Alzheimer's Disease 0.003267234 3 0 BeFree_LHGDN
Malignant neoplasm of breast 0.000542884 2 0 BeFree
Chronic Obstructive Airway Disease 0.000542884 2 0 BeFree
Neuroblastoma 0.000542884 2 0 BeFree
Tumor Progression 0.000542884 2 0 BeFree
Memory impairment 0.000542884 2 0 BeFree
Breast Carcinoma 0.000542884 2 0 BeFree
Central neuroblastoma 0.000542884 2 0 BeFree
Liver carcinoma 0.000542884 2 0 BeFree
Acidosis, Lactic 0.000271442 1 0 BeFree
Rheumatoid Arthritis 0.000271442 1 0 BeFree
Mental disorders 0.000271442 1 0 BeFree
Non-Small Cell Lung Carcinoma 0.000271442 1 0 BeFree
Colorectal Carcinoma 0.000271442 1 0 BeFree
Cytomegalovirus Infections 0.000271442 1 0 BeFree
Diabetes 0.000271442 1 0 BeFree
Diabetes Mellitus 0.000271442 1 0 BeFree
Fibrosarcoma 0.000271442 1 0 BeFree
Liver neoplasms 0.000271442 1 0 BeFree
Malignant neoplasm of stomach 0.000271442 1 0 BeFree
Neoplasm Metastasis 0.000271442 1 0 BeFree
Retinal Diseases 0.000271442 1 0 BeFree
Pancreatitis, Chronic 0.000271442 1 0 BeFree
Idiopathic pulmonary hypertension 0.000271442 1 0 BeFree
Adrenoleukodystrophy 0.000271442 1 0 BeFree
Malignant neoplasm of lung 0.000271442 1 0 BeFree
Simple renal cyst 0.000271442 1 0 BeFree
Solid tumour 0.000271442 1 0 BeFree
stage, neuroblastoma 0.000271442 1 0 BeFree
Familial aplasia of the vermis 0.000271442 1 0 BeFree
Carcinogenesis 0.000271442 1 0 BeFree
Carcinoma of lung 0.000271442 1 0 BeFree
Secondary malignant neoplasm of lymph node 0.000271442 1 0 BeFree
Stomach Carcinoma 0.000271442 1 0 BeFree
Inclusion Body Myopathy, Sporadic 0.000271442 1 0 BeFree
Heartburn acidity 0.000271442 1 0 BeFree
Well Differentiated Pancreatic Endocrine Tumor 0.000271442 1 0 BeFree
Colorectal Cancer 0.000271442 1 0 BeFree
Idiopathic Pulmonary Fibrosis 0.000271442 1 0 BeFree
Childhood Ataxia with Central Nervous System Hypomyelinization 0.000271442 1 0 BeFree
Pulmonary arterial hypertension 0.000271442 1 0 BeFree
Triple Negative Breast Neoplasms 0.000271442 1 0 BeFree
Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia 0.000271442 1 0 BeFree

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