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This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]
[中文简述(自动翻译):]  该基因编码哺乳动物活化转录因子/ cAMP反应元件结合(CREB)的蛋白家族的转录因子的成员。该基因是由多种信号,其中包括许多那些癌细胞遇到的诱导,并参与细胞应激反应的复杂过程。已发现该基因编码不同亚型的多个抄本变形。这可能是该基因的选择性剪接可以是靶基因的调控生理重要。 [由RefSeq的,2011年4月提供]
ATF3基因(以及对应的蛋白质)的细胞分布位置:
ATF3基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Hypospadias | 0.129087065 | 6 | 0 | BeFree_CTD_human_GAD_LHGDN |
Prostatic Neoplasms | 0.122995792 | 3 | 0 | BeFree_CTD_human_LHGDN |
Diabetes Mellitus, Non-Insulin-Dependent | 0.120542884 | 3 | 0 | BeFree_CTD_human |
Non-Small Cell Lung Carcinoma | 0.12 | 1 | 0 | CTD_human |
Diabetes Mellitus, Experimental | 0.12 | 1 | 0 | CTD_human |
Influenza | 0.12 | 1 | 0 | CTD_human |
Liver neoplasms | 0.12 | 1 | 0 | CTD_human |
nervous system disorder | 0.12 | 2 | 0 | CTD_human |
Peripheral Neuropathy | 0.12 | 1 | 0 | CTD_human |
Infarction, Middle Cerebral Artery | 0.12 | 1 | 0 | CTD_human |
Cardiomyopathies | 0.12 | 1 | 0 | CTD_human |
ovarian neoplasm | 0.12 | 1 | 0 | CTD_human |
Neoplasm Metastasis | 0.006795978 | 15 | 0 | BeFree_LHGDN |
Colorectal Carcinoma | 0.003800186 | 14 | 0 | BeFree |
Colorectal Cancer | 0.003800186 | 14 | 0 | BeFree |
Colorectal Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Reperfusion Injury | 0.00272435 | 1 | 0 | LHGDN |
Hyperhomocysteinemia | 0.00272435 | 1 | 0 | LHGDN |
Cryptorchidism | 0.002367032 | 1 | 0 | GAD |
Malignant tumor of colon | 0.002171535 | 8 | 0 | BeFree |
Colon Carcinoma | 0.002171535 | 8 | 0 | BeFree |
Malignant neoplasm of breast | 0.001900093 | 7 | 0 | BeFree |
Breast Carcinoma | 0.001900093 | 7 | 0 | BeFree |
Penile hypospadias | 0.001628651 | 6 | 0 | BeFree |
Prostate carcinoma | 0.001357209 | 5 | 0 | BeFree |
Obesity | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of prostate | 0.001085767 | 4 | 0 | BeFree |
Carcinogenesis | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of skin | 0.000814326 | 3 | 0 | BeFree |
Ischemia | 0.000814326 | 3 | 0 | BeFree |
Kidney Failure, Acute | 0.000814326 | 3 | 0 | BeFree |
Squamous cell carcinoma | 0.000542884 | 2 | 0 | BeFree |
Malignant tumor of cervix | 0.000542884 | 2 | 0 | BeFree |
Hyperglycemia | 0.000542884 | 2 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of lung | 0.000542884 | 2 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.000542884 | 2 | 0 | BeFree |
Cervix carcinoma | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
Renal ischaemia | 0.000542884 | 2 | 0 | BeFree |
Mammary Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Congenital Abnormality | 0.000271442 | 1 | 0 | BeFree |
Asthma | 0.000271442 | 1 | 0 | BeFree |
Mental disorders | 0.000271442 | 1 | 0 | BeFree |
Bipolar Disorder | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.000271442 | 1 | 0 | BeFree |
Cockayne Syndrome | 0.000271442 | 1 | 0 | BeFree |
Coronary Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
Crohn Disease | 0.000271442 | 1 | 0 | BeFree |
Diabetes | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus, Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Hamartoma Syndrome, Multiple | 0.000271442 | 1 | 0 | BeFree |
Hepatitis, Alcoholic | 0.000271442 | 1 | 0 | BeFree |
Hypercholesterolemia | 0.000271442 | 1 | 0 | BeFree |
Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
Fibroid Tumor | 0.000271442 | 1 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.000271442 | 1 | 0 | BeFree |
Leukemia, T-Cell | 0.000271442 | 1 | 0 | BeFree |
Adult T-Cell Lymphoma/Leukemia | 0.000271442 | 1 | 0 | BeFree |
Chronic Obstructive Airway Disease | 0.000271442 | 1 | 0 | BeFree |
Lung Neoplasms | 0.000271442 | 1 | 0 | BeFree |
melanoma | 0.000271442 | 1 | 0 | BeFree |
Multiple Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Mycoses | 0.000271442 | 1 | 0 | BeFree |
Nephroblastoma | 0.000271442 | 1 | 0 | BeFree |
Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Pneumonia | 0.000271442 | 1 | 0 | BeFree |
Retinoblastoma | 0.000271442 | 1 | 0 | BeFree |
Schizophrenia | 0.000271442 | 1 | 0 | BeFree |
Septicemia | 0.000271442 | 1 | 0 | BeFree |
Uterine Fibroids | 0.000271442 | 1 | 0 | BeFree |
Varicose Ulcer | 0.000271442 | 1 | 0 | BeFree |
Xeroderma Pigmentosum | 0.000271442 | 1 | 0 | BeFree |
Myocardial Ischemia | 0.000271442 | 1 | 0 | BeFree |
Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
Adrenocortical carcinoma | 0.000271442 | 1 | 0 | BeFree |
Uveal melanoma | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Sepsis | 0.000271442 | 1 | 0 | BeFree |
Carcinoma breast stage IV | 0.000271442 | 1 | 0 | BeFree |
Stage IV Bladder Cancer AJCC v6 | 0.000271442 | 1 | 0 | BeFree |
Malignant mesothelioma | 0.000271442 | 1 | 0 | BeFree |
Intestinal Cancer | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
Chronic Kidney Insufficiency | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
Metabolic Syndrome X | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of skin | 0.000271442 | 1 | 0 | BeFree |
Maternal hypertension | 0.000271442 | 1 | 2 | BeFree |
Carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
airway disease | 0.000271442 | 1 | 0 | BeFree |
Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Middle Cerebral Artery Occlusion | 0.000271442 | 1 | 0 | BeFree |
Helicobacter pylori infection | 0.000271442 | 1 | 0 | BeFree |
Stromal Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Classical Hodgkin's Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Conn Syndrome | 0.000271442 | 1 | 0 | BeFree |
Tumor-Associated Vasculature | 0.000271442 | 1 | 0 | BeFree |
Chronic Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma Multiforme | 0.000271442 | 1 | 0 | BeFree |
Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
Prostatic Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
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