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This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011]
[中文简述(自动翻译):]  这个基因代表了细菌基因ARSA的人类同源,编码负责为砷化物阻力砷转运的砷刺激的ATP酶的组成部分。这种蛋白也是参与翻译后输送尾锚(TA)的蛋白质从细胞质至内质网(ER)的跨膜结构域(TMD)识别复合物(TRC)的一个重要组成部分。它识别并选择性地在细胞溶质结合的TA的TMD的蛋白质,并将它们传送到ER用于插入。 [由RefSeq的,2011年10月提供]
ASNA1基因(以及对应的蛋白质)的细胞分布位置:
ASNA1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Leukodystrophy, Metachromatic | 0.003257302 | 12 | 0 | BeFree |
Mental disorders | 0.000271442 | 1 | 0 | BeFree |
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