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This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011]
[中文简述(自动翻译):]  该基因编码的7个亚基的人类的Arp2 / 3蛋白质复合物中的一个。这亚基是SOP2蛋白质家族的成员,并且是最相似的由基因ARPC1A编码的蛋白质。这两种蛋白质之间的相似性表明,它们都可以如已在细胞中的肌动蛋白聚合的控制牵连人类Arp2 / 3复合的P41亚基起作用。这可能是在P41亚基是涉及在组装和维护Arp2 / 3复合的结构。的P41亚基的多个版本可以适应复杂的功能,以不同的细胞类型或发育阶段。这种蛋白质也有中心体动态平衡由是极光激酶的活化剂和底物的作用。 [由RefSeq的,2011年3月提供]
ARPC1B基因(以及对应的蛋白质)的细胞分布位置:
ARPC1B基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
melanoma | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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