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This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
[中文简述(自动翻译):]  该基因编码属于PAS(PER,ARNT,SIM卡)超家族一个基本的螺旋 - 环 - 螺旋转录因子。该PAS蛋白在适应中发挥重要作用,以较低的大气和细胞氧含量,暴露于某些环境污染物,并在光照和温度昼夜振荡。此蛋白与生物钟蛋白,所述结构相关MOP4和缺氧诱导因子,如HIF1alpha转录活性异二聚体。以其作为昼夜和缺氧因素生物相关的伙伴角色一致,这种蛋白是在脑的区域如丘脑,下丘脑,和杏仁核共表达。编码不同同种型的可变剪接转录物变体已被用于这个基因说明。 [由RefSeq的,2011年10月提供]
ARNTL2基因(以及对应的蛋白质)的细胞分布位置:
ARNTL2基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| IGA Glomerulonephritis | 0.12 | 1 | 0 | CTD_human |
| Bipolar Disorder | 0.007101096 | 3 | 0 | GAD |
| Mental Depression | 0.002367032 | 1 | 0 | GAD |
| Schizophrenia | 0.002367032 | 1 | 0 | GAD |
| Metabolic Syndrome X | 0.002367032 | 1 | 0 | GAD |
| Sleep Disorders | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of breast | 0.000542884 | 2 | 9 | BeFree |
| Phobia, Social | 0.000542884 | 2 | 4 | BeFree |
| Alcohol abuse | 0.000542884 | 2 | 3 | BeFree |
| Breast Carcinoma | 0.000542884 | 2 | 9 | BeFree |
| alcohol use disorder | 0.000271442 | 1 | 3 | BeFree |
| Alzheimer's Disease | 0.000271442 | 1 | 1 | BeFree |
| Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Mucopolysaccharidosis II | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
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