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Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  精氨酸酶催化精氨酸至鸟氨酸和尿素的水解。哺乳动物精氨酸酶的至少两个同种型存在其中在其组织分布不同(类型I和II),亚细胞定位,免疫交叉反应性和生理功能。由该基因编码的II型同种型,位于线粒体和肝外组织中,特别是肾脏中表达。该亚型的生理作用是知之甚少;它被认为在一氧化氮和多胺代谢的作用。从使用替代聚腺苷酸化位点而产生的II型基因的转录物变体已有描述。 [由RefSeq的,2008年7月提供]
ARG2基因(以及对应的蛋白质)的细胞分布位置:
ARG2基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Asthma | 0.126634157 | 7 | 1 | BeFree_CTD_human_GAD |
Prostatic Neoplasms | 0.12272435 | 2 | 0 | CTD_human_LHGDN |
Carcinoma, Pancreatic Ductal | 0.120271442 | 1 | 0 | BeFree_CTD_human |
Pulmonary Hypertension | 0.12 | 1 | 0 | CTD_human |
Necrosis | 0.12 | 1 | 0 | CTD_human |
Disease Progression | 0.12 | 1 | 0 | CTD_human |
Hypertensive disease | 0.08272435 | 4 | 0 | LHGDN_RGD |
Diabetes Mellitus, Experimental | 0.08 | 1 | 0 | RGD |
Kidney Failure, Chronic | 0.08 | 1 | 0 | RGD |
Liver Cirrhosis, Experimental | 0.08 | 1 | 0 | RGD |
Shock, Hemorrhagic | 0.08 | 1 | 0 | RGD |
Ureteral obstruction | 0.08 | 1 | 0 | RGD |
Hyperoxia | 0.08 | 1 | 0 | RGD |
Sepsis | 0.08 | 1 | 0 | RGD |
Acute kidney injury | 0.08 | 1 | 0 | RGD |
Lung Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Atopy | 0.002367032 | 1 | 0 | GAD |
Childhood asthma | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000814326 | 3 | 0 | BeFree |
Prostate carcinoma | 0.000814326 | 3 | 0 | BeFree |
Erectile dysfunction | 0.000542884 | 2 | 0 | BeFree |
Airway Obstruction | 0.000271442 | 1 | 2 | BeFree |
Arthritis | 0.000271442 | 1 | 0 | BeFree |
Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
Gyrate Atrophy | 0.000271442 | 1 | 0 | BeFree |
Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Polycythemia Vera | 0.000271442 | 1 | 0 | BeFree |
Sexual Arousal Disorder | 0.000271442 | 1 | 0 | BeFree |
Thrombocythemia, Essential | 0.000271442 | 1 | 0 | BeFree |
Thyroid Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Obstructive nephropathy | 0.000271442 | 1 | 0 | BeFree |
Allergic asthma | 0.000271442 | 1 | 0 | BeFree |
Liver Failure, Acute | 0.000271442 | 1 | 0 | BeFree |
Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Impaired glucose tolerance | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
Follicular neoplasm | 0.000271442 | 1 | 0 | BeFree |
Thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Vascular degeneration | 0.000271442 | 1 | 0 | BeFree |
Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
IMMUNE SUPPRESSION | 0.000271442 | 1 | 0 | BeFree |
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