ARG1(arginase 1)

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

6q23
基因染色体位置图

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

[中文简述(自动翻译):]  精氨酸酶催化精氨酸鸟氨酸和尿素的水解。哺乳动物精氨酸酶的至少两个同种型存在其中在其组织分布不同(类型I和II),亚细胞定位,免疫交叉反应性和生理功能。我同种型由该基因编码的类型,是一种胞质酶和在肝脏中作为尿素循环的成分主要表达。这种酶的先天性缺乏导致argininemia,常染色体隐性遗传疾病的特点是高血氨症。已发现该基因编码不同亚型的两个转录变异体。 [由RefSeq的,2011年9月提供]

ARG1基因的碱基序列:[NCBI]
ARG1基因的碱基突变:           显示全部snp
rs2246012       rs2297637       rs2608897       rs2608898       rs2781663       rs2781664       rs2781665       rs2781666       rs2781667       rs2781668       rs3756780       rs3850245       rs9483309       rs9493029       rs10484766       rs12111151       rs12193902       rs12205666       rs17184300       rs17599586       rs17657775       rs17657817       rs17657829       rs17788484       rs28941474       rs34484161       rs34504481       rs34724840       rs41285336       rs41285338       rs55706510       rs56325116       rs59196638       rs60389358       rs60712846       rs62423373       rs66799332      
rs72999266       rs73544620       rs73544627       rs73544630       rs73778020       rs73778022       rs74451798       rs74707177       rs74812906       rs74833328       rs75012666       rs75155115       rs75365508       rs75890079       rs76388742       rs76645384       rs76742143       rs76770001       rs76803965       rs77165245       rs77656388       rs78058817       rs78404021       rs78635741       rs79050546       rs80324912       rs104893940       rs104893944       rs104893947       rs111253965       rs111292763       rs111314809       rs111640755       rs111885649       rs111979012       rs112185951       rs112432420       rs112526534       rs113089165       rs113212943       rs113295138       rs113645893       rs113784138       rs113865017       rs113901887       rs114361028       rs115620963       rs115984549       rs116284369       rs116372949       rs117272946       rs138457449       rs138489548       rs138541090       rs138584410       rs138585002       rs138705915       rs139025033       rs139165092       rs140066599       rs140535285       rs140549609       rs140607078       rs140618233       rs140674874       rs141471733       rs141689359       rs141713726       rs142107090       rs142304006       rs142367668       rs142407022       rs142782396       rs142812031       rs144093422       rs144383156       rs144403253       rs144478258       rs144544360       rs144604179       rs144994895       rs145177175       rs145181256       rs145344967       rs145735519       rs145943637       rs146174141       rs146621050       rs146625637       rs147146526       rs147240575       rs147409787       rs147419581       rs147679567       rs148013696       rs148113697       rs148619575       rs148939143       rs148958054       rs149267228       rs149310631       rs149496218       rs149777244       rs149935317       rs150457491       rs150766204       rs151277976       rs180993499       rs181201168       rs181472754       rs181651242       rs182289146       rs182374446       rs182629337       rs182650447       rs183115803       rs183249041       rs183856847       rs183896871       rs184383419       rs184952013       rs185108701       rs185623005       rs185743161       rs186112394       rs186138468       rs187050862       rs187266962       rs187285609       rs187362616       rs187855396       rs188114606       rs188381217       rs188627941       rs188662464       rs188888028       rs189404945       rs189651750       rs190201884       rs190230141       rs190286122       rs190824752       rs190945996       rs191104481       rs191325074       rs191761957       rs191786325       rs191964803       rs192486412       rs192988987       rs193256900       rs200100607       rs200270063       rs200319835       rs200458963       rs200496725       rs201481295       rs201484132       rs201484191       rs201959088       rs202219126       rs367574484       rs367653966       rs367756244       rs368486544       rs368493607       rs368656171       rs369360991       rs369393679       rs370022660       rs370289649       rs370747314       rs371203992       rs371402138       rs371686924       rs371976737       rs371980294       rs372616951       rs373279537       rs373480378       rs373491227       rs373590467       rs373857039       rs374033743       rs374040136       rs374676787       rs374805901       rs374962545       rs375655714       rs376196920       rs377253372       rs377280518       rs377721661       rs397748921       rs397782263       rs527679047       rs527680991       rs528045807       rs528649806       rs529047462       rs529068238       rs529105053       rs529216059       rs530009746       rs530409317       rs530442662       rs531117440       rs531155367       rs531284470       rs531412785       rs531544697       rs531680947       rs532250558       rs532523411       rs532546947       rs532725209       rs532764881       rs532943866       rs533096754       rs533289516       rs533492220       rs533715421       rs533761321       rs534453895       rs534906689       rs534993955       rs535161157       rs535456448       rs535523725       rs535584884       rs535630197       rs535643401       rs536255401       rs536616233       rs537503803       rs537670623       rs538034569       rs538115055       rs538893176       rs539017021       rs539184825       rs539485326       rs539633320       rs540283386       rs540828658       rs540865287       rs540891806       rs541225241       rs541567952       rs541784328       rs541810173       rs541871489       rs541909945       rs542424700       rs542437920       rs542658585       rs542902378       rs543245025       rs543655127       rs543818754       rs544771476       rs544798219       rs544887927       rs545839721       rs545842084       rs545874005       rs547085340       rs547122192       rs547246779       rs547605356       rs547630843       rs547659026       rs548053997       rs548213127       rs548553326       rs548689000       rs548987949       rs549339306       rs549575950       rs549936624       rs550343822       rs550414963       rs550988574       rs551050123       rs551387878       rs551471357       rs552025085       rs552059873       rs552184214       rs553287848       rs553473475       rs553531190       rs553833088       rs553843535       rs553850577       rs554452065       rs554516926       rs555549087       rs555778082       rs555926925       rs556545273       rs556580014       rs556756212       rs556817812       rs557255252       rs557422237       rs557816264       rs557960412       rs558197443       rs558377642       rs558561636       rs558953418       rs559209264       rs559470967       rs559600456       rs559627879       rs560657387       rs560843759       rs561587996       rs561821926       rs561880971       rs561984620       rs562828400       rs562985287       rs563536870       rs564014633       rs564178278       rs564201797       rs564210770       rs564604321       rs564643108       rs565522175       rs565522210       rs565662481       rs566447332       rs566712237       rs566737861       rs567211156       rs568060844       rs568142827       rs568284407       rs568448573       rs569195083       rs569846000       rs569992296       rs570050427       rs570263744       rs570427155       rs570506423       rs571159069       rs571322919       rs571619062       rs572026688       rs572074133       rs572234646       rs572633761       rs573069792       rs573475393       rs573609269       rs573845720       rs573949873       rs574175367       rs574320679       rs574480177       rs574637756       rs575110162       rs575485735       rs575610266       rs575979513       rs576331835       rs576404166       rs577341524       rs577989206       rs587776539       rs745500077       rs745580041       rs745624953       rs745714525       rs745787043       rs745838058       rs745875961       rs746107017       rs746381302       rs746467226       rs747268449       rs747275658       rs747313511       rs747543156       rs747579073       rs747646903       rs747875285       rs747883555       rs748252743       rs748414362       rs748654016       rs748708936       rs748734055       rs748744950       rs748924712       rs748979820       rs749043086       rs749225699       rs749521049       rs749556084       rs749799579       rs749859983       rs749865319       rs749966465       rs750083218       rs750244206       rs750244366       rs750397270       rs750758012       rs750937576       rs751084231       rs751231138       rs751272310       rs751362545       rs751567681       rs751647696       rs751924194       rs752122488       rs752210323       rs752395217       rs752788818       rs752966614       rs753111447       rs753260969       rs753347547       rs753829097       rs753875123       rs754000888       rs754205928       rs754259099       rs754655577       rs754896172       rs755359126       rs755511669       rs755779260       rs755973004       rs755975244       rs756080885       rs756314681       rs756330677       rs756616090       rs756783454       rs756819223       rs756825623       rs756915518       rs756944730       rs757133426       rs757187110       rs757327323       rs757439680       rs757468683       rs757518422       rs757762475       rs757852473       rs757959356       rs758094530       rs758330818       rs758338836       rs758420954       rs758675444       rs758905397       rs759048430       rs759282838       rs759540806       rs759832639       rs760015789       rs760069095       rs760319794       rs760349584       rs760628925       rs760873925       rs761148101       rs761201274       rs761361984       rs761516831       rs761712444       rs761773853       rs761882497       rs761914559       rs762145115       rs762210089       rs762306280       rs762486648       rs762590716       rs762633715       rs763070677       rs763249487       rs763301564       rs763302987       rs763312659       rs763625573       rs763780314       rs763868954       rs763958621       rs763960889       rs764066842       rs764273304       rs764610587       rs764770439       rs764788600       rs765495464       rs765556316       rs765617697       rs765859028       rs766077763       rs766240618       rs766662245       rs766705948       rs766715122       rs766853875       rs766868484       rs767211950       rs767219084       rs767301672       rs767964945       rs767964970       rs768028958       rs768201589       rs768303250       rs768343568       rs768686705       rs768972828       rs769045782       rs769118957       rs769207030       rs769346375       rs769396581       rs769413406       rs769778089       rs770050608       rs770387974       rs770529240       rs770776974       rs771010341       rs771190594       rs771334658       rs771753283       rs772208283       rs772473981       rs772474140       rs772521719       rs772855821       rs773038629       rs773398169       rs773399859       rs773451145       rs773465984       rs773629257       rs773968554       rs774010625       rs774211424       rs774273532       rs774347014       rs774505525       rs774603245       rs774722903       rs775104877       rs775225648       rs775340210       rs775435820       rs775638241       rs775687110       rs775853882       rs776119677       rs776185609       rs776217305       rs776376445       rs776413696       rs776530369       rs776782905       rs776939220       rs777029258       rs777241666       rs777462361       rs777467993       rs777553747       rs777817531       rs778359686       rs778360659       rs778376916       rs778602133       rs779017704       rs779060814       rs779072486       rs779135201       rs779192094       rs779219793       rs779949397       rs779978565       rs779986367       rs780037541       rs780157621       rs780484813       rs780487191       rs780600712       rs781128236       rs781676090       rs781780752      

ARG1基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CTTTCACACCAGCTACTGG
58
AATCCTGAGAGTAGCCCTG
58
CCACTGACAACCACAAGTG
59
GCACATCGGGAATCTTTCC
59
CTTTCACACCAGCTACTGG
58
AATCCTGAGAGTAGCCCTG
58
TTTCTCAAAGGGACAGAGTG
58
TTGAAAGGGACTGTCATTAGG
58
TTTCTCAAAGGGACAGAGTG
58
TTGAAAGGGACTGTCATTAGG
58
CTCCTTTCTCAAAGGGACAG
58
TTTCTCAATACTGTAGGGCC
57
CACTGACAACCACAAGTGG
59
GCACATCGGGAATCTTTCC
59
CCTTTCTCAAAGGGACAGC
59
CCTTTCTCAATACTGTAGGGC
58
ATCTTTCACACCAGCTACTG
58
AATCCTGAGAGTAGCCCTG
58
CTTTCACACCAGCTACTGG
58
TAATCCTGAGAGTAGCCCTG
58
      尚未收录相关数据

ARG1基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

ARG1基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0000050
P05089(UniProtKB)
IEA
GO:0000050
P05089(UniProtKB)
TAS
GO:0001889
P05089(UniProtKB)
IEA
GO:0001938
P05089(UniProtKB)
IEA
GO:0004053
P05089(UniProtKB)
EXP
GO:0005615
P05089(UniProtKB)
IEA
GO:0005634
P05089(UniProtKB)
IDA
GO:0005737
P05089(UniProtKB)
TAS
GO:0005741
P05089(UniProtKB)
IEA
GO:0005829
P05089(UniProtKB)
TAS
GO:0006527
P05089(UniProtKB)
TAS
GO:0007568
P05089(UniProtKB)
IEA
GO:0009635
P05089(UniProtKB)
IEA
GO:0010042
P05089(UniProtKB)
IEA
GO:0010043
P05089(UniProtKB)
IEA
GO:0010269
P05089(UniProtKB)
IEA
GO:0010963
P05089(UniProtKB)
IEA
GO:0014075
P05089(UniProtKB)
IEA
GO:0019547
P05089(UniProtKB)
IEA
GO:0030145
P05089(UniProtKB)
IEA
GO:0030324
P05089(UniProtKB)
IEA
GO:0032964
P05089(UniProtKB)
IEA
GO:0033189
P05089(UniProtKB)
IEA
GO:0033197
P05089(UniProtKB)
IEA
GO:0042493
P05089(UniProtKB)
IEA
GO:0043005
P05089(UniProtKB)
IEA
GO:0043025
P05089(UniProtKB)
IEA
GO:0043200
P05089(UniProtKB)
IEA
GO:0046686
P05089(UniProtKB)
IEA
GO:0048678
P05089(UniProtKB)
IEA
GO:0051597
P05089(UniProtKB)
IEA
GO:0060056
P05089(UniProtKB)
IEA
GO:0060135
P05089(UniProtKB)
IEA
GO:0070062
P05089(UniProtKB)
IDA
GO:0070207
P05089(UniProtKB)
IEA
GO:0070301
P05089(UniProtKB)
IEA
GO:0071222
P05089(UniProtKB)
IEA
GO:0071353
P05089(UniProtKB)
IEA
GO:0071377
P05089(UniProtKB)
IEA
GO:0071549
P05089(UniProtKB)
IEA
GO:0071560
P05089(UniProtKB)
IEA
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控ARG1基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Hyperargininemia 0.563257302 12 3 BeFree_CLINVAR_CTD_human_MGD_ORPHANET_UNIPROT
Silicosis 0.2 2 0 CTD_human_RGD
Asthma 0.129901391 11 0 BeFree_CTD_human_GAD_LHGDN
Precancerous Conditions 0.122367032 2 0 CTD_human_GAD
Amino Acid Metabolism, Inborn Errors 0.12 1 0 CTD_human
Hair Diseases 0.12 1 0 CTD_human
Immune System Diseases 0.12 1 0 CTD_human
Leishmaniasis 0.12 1 0 CTD_human
Myopathy 0.12 1 0 CTD_human
Drug-Induced Liver Injury 0.12 1 0 CTD_human
Hypertensive disease 0.08272435 3 0 LHGDN_RGD
Cholestasis 0.08 1 0 RGD
Diabetes Mellitus, Experimental 0.08 1 0 RGD
Hypercapnia 0.08 1 0 RGD
Insulin Resistance 0.08 1 0 RGD
Intestinal Fistula 0.08 1 0 RGD
Liver Cirrhosis, Experimental 0.08 1 0 RGD
Liver diseases 0.08 1 0 RGD
Reperfusion Injury 0.08 1 0 RGD
Ureteral obstruction 0.08 1 0 RGD
Uveitis 0.08 1 0 RGD
Liver Failure 0.08 1 0 RGD
Hyperoxia 0.08 1 0 RGD
Pancreatitis, Acute Necrotizing 0.08 1 0 RGD
Acute kidney injury 0.08 1 0 RGD
Myocardial Infarction 0.005905708 3 1 BeFree_GAD_LHGDN
Pulmonary Hypertension 0.002995792 2 0 BeFree_LHGDN
Neoplasm Metastasis 0.002995792 2 0 BeFree_LHGDN
Colorectal Neoplasms 0.00272435 1 0 LHGDN
Hepatitis, Autoimmune 0.00272435 1 0 LHGDN
Coronary heart disease 0.002638474 1 0 BeFree_GAD
Bronchiolitis, Viral 0.002367032 1 0 GAD
Inflammation 0.002367032 1 0 GAD
Respiratory Syncytial Virus Infections 0.002367032 1 0 GAD
Stomach Neoplasms 0.002367032 1 0 GAD
Helicobacter Infections 0.002367032 1 0 GAD
Atopy 0.002367032 1 0 GAD
Arteriosclerosis 0.000814326 3 0 BeFree
Atherosclerosis 0.000814326 3 0 BeFree
Ischemia 0.000814326 3 0 BeFree
Childhood asthma 0.000814326 3 0 BeFree
Liver carcinoma 0.000814326 3 0 BeFree
Non-Small Cell Lung Carcinoma 0.000542884 2 0 BeFree
Cardiovascular Diseases 0.000542884 2 0 BeFree
Esophageal Neoplasms 0.000542884 2 0 BeFree
Neuroblastoma 0.000542884 2 0 BeFree
Tuberculosis 0.000542884 2 0 BeFree
Esophageal carcinoma 0.000542884 2 0 BeFree
Malignant neoplasm of esophagus 0.000542884 2 0 BeFree
Central neuroblastoma 0.000542884 2 0 BeFree
Anorexia 0.000271442 1 0 BeFree
Rheumatoid Arthritis 0.000271442 1 0 BeFree
Bronchopulmonary Dysplasia 0.000271442 1 0 BeFree
Renal Cell Carcinoma 0.000271442 1 0 BeFree
Hemangiosarcoma 0.000271442 1 0 BeFree
Hepatitis C 0.000271442 1 0 BeFree
Myeloid Leukemia, Chronic 0.000271442 1 0 BeFree
melanoma 0.000271442 1 0 BeFree
Metabolic Diseases 0.000271442 1 0 BeFree
Muscle Spasticity 0.000271442 1 0 BeFree
Obesity 0.000271442 1 0 BeFree
Psoriasis 0.000271442 1 0 BeFree
Pulmonary Fibrosis 0.000271442 1 0 BeFree
B-Cell Lymphomas 0.000271442 1 0 BeFree
Diffuse cutaneous leishmaniasis 0.000271442 1 0 BeFree
Obstructive nephropathy 0.000271442 1 0 BeFree
Allergic asthma 0.000271442 1 0 BeFree
Hepatoblastoma 0.000271442 1 0 BeFree
Cholangiocarcinoma 0.000271442 1 0 BeFree
Pulmonary granuloma 0.000271442 1 0 BeFree
Disseminated neuroblastoma 0.000271442 1 0 BeFree
Stable angina 0.000271442 1 0 BeFree
Malignant neoplasm of prostate 0.000271442 1 0 BeFree
Spastic Quadriplegia 0.000271442 1 0 BeFree
Overweight 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
Mental impairment 0.000271442 1 0 BeFree
Carbamoyl-Phosphate Synthase I Deficiency Disease 0.000271442 1 0 BeFree
Endothelial dysfunction 0.000271442 1 0 BeFree
Post MI 0.000271442 1 0 BeFree
Tauopathies 0.000271442 1 0 BeFree
Stage 4S neuroblastoma 0.000271442 1 0 BeFree
Hepatocarcinogenesis 0.000271442 1 0 BeFree
Idiopathic Pulmonary Fibrosis 0.000271442 1 0 BeFree
RETINOSCHISIS 1, X-LINKED, JUVENILE 0.000271442 1 0 BeFree
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