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This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码的人类ARF基因家族,它是在RAS超家族的部分的构件。 ARF的基因编码刺激霍乱毒素的ADP-核糖基转移酶活性,并在囊泡运输和作为该基因的产物被定位于质膜的磷脂酶D的活化剂发挥作用小鸟嘌呤核苷酸结合蛋白,并调节囊泡运输,重塑膜脂的,和信令,导致肌动蛋白重塑通路。该基因的假基因位于[由RefSeq的,2008年7月提供] 7号染色体
ARF6基因(以及对应的蛋白质)的细胞分布位置:
ARF6基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Mammary Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
Glioma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
melanoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Neoplasm Metastasis | 0.001900093 | 7 | 0 | BeFree |
Malignant neoplasm of breast | 0.001357209 | 5 | 0 | BeFree |
Breast Carcinoma | 0.001357209 | 5 | 0 | BeFree |
HIV Infections | 0.000814326 | 3 | 0 | BeFree |
Invasive breast carcinoma | 0.000814326 | 3 | 0 | BeFree |
Cyst | 0.000271442 | 1 | 0 | BeFree |
Ischemia | 0.000271442 | 1 | 0 | BeFree |
Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
Pregnancy Complications | 0.000271442 | 1 | 0 | BeFree |
Seizures | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Niemann-Pick Disease, Type C | 0.000271442 | 1 | 0 | BeFree |
Vesicular Stomatitis | 0.000271442 | 1 | 0 | BeFree |
Epilepsy, Myoclonic, Infantile | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
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