AREG(amphiregulin) 转至新版数据库
基因简称(symbol)
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
omim代码
entrez码
vega基因码
ensembl基因码
基因家族(gene family)
refseq数据库代号
更多...
基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库
收起
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014]
[中文简述(自动翻译):] 由该基因编码的蛋白是表皮生长因子家族的一个成员。它是一种自分泌生长因子，以及为星形胶质细胞，施万细胞和成纤维细胞有丝分裂原。它是涉及表皮生长因子（EGF）和转化生长因子α（TGF-α）。该蛋白质与EGF / TG??F-α受体促进正常上皮细胞的生长交互，它抑制某些侵袭性癌细胞系的生长。它还可以在乳腺，卵母细胞和骨组织的发展。该基因与银屑病样皮肤的表型相关联，并且还与其他的病理病症，包括各种癌症和炎性病症的关联。 [由RefSeq的，2014年4月提供]
AREG基因的碱基突变：
显示全部snp
rs1246408
rs1246409
rs1246410
rs1691264
rs1797580
rs2007969
rs2291717
rs2643003
rs2643004
rs2643005
rs3775492
rs3775493
rs3775494
rs7656521
rs7665012
rs7666350
rs12646776
rs28364976
rs28364977
rs28364979
rs28364983
rs28743769
rs62314511
rs184582892
rs199817488
rs200075268
rs201209086
rs202131515
rs202153998
rs368333574
rs368667736
rs369221374
rs370296348
rs371101891
rs373527160
rs373742906
rs376363217
rs376784024
rs528096448
rs528168540
rs529924861
rs530012865
rs530764462
rs530974349
rs532016559
rs534791755
rs535058571
rs536424922
rs537529929
rs538538186
rs538599725
rs539970747
rs542858058
rs544188364
rs545393587
rs545611903
rs546052089
rs546266616
rs548395575
rs548434036
rs548689658
rs550831354
rs553398398
rs554719354
rs556871843
rs557238532
rs558402744
rs560005275
rs560601467
rs562813220
rs563611240
rs564714221
rs564967078
rs566564409
rs567793773
rs569090489
rs571255372
rs571561524
rs571573179
rs574105996
rs575435028
rs575520952
rs576641840
rs578222639
rs745375419
rs745461699
rs746588951
rs746773348
rs746826689
rs747434597
rs748061867
rs748714861
rs748723511
rs748850635
rs749414466
rs749457322
rs749700682
rs750666473
rs750711917
rs750763869
rs750816758
rs751373903
rs751836749
rs752162713
rs752777371
rs753584758
rs753945960
rs754181546
rs754602025
rs754621186
rs755151100
rs755492573
rs755711979
rs756247595
rs756509675
rs757715918
rs757742243
rs758026110
rs758227735
rs758365280
rs758793293
rs758961810
rs759092294
rs759404710
rs759675329
rs759769941
rs761715191
rs761927337
rs762292477
rs762340079
rs762809598
rs762925407
rs763145339
rs764174822
rs765125607
rs765353878
rs765591544
rs765602741
rs766017419
rs766481063
rs766645054
rs766672754
rs767771376
rs767981241
rs768032557
rs768669393
rs768788345
rs769289496
rs769347474
rs769439500
rs770444196
rs770624247
rs770904635
rs771830685
rs771960969
rs772141508
rs772781019
rs772908595
rs773105071
rs773773793
rs774296008
rs774388692
rs774814698
rs774990847
rs775469455
rs775967339
rs777911063
rs778369524
rs778420891
rs779498928
rs779558651
rs779730353
rs779930404
rs781465767
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GTAACATGCAAATGTCAGCA
57
TACTGTCAATCATGCTGTGAG
58
AATTGCATTAGCAGCCATAGC
60
CTTCTAAGCTGGACTGTAATAACAG
59
GTAACATGCAAATGTCAGCA
57
TACTGTCAATCATGCTGTGAG
58
ACAGTCCAGATATCACATTGG
58
CTTATGATCCACTGGAAAGAGG
58
GTTATTACAGTCCAGCTTAGAAGAC
59
TCTCTTGTCGAAGTTTCTTTCG
59
ACAGTCCAGATATCACATTGGA
59
CTTATGATCCACTGGAAAGAGG
58
GTAACATGCAAATGTCAGCA
57
ACTGTCAATCATGCTGTGAG
58
CAGTAACATGCAAATGTCAGC
59
ACTGTCAATCATGCTGTGAG
58
TACAGTCCAGATATCACATTGG
58
TTATGATCCACTGGAAAGAGG
57
CAGTAACATGCAAATGTCAGC
59
ACTGTCAATCATGCTGTGAG
58
基因本体信息
AREG基因（以及对应的蛋白质）的细胞分布位置：
- 溶酶体
- 内涵体
- 细胞核
- 细胞质
- 液泡
- 细胞膜
- 细胞外基质
- 内质网
- 线粒体
- 高尔基体
- 细胞骨架
AREG基因的本体（GO）信息：
GO库代码
对应的蛋白质
来源代码
GO:0016021
D6RFX5(UniProtKB)
IEA
GO:0000139
P15514(UniProtKB)
IEA
GO:0005125
P15514(UniProtKB)
IEA
GO:0005154
P15514(UniProtKB)
IBA
GO:0005515
P15514(UniProtKB)
IPI
GO:0005615
P15514(UniProtKB)
IBA
GO:0005615
P15514(UniProtKB)
IDA
GO:0005615
P15514(UniProtKB)
IDA
GO:0005634
P15514(UniProtKB)
IEA
GO:0005789
P15514(UniProtKB)
TAS
GO:0005789
P15514(UniProtKB)
TAS
GO:0005789
P15514(UniProtKB)
TAS
GO:0005789
P15514(UniProtKB)
TAS
GO:0005789
P15514(UniProtKB)
TAS
GO:0005789
P15514(UniProtKB)
TAS
GO:0006888
P15514(UniProtKB)
TAS
GO:0007173
P15514(UniProtKB)
IBA
GO:0007173
P15514(UniProtKB)
IDA
GO:0007186
P15514(UniProtKB)
IDA
GO:0007267
P15514(UniProtKB)
TAS
GO:0008083
P15514(UniProtKB)
IBA
GO:0008283
P15514(UniProtKB)
TAS
GO:0008284
P15514(UniProtKB)
IBA
GO:0009986
P15514(UniProtKB)
IDA
GO:0012507
P15514(UniProtKB)
TAS
GO:0012507
P15514(UniProtKB)
TAS
GO:0012507
P15514(UniProtKB)
TAS
GO:0012507
P15514(UniProtKB)
TAS
GO:0012507
P15514(UniProtKB)
TAS
GO:0012507
P15514(UniProtKB)
TAS
GO:0014009
P15514(UniProtKB)
IEA
GO:0016021
P15514(UniProtKB)
IEA
GO:0031175
P15514(UniProtKB)
IEA
GO:0032355
P15514(UniProtKB)
IEA
GO:0033116
P15514(UniProtKB)
TAS
GO:0042327
P15514(UniProtKB)
IEA
GO:0042542
P15514(UniProtKB)
IEA
GO:0043434
P15514(UniProtKB)
IEA
GO:0045668
P15514(UniProtKB)
IEA
GO:0045740
P15514(UniProtKB)
IMP
GO:0048208
P15514(UniProtKB)
TAS
GO:0051384
P15514(UniProtKB)
IEA
GO:0051591
P15514(UniProtKB)
IEA
GO:0060598
P15514(UniProtKB)
IEA
GO:0060744
P15514(UniProtKB)
IEA
GO:0060749
P15514(UniProtKB)
IEA
GO:0060750
P15514(UniProtKB)
IEA
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Mammary Neoplasms | 0.128715934 | 6 | 0 | BeFree_CTD_human_LHGDN |
| Asthma | 0.124624443 | 7 | 0 | BeFree_CTD_human_LHGDN |
| Squamous cell carcinoma | 0.123538676 | 4 | 0 | BeFree_CTD_human_LHGDN |
| Non-Small Cell Lung Carcinoma | 0.121357209 | 6 | 0 | BeFree_CTD_human |
| ovarian neoplasm | 0.120271442 | 2 | 0 | BeFree_CTD_human |
| Endometriosis | 0.12 | 1 | 0 | CTD_human |
| Head and Neck Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Stomach Neoplasms | 0.12 | 3 | 0 | CTD_human |
| Myocardial Ischemia | 0.12 | 1 | 0 | CTD_human |
| Erythropoietic Protoporphyria | 0.12 | 1 | 0 | CTD_human |
| Juvenile arthritis | 0.12 | 1 | 0 | CTD_human |
| Glioma | 0.080271442 | 2 | 0 | BeFree_RGD |
| Animal Mammary Neoplasms | 0.08 | 1 | 0 | RGD |
| Mammary Neoplasms, Experimental | 0.08 | 1 | 0 | RGD |
| Breast Carcinoma | 0.005700279 | 21 | 0 | BeFree |
| Malignant neoplasm of breast | 0.005428837 | 20 | 0 | BeFree |
| Psoriasis | 0.00408156 | 6 | 0 | BeFree_LHGDN |
| Multiple Myeloma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Arthritis, Psoriatic | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Fibrosis | 0.00272435 | 1 | 0 | LHGDN |
| Gastritis, Atrophic | 0.00272435 | 1 | 0 | LHGDN |
| Hyperplasia | 0.00272435 | 1 | 0 | LHGDN |
| keratoacanthoma | 0.00272435 | 1 | 0 | LHGDN |
| Lung Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Prostatic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Malignant neoplasm of ovary | 0.002638474 | 2 | 0 | BeFree_GAD |
| Colorectal Carcinoma | 0.002171535 | 8 | 0 | BeFree |
| Colorectal Cancer | 0.002171535 | 8 | 0 | BeFree |
| Liver carcinoma | 0.002171535 | 8 | 0 | BeFree |
| Colon Carcinoma | 0.001900093 | 7 | 0 | BeFree |
| Carcinogenesis | 0.001628651 | 6 | 0 | BeFree |
| Stomach Carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Malignant tumor of colon | 0.001085767 | 4 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.001085767 | 4 | 0 | BeFree |
| Ovarian Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Squamous cell carcinoma of the head and neck | 0.001085767 | 4 | 0 | BeFree |
| Adenocarcinoma | 0.000814326 | 3 | 0 | BeFree |
| Pulmonary Fibrosis | 0.000814326 | 3 | 0 | BeFree |
| Pancreatic carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000814326 | 3 | 0 | BeFree |
| Prostate carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Colorectal cancer metastatic | 0.000814326 | 3 | 0 | BeFree |
| Mammary Tumorigenesis | 0.000814326 | 3 | 0 | BeFree |
| Colitis | 0.000542884 | 2 | 0 | BeFree |
| Colorectal Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Glioblastoma | 0.000542884 | 2 | 0 | BeFree |
| Liver neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
| Dermatologic disorders | 0.000542884 | 2 | 0 | BeFree |
| Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
| Mucoepidermoid Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Epithelial ovarian cancer | 0.000542884 | 2 | 0 | BeFree |
| Helicobacter pylori infection | 0.000542884 | 2 | 0 | BeFree |
| Liver regeneration disorder | 0.000542884 | 2 | 0 | BeFree |
| Hepatocarcinogenesis | 0.000542884 | 2 | 0 | BeFree |
| Adenoma | 0.000271442 | 1 | 0 | BeFree |
| Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
| Bronchitis | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of prostate | 0.000271442 | 1 | 0 | BeFree |
| Rectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of skin | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma, Papillary | 0.000271442 | 1 | 0 | BeFree |
| Exanthema | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis, Chronic | 0.000271442 | 1 | 0 | BeFree |
| HIV Infections | 0.000271442 | 1 | 0 | BeFree |
| Immunologic Deficiency Syndromes | 0.000271442 | 1 | 0 | BeFree |
| Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
| Influenza | 0.000271442 | 1 | 0 | BeFree |
| Liver Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
| Lung diseases | 0.000271442 | 1 | 0 | BeFree |
| Nephroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Diseases | 0.000271442 | 1 | 0 | BeFree |
| Synovitis | 0.000271442 | 1 | 0 | BeFree |
| Virus Diseases | 0.000271442 | 1 | 0 | BeFree |
| Pleural Effusion, Malignant | 0.000271442 | 1 | 0 | BeFree |
| Bronchial Hyperreactivity | 0.000271442 | 1 | 0 | BeFree |
| Polycystic Kidney, Autosomal Dominant | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Metastatic malignant neoplasm to brain | 0.000271442 | 1 | 0 | BeFree |
| Gastrointestinal Stromal Tumors | 0.000271442 | 1 | 0 | BeFree |
| Fibrosis, Liver | 0.000271442 | 1 | 0 | BeFree |
| Epithelial hyperplasia of skin | 0.000271442 | 1 | 0 | BeFree |
| Childhood asthma | 0.000271442 | 1 | 0 | BeFree |
| Liver and Intrahepatic Biliary Tract Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Prostatic Intraepithelial Neoplasias | 0.000271442 | 1 | 0 | BeFree |
| Helicobacter-associated gastritis | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
| Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
| Non-alcoholic Fatty Liver Disease | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
| Progressive Neoplastic Disease | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of gastrointestinal tract | 0.000271442 | 1 | 0 | BeFree |
| Skin toxicity | 0.000271442 | 1 | 0 | BeFree |
| Ductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Tumor Angiogenesis | 0.000271442 | 1 | 0 | BeFree |
| Tumor Promotion | 0.000271442 | 1 | 0 | BeFree |
| Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
| Alcoholic Steatohepatitis | 0.000271442 | 1 | 0 | BeFree |
| Progressive cGVHD | 0.000271442 | 1 | 0 | BeFree |
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