APOC2(apolipoprotein C-II) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

19q13.2
基因染色体位置图

基因简述

基因简述

This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]

[中文简述(自动翻译):]  该基因编码属于载脂蛋白基因家族的脂质结合蛋白。该蛋白在血浆中，其中它是极低密度脂蛋白的组分分泌。这种蛋白激活酶脂蛋白脂肪酶，它水解甘油三酯和因此提供游离脂肪酸的细胞。突变该基因引起血症IB型，其特点是高甘油三酯血症，黄瘤和胰腺炎和早期动脉粥样硬化的危险性增加。这种基因存在于与染色体19上的其他相关的载脂蛋白基因簇的天然存在的这种基因与相邻上游载脂蛋白C-IV（APOC4）基因之间存在通读转录。 [由RefSeq的，2011年3月提供]

OMIM数据库中对APOC2基因的介绍     Wikipedia数据库中对APOC2基因的介绍

基因序列

基因序列

APOC2基因的碱基序列：[NCBI]

基因突变

基因突变

APOC2基因的碱基突变：           显示全部snp
rs5120       rs5121       rs5122       rs5123       rs5125       rs5126       rs5127       rs5159       rs5160       rs5161       rs5162       rs5163       rs5164       rs5165       rs5166       rs5167       rs5168       rs1130742       rs1132899       rs2288911       rs2288912       rs3745152       rs4803774       rs4803775       rs4803776       rs7249138       rs7253690       rs7256684       rs7257095       rs7257468       rs7257476       rs7258345       rs9304644       rs9304645       rs9304646       rs10419086       rs10420434      
rs10422603       rs10423683       rs10425530       rs10622462       rs11879392       rs12691089       rs12691090       rs12709883       rs12709884       rs12709885       rs12709886       rs12709887       rs12709888       rs12709889       rs12721058       rs12721060       rs12721061       rs12721062       rs12721063       rs12721072       rs12721076       rs12721104       rs12721106       rs12721107       rs12721108       rs13306207       rs28616151       rs60170431       rs61069916       rs71338739       rs74500990       rs75463753       rs111268759       rs111356234       rs111782345       rs111795665       rs111893784       rs112068040       rs112265403       rs112321936       rs112408231       rs112698600       rs112954380       rs113292373       rs113329239       rs113637966       rs113743508       rs113941762       rs114780592       rs115943687       rs116489256       rs118034179       rs118114277       rs120074114       rs138548797       rs138693236       rs138974647       rs140169122       rs140297311       rs140812055       rs141530175       rs142212854       rs143008323       rs144011332       rs144145394       rs145104396       rs145341903       rs145690472       rs145771233       rs145931717       rs146151391       rs146500837       rs147242592       rs147674610       rs148343756       rs148445956       rs148616221       rs148886031       rs150368388       rs150432637       rs150448996       rs150665000       rs150887575       rs151176577       rs151184718       rs180809422       rs180932260       rs182695610       rs183066391       rs186152230       rs186448850       rs186573950       rs187834478       rs188175781       rs188546506       rs191136761       rs192796411       rs199563828       rs199658000       rs199687805       rs199828513       rs200355132       rs200404502       rs200803089       rs201090455       rs201331307       rs201709243       rs201805075       rs202190413       rs202196766       rs367610731       rs367812198       rs368368908       rs368487465       rs368649437       rs369933487       rs370516106       rs371012807       rs371145349       rs371203977       rs371297627       rs371548125       rs372578604       rs372783963       rs373211202       rs373756895       rs374888893       rs375192208       rs375438169       rs375614714       rs375945781       rs376048961       rs376235366       rs376887357       rs527585098       rs527786250       rs527932628       rs528095754       rs528176006       rs528576295       rs529867286       rs530105873       rs533467250       rs534018174       rs534263179       rs534606011       rs534961316       rs535665191       rs535682029       rs536243786       rs537917972       rs538075577       rs539670683       rs539679765       rs539827923       rs540013556       rs540279136       rs541629318       rs541874945       rs542641865       rs543275108       rs543899554       rs544199287       rs544248196       rs544284610       rs545692408       rs545959147       rs546233268       rs547494676       rs547911169       rs549587863       rs550222346       rs551537074       rs551738733       rs552030000       rs552155927       rs552498742       rs552579712       rs553278142       rs553668736       rs555012482       rs555315266       rs555381501       rs555742271       rs555887357       rs557951378       rs558234639       rs559213909       rs559469289       rs559706335       rs560877705       rs560882440       rs561256642       rs561298361       rs562093197       rs562108646       rs562831231       rs563766111       rs564017846       rs566874952       rs567369008       rs568783061       rs569192609       rs569390765       rs569430074       rs569591876       rs571157988       rs572723052       rs573032402       rs573272829       rs573619009       rs574395822       rs575129367       rs575415067       rs575588031       rs575590958       rs577082578       rs577399292       rs577435077       rs577523360       rs745590642       rs746044444       rs746338249       rs746636795       rs746715271       rs746811445       rs747255298       rs747564547       rs748169805       rs748260064       rs748283419       rs749470744       rs750133809       rs750328283       rs750370010       rs750459826       rs751195283       rs751214954       rs751351526       rs751446774       rs751752773       rs751963712       rs752198029       rs752394160       rs752572376       rs752909963       rs753096367       rs753285305       rs753375245       rs753384481       rs753474703       rs754265092       rs754286184       rs754423238       rs755352904       rs755526225       rs755642155       rs756555901       rs756916028       rs756927594       rs757247241       rs757261220       rs757506929       rs758335932       rs758859455       rs759339514       rs759445478       rs759455284       rs759703598       rs759904322       rs759967329       rs760665826       rs760962787       rs761293041       rs761312573       rs761402543       rs761724352       rs762369098       rs762562284       rs762824970       rs763645870       rs764088242       rs764950395       rs764993276       rs764998450       rs765264605       rs765634049       rs766133260       rs766348678       rs766438817       rs766906156       rs766981254       rs767445579       rs767541073       rs767733282       rs767857359       rs767972302       rs768281386       rs768288162       rs768894898       rs769051134       rs769388854       rs769704371       rs770092327       rs770516305       rs770604206       rs770758370       rs771464520       rs771619436       rs772229584       rs773049095       rs773213329       rs773240618       rs773375440       rs773505291       rs773707513       rs773976394       rs774308856       rs774931157       rs775028847       rs775244436       rs775692039       rs776657518       rs776748082       rs776961967       rs777678252       rs777872356       rs778066288       rs778175608       rs778728968       rs779122649       rs779492201       rs779891651       rs780350789       rs780705725       rs780724569       rs781105747       rs781191811       rs781606926       rs781728790      

基因表达

基因表达

APOC2基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CAGAACCTGGACTTGTACAG
58
CAGCACAGAAAGAACTTGGT
59
TATTGGGATTTGAGGTCCAGG
60
ATTCCTTCACCTGGGTGAG
59
TATTGGGATTTGAGGTCCAGG
59
ATTCCTTCACCTGGGTGAG
59
CAGAACCTGGACTTGTACAG
58
AGCACAGAAAGAACTTGGTC
59
GAAACTCAGGGACTTGTACAG
58
AGCACAGAAAGAACTTGGTC
59
AGAAACTCAGGGACTTGTACAG
60
GCACAGAAAGAACTTGGTCAG
60
ATTGGGATTTGAGGTCCAGG
59
ATTCCTTCACCTGGGTGAG
59
ATTGGGATTTGAGGTCCAGG
60
ATTCCTTCACCTGGGTGAG
59
TTGGGATTTGAGGTCCAGG
59
ATTCCTTCACCTGGGTGAG
59
GGTATTGGGATTTGGTGAAGG
59
TCTTCTCGTACAGGTTCTGG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

APOC2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

APOC2基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0006629
A0A024R0T9(UniProtKB)
IEA
GO:0006869
A0A024R0T9(UniProtKB)
IEA
GO:0008047
A0A024R0T9(UniProtKB)
IEA
GO:0042627
A0A024R0T9(UniProtKB)
IEA
GO:0043085
A0A024R0T9(UniProtKB)
IEA
GO:0001523
P02655(UniProtKB)
TAS
GO:0005576
P02655(UniProtKB)
NAS
GO:0005576
P02655(UniProtKB)
TAS
GO:0005576
P02655(UniProtKB)
TAS
GO:0005576
P02655(UniProtKB)
TAS
GO:0005576
P02655(UniProtKB)
TAS
GO:0005576
P02655(UniProtKB)
TAS
GO:0005576
P02655(UniProtKB)
TAS
GO:0005576
P02655(UniProtKB)
TAS
GO:0005576
P02655(UniProtKB)
TAS
GO:0005615
P02655(UniProtKB)
IDA
GO:0005769
P02655(UniProtKB)
TAS
GO:0005769
P02655(UniProtKB)
TAS
GO:0005769
P02655(UniProtKB)
TAS
GO:0008289
P02655(UniProtKB)
IDA
GO:0010518
P02655(UniProtKB)
IDA
GO:0010898
P02655(UniProtKB)
IDA
GO:0010902
P02655(UniProtKB)
IC
GO:0010916
P02655(UniProtKB)
IDA
GO:0016004
P02655(UniProtKB)
IDA
GO:0016042
P02655(UniProtKB)
IEA
GO:0032375
P02655(UniProtKB)
IMP
GO:0033344
P02655(UniProtKB)
IDA
GO:0033700
P02655(UniProtKB)
IDA
GO:0034361
P02655(UniProtKB)
IDA
GO:0034362
P02655(UniProtKB)
IDA
GO:0034363
P02655(UniProtKB)
IDA
GO:0034366
P02655(UniProtKB)
IDA
GO:0034370
P02655(UniProtKB)
TAS
GO:0034371
P02655(UniProtKB)
IC
GO:0034372
P02655(UniProtKB)
TAS
GO:0034382
P02655(UniProtKB)
IDA
GO:0034384
P02655(UniProtKB)
IMP
GO:0042157
P02655(UniProtKB)
TAS
GO:0042157
P02655(UniProtKB)
TAS
GO:0042627
P02655(UniProtKB)
IDA
GO:0042632
P02655(UniProtKB)
IC
GO:0042803
P02655(UniProtKB)
IMP
GO:0043086
P02655(UniProtKB)
IEA
GO:0043274
P02655(UniProtKB)
IPI
GO:0043691
P02655(UniProtKB)
IC
GO:0045723
P02655(UniProtKB)
IDA
GO:0045833
P02655(UniProtKB)
IDA
GO:0048261
P02655(UniProtKB)
IDA
GO:0051006
P02655(UniProtKB)
IDA
GO:0051006
P02655(UniProtKB)
IDA
GO:0055102
P02655(UniProtKB)
IDA
GO:0060230
P02655(UniProtKB)
IDA
GO:0060230
P02655(UniProtKB)
IDA
GO:0060697
P02655(UniProtKB)
IDA
GO:0070062
P02655(UniProtKB)
IDA
GO:0070328
P02655(UniProtKB)
IMP
GO:0006629
Q6P163(UniProtKB)
IEA
GO:0006869
Q6P163(UniProtKB)
IEA
GO:0008047
Q6P163(UniProtKB)
IEA
GO:0042627
Q6P163(UniProtKB)
IEA
GO:0043085
Q6P163(UniProtKB)
IEA
GO:0006629
V9GYJ8(UniProtKB)
IEA
GO:0006869
V9GYJ8(UniProtKB)
IEA
GO:0008047
V9GYJ8(UniProtKB)
IEA
GO:0042627
V9GYJ8(UniProtKB)
IEA
GO:0043085
V9GYJ8(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控APOC2基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Apolipoprotein C-II Deficiency (disorder) 0.241085767 5 0 BeFree_CLINVAR_UNIPROT
Hyperlipoproteinemia Type I 0.121900093 7 0 BeFree_CTD_human
Drug Eruptions 0.12 1 0 CTD_human
Liver Neoplasms, Experimental 0.12 1 0 CTD_human
Familial apolipoprotein C-II deficiency 0.12 0 0 ORPHANET
Coronary heart disease 0.00973957 4 2 BeFree_GAD
Hypertriglyceridemia 0.007815732 3 0 GAD_LHGDN
Diabetes Mellitus, Non-Insulin-Dependent 0.007372538 3 0 BeFree_GAD
Myotonic Dystrophy 0.007057489 26 0 BeFree
Congenital Myotonic Dystrophy 0.006514605 24 0 BeFree
Hyperlipidemia 0.005005506 3 0 BeFree_GAD
Coronary Artery Disease 0.004734064 2 0 GAD
Pancreatitis 0.003181358 3 0 BeFree_GAD
Alzheimer's Disease 0.002638474 2 0 BeFree_GAD
Atherosclerosis 0.002638474 2 0 BeFree_GAD
Cardiovascular Diseases 0.002638474 2 0 BeFree_GAD
Hyperlipoproteinemia Type III 0.002638474 1 0 BeFree_GAD
Multiple Sclerosis 0.002638474 1 0 BeFree_GAD
Hepatitis C 0.002367032 1 0 GAD
Steatorrhea 0.002367032 1 0 GAD
Hypertriglyceridemia result 0.002367032 1 0 GAD
Adenomatous Polyposis Coli 0.001357209 5 0 BeFree
Pancreatitis, Chronic 0.000542884 2 0 BeFree
Adenocarcinoma 0.000271442 1 0 BeFree
Arteriosclerosis 0.000271442 1 0 BeFree
Malignant tumor of colon 0.000271442 1 0 BeFree
Down Syndrome 0.000271442 1 0 BeFree
Glioma 0.000271442 1 0 BeFree
Hypercholesterolemia, Familial 0.000271442 1 0 BeFree
Hyperlipoproteinemias 0.000271442 1 0 BeFree
Hypobetalipoproteinemias 0.000271442 1 0 BeFree
insulinoma 0.000271442 1 0 BeFree
Liver neoplasms 0.000271442 1 0 BeFree
Ovarian Carcinoma 0.000271442 1 0 BeFree
Retinoblastoma 0.000271442 1 0 BeFree
Adenocarcinoma of lung (disorder) 0.000271442 1 0 BeFree
Tumor Progression 0.000271442 1 0 BeFree
myotonic muscular dystrophy 0.000271442 1 0 BeFree
Dyslipidemias 0.000271442 1 0 BeFree
Impaired glucose tolerance 0.000271442 1 0 BeFree
Xanthoma 0.000271442 1 0 BeFree
Alzheimer Disease, Late Onset 0.000271442 1 0 BeFree
Metabolic Syndrome X 0.000271442 1 0 BeFree
Colon Carcinoma 0.000271442 1 0 BeFree
Malignant neoplasm of ovary 0.000271442 1 0 BeFree
Mild cognitive disorder 0.000271442 1 0 BeFree
Chylomicronemia syndrome 0.000271442 1 0 BeFree
Deficiency of triacylglycerol lipase 0.000271442 1 0 BeFree
Familial hypobetalipoproteinemia 0.000271442 1 0 BeFree
Liver carcinoma 0.000271442 1 0 BeFree
Familial hyperchylomicronemia syndrome 0.000271442 1 0 BeFree
Insulin resistance syndrome 0.000271442 1 0 BeFree

基因相关文献

基因相关文献

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