APOBEC3A(apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

22q13.1-q13.2
基因染色体位置图

基因简述

基因简述

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

[中文简述(自动翻译):]  此基因是胞苷脱氨酶的基因家族的一个成员。它是七相关基因或假基因的簇中发现，认为是由基因复制导致之一，对染色体22被结构和功能上相关的C向U的RNA编辑胞苷脱氨酶APOBEC1簇编码的蛋白质的成员。由该基因编码的蛋白质缺少其他家庭成员的锌结合活性。该蛋白在免疫中的作用，通过限制外源DNA的传输（如病毒）。外源DNA的限制性的一种机制是外国双链DNA胞苷到尿苷，从而导致DNA降解的脱氨。然而，其它机制也被认为参与，如抗病毒效果不依赖于脱氨酶的活性。已发现该基因编码不同亚型的两个转录变异体。 [由RefSeq的，2012年7月提供]

OMIM数据库中对APOBEC3A基因的介绍     Wikipedia数据库中对APOBEC3A基因的介绍

基因序列

基因序列

APOBEC3A基因的碱基序列：[NCBI]

基因突变

基因突变

APOBEC3A基因的碱基突变：           显示全部snp
rs1065183       rs1977066       rs1977067       rs1977068       rs1977069       rs2019896       rs2020232       rs2294363       rs3985950       rs4365560       rs4821845       rs5750717       rs6001341       rs6001342       rs7286317       rs7290153       rs7292690       rs9611054       rs9622889       rs9754448       rs11435490       rs11912424       rs12157810       rs12628403       rs17000556       rs35994173       rs55894125       rs55935155       rs57320329       rs60486763       rs61743667       rs70950554       rs73419910       rs73419917       rs74554637       rs76052763       rs76929059      
rs111768893       rs112157058       rs112255700       rs112615685       rs113201012       rs113297773       rs113723869       rs113819742       rs113909418       rs114626243       rs115345564       rs116426463       rs116576164       rs117604034       rs117767209       rs117824653       rs137881788       rs138587143       rs138829754       rs138878723       rs139514304       rs139583460       rs140052693       rs140719713       rs140765870       rs141050367       rs141191881       rs141256690       rs141261676       rs141631289       rs142024939       rs142089515       rs142410894       rs143181393       rs143569581       rs143613273       rs144004124       rs144160443       rs144293069       rs145534039       rs146292300       rs146311353       rs146939245       rs147052734       rs147803538       rs148262740       rs148268950       rs149599713       rs149708297       rs149812529       rs149972540       rs150243518       rs150568010       rs151100425       rs151104463       rs181918851       rs182044322       rs182350485       rs182427924       rs183250352       rs183724359       rs184666573       rs184902452       rs185480905       rs186042990       rs186719701       rs187551839       rs187808821       rs187811482       rs188139463       rs188336927       rs189459077       rs190305946       rs190436756       rs190898493       rs191057273       rs191157783       rs192684980       rs193155851       rs199657816       rs199670159       rs199805721       rs199853737       rs199860184       rs200049153       rs200573721       rs200623568       rs201179078       rs201260085       rs201396669       rs201468024       rs201903595       rs367569531       rs367976876       rs368272458       rs368614420       rs369486114       rs370076950       rs370149028       rs370196237       rs370466702       rs370496117       rs372061663       rs372764555       rs372925731       rs373304916       rs373365977       rs373550163       rs373904674       rs374077087       rs374350342       rs374922066       rs375240008       rs375542345       rs375631108       rs375672851       rs375717618       rs376507954       rs376709781       rs377141075       rs377238459       rs527241466       rs527403019       rs527920478       rs528405374       rs528485508       rs528602803       rs529240232       rs529511251       rs529564254       rs529648211       rs529703254       rs529719075       rs529754448       rs530607318       rs530644008       rs530837419       rs530922558       rs531468874       rs531932878       rs531942085       rs531978868       rs532014839       rs532168927       rs532296073       rs532507613       rs533160280       rs533187586       rs533198155       rs533467459       rs534312021       rs534427456       rs534466884       rs535439309       rs535595523       rs535618510       rs535717782       rs535934159       rs536113770       rs536312375       rs536349757       rs536424194       rs536911970       rs537029366       rs537516882       rs537791432       rs537826639       rs538023461       rs538494446       rs538538874       rs538739087       rs539519994       rs539719577       rs540023365       rs540307237       rs540617000       rs540777443       rs541859459       rs541909316       rs542076642       rs542353148       rs542439847       rs543024517       rs543186580       rs543346736       rs543459533       rs544013548       rs544054978       rs544332986       rs544535616       rs545173066       rs545331172       rs545659375       rs545970618       rs546451620       rs546451702       rs547075219       rs547409829       rs547636836       rs547732024       rs547859607       rs548029492       rs548312592       rs548965688       rs549413507       rs550178296       rs550413614       rs550441659       rs550679969       rs551314189       rs551609285       rs552186565       rs552638587       rs552677431       rs552817640       rs552817783       rs552929900       rs553849226       rs553883941       rs553901144       rs553901262       rs554278400       rs554961632       rs554998288       rs555204891       rs555336966       rs555363019       rs555997309       rs556104949       rs556419231       rs556454082       rs556539825       rs557821019       rs557857787       rs558074412       rs558477425       rs559320457       rs559523072       rs559595868       rs559984247       rs560058014       rs560190713       rs560264105       rs560382943       rs560713898       rs561101741       rs561148192       rs561346705       rs561920289       rs562153055       rs562352903       rs562477303       rs562637795       rs562834966       rs563004238       rs563178299       rs563506360       rs564003915       rs564151909       rs564187450       rs564342499       rs564581523       rs564816688       rs565244211       rs565358902       rs565690949       rs565853214       rs566421544       rs567022161       rs567103731       rs567109495       rs567311359       rs568201706       rs568404063       rs568612511       rs568645971       rs568731818       rs569481446       rs569544849       rs569685489       rs569721723       rs569915924       rs570600640       rs570953524       rs570995322       rs571039142       rs571063068       rs571188228       rs572102584       rs572224274       rs572694836       rs572729661       rs573497335       rs573596356       rs573694602       rs574179413       rs574341761       rs574526536       rs574659206       rs574825947       rs575422080       rs575710987       rs575918279       rs576594760       rs577212590       rs577357363       rs577772381       rs577860930       rs745376781       rs745470971       rs745506417       rs745627850       rs745757303       rs746238737       rs746328707       rs746622280       rs746781641       rs746800599       rs746848561       rs747092505       rs747958205       rs748646311       rs748814654       rs748909976       rs749085108       rs749173102       rs749426005       rs749827386       rs749941381       rs749941784       rs749960014       rs750248680       rs750512993       rs751665529       rs751819531       rs751903528       rs752263105       rs752810094       rs753101303       rs753216422       rs753529449       rs753619669       rs754053643       rs754279507       rs754491498       rs754652109       rs755185311       rs755419580       rs755695458       rs755785465       rs756267400       rs756603089       rs756712241       rs756961069       rs757093539       rs757183675       rs757405978       rs757443760       rs757872889       rs757927103       rs758034453       rs758206319       rs758387397       rs758545565       rs758799612       rs758906103       rs759462428       rs759478750       rs759748460       rs759832687       rs760148873       rs761004193       rs761073249       rs761198858       rs761316864       rs761457321       rs761765846       rs761770893       rs762034495       rs762323222       rs762851600       rs763073938       rs763180526       rs763310877       rs763545604       rs763713712       rs763803673       rs763929629       rs764187184       rs764191913       rs764679480       rs764767036       rs764951988       rs765322840       rs765427744       rs765813143       rs766027566       rs766650526       rs766706417       rs766888756       rs766912767       rs767539779       rs767629777       rs767639299       rs767725055       rs767872287       rs768116271       rs768218149       rs768538579       rs768628534       rs768983168       rs769220062       rs769302988       rs769305431       rs769498061       rs769753463       rs769811843       rs770010294       rs770958352       rs771161672       rs771368108       rs771846964       rs771865705       rs772617681       rs772953172       rs773290719       rs773629271       rs773648318       rs774349464       rs774476168       rs774811235       rs774888537       rs775358894       rs775624056       rs776056412       rs776323734       rs776770641       rs777128277       rs778430692       rs778509304       rs778598921       rs778773881       rs778880400       rs779192995       rs779665399       rs779700089       rs779826674       rs779833546       rs779942432       rs780423725       rs780760109       rs780970907       rs781448546       rs781751447      

基因表达

基因表达

APOBEC3A基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CAGGCATGGAATCTTCCCT
60
TGTATGGTGTCTTCCGCTG
60
GACACTTGATGGATCCACAC
59
AAGATTCTTAGCCTGGTTGTG
58
AATTTAAGCACTGCTGGGAC
59
TTCCCTGATTCTGGAGAATGG
60
CTTGAGCAAGTCGCAAGAG
59
TGGATCCATCAAGTGTCTGG
60
CTTGAGCAAGTCGCAAGAG
59
GTGGATCCATCAAGTGTCTG
58
AATTTAAGCACTGCTGGGAC
59
TCCCTGATTCTGGAGAATGG
59
ATTTAAGCACTGCTGGGAC
58
TCCCTGATTCTGGAGAATGG
59
ATTTAAGCACTGCTGGGAC
58
TCCCTGATTCTGGAGAATGG
59
AATTTAAGCACTGCTGGGAC
59
TCCCTGATTCTGGAGAATGG
59
CAGGCATGGAATCTTCCCT
60
TATGGTGTCTTCCGCTGTC
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

APOBEC3A基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

APOBEC3A基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004126
P31941(UniProtKB)
IDA
GO:0004126
P31941(UniProtKB)
IMP
GO:0004126
P31941(UniProtKB)
IDA
GO:0005515
P31941(UniProtKB)
IPI
GO:0005634
P31941(UniProtKB)
IDA
GO:0005634
P31941(UniProtKB)
IDA
GO:0005634
P31941(UniProtKB)
IDA
GO:0005654
P31941(UniProtKB)
IDA
GO:0005737
P31941(UniProtKB)
IDA
GO:0005737
P31941(UniProtKB)
IDA
GO:0005737
P31941(UniProtKB)
IDA
GO:0005737
P31941(UniProtKB)
IDA
GO:0008270
P31941(UniProtKB)
IEA
GO:0009972
P31941(UniProtKB)
IEA
GO:0010529
P31941(UniProtKB)
IDA
GO:0010529
P31941(UniProtKB)
IDA
GO:0010529
P31941(UniProtKB)
IDA
GO:0044356
P31941(UniProtKB)
IDA
GO:0045071
P31941(UniProtKB)
IDA
GO:0045087
P31941(UniProtKB)
IDA
GO:0047844
P31941(UniProtKB)
IMP
GO:0051607
P31941(UniProtKB)
IDA
GO:0051607
P31941(UniProtKB)
IDA
GO:0070383
P31941(UniProtKB)
IDA
GO:0070383
P31941(UniProtKB)
IMP
GO:0070383
P31941(UniProtKB)
IDA
GO:0071466
P31941(UniProtKB)
IDA
GO:0080111
P31941(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控APOBEC3A基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Mammary Neoplasms 0.12 1 0 CTD_human
Juvenile arthritis 0.12 1 0 CTD_human
HIV Infections 0.001085767 4 0 BeFree
Malignant neoplasm of breast 0.000542884 2 0 BeFree
Breast Carcinoma 0.000542884 2 0 BeFree
Malignant neoplasm of skin 0.000271442 1 0 BeFree
Glioblastoma 0.000271442 1 0 BeFree
Glioma 0.000271442 1 0 BeFree
Psychotic Disorders 0.000271442 1 0 BeFree
Lentivirus Infections 0.000271442 1 0 BeFree
Liver and Intrahepatic Biliary Tract Carcinoma 0.000271442 1 0 BeFree
Malignant neoplasm of liver 0.000271442 1 0 BeFree
Nonorganic psychosis 0.000271442 1 0 BeFree
ovarian neoplasm 0.000271442 1 0 BeFree

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基因相关文献

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基因相关服务

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