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Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  经常发生在自发水解DNA分子嘌呤/嘧啶(AP)位点,通过DNA损伤剂或通过DNA糖基化酶的删除特定的异常基地。 AP位点是预先诱变病变,会影响正常的DNA复制使单元格中包含系统可以发现并修复这些网站。 II级的AP核酸内切酶切割磷酸二酯骨架的5‘到AP位点。该基因编码在人类细胞中的主要的AP核酸内切酶。剪接变异体已经发现了这种基因;都编码相同的蛋白质。 [由RefSeq的,2008年7月提供]
APEX1基因(以及对应的蛋白质)的细胞分布位置:
APEX1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Seizures | 0.2 | 2 | 0 | CTD_human_RGD |
| melanoma | 0.133907006 | 8 | 0 | BeFree_CTD_human_GAD_LHGDN |
| Stomach Neoplasms | 0.127101096 | 4 | 0 | CTD_human_GAD |
| Liver carcinoma | 0.124895885 | 8 | 0 | BeFree_CTD_human_LHGDN |
| Heart Diseases | 0.12 | 1 | 0 | CTD_human |
| Prostatic Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Disease Progression | 0.12 | 1 | 0 | CTD_human |
| Micronuclei, Chromosome-Defective | 0.12 | 1 | 0 | CTD_human |
| Brain Ischemia | 0.08 | 1 | 0 | RGD |
| Lung diseases | 0.08 | 1 | 0 | RGD |
| Myocardial Reperfusion Injury | 0.08 | 1 | 0 | RGD |
| Reperfusion Injury | 0.08 | 1 | 0 | RGD |
| Status Epilepticus | 0.08 | 1 | 0 | RGD |
| Cerebral Hemorrhage | 0.08 | 1 | 0 | RGD |
| Malignant neoplasm of lung | 0.048925684 | 40 | 6 | BeFree_GAD |
| Malignant neoplasm of urinary bladder | 0.027937445 | 14 | 4 | BeFree_GAD |
| Malignant neoplasm of breast | 0.018816704 | 20 | 8 | BeFree_GAD |
| Glioma | 0.014264324 | 9 | 0 | BeFree_GAD_LHGDN |
| Colorectal Cancer | 0.011911105 | 11 | 4 | BeFree_GAD |
| leukemia | 0.011268532 | 7 | 0 | BeFree_GAD_LHGDN |
| Lung Neoplasms | 0.011168843 | 5 | 0 | BeFree_LHGDN |
| DNA Damage | 0.009468128 | 4 | 0 | GAD |
| Carcinoma of lung | 0.00868614 | 32 | 6 | BeFree |
| Mammary Neoplasms | 0.008173051 | 3 | 0 | LHGDN |
| Adenocarcinoma | 0.008001298 | 5 | 1 | BeFree_GAD_LHGDN |
| Cerebrovascular accident | 0.008001298 | 2 | 0 | BeFree_GAD_LHGDN |
| Colorectal Neoplasms | 0.007815732 | 3 | 0 | GAD_LHGDN |
| Malignant neoplasm of prostate | 0.006634157 | 8 | 1 | BeFree_GAD |
| Malignant neoplasm of pancreas | 0.006091273 | 6 | 0 | BeFree_GAD |
| Myocardial Infarction | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
| Uterine Cervical Neoplasm | 0.005091382 | 1 | 0 | GAD_LHGDN |
| Thyroid Neoplasm | 0.005091382 | 1 | 0 | GAD_LHGDN |
| Brain Neoplasms | 0.005005506 | 3 | 0 | BeFree_GAD |
| Esophageal Neoplasms | 0.005005506 | 3 | 0 | BeFree_GAD |
| Breast Carcinoma | 0.004885954 | 18 | 8 | BeFree |
| Skin Neoplasms | 0.004734064 | 2 | 0 | GAD |
| Osteosarcoma | 0.004624443 | 7 | 0 | BeFree_LHGDN |
| Amyotrophic Lateral Sclerosis | 0.00408156 | 5 | 1 | BeFree_LHGDN |
| Neoplasm Metastasis | 0.00408156 | 6 | 0 | BeFree_LHGDN |
| Multiple Myeloma | 0.003810118 | 4 | 0 | BeFree_LHGDN |
| Non-Small Cell Lung Carcinoma | 0.003800186 | 14 | 15 | BeFree |
| Alveolar rhabdomyosarcoma | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| ovarian neoplasm | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Carcinogenesis | 0.002985861 | 11 | 1 | BeFree |
| Endometriosis | 0.002909916 | 2 | 1 | BeFree_GAD |
| Cancer of Head and Neck | 0.002909916 | 3 | 2 | BeFree_GAD |
| Cervix carcinoma | 0.002909916 | 3 | 0 | BeFree_GAD |
| Cockayne Syndrome | 0.00272435 | 1 | 0 | LHGDN |
| Hyperplasia | 0.00272435 | 1 | 0 | LHGDN |
| Pancreatic Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Rhabdomyosarcoma, Embryonal | 0.00272435 | 1 | 0 | LHGDN |
| Infection | 0.00272435 | 1 | 0 | LHGDN |
| Colorectal Carcinoma | 0.002714419 | 10 | 4 | BeFree |
| Alzheimer's Disease | 0.002638474 | 2 | 0 | BeFree_GAD |
| Kidney Diseases | 0.002638474 | 2 | 0 | BeFree_GAD |
| Pterygium | 0.002638474 | 1 | 0 | BeFree_GAD |
| Malignant neoplasm of stomach | 0.002442977 | 9 | 10 | BeFree |
| Stomach Carcinoma | 0.002442977 | 9 | 10 | BeFree |
| Biliary Tract Neoplasm | 0.002367032 | 1 | 0 | GAD |
| Chromosome Aberrations | 0.002367032 | 1 | 0 | GAD |
| Graft-vs-Host Disease | 0.002367032 | 1 | 0 | GAD |
| Head and Neck Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Laryngeal neoplasm | 0.002367032 | 1 | 0 | GAD |
| Myeloid Leukemia | 0.002367032 | 1 | 0 | GAD |
| Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
| Lymphatic Metastasis | 0.002367032 | 1 | 0 | GAD |
| Lymphoma, Follicular | 0.002367032 | 1 | 0 | GAD |
| Meningeal Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Meningioma | 0.002367032 | 1 | 0 | GAD |
| Mouth Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Multiple Sclerosis | 0.002367032 | 1 | 0 | GAD |
| Neural Tube Defects | 0.002367032 | 1 | 0 | GAD |
| Acoustic Neuroma | 0.002367032 | 1 | 0 | GAD |
| Pharyngeal Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Adenomatous Polyposis Coli | 0.002367032 | 1 | 0 | GAD |
| Pre-Eclampsia | 0.002367032 | 1 | 0 | GAD |
| Precancerous Conditions | 0.002367032 | 1 | 0 | GAD |
| Helicobacter Infections | 0.002367032 | 1 | 0 | GAD |
| Diffuse Large B-Cell Lymphoma | 0.002367032 | 1 | 0 | GAD |
| Arsenic Poisoning | 0.002367032 | 1 | 0 | GAD |
| Hematologic Neoplasms | 0.002367032 | 1 | 0 | GAD |
| subcutaneous fibrosis | 0.002367032 | 1 | 0 | GAD |
| Epithelial ovarian cancer | 0.002367032 | 1 | 0 | GAD |
| Papillomavirus Infections | 0.002367032 | 1 | 0 | GAD |
| Osteosarcoma of bone | 0.001900093 | 7 | 0 | BeFree |
| Prostate carcinoma | 0.001900093 | 7 | 1 | BeFree |
| Carcinoma of bladder | 0.001900093 | 7 | 4 | BeFree |
| Adenocarcinoma of lung (disorder) | 0.001357209 | 5 | 2 | BeFree |
| Pancreatic carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Helicobacter pylori infection | 0.001357209 | 5 | 0 | BeFree |
| Ovarian Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Malignant tumor of colon | 0.000814326 | 3 | 2 | BeFree |
| Malignant neoplasm of endometrium | 0.000814326 | 3 | 7 | BeFree |
| HIV Infections | 0.000814326 | 3 | 0 | BeFree |
| Huntington Disease | 0.000814326 | 3 | 0 | BeFree |
| Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.000814326 | 3 | 0 | BeFree |
| Endometrial Carcinoma | 0.000814326 | 3 | 7 | BeFree |
| Colon Carcinoma | 0.000814326 | 3 | 2 | BeFree |
| Malignant neoplasm of ovary | 0.000814326 | 3 | 0 | BeFree |
| Squamous cell carcinoma of the head and neck | 0.000814326 | 3 | 0 | BeFree |
| Tumor Angiogenesis | 0.000814326 | 3 | 0 | BeFree |
| Uterine Corpus Cancer | 0.000814326 | 3 | 7 | BeFree |
| Adenoma | 0.000542884 | 2 | 0 | BeFree |
| Squamous cell carcinoma | 0.000542884 | 2 | 1 | BeFree |
| Malignant tumor of cervix | 0.000542884 | 2 | 0 | BeFree |
| Ulcerative Colitis | 0.000542884 | 2 | 0 | BeFree |
| Glioblastoma | 0.000542884 | 2 | 0 | BeFree |
| Leptospirosis | 0.000542884 | 2 | 0 | BeFree |
| Pneumonia | 0.000542884 | 2 | 0 | BeFree |
| Retinoblastoma | 0.000542884 | 2 | 0 | BeFree |
| Meningitis, Bacterial | 0.000542884 | 2 | 2 | BeFree |
| Essential Hypertension | 0.000542884 | 2 | 0 | BeFree |
| Cutaneous Melanoma | 0.000542884 | 2 | 0 | BeFree |
| Xeroderma Pigmentosum, Complementation Group D | 0.000542884 | 2 | 0 | BeFree |
| Solid tumour | 0.000542884 | 2 | 0 | BeFree |
| Glaucoma, Primary Open Angle | 0.000542884 | 2 | 1 | BeFree |
| Biliary Tract Cancer | 0.000542884 | 2 | 0 | BeFree |
| Xenograft Model | 0.000542884 | 2 | 0 | BeFree |
| Pneumonitis | 0.000542884 | 2 | 0 | BeFree |
| AIDS related complex | 0.000271442 | 1 | 0 | BeFree |
| Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
| Atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
| Female Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Primary biliary cirrhosis | 0.000271442 | 1 | 0 | BeFree |
| Coronary heart disease | 0.000271442 | 1 | 0 | BeFree |
| Muscular Dystrophy, Duchenne | 0.000271442 | 1 | 0 | BeFree |
| Epilepsy, Temporal Lobe | 0.000271442 | 1 | 0 | BeFree |
| Gastritis | 0.000271442 | 1 | 0 | BeFree |
| Hodgkin Disease | 0.000271442 | 1 | 0 | BeFree |
| Hypertensive disease | 0.000271442 | 1 | 0 | BeFree |
| Male infertility | 0.000271442 | 1 | 0 | BeFree |
| Keratosis | 0.000271442 | 1 | 6 | BeFree |
| Fibroid Tumor | 0.000271442 | 1 | 0 | BeFree |
| leiomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
| Liver diseases | 0.000271442 | 1 | 0 | BeFree |
| Melanosis | 0.000271442 | 1 | 6 | BeFree |
| Meningitis | 0.000271442 | 1 | 2 | BeFree |
| Aseptic Meningitis | 0.000271442 | 1 | 0 | BeFree |
| Osteoporosis | 0.000271442 | 1 | 0 | BeFree |
| Seminoma | 0.000271442 | 1 | 0 | BeFree |
| Age-related cataract | 0.000271442 | 1 | 0 | BeFree |
| Hereditary spherocytosis | 0.000271442 | 1 | 0 | BeFree |
| Trisomy | 0.000271442 | 1 | 0 | BeFree |
| Uterine Fibroids | 0.000271442 | 1 | 0 | BeFree |
| Vitiligo | 0.000271442 | 1 | 0 | BeFree |
| Cataract | 0.000271442 | 1 | 0 | BeFree |
| Gastric adenoma | 0.000271442 | 1 | 0 | BeFree |
| Migraine Disorders | 0.000271442 | 1 | 0 | BeFree |
| Esophageal carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of testis | 0.000271442 | 1 | 0 | BeFree |
| Smith-Lemli-Opitz Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Germ cell tumor | 0.000271442 | 1 | 0 | BeFree |
| Smooth Muscle Tumor | 0.000271442 | 1 | 0 | BeFree |
| Melanosis coli | 0.000271442 | 1 | 6 | BeFree |
| Malignant neoplasm of female breast | 0.000271442 | 1 | 0 | BeFree |
| Pick Disease of the Brain | 0.000271442 | 1 | 0 | BeFree |
| Parkinsonian Disorders | 0.000271442 | 1 | 0 | BeFree |
| Gastric Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant Childhood Neoplasm | 0.000271442 | 1 | 1 | BeFree |
| Intraocular retinoblastoma | 0.000271442 | 1 | 0 | BeFree |
| Liver and Intrahepatic Biliary Tract Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma of esophagus | 0.000271442 | 1 | 0 | BeFree |
| Teratoma, Malignant | 0.000271442 | 1 | 0 | BeFree |
| Frontotemporal dementia | 0.000271442 | 1 | 0 | BeFree |
| Amnesia, Transient Global | 0.000271442 | 1 | 0 | BeFree |
| Ocular albinism, type I | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
| Familial aplasia of the vermis | 0.000271442 | 1 | 1 | BeFree |
| Overweight | 0.000271442 | 1 | 0 | BeFree |
| Neurodegenerative Disorders | 0.000271442 | 1 | 0 | BeFree |
| Environmental Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of esophagus | 0.000271442 | 1 | 0 | BeFree |
| Intraocular pressure disorder | 0.000271442 | 1 | 0 | BeFree |
| Hyperhomocysteinemia | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of gastrointestinal tract | 0.000271442 | 1 | 1 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
| Testicular malignant germ cell tumor | 0.000271442 | 1 | 0 | BeFree |
| Hyperkeratosis | 0.000271442 | 1 | 6 | BeFree |
| Carcinoma, Pancreatic Ductal | 0.000271442 | 1 | 0 | BeFree |
| Adenoma of large intestine | 0.000271442 | 1 | 0 | BeFree |
| Pediatric Intraocular Retinoblastoma | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Differentiated Thyroid Gland Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Hepatocarcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Tumor Promotion | 0.000271442 | 1 | 0 | BeFree |
| Rash and Dermatitis Adverse Event Associated with Chemoradiation | 0.000271442 | 1 | 7 | BeFree |
| VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | 0.000271442 | 1 | 0 | BeFree |
| Amyotrophic Lateral Sclerosis, Sporadic | 0.000271442 | 1 | 1 | BeFree |
| SPHEROCYTOSIS, TYPE 1 (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Early-Stage Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Homocysteinemia | 0.000271442 | 1 | 0 | BeFree |
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