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Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  Adaptins是网格蛋白包被的小泡从质膜或从反面高尔基网到溶酶体运输配体 - 受体复合物的重要组成部分。蛋白质的adaptin系列由四个班命名为α,β-,β初免和伽玛adaptins分子的。 Adaptins,中等和小亚基一起形成异四聚体复合物称为适配器,其作用是促进网格蛋白小窝和囊泡的形成。由该基因编码的蛋白质是γ - adaptin蛋白和它所属的适配器配合物大亚基家族。已发现该基因编码不同亚型的两个转录变异体。 [由RefSeq的,2008年7月提供]
AP1G1基因(以及对应的蛋白质)的细胞分布位置:
AP1G1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Hepatitis B | 0.00272435 | 1 | 0 | LHGDN |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
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